Research output per year
Research output per year
Research output
- 9 Article
Search results
-
2023
Improving the predictive power of xenograft and syngeneic anti-tumour studies using mice humanised for pathways of drug metabolism
Henderson, C. J., McLaren, A. W., Kapelyukh, Y. & Wolf, C. R. (Lead / Corresponding author), 27 Mar 2023, In: F1000 Research. 11, 15 p., 1081.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)76 Downloads (Pure) -
2020
The pyrrolizidine alkaloid senecionine induces CYP-dependent destruction of sinusoidal endothelial cells and cholestasis in mice
Hessel-Pras, S. (Lead / Corresponding author), Braeuning, A., Guenther, G., Adawy, A., Enge, A.-M., Ebmeyer, J., Henderson, C. J., Hengstler, J. G., Lampen, A. & Reif, R., Jan 2020, In: Archives of Toxicology. 94, 1, p. 219-229 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile40 Citations (Scopus)377 Downloads (Pure) -
2019
An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials
Henderson, C. J., Kapelyukh, Y., Scheer, N., Rode, A., McLaren, A., MacLeod, K., Lin, D., Wright, J., Stanley, L. A. & Wolf, C. R. (Lead / Corresponding author), Jun 2019, In: Drug Metabolism and Disposition. 47, 6, p. 601-615 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)269 Downloads (Pure) -
Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine
Reed, L., Indra, R., Mrizova, I., Moserova, M., Schmeiser, H. H., Wolf, C. R., Henderson, C. J., Stiborova, M., Phillips, D. H. & Arlt, V. M. (Lead / Corresponding author), 1 Mar 2019, In: Toxicology and Applied Pharmacology. 366, p. 64-74 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)197 Downloads (Pure) -
Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice
Kapelyukh, Y., Henderson, C. J., Scheer, N., Rode, A. & Wolf, R. (Lead / Corresponding author), 1 Aug 2019, In: Drug Metabolism and Disposition. 47, 8, p. 907-918 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Citations (Scopus)192 Downloads (Pure) -
Drug-induced chromatin accessibility changes associate with sensitivity to liver tumor promotion
Vitobello, A., Perner, J., Beil, J., Zhu, J., Del Río-Espínola, A., Morawiec, L., Westphal, M., Dubost, V., Altorfer, M., Naumann, U., Mueller, A., Kapur, K., Borowsky, M., Henderson, C., Wolf, C. R., Schwarz, M., Moggs, J. & Terranova, R. (Lead / Corresponding author), Oct 2019, In: Life Science Alliance. 2, 5, 18 p., e201900461.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)192 Downloads (Pure) -
2018
Identification of novel pathways of osimertinib disposition and potential implications for the outcome of lung cancer therapy
MacLeod, A. K., Lin, D., Huang, J.T.-J., McLaughlin, L. A., Henderson, C. J. & Wolf, C. R. (Lead / Corresponding author), May 2018, In: Clinical Cancer Research. 24, 9, p. 2138-2147 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)243 Downloads (Pure) -
Measuring in vivo responses to endogenous and exogenous oxidative stress using a novel haem oxygenase 1 reporter mouse
McMahon, M., Ding, S., Acosta-Jimenez, L. P., Frangova, T. G., Henderson, C. J. & Wolf, C. R. (Lead / Corresponding author), 1 Jan 2018, In: Journal of Physiology. 596, 1, p. 105-127 23 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)207 Downloads (Pure) -
2015
Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability
Henderson, C. J., McLaughlin, L. A., Osuna-Cabello, M., Taylor, M., Gilbert, I., McLaren, A. W. & Wolf, C. R. (Lead / Corresponding author), Feb 2015, In: Biochemical Journal. 465, 3, p. 479-488 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)100 Downloads (Pure)