Molecular Mechanisms of Encystation and Sporulation (Senior Investigator Award)

Research output

Research output per year 2014 2014 2015 2016 2017 2018 2019 2021 2022 2023

• 35 Article
• 2 Review article

Research output per year

Research output per year

Search results

• 2023

  Emerging roles for diguanylate cyclase during the evolution of soma in dictyostelia

  Kawabe, Y., Du, Q., Narita, T. B., Bell, C., Schilde, C., Kin, K. & Schaap, P. (Lead / Corresponding author), 6 Oct 2023, In: BMC Ecology and Evolution. 23, 14 p., 60.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dictyostelia 100%
  • Diguanylate Cyclase 100%
  • Evolution of Soma 100%
  • Carisoprodol 100%
  • Polysphondylium Violaceum 80%

  2   Link opens in a new tab Citations (Scopus)

  110 Downloads (Pure)

• The protein kinases of Dictyostelia and their incorporation into a signalome

  Kin, K., Chen, Z.-H., Forbes, G., Lawal, H., Schilde, C., Singh, R., Cole, C., Barton, G. J. & Schaap, P. (Lead / Corresponding author), Aug 2023, In: Cellular Signalling. 108, 12 p., 110714.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dictyostelia 100%
  • Protein Kinase 100%
  • Signalome 100%
  • Protein Kinases 100%
  • Transcriptomics 28%

  5   Link opens in a new tab Citations (Scopus)

  215 Downloads (Pure)

• 2022

  Evolution of a novel cell type in Dictyostelia required gene duplication of a cudA-like transcription factor

  Kin, K., Chen, Z.-H., Forbes, G. & Schaap, P. (Lead / Corresponding author), 24 Jan 2022, In: Current Biology. 32, 2, p. 428-437.E4 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dictyostelia 100%
  • Transcription Factor 100%
  • Gene Duplication 100%
  • Fruiting Body 100%
  • Duplication 100%

  8   Link opens in a new tab Citations (Scopus)

  123 Downloads (Pure)

• Interactome and evolutionary conservation of Dictyostelid small GTPases and their direct regulators

  Forbes, G., Schilde, C., Lawal, H., Kin, K., Du, Q., Chen, Z.-H., Rivero, F. & Schaap, P. (Lead / Corresponding author), 31 Dec 2022, In: Small GTPases. 13, 1, p. 239-254 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dictyostelids 100%
  • Small GTPase 100%
  • Guanine nucleotide Exchange Factor 100%
  • GTPase 100%
  • Evolutionary Conservation 100%

  6   Link opens in a new tab Citations (Scopus)

  173 Downloads (Pure)

• Novel RNAseq-informed cell-type markers and their regulation alter paradigms of Dictyostelium developmental control

  Forbes, G., Chen, Z.-H., Kin, K. & Schaap, P. (Lead / Corresponding author), 5 May 2022, In: Frontiers in Cell and Developmental Biology. 10, 13 p., 899316.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dictyostelium 100%
  • Development Control 100%
  • RNA Sequencing (RNA-seq) 100%
  • Cell Markers 100%
  • Guanosine Monophosphate 100%

  2   Link opens in a new tab Citations (Scopus)

  110 Downloads (Pure)

• 2021

  Loss of Pikfyve causes Transdifferentiation of Dictyostelium Spores into Basal Disc Cells

  Yamada, Y., Forbes, G., Du, Q., Kawata, T. (Lead / Corresponding author) & Schaap, P. (Lead / Corresponding author), 19 Aug 2021, In: Frontiers in Cell and Developmental Biology. 9, 11 p., 692473.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dictyostelium 100%
  • Gene Expression 100%
  • Autophagy 100%
  • Transdifferentiation 100%
  • Amoeba (Life Cycle Stage) 33%

  2   Link opens in a new tab Citations (Scopus)

  108 Downloads (Pure)

• The proppin Bcas3 and its interactor KinkyA localize to the early phagophore and regulate autophagy

  Yamada, Y. & Schaap, P. (Lead / Corresponding author), 2021, In: Autophagy. 17, 3, p. 640-655 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phosphoinositide 100%
  • Autophagy 100%
  • Cyclic Adenosine Monophosphate 60%
  • Sporogenesis 60%
  • Dictyostelium 40%

