Molecular Mechanisms of O-GICNAC Signalling (Investigator award)

Research Output

Research Output per year

2017 2020

• 13 Article

Research Output per year

Research Output per year

Search results

• 2020

  A missense mutation in a patient with developmental delay affects the activity and structure of the hexosamine biosynthetic pathway enzyme AGX1

  Chen, X., Raimi, O., Ferenbach, A. & van Aalten, D., 24 Oct 2020, In: FEBS Letters. 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Biosynthetic Pathways
  • O-GlcNAc transferase
  • Hexosamines
  • Missense Mutation
  • Mutation
  18 Downloads (Pure)

• Native detection of protein O-GlcNAcylation by gel electrophoresis

  Fu, C. & van Aalten, D. M. F., 7 Nov 2020, In: Analyst. 145, 21, p. 6826-6830 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Electrophoresis
  • Gels
  • electrokinesis
  • Proteins
  • gel
  1 Citation (Scopus)

  25 Downloads (Pure)

• Tools for functional dissection of site-specific O-GlcNAcylation

  Gorelik, A. & van Aalten, D., 12 Jun 2020, In: RSC Chemical Biology. 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Dissection
  • Homeostasis
  • Proteins
  • Monosaccharides
  • Acetylglucosamine
• 2019

  A missense mutation in the catalytic domain of O-GlcNAc transferase links perturbations in protein O-GlcNAcylation to X-linked intellectual disability

  Pravata, V. M., Gundogdu, M., Bartual, S. G., Ferenbach, A. T., Stavridis, M., Õunap, K., Pajusalu, S., Žordania, R., Wojcik, M. H. & van Aalten, D. M. F., 7 Nov 2019, In: FEBS Letters. 594, 4, p. 717-727 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • O-GlcNAc transferase
  • Missense Mutation
  • Intellectual Disability
  • Catalytic Domain
  • X ray crystallography
  7 Citations (Scopus)

  12 Downloads (Pure)

• Catalytic deficiency of O-GlcNAc transferase leads to X-linked intellectual disability

  Pravata, V., Muha, V., Gundogdu, M., Ferenbach, A., Kakade, P., Vandadi, V., Wilmes, A. C., Borodkin, V., Joss, S., Stavridis, M. & van Aalten, D., 23 Jul 2019, In: Proceedings of the National Academy of Sciences. 116, 30, p. 14961-14970 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • O-GlcNAc transferase
  • Intellectual Disability
  • Host Factor 1 Protein
  • Proteome
  • Missense Mutation
  14 Citations (Scopus)

  142 Downloads (Pure)

• Genetic recoding to dissect the roles of site-specific protein O-GlcNAcylation

  Gorelik, A., Galan Bartual, S., Borodkin, V., Varghese, J., Ferenbach, A. & van Aalten, D., Nov 2019, In: Nature Structural & Molecular Biology. 26, 11, p. 1071-1077 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • hexosaminidase C
  • O-GlcNAc transferase
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Proteins
  • Proteome
  6 Citations (Scopus)

  42 Downloads (Pure)
• 2018

  Effects of hypo O-GlcNAcylation on Drosophila development

  Mariappa, D. N., Ferenbach, A. & van Aalten, D. M. F., 11 May 2018, In: Journal of Biological Chemistry. 293, 19, p. 7209-7221 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Drosophila host cell factor
  • Drosophila
  • Genes
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Phenotype
  7 Citations (Scopus)

  145 Downloads (Pure)

• The conserved threonine-rich region of the HCF-1PRO repeat activates promiscuous OGT: UDP-GlcNAc glycosylation and proteolysis activities

  Kapuria, V., Röhrig, U. F., Waridel, P., Lammers, F., Borodkin, V. S., van Aalten, D. M. F., Zoete, V. & Herr, W., 16 Nov 2018, In: Journal of Biological Chemistry. 293, 46, p. 17754-17768 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Proteolysis
  • UDP-N-acetylglucosamine-peptide beta-N-acetylglucosaminyltransferase
  • Glycosylation
  • O-GlcNAc transferase
  • Host Factor 1 Protein
  1 Citation (Scopus)

  152 Downloads (Pure)

• The O-GlcNAc Transferase Intellectual Disability Mutation L254F Distorts the TPR Helix

  Gundogdu, M., Llabres, S., Gorelik, A., Ferenbach, A., Zachariae, U. & Van Aalten, D., 17 May 2018, In: Cell Chemical Biology. 25, 5, p. 513-518.e4 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • O-GlcNAc transferase
  • Intellectual Disability
  • Mutation
  • Tetratricopeptide Repeat
  • Acetylglucosamine
  13 Citations (Scopus)

  181 Downloads (Pure)
• 2017

  Direct Monitoring of Protein O-GlcNAcylation by High-Resolution Native Mass Spectrometry

  Leney, A. C., Rafie, K., Van Aalten, D. M. F. & Heck, A. J. R., 18 Aug 2017, In: ACS Chemical Biology. 12, 8, p. 2078-2084 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mass spectrometry
  • Mass Spectrometry
  • Kinetics
  • Post Translational Protein Processing
  • Stoichiometry
  8 Citations (Scopus)

  159 Downloads (Pure)

• Mutations in N-acetylglucosamine (O-GlcNAc) transferase in patients with X-linked intellectual disability

  Willems, A. P., Gundogdu, M., Kempers, M. J. E., Giltay, J. C., Pfundt, R., Elferink, M., Loza, B. F., Fuijkschot, J., Ferenbach, A. T., van Gassen, K. L. I., van Aalten, D. M. F. & Lefeber, D. J., 28 Jul 2017, In: Journal of Biological Chemistry. 292, 30, p. 12621-12631 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • O-GlcNAc transferase
  • Acetylglucosamine
  • Intellectual Disability
  • Mutation
  • Host Factor 1 Protein
  29 Citations (Scopus)

  105 Downloads (Pure)

• Recognition of a glycosylation substrate by the O-GlcNAc transferase TPR repeats

  Rafie, K., Raimi, O., Ferenbach, A. T., Borodkin, V. S., Kapuria, V. & van Aalten, D. M. F., 28 Jun 2017, In: Open Biology. 7, p. 1-9 9 p., 70078.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Glycosylation
  • O-GlcNAc transferase
  • Substrates
  • Proteome
  • Mutagenesis
  21 Citations (Scopus)

  168 Downloads (Pure)

• Structure of PINK1 and mechanisms of Parkinson's disease associated mutations

  Kumar, A., Tamjar, J., Waddell, A. D., Woodroof, H. I., Raimi, O. G., Shaw, A. M., Peggie, M., Muqit, M. M. K. & van Aalten, D. M. F., 9 Nov 2017, In: eLife. 6, p. 1-16 16 p., e29985.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Parkinson Disease
  • Phosphotransferases
  • Tribolium
  • Mutation
  • Ubiquitin
  32 Citations (Scopus)

  213 Downloads (Pure)