Molecular and Cellular Biology PhD Programme (4 Year PhD)

Owen-Hughes, Tom (Investigator)

Gene Regulation and Expression

Status	Finished
Effective start/end date	2/09/13 → 1/09/17

Funding

Wellcome Trust (102398/Z/13/Z): £151,392.00
Wellcome Trust (102398/Z/13/Z): £151,392.00

3 Article

Von Hippel-Lindau (VHL) small molecule inhibitor binding increases stability and intracellular levels of VHL protein
Frost, J., Rocha, S. & Ciulli, A., Aug 2021, In: Journal of Biological Chemistry. 297, 2, 12 p., 100910.
Research output: Contribution to journal › Article › peer-review

Open Access
File
1 Citation (Scopus)

10 Downloads (Pure)
RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response
Frost, J., Ciulli, A. & Rocha, S., 29 Jan 2019, In: Wellcome Open Research. 4, p. 1-17 17 p., 17.
Research output: Contribution to journal › Article › peer-review

File
8 Citations (Scopus)

139 Downloads (Pure)
Group-based optimization of potent and cell-active inhibitors of the von Hippel-Lindau (VHL) E3 ubiquitin ligase: structure-activity relationships leading to the chemical probe (2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)
Soares, P., Gadd, M., Frost, J., Galdeano, C., Ellis, L., Epemolu, R., Rocha, S., Read, K. & Ciulli, A., 25 Jan 2018, In: Journal of Medicinal Chemistry. 61, p. 599-618 19 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
67 Citations (Scopus)

203 Downloads (Pure)