  14   Link opens in a new tab Citations (Scopus)

  165 Downloads (Pure)

• 2020

  Cold climate adaptation is a plausible cause for evolution of multicellular sporulation in Dictyostelia

  Lawal, H. M., Schilde, C., Kin, K., Brown, M. W., James, J., Prescott, A. R. & Schaap, P. (Lead / Corresponding author), 29 May 2020, In: Scientific Reports. 10, 9 p., 8797.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sporogenesis 100%
  • Dictyostelium 50%
  • Protozoa 50%
  • Long Term Survival 50%
  • Cladistics 50%

  8   Link opens in a new tab Citations (Scopus)

  150 Downloads (Pure)

• Loss of the Polyketide Synthase StlB Results in Stalk Cell Over production in Polysphondylium violaceum

  Narita, T. B., Kawabe, Y., Kin, K., Gibbs, R. A., Kuspa, A., Muzny, D., Richards, S., Strassmann, J. E., Sucgang, R., Worley, K. C. & Schaap, P. (Lead / Corresponding author), May 2020, In: Genome Biology and Evolution. 12, 5, p. 674-683 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Stalk Cells 100%
  • Polyketide Synthase 100%
  • Polysphondylium Violaceum 100%
  • Fruiting 100%
  • Dictyostelia 50%

  14   Link opens in a new tab Citations (Scopus)

  118 Downloads (Pure)

• 2019

  A well supported multi gene phylogeny of 52 dictyostelia

  Schilde, C., Lawal, H. M., Kin, K., Shibano-Hayakawa, I., Inouye, K. & Schaap, P. (Lead / Corresponding author), May 2019, In: Molecular Phylogenetics and Evolution. 134, p. 66-73 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cladistics 100%
  • Genome Phylogeny 40%
  • Dictyosteliida 25%
  • Amoeba (Life Cycle Stage) 12%
  • Dictyostelium 12%

  31   Link opens in a new tab Citations (Scopus)

  277 Downloads (Pure)

• Cyclic AMP induction of Dictyostelium prespore gene expression requires autophagy

  Yamada, Y. & Schaap, P. (Lead / Corresponding author), 15 Aug 2019, In: Developmental Biology. 452, 2, p. 114-126 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dictyostelium 100%
  • Gene Expression 100%
  • Prespore 100%
  • Autophagy 100%
  • Cyclic Adenosine Monophosphate (cAMP) 100%

  19   Link opens in a new tab Citations (Scopus)

  227 Downloads (Pure)

• Diversity and Evolution of Sensor Histidine Kinases in Eukaryotes

  Kabbara, S., Hérivaux, A., Dugé de Bernonville, T., Courdavault, V., Clastre, M., Gastebois, A., Osman, M., Hamze, M., Cock, J. M., Schaap, P. & Papon, N. (Lead / Corresponding author), Jan 2019, In: Genome Biology and Evolution. 11, 1, p. 86-108 23 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Eukaryotes 100%
  • Histidine Kinase 100%
  • Eukaryote 100%
  • Two-component System 25%
  • Supergroups 25%

  35   Link opens in a new tab Citations (Scopus)

  342 Downloads (Pure)

• Evolution of multicellularity in Dictyostelia

  Kawabe, Y., Du, Q., Schilde, C. & Schaap, P. (Lead / Corresponding author), 2019, In: International Journal of Developmental Biology. 63, 8-9-10, p. 359-369 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dictyostelia 100%
  • Evolution of multicellularity 100%
  • cAMP Signaling 100%
  • D. Discoideum 60%
  • Amoeba (Life Cycle Stage) 50%

  28   Link opens in a new tab Citations (Scopus)

  217 Downloads (Pure)

• Phylogeny-wide conservation and change in developmental expression, cell-type specificity and functional domains of the transcriptional regulators of social amoebas

  Forbes, G. (Lead / Corresponding author), Chen, Z.-H., Kin, K., Lawal, H. M., Schilde, C., Yamada, Y. & Schaap, P. (Lead / Corresponding author), 21 Nov 2019, In: BMC Genomics. 20, 1, p. 1-13 13 p., 890.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Amoeba (Life Cycle Stage) 100%
  • Transcription Factors 100%
  • Cladistics 100%
  • Taxon 16%
  • Evolution of Gene Regulation 10%

