Molecular and Pharmacological Characterisation of Pathways Which Determine the Sensitivity of Cells to Anti-Cancer Drugs and Chemopreventive Agents

Project Details

StatusFinished
Effective start/end date1/07/141/05/16

Funding

  • Cancer Research UK (C4639/A10822): £643,447.00
  • Cancer Research UK (A10822): £133,109.00
  • Cancer Research UK (C4639/A22357): £54,144.37
  • Cancer Research UK (C4639/A15709): £58,051.00

Research Output

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials

Henderson, C. J., Kapelyukh, Y., Scheer, N., Rode, A., McLaren, A., MacLeod, K., Lin, D., Wright, J., Stanley, L. A. & Wolf, C. R., Jun 2019, In : Drug Metabolism and Disposition. 47, 6, p. 601-615 15 p.

Research output: Contribution to journalArticle

Open Access
File
  • 2 Citations (Scopus)
    78 Downloads (Pure)

    Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

    Reed, L., Indra, R., Mrizova, I., Moserova, M., Schmeiser, H. H., Wolf, C. R., Henderson, C. J., Stiborova, M., Phillips, D. H. & Arlt, V. M., 1 Mar 2019, In : Toxicology and Applied Pharmacology. 366, p. 64-74 11 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 1 Citation (Scopus)
    120 Downloads (Pure)
    Open Access
    File
  • 2 Citations (Scopus)
    6 Downloads (Pure)