Molecular Mechanisms of O-GICNAC Signalling (Investigator award)

Research output

Research output per year 2016 2021

• 25 Article

Research output per year

Research output per year

Search results

• 2021

  A missense mutation in a patient with developmental delay affects the activity and structure of the hexosamine biosynthetic pathway enzyme AGX1

  Chen, X., Raimi, O., Ferenbach, A. & van Aalten, D., Jan 2021, In: FEBS Letters. 595, 1, p. 110-122 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • O-GlcNAc transferase 100%
  • Hexosamine 87%
  • Hexosamines 86%
  • Developmental 74%
  • Biosynthetic Pathways 74%
  12 Downloads (Pure)

• Loss of O-GlcNAcase catalytic activity leads to defects in mouse embryogenesis

  Muha, V., Authier, F., Szoke-Kovacs, Z., Johnson, S., Gallagher, J., McNeilly, A., McCrimmon, R., Teboul, L. & van Aalten, D., 2021, In: Journal of Biological Chemistry. 296, 15 p., 100439.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • hexosaminidase C 100%
  • Histone 63%
  • Embryonic Development 54%
  • Histone Acetyltransferases 33%
  • Developmental 23%
  1 Citation (Scopus)

  6 Downloads (Pure)
• 2020

  A mechanism-inspired UDP-N-acetylglucosamine pyrophosphorylase inhibitor

  Raimi, O., Hurtado-Guerrero, R., Borodkin, V., Ferenbach, A., Urbaniak, M., Ferguson, M. & van Aalten, D., 1 Apr 2020, In: RSC Chemical Biology. 1, p. 13-25 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Nucleotide-Sugar 100%
  • Drug Target 80%
  • Uridine 78%
  • Lysine 66%
  • Biosynthesis 58%

• An intellectual disability syndrome with single nucleotide variants in O-GlcNAc Transferase

  Pravata, V., Omelkova, M., Stavridis, M., Desbiens, C. M., Stephen, H. M., Lefeber, D. J., Gécz, J., Gundogdu, M., Õunap, K., Joss, S., Schwartz, C. E., Wells, L. & van Aalten, D., 1 Jun 2020, In: European Journal of Human Genetics. 28, 6, p. 706-714 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • N-Acetylglucosaminyltransferases 100%
  • O-GlcNAc transferase 65%
  • Glycosylation 55%
  • Intellectual Disability 50%
  • Nucleotides 43%
  6 Citations (Scopus)

  36 Downloads (Pure)

• Native detection of protein O-GlcNAcylation by gel electrophoresis

  Fu, C. & van Aalten, D. M. F., 7 Nov 2020, In: Analyst. 145, 21, p. 6826-6830 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Electrophoresis 100%
  • Gels 80%
  • Gel Electrophoresis 75%
  • electrokinesis 72%
  • Proteins 70%
  2 Citations (Scopus)

  9 Downloads (Pure)

• O-GlcNAcase contributes to cognitive function in Drosophila

  Muha, V., Fenckova, M., Ferenbach, A., Catinozzi, M., Eidhof, I., Storkebaum, E., Schenck, A. & van Aalten, D., 26 Jun 2020, In: Journal of Biological Chemistry. 295, 26, p. 8636-8646 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • hexosaminidase C 100%
  • Neuromuscular 82%
  • Plastic Property 68%
  • Drosophila 55%
  • Cognition 46%
  3 Citations (Scopus)

  48 Downloads (Pure)

• Tools for functional dissection of site-specific O-GlcNAcylation

  Gorelik, A. & van Aalten, D., 12 Jun 2020, (E-pub ahead of print) In: RSC Chemical Biology. 1, p. 98-109 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dissection 100%
  • Proteins 42%
  • Homeostasis 42%
  • Acetylglucosamine 37%
  • Monosaccharides 37%
  43 Downloads (Pure)
• 2019

  A missense mutation in the catalytic domain of O-GlcNAc transferase links perturbations in protein O-GlcNAcylation to X-linked intellectual disability

  Pravata, V. M., Gundogdu, M., Bartual, S. G., Ferenbach, A. T., Stavridis, M., Õunap, K., Pajusalu, S., Žordania, R., Wojcik, M. H. & van Aalten, D. M. F., 7 Nov 2019, In: FEBS Letters. 594, 4, p. 717-727 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • O-GlcNAc transferase 100%
  • Missense Mutation 63%
  • Intellectual Disability 58%
  • Catalytic Domain 55%
  • Mutation 52%
  10 Citations (Scopus)