  11   Link opens in a new tab Citations (Scopus)

  167 Downloads (Pure)

• 2018

  Cell-type specific RNA-Seq reveals novel roles and regulatory programs for terminally differentiated Dictyostelium cells

  Kin, K., Forbes, G., Cassidy, A. & Schaap, P. (Lead / Corresponding author), 22 Oct 2018, In: BMC Genomics. 19, 1, p. 1-18 18 p., 764.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Stalk Cells 100%
  • Dictyostelium Cells 100%
  • Type-specific 100%
  • RNA Sequencing (RNA-seq) 100%
  • Regulatory Programs 100%

  27   Link opens in a new tab Citations (Scopus)

  271 Downloads (Pure)

• Glycogen synthase kinase 3 promotes multicellular development over unicellular encystation in encysting Dictyostelia

  Kawabe, Y., Morio, T., Tanaka, Y. & Schaap, P., 9 May 2018, In: EvoDevo. 9, 1, 11 p., 12.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dictyostelia 100%
  • Encystation 100%
  • Glycogen Synthase kinase-3β (GSK-3β) 100%
  • Multicellular Development 100%
  • Kinase 100%

  5   Link opens in a new tab Citations (Scopus)

  279 Downloads (Pure)

• Multiple roots of fruiting body formation in Amoebozoa

  Hillmann, F. (Lead / Corresponding author), Forbes, G., Novohradská, S., Ferling, I., Riege, K., Groth, M., Westermann, M., Marz, M., Spaller, T., Winckler, T., Schaap, P. & Glöckner, G. (Lead / Corresponding author), 1 Feb 2018, In: Genome Biology and Evolution. 10, 2, p. 591-606 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Fruiting 100%
  • Amoebozoa 100%
  • Fruiting Body 100%
  • Multicellular Interactions 25%
  • Amoeba (Life Cycle Stage) 20%

  38   Link opens in a new tab Citations (Scopus)

  3055 Downloads (Pure)

• The transcription factor Spores Absent A is a PKA dependent inducer of Dictyostelium sporulation

  Yamada, Y., Cassidy, A. & Schaap, P. (Lead / Corresponding author), 2018, In: Scientific Reports. 8, 1, p. 1-13 13 p., 6643.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dictyostelium 100%
  • Transcription Factors 100%
  • Sporogenesis 100%
  • Sporulation 100%
  • Inducer 100%

  13   Link opens in a new tab Citations (Scopus)

  234 Downloads (Pure)

• 2017

  Adenylate cyclase A acting on PKA mediates induction of stalk formation by cyclic diguanylate at the Dictyostelium organizer

  Chen, Z.-H., Singh, R., Cole, C., Lawal, H. M., Schilde, C., Febrer, M., Barton, G. & Schaap, P. (Lead / Corresponding author), 17 Jan 2017, In: Proceedings of the National Academy of Sciences. 114, 3, p. 516-521 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dictyostelium 100%
  • Adenylate Cyclase 100%
  • Guanosine Monophosphate 100%
  • Cyclic Adenosine Monophosphate 55%
  • Cell Migration 22%

  26   Link opens in a new tab Citations (Scopus)

  504 Downloads (Pure)

• Effects of deletion of the receptor CrlA on Dictyostelium aggregation and MPBD mediated responses are strain-dependent and not evident in strain Ax2

  Narita, T. B. (Lead / Corresponding author), Schaap, P. & Saito, T., 2 Feb 2017, In: FEMS Microbiology Letters. 364, 4, p. 1-7 7 p., fnx022.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dictyostelium 100%
  • Methyl 100%
  • Strain-dependent 100%
  • 1,3-diol 100%
  • Cell Aggregation 100%

  4   Link opens in a new tab Citations (Scopus)

  266 Downloads (Pure)

• Improved annotation with de novo transcriptome assembly in four social amoeba species

  Singh, R., Lawal, H. M., Schilde, C., Glöckner, G., Barton, G. J., Schaap, P. & Cole, C. (Lead / Corresponding author), 31 Jan 2017, In: BMC Genomics. 18, p. 1-17 17 p., 120.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Amoeba (Life Cycle Stage) 100%
  • Transcriptome 100%
  • Genome Annotation 40%
  • Genome Sequencing 40%
  • RNA Sequence 40%

