Molecular Mechanisms in Atopic Skin (Senior Research Fellowship in Clinical Science)

Research output

Research output per year 2015 2017 2019 2020 2021 2023

• 12 Article
• 4 Letter
• 2 Comment/debate
• 2 Editorial
• 2 More
  • 2 Review article

Research output per year

Research output per year

Search results

• 2023

  Emollients for prevention of atopic dermatitis: 5-year findings from the BEEP randomized trial

  Bradshaw, L. E., Wyatt, L. A., Brown, S. J., Haines, R. H., Montgomery, A. A., Perkin, M. R., Lawton, S., Sach, T. H., Chalmers, J. R., Ridd, M. J., Flohr, C., Brooks, J., Swinden, R., Mitchell, E. J., Tarr, S., Jay, N., Thomas, K. S., Allen, H., Cork, M. J., Kelleher, M. M., & 5 othersSimpson, E. L., Lartey, S. T., Davies-Jones, S., Boyle, R. J. & Williams, H. C., Apr 2023, In: Allergy. 78, 4, p. 995-1006 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dermatitis, Atopic, 5 100%
  • Emollients 76%
  • Atopic Dermatitis 37%
  • Food Hypersensitivity 20%
  • Skin Care 15%
  5 Citations (Scopus)

  79 Downloads (Pure)
• 2021

  Assessment of a causal relationship between body mass index and atopic dermatitis

  Budu-Aggrey, A., Watkins, S. H., Brumpton, B., Løset, M., Tyrrell, J., Modalsli, E. H., Vie, G. Å., Palmer, T., Fritsche, L. G., Nielsen, J. B., Romundstad, P. R., Davey Smith, G., Åsvold, B. O., Paternoster, L. & Brown, S. J., 1 Jan 2021, In: Journal of Allergy and Clinical Immunology. 147, 1, p. 400-403 4 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

  File
  12 Citations (Scopus)

  93 Downloads (Pure)

• Priority research questions in atopic dermatitis: An International Eczema Council eDelphi consensus

  Abuabara, K., Nicholls, S. G., Langan, S. M., Guttman-Yassky, E., Reynolds, N. J., Paller, A. S., Brown, S. J. & International Eczema Council Priority Research Group, Jul 2021, In: British Journal of Dermatology. 185, 1, p. 203-205 3 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

  File

  • Eczema 100%
  • Atopic Dermatitis 90%
  • Patient Care 67%
  • Therapeutics 7%
  3 Citations (Scopus)

  44 Downloads (Pure)

• Translational genetics: a challenging but important path

  Brown, S. J., 4 May 2021, In: British Journal of Dermatology. 184, 5, p. 800-801 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  File
  67 Downloads (Pure)

• What have we learned from GWAS for atopic dermatitis?

  Brown, S. J., Jan 2021, In: Journal of Investigative Dermatology. 141, 1, p. 19-22 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Atopic Dermatitis 100%
  • Genome-Wide Association Study 99%
  • Intergenic DNA 30%
  • Autoimmunity 23%
  • Inflammation 14%
  13 Citations (Scopus)

  93 Downloads (Pure)
• 2020

  Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial

  Chalmers, J. R., Haines, R. H., Bradshaw, L. E., Montgomery, A. A., Thomas, K. S., Brown, S. J., Ridd, M. J., Lawton, S., Simpson, E. L., Cork, M. J., Sach, T. H., Flohr, C., Mitchell, E. J., Swinden, R., Tarr, S., Davies-Jones, S., Jay, N., Kelleher, M. M., Perkin, M. R., Boyle, R. J., & 1 othersWilliams, H. C., 21 Mar 2020, In: Lancet. 395, 10228, p. 962-972 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Emollients 100%
  • Eczema 80%
  • Randomized Controlled Trials 46%
  • Skin Care 18%
  • Doublebase 16%
  145 Citations (Scopus)

  54 Downloads (Pure)

• Genetics in Atopic Dermatitis: Historical Perspective and Future Prospects

  Brown, S. J., Elias, M. S. & Bradley, M., 9 Jun 2020, In: Acta Dermato-Venereologica. 100, 100-year theme: Atopic dermatitis, p. 349-357 9 p., adv00163.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Atopic Dermatitis 100%
  • Skin 31%
  • filaggrin 27%
  • Molecular Models 24%
  • Genetic Research 24%
  15 Citations (Scopus)

  140 Downloads (Pure)

• What is the evidence for interactions between filaggrin null mutations and environmental exposures in the aetiology of atopic dermatitis? A systematic review