  11 Downloads (Pure)

• A mouse model for functional dissection of TAB1 O-GlcNAcylation

  Authier, F., Muha, V. & van Aalten, D. M. F., 27 Aug 2019, In: Wellcome Open Research. 4, 16 p., 128.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dissection 100%
  • Carrier Proteins 98%
  • Phosphotransferases 89%
  • Mutation 49%
  • Protein 47%
  10 Downloads (Pure)

• Catalytic deficiency of O-GlcNAc transferase leads to X-linked intellectual disability

  Pravata, V., Muha, V., Gundogdu, M., Ferenbach, A., Kakade, P., Vandadi, V., Wilmes, A. C., Borodkin, V., Joss, S., Stavridis, M. & van Aalten, D., 23 Jul 2019, In: Proceedings of the National Academy of Sciences. 116, 30, p. 14961-14970 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • O-GlcNAc transferase 100%
  • Intellectual Disability 58%
  • Host Factor 1 Protein 45%
  • Proteome 25%
  • Missense Mutation 25%
  18 Citations (Scopus)

  117 Downloads (Pure)

• Genetic recoding to dissect the roles of site-specific protein O-GlcNAcylation

  Gorelik, A., Galan Bartual, S., Borodkin, V., Varghese, J., Ferenbach, A. & van Aalten, D., Nov 2019, In: Nature Structural & Molecular Biology. 26, 11, p. 1071-1077 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • hexosaminidase C 100%
  • O-GlcNAc transferase 63%
  • Clustered Regularly Interspaced Short Palindromic Repeats 22%
  • Proteins 21%
  • Proteome 20%
  13 Citations (Scopus)

  33 Downloads (Pure)

• Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

  Muha, V., Williamson, R., Hills, R., McNeilly, A., McWilliams, T. G., Alonso, J., Schimpl, M., Leney, A. C., Heck, A. J. R., Sutherland, C., Read, K., McCrimmon, R., Brooks, S. P. & van Aalten, D., 27 Nov 2019, In: Open Biology. 9, 11, p. 1-15 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • collapsin response mediator protein-2 100%
  • Psychology Recognition 51%
  • Microtubule Proteins 40%
  • Modification 32%
  • Weight 31%
  4 Citations (Scopus)

  48 Downloads (Pure)
• 2018

  Effects of hypo O-GlcNAcylation on Drosophila development

  Mariappa, D. N., Ferenbach, A. & van Aalten, D. M. F., 11 May 2018, In: Journal of Biological Chemistry. 293, 19, p. 7209-7221 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Drosophila host cell factor 100%
  • Drosophila 98%
  • Phenotype 63%
  • Comb and Wattles 61%
  • Threonine Residue 48%
  9 Citations (Scopus)

  118 Downloads (Pure)

• O-GlcNAcase Fragment Discovery with Fluorescence Polarimetry

  Borodkin, V. S., Rafie, K., Selvan, N., Aristotelous, T., Navratilova, I., Ferenbach, A. T. & Van Aalten, D. M. F., 18 May 2018, In: ACS Chemical Biology. 13, 5, p. 1353-1360 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • hexosaminidase C 100%
  • Polarimetry 83%
  • Fluorescence 48%
  • N-Acetyl-D-Glucosamine 29%
  • Threonine Residue 27%
  5 Citations (Scopus)

  147 Downloads (Pure)

• The conserved threonine-rich region of the HCF-1PRO repeat activates promiscuous OGT: UDP-GlcNAc glycosylation and proteolysis activities

  Kapuria, V., Röhrig, U. F., Waridel, P., Lammers, F., Borodkin, V. S., van Aalten, D. M. F., Zoete, V. & Herr, W., 16 Nov 2018, In: Journal of Biological Chemistry. 293, 46, p. 17754-17768 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • O-GlcNAc transferase 100%
  • Host Factor 1 Protein 81%
  • Uridine Diphosphate 79%
  • Threonine 68%
  • Protein Hydrolysis 66%
  2 Citations (Scopus)

  119 Downloads (Pure)

• The O-GlcNAc Transferase Intellectual Disability Mutation L254F Distorts the TPR Helix

  Gundogdu, M., Llabres, S., Gorelik, A., Ferenbach, A., Zachariae, U. & Van Aalten, D., 17 May 2018, In: Cell Chemical Biology. 25, 5, p. 513-518.e4 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • O-GlcNAc transferase 100%
  • Intellectual Disability 58%
  • Mutation 52%
  • Tetratricopeptide Repeat 23%
  • Acetylglucosamine 19%
  14 Citations (Scopus)

