Keyphrases
Von Hippel-Lindau
100%
VH298
45%
Hypoxia-inducible Factor
35%
Stability Level
33%
Pyrrolidine-2
33%
Von Hippel-Lindau Disease
33%
Hypoxia Response
33%
E3 Ubiquitin Ligase
33%
Group-based
33%
Benzyl
33%
Prolyl Hydroxylase
33%
Carboxamide
33%
Structure-activity Relationship
33%
Inhibitor Binding
33%
RNA-seq Analysis
33%
Small Molecule Inhibitors
33%
Chemical Probes
33%
Intracellular Level
33%
Hypoxia
25%
Prolyl Hydroxylase Inhibitor
20%
Transcriptional Response
20%
Gene Activation
13%
IOX2
12%
Proteolysis Targeting chimera (PROTAC)
11%
Transcription Factor
9%
Hypoxia-inducible
8%
Ubiquitination
6%
Anemia
6%
Clinical Trial Phases
6%
FG-4592
6%
Quantitative PCR
6%
RNA Sequencing (RNA-seq)
6%
Gene Transcription
6%
Cellular Response
6%
Pharmacological Agents
6%
Chemical Agents
6%
Gene Repression
6%
Hypoxia Signaling
6%
HeLa Cells
6%
Biochemistry, Genetics and Molecular Biology
Procollagen-Proline Dioxygenase
66%
Hypoxia-Inducible Factors
66%
Protein Catabolism
55%
Ubiquitination
44%
Tumor Suppressor Protein
44%
Ligase
44%
Transcription Factors
41%
Proteome
33%
Enzyme Inhibitor
33%
Von Hippel-Lindau Disease
33%
Oxygen Sensing
33%
RNA Sequencing
33%
Proteomics
33%
Mitochondrial Disease
33%
Structure Activity Relation
33%
Isoform
33%
Ubiquitin-Conjugating Enzyme
33%
Small Molecule
33%
Gene Activation
16%
Protein-Protein Interaction
11%
Hypoxia Inducible Factor 1
11%
Dissociation Constant
11%
Gene Repression
8%
Signal Transduction
8%
RNA Sequence
8%
Quantitative Reverse Transcription Polymerase Chain Reaction
8%
Genetic Transcription
8%
Clinical Trial
8%
Pharmacology, Toxicology and Pharmaceutical Science
Ubiquitin Protein Ligase E3
33%
Carboxamide
33%
Pyrrolidine Derivative
33%
Structure Activity Relationship
33%
Hypoxia Inducible Factor
33%
Von Hippel Lindau Protein
33%
Hypoxia
33%
Anemia
17%
Ligase
17%
Tumor Suppressor Protein
17%
Ischemia
11%
Hypoxia Inducible Factor 1
11%
Disorders of Mitochondrial Functions
6%
Therapeutic Use
6%
Procollagen Proline 2 Oxoglutarate 4 Dioxygenase
6%
Von Hippel Lindau Disease
6%
Enzyme Inhibitor
6%
Transcription Factors
6%
Side Effect
6%