  Blakeway, H., Van-de-Velde, V., Allen, V. B., Kravvas, G., Palla, L., Page, M. J., Flohr, C., Weller, R. B., Irvine, A. D., McPherson, T., Roberts, A., Williams, H. C., Reynolds, N., Brown, S. J., Paternoster, L. & Langan, S. M., Sept 2020, In: British Journal of Dermatology. 183, 3, p. 1-9 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • filaggrin 100%
  • Loss of Function Mutation 78%
  • Environmental Exposure 75%
  • Atopic Dermatitis 72%
  • Systematic Reviews 51%
  17 Citations (Scopus)

  67 Downloads (Pure)
• 2019

  Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study

  Budu-Aggrey, A., Brumpton, B., Tyrrell, J., Watkins, S., Modalsli, E. H., Celis-Morales, C., Ferguson, L. D., Vie, G. Å., Palmer, T., Fritsche, L. G., Løset, M., Nielsen, J. B., Zhou, W., Tsoi, L. C., Wood, A. R., Jones, S. E., Beaumont, R., Saunes, M., Romundstad, P. R., Siebert, S., & 8 othersMcInnes, I. B., Elder, J. T., Davey Smith, G., Frayling, T. M., Åsvold, B. O., Brown, S. J., Sattar, N. & Paternoster, L., 31 Jan 2019, In: PLoS Medicine. 16, 1, p. 1-18 18 p., e1002739.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Psoriasis 100%
  • Random Allocation 99%
  • Body Mass Index 72%
  • Mendelian Randomization Analysis 20%
  • Skin Diseases 12%
  117 Citations (Scopus)

  191 Downloads (Pure)

• Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid model

  Elias, M. S., Wright, S. C., Nicholson, W. V., Morrison, K. D., Prescott, A. R., Ten Have, S., Whitfield, P. D., Lamond, A. I. & Brown, S. J., 9 Sept 2019, (E-pub ahead of print) In: Wellcome Open Research. 4, p. 134 28 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • filaggrin 100%
  • Organoids 91%
  • Proteomics 63%
  • Neurogenic 39%
  • Skin 38%
  92 Downloads (Pure)

• Genetics of Atopic Dermatitis: From DNA Sequence to Clinical Relevance

  Løset, M., Brown, S. J., Saunes, M. & Hveem, K., Aug 2019, In: Dermatology . 235, 5, p. 355-364 10 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Atopic Dermatitis 100%
  • filaggrin 34%
  • Genes 24%
  • Gene-Environment Interaction 14%
  • Twin Studies 14%
  47 Citations (Scopus)

  117 Downloads (Pure)

• Male genital lichen sclerosus and filaggrin

  Shim, T. N., Brown, S. J., Francis, N. D., Dinneen, M., Hawkins, D., Muneer, A., Minhas, S., McLean, W. H. I. & Bunker, C. B., 13 Dec 2019, In: Clinical and Experimental Dermatology. 45, 1, p. 127-128 2 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

  File

  • Lichen Sclerosus et Atrophicus 100%
  • filaggrin 99%
  • Male Genitalia 88%
  • Genitalia 63%
  • Epidermis 34%
  3 Citations (Scopus)

  91 Downloads (Pure)

• Proteomic analysis of a filaggrin-deficient skin organoid model shows evidence of increased transcriptional-translational activity, keratinocyte-immune crosstalk and disordered axon guidance

  Elias, M. S., Wright, S. C., Nicholson, W. V., Morrison, K. D., Prescott, A. R., Ten Have, S., Whitfield, P. D., Lamond, A. I. & Brown, S. J., 30 Sept 2019, (E-pub ahead of print) In: Wellcome Open Research. 4, p. 1-21 21 p., 134.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • filaggrin 100%
  • Organoids 91%
  • Axon Guidance 88%
  • Keratinocytes 67%
  • Proteomics 63%
  11 Citations (Scopus)

  92 Downloads (Pure)
• 2018

  Research Techniques Are Not Simple

  Brown, S. J., Oct 2018, In: Journal of Investigative Dermatology. 138, 10, p. 2089-2090 2 p.