  137 Downloads (Pure)

• UDP-GlcNAc Analogues as Inhibitors of O-GlcNAc Transferase (OGT): Spectroscopic, Computational, and Biological Studies

  Ghirardello, M., Perrone, D., Chinaglia, N., Sádaba, D., Delso, I., Tejero, T., Marchesi, E., Fogagnolo, M., Rafie, K., van Aalten, D. M. F. & Merino, P., 17 May 2018, In: Chemistry: a European Journal. 24, 28, p. 7264-7272 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pyrroline 100%
  • Phosphates 79%
  • Pyrrolidine 75%
  • Epitope 71%
  • Carbohydrate 57%
  6 Citations (Scopus)

  101 Downloads (Pure)
• 2017

  A mutant O-GlcNAcase enriches Drosophila developmental regulators

  Selvan, N., Williamson, R., Mariappa, D., Campbell, D. G., Gourlay, R., Ferenbach, A. T., Aristotelous, T., Hopkins-Navratilova, I., Trost, M. & van Aalten, D. M. F., Aug 2017, In: Nature Chemical Biology. 13, 8, p. 882-887 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • hexosaminidase C 100%
  • O-GlcNAc transferase 57%
  • Drosophila 55%
  • Embryonic Development 32%
  • Proteins 21%
  27 Citations (Scopus)

  146 Downloads (Pure)

• Direct Monitoring of Protein O-GlcNAcylation by High-Resolution Native Mass Spectrometry

  Leney, A. C., Rafie, K., Van Aalten, D. M. F. & Heck, A. J. R., 18 Aug 2017, In: ACS Chemical Biology. 12, 8, p. 2078-2084 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mass Spectrometry 100%
  • Kinetics 80%
  • Post Translational Protein Processing 76%
  • Reaction Stoichiometry 59%
  • Post-Translational Protein Modification 57%
  11 Citations (Scopus)

  119 Downloads (Pure)

• Mutations in N-acetylglucosamine (O-GlcNAc) transferase in patients with X-linked intellectual disability

  Willems, A. P., Gundogdu, M., Kempers, M. J. E., Giltay, J. C., Pfundt, R., Elferink, M., Loza, B. F., Fuijkschot, J., Ferenbach, A. T., van Gassen, K. L. I., van Aalten, D. M. F. & Lefeber, D. J., 28 Jul 2017, In: Journal of Biological Chemistry. 292, 30, p. 12621-12631 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • O-GlcNAc transferase 100%
  • Acetylglucosamine 79%
  • N-Acetylglucosamine 75%
  • Intellectual Disability 58%
  • Mutation 52%
  35 Citations (Scopus)

  89 Downloads (Pure)

• Recognition of a glycosylation substrate by the O-GlcNAc transferase TPR repeats

  Rafie, K., Raimi, O., Ferenbach, A. T., Borodkin, V. S., Kapuria, V. & van Aalten, D. M. F., 28 Jun 2017, In: Open Biology. 7, p. 1-9 9 p., 70078.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • O-GlcNAc transferase 100%
  • Glycosylation 63%
  • Proteome 42%
  • Tetratricopeptide Repeat 30%
  • Acetylglucosamine 26%
  23 Citations (Scopus)

  129 Downloads (Pure)

• Structure of PINK1 and mechanisms of Parkinson's disease associated mutations

  Kumar, A., Tamjar, J., Waddell, A. D., Woodroof, H. I., Raimi, O. G., Shaw, A. M., Peggie, M., Muqit, M. M. K. & van Aalten, D. M. F., 9 Nov 2017, In: eLife. 6, p. 1-16 16 p., e29985.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mutation 100%
  • Parkinson Disease 99%
  • Phosphotransferases 91%
  • Tribolium 88%
  • Ubiquitin 50%
  34 Citations (Scopus)

  183 Downloads (Pure)
• 2016

  Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

  Swamy, M., Pathak, S., Grzes, K. M., Damerow, S., Sinclair, L. V., van Aalten, D. M. F. & Cantrell, D. A., Jun 2016, In: Nature Immunology. 17, 6, p. 712-720 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cell Self Renewal 100%
  • Glutamine 84%
  • Glucose 50%
  • T-Lymphocytes 49%
  • Glycosyltransferases 45%
  143 Citations (Scopus)

  147 Downloads (Pure)

• Nucleocytoplasmic human O-GlcNAc transferase is sufficient for O-GlcNAcylation of mitochondrial proteins

  Trapannone, R., Mariappa, D., Ferenbach, A. T. & van Aalten, D. M. F., 10 Jun 2016, In: Biochemical Journal. 473, 12, p. 1693-1702 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • O-GlcNAc transferase 