  5   Link opens in a new tab Citations (Scopus)

  254 Downloads (Pure)

• 2016

  A core phylogeny of Dictyostelia inferred from genomes representative of the eight major and minor taxonomic divisions of the group

  Singh, R., Schilde, C. & Schaap, P. (Lead / Corresponding author), 17 Nov 2016, In: BMC Evolutionary Biology. 16, p. 1-11 11 p., 251.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cladistics 100%
  • Taxon 88%
  • Amoebozoa 33%
  • Branches 33%
  • Dictyostelium 22%

  21   Link opens in a new tab Citations (Scopus)

  319 Downloads (Pure)

• A set of genes conserved in sequence and expression traces back the establishment of multicellularity in social amoebae

  Schilde, C., Lawal, H. M., Noegel, A., Eichinger, L., Schaap, P. & Glöckner, G. (Lead / Corresponding author), 4 Nov 2016, In: BMC Genomics. 17, p. 1-10 10 p., 871.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Development Program 100%
  • Multicellularity 100%
  • Social Amoeba 100%
  • Traceback 100%
  • Amoeba (Life Cycle Stage) 100%

  11   Link opens in a new tab Citations (Scopus)

  241 Downloads (Pure)

• Evolution of developmental signalling in Dictyostelid social amoebas

  Schaap, P. (Lead / Corresponding author), 1 Aug 2016, In: Current Opinion in Genetics & Development. 39, p. 29-34 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dictyostelids 100%
  • Social Amoeba 100%
  • Developmental Signaling Pathways 100%
  • Cell Specialization 100%
  • Amoeba (Life Cycle Stage) 100%

  34   Link opens in a new tab Citations (Scopus)

  283 Downloads (Pure)

• Secreted cyclic di-GMP induces stalk cell differentiation in the eukaryote Dictyostelium discoideum

  Chen, Z. H. & Schaap, P. (Lead / Corresponding author), Jan 2016, In: Journal of Bacteriology. 198, 1, p. 27-31 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dictyostelium Discoideum 100%
  • Eukaryotes 100%
  • Cyclic GMP 100%
  • Stalk Cell Differentiation 100%
  • Dictyostelium discoideum 100%

  20   Link opens in a new tab Citations (Scopus)

• The multicellularity genes of dictyostelid social amoebas

  Schaap, P. (Lead / Corresponding author), Gloeckner, G., Lawal, H. M., Singh, R., Singer, G., Weijer, C. & Schaap, P. (Lead / Corresponding author), 30 Jun 2016, In: Nature Communications. 7, 11 p., 12085.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Amoeba (Life Cycle Stage) 100%
  • Gene Expression 100%
  • Dictyosteliida 100%
  • Cellular Differentiation 100%
  • Protein Kinases 100%

  66   Link opens in a new tab Citations (Scopus)

  361 Downloads (Pure)

• The Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-Component and Metazoan-Type Tyrosine Kinase Signaling

  Schaap, P., Barrantes, I., Minx, P., Sasaki, N., Anderson, R. W., Bénard, M., Biggar, K. K., Buchler, N. E., Bundschuh, R., Chen, X., Fronick, C., Fulton, L., Golderer, G., Jahn, N., Knoop, V., Landweber, L. F., Maric, C., Miller, D., Noegel, A. A. & Peace, R. & 18 others, Pierron, G., Sasaki, T., Schallenberg-Rüdinger, M., Schleicher, M., Singh, R., Spaller, T., Storey, K. B., Suzuki, T., Tomlinson, C., Tyson, J. J., Warren, W. C., Werner, E. R., Werner-Felmayer, G., Wilson, R. K., Winckler, T., Gott, J. M., Glöckner, G. & Marwan, W. (Lead / Corresponding author), Jan 2016, In: Genome Biology and Evolution. 8, 1, p. 109-125 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Two-component 100%
  • Tyrosine Kinase Signaling 100%
  • Physarum Polycephalum 100%
  • Extensive Use 100%
  • Metazoans 100%

  79   Link opens in a new tab Citations (Scopus)

  270 Downloads (Pure)

• 2015

  A conserved signalling pathway for amoebozoan encystation that was co-opted for multicellular development

  Kawabe, Y., Schilde, C., Du, Q. & Schaap, P. (Lead / Corresponding author), 16 Apr 2015, In: Scientific Reports. 5, 6 p., 9644.