  Research output: Contribution to journal › Editorial › peer-review

• The micro-evolution and epidemiology of Staphylococcus aureus colonization during atopic eczema disease flare

  Harkins, C., Pettigrew, K. A., Oravcová, K., Gardner, J., Hearn, R. M. R., Rice, D., Mather, A. E., Parkhill, J., Brown, S., Proby, C. & Holden, M. T. G., Feb 2018, In: Journal of Investigative Dermatology. 138, 2, p. 336-343 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Atopic Dermatitis 100%
  • Heterogeneity 88%
  • Staphylococcus aureus 82%
  • Epidemiology 75%
  • Resistance 59%
  38 Citations (Scopus)

  239 Downloads (Pure)
• 2017

  A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis

  Naeem, A. S., Tommasi, C., Cole, C., Brown, S. J., Zhu, Y., Way, B., Willis Owen, S. A. G., Moffatt, M., Cookson, W. O., Harper, J. I., Di, W. L., Brown, S. J., Reinheckel, T. & O'Shaughnessy, R. F. L., Apr 2017, In: Journal of Allergy and Clinical Immunology. 139, 4, p. 1228-1241 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cathepsin H 100%
  • filaggrin 84%
  • Mechanistic Target of Rapamycin Complex 2 84%
  • Mechanistic Target of Rapamycin Complex 1 73%
  • Thymoma 70%
  29 Citations (Scopus)

  219 Downloads (Pure)

• Effectiveness and cost-effectiveness of daily all-over-body application of emollient during the first year of life for preventing atopic eczema in high-risk children (The BEEP trial): protocol for a randomised controlled trial

  Chalmers, J. R., Haines, R. H., Mitchell, E. J., Thomas, K. S., Brown, S. J., Ridd, M. J., Lawton, S., Simpson, E. L., Cork, M. J., Sach, T. H., Bradshaw, L. E., Montgomery, A. A., Boyle, R. J. & Williams, H. C., 21 Jul 2017, In: Trials. 18, p. 1-11 11 p., 343.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Emollients 100%
  • Atopic Dermatitis 72%
  • Cost-Benefit Analysis 60%
  • Randomized Controlled Trials 46%
  • Child 30%
  57 Citations (Scopus)

  184 Downloads (Pure)

• Silk garments plus standard care compared with standard care for treating eczema in children: A randomised, controlled, observer-blind, pragmatic trial (CLOTHES Trial)

  Thomas, K. S., Bradshaw, L. E., Sach, T. H., Batchelor, J. M., Lawton, S., Harrison, E. F., Haines, R. H., Ahmed, A., Williams, H. C., Dean, T., Burrows, N. P., Pollock, I., Llewellyn, J., Crang, C., Grundy, J. D., Guiness, J., Gribbin, A., Mitchell, E. J., Cowdell, F., Brown, S. J., & 2 othersMontgomery, A. A. & UK Dermatology Clinical Trials Network’s CLOTHES Trial Team, 11 Apr 2017, In: PLoS Medicine. 14, 4, p. 1-23 23 p., e1002280.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pragmatic Clinical Trials 100%
  • Silk 91%
  • Clothing 83%
  • Eczema 81%
  • Child 30%
  32 Citations (Scopus)

  163 Downloads (Pure)

• What progress have we made in the treatment of atopic eczema? Putting the new biological therapies into a wider context

  Brown, S. J., Jul 2017, In: British Journal of Dermatology. 177, 1, p. 4-6 3 p.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access
  3 Citations (Scopus)
• 2016

  Filaggrin genotype does not determine the skin's threshold to UV-induced erythema

  Forbes, D., Johnston, L., Gardner, J., MacCallum, S. F., Campbell, L. E., Dinkova-Kostova, A. T., McLean, W. H. I., Ibbotson, S. H., Dawe, R. S. & Brown, S. J., Apr 2016, In: Journal of Allergy and Clinical Immunology. 137, 4, p. 1280-1282.e3 6 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

  File
  6 Citations (Scopus)

  140 Downloads (Pure)

• Hand dermatitis in construction workers: a lesson in genetic epidemiology

  Brown, S. J., Feb 2016, In: British Journal of Dermatology. 174, 2, p. 263-265 3 p.

  Research output: Contribution to journal › Comment/debate › peer-review
  1 Citation (Scopus)
• 2015

  A multi-centre, parallel group superiority trial of silk therapeutic clothing compared to standard care for the management of eczema in children (CLOTHES Trial): study protocol for a randomised controlled trial

  Harrison, E. F., Haines, R. H., Cowdell, F., Sach, T. H., Dean, T., Pollock, I., Burrows, N. P., Buckley, H., Batchelor, J., Williams, H. C., Lawton, S., Brown, S. J., Bradshaw, L. E., Ahmed, A., Montgomery, A. A., Mitchell, E. J. & Thomas, K. S., 2 Sept 2015, In: Trials. 16, 12 p., 390.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Equivalence Trials 100%
  • Silk 96%
  • Clothing 88%
  • Eczema 86%
  • Standard of Care 72%
  10 Citations (Scopus)

  167 Downloads (Pure)