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Molecular and Cellular Biology PhD Programme (4 Year PhD)
Owen-Hughes, Tom
(Investigator)
Gene Regulation and Expression
Overview
Fingerprint
Research Outputs
(3)
Project Details
Status
Finished
Effective start/end date
2/09/13
→
1/09/17
Funding
Wellcome Trust
(102398/Z/13/Z):
£151,392.00
Wellcome Trust
(102398/Z/13/Z):
£151,392.00
View all
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Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
VH298
Medicine & Life Sciences
100%
Hypoxia
Medicine & Life Sciences
57%
Prolyl Hydroxylases
Medicine & Life Sciences
45%
RNA Sequencing
Chemical Compounds
40%
pyrrolidine
Medicine & Life Sciences
37%
Ubiquitin-Protein Ligases
Medicine & Life Sciences
36%
Pharmacologic Agent
Chemical Compounds
35%
Proteolysis
Medicine & Life Sciences
30%
Research output
Research output per year
2018
2018
2019
2021
2021
3
Article
Research output per year
Research output per year
Von Hippel-Lindau (VHL) small molecule inhibitor binding increases stability and intracellular levels of VHL protein
Frost, J.
,
Rocha, S.
&
Ciulli, A.
,
Aug 2021
,
In:
Journal of Biological Chemistry.
297
,
2
,
12 p.
, 100910.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
VH298
100%
Hypoxia
50%
Von Hippel-Lindau Tumor Suppressor Protein
37%
Prolyl Hydroxylases
29%
von Hippel-Lindau Disease
29%
1
Citation (Scopus)
10
Downloads (Pure)
RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response
Frost, J.
,
Ciulli, A.
&
Rocha, S.
,
29 Jan 2019
,
In:
Wellcome Open Research.
4
,
p. 1-17
17 p.
, 17.
Research output
:
Contribution to journal
›
Article
›
peer-review
File
RNA Sequencing
100%
Pharmacologic Agent
87%
Prolyl Hydroxylases
84%
Chemical Agent
75%
RNA-Seq
70%
8
Citations (Scopus)
139
Downloads (Pure)
Group-based optimization of potent and cell-active inhibitors of the von Hippel-Lindau (VHL) E3 ubiquitin ligase: structure-activity relationships leading to the chemical probe (2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)
Soares, P.
,
Gadd, M.
,
Frost, J.
,
Galdeano, C.
,
Ellis, L.
,
Epemolu, R.
,
Rocha, S.
,
Read, K.
&
Ciulli, A.
,
25 Jan 2018
,
In:
Journal of Medicinal Chemistry.
61
,
p. 599-618
19 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
VH298
100%
pyrrolidine
66%
Structure-Activity Relationship
50%
Ubiquitin-Protein Ligases
48%
Protein Hydrolysis
46%
67
Citations (Scopus)
203
Downloads (Pure)