Molecular and Cellular Biology PhD Programme (4 Year PhD)

Project Details

StatusFinished
Effective start/end date2/09/13 → 1/09/17

Funding

  • Wellcome Trust (102398/Z/13/Z): £151,392.00
  • Wellcome Trust (102398/Z/13/Z): £151,392.00
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Research Output

RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response

Frost, J., Ciulli, A. & Rocha, S., 29 Jan 2019, In : Wellcome Open Research. 4, p. 1-17 17 p., 17.

Research output: Contribution to journal › Article

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    • 117 Downloads (Pure)

    Group-based optimization of potent and cell-active inhibitors of the von Hippel-Lindau (VHL) E3 ubiquitin ligase: structure-activity relationships leading to the chemical probe (2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

    Soares, P., Gadd, M., Frost, J., Galdeano, C., Ellis, L., Epemolu, R., Rocha, S., Read, K. & Ciulli, A., 2018, In : Journal of Medicinal Chemistry. 61, p. 599-618 19 p.

    Research output: Contribution to journal › Article

    Open Access
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    • 29 Citations (Scopus)
    141 Downloads (Pure)