  Research output: Contribution to journal › Article › peer-review

  • Signal Transduction 100%
  • Amoebozoa 100%
  • Kinase 100%
  • Phosphotransferase 100%
  • Protein Kinases 100%

  30   Link opens in a new tab Citations (Scopus)

• Root of Dictyostelia based on 213 universal proteins

  Sheikh, S. (Lead / Corresponding author), Gloeckner, G., Kuwayama, H., Schaap, P., Urushihara, H. & Baldauf, S. L., Nov 2015, In: Molecular Phylogenetics and Evolution. 92, p. 53-62 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Cladistics 100%
  • Dictyosteliida 66%
  • Amoebozoa 66%
  • Amino Acid Sequence 33%
  • Lineages 33%

  14   Link opens in a new tab Citations (Scopus)

• The evolution of aggregative multicellularity and cell-cell communication in the Dictyostelia

  Du, Q., Kawabe, Y., Schilde, C., Chen, Z.-H. & Schaap, P. (Lead / Corresponding author), 20 Nov 2015, In: Journal of Molecular Biology. 427, 23, p. 3722-3733 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cell Communication 100%
  • cAMP Signaling 100%
  • Aggregative multicellularity 100%
  • Eukaryote 66%
  • Cyclic Adenosine Monophosphate 66%

  89   Link opens in a new tab Citations (Scopus)

  333 Downloads (Pure)

• 2014

  A cyanobacterial light activated adenylyl cyclase partially restores development of a Dictyostelium discoideum, adenylyl cyclase a null mutant

  Chen, Z.-H., Raffelberg, S., Losi, A., Schaap, P. (Lead / Corresponding author) & Gärtner, W. (Lead / Corresponding author), 10 Dec 2014, In: Journal of Biotechnology. 191, p. 246-249 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Dictyostelium discoideum 100%
  • Adenylate Cyclase 100%
  • Fruiting Body 100%
  • Eukaryote 66%
  • Blue Light 66%

  20   Link opens in a new tab Citations (Scopus)

• Evolutionary reconstruction of pattern formation in 98 Dictyostelium species reveals that cell-type specialization by lateral inhibition is a derived trait

  Schilde, C., Skiba, A. & Schaap, P. (Lead / Corresponding author), 1 Oct 2014, In: EvoDevo. 5, 13 p., 34.

  Research output: Contribution to journal › Article › peer-review

  • Dictyostelium 100%
  • Pattern Formation 100%
  • Prespore 100%
  • Lateral Inhibition 100%
  • Evolutionary Reconstruction 100%

  30   Link opens in a new tab Citations (Scopus)

• The cyclic AMP phosphodiesterase RegA critically regulates encystation in social and pathogenic amoebas

  Du, Q., Schilde, C., Birgersson, E., Chen, Z.-H., McElroy, S. & Schaap, P. (Lead / Corresponding author), Feb 2014, In: Cellular Signalling. 26, 2, p. 453-459 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Social Amoeba 100%
  • Encystation 100%
  • Cyclic AMP Phosphodiesterase 100%
  • Pathogenic Amoebae 100%
  • RegA 100%

  32   Link opens in a new tab Citations (Scopus)

  254 Downloads (Pure)

• The Hybrid Type Polyketide Synthase SteelyA Is Required for cAMP Signalling in Early Dictyostelium Development

  Narita, T. B., Chen, Z.-H., Schaap, P. & Saito, T. (Lead / Corresponding author), 15 Sept 2014, In: PLoS ONE. 9, 9, 9 p., e106634.

  Research output: Contribution to journal › Article › peer-review

  • Null mutant 100%
  • Dictyostelium Development 100%
  • CAMP Signaling 100%
  • Polyketide Synthase 100%
  • Hybrid Type 100%

  20   Link opens in a new tab Citations (Scopus)

• The Social Amoeba Polysphondylium pallidum Loses Encystation and Sporulation, but Can Still Erect Fruiting Bodies in the Absence of Cellulose

  Du, Q. & Schaap, P. (Lead / Corresponding author), Sept 2014, In: Protist. 165, 5, p. 569-579 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Amoeba 100%
  • Cellulose 100%
  • Social Amoeba 100%
  • Sporulation 100%
  • Encystation 100%

  6   Link opens in a new tab Citations (Scopus)

  221 Downloads (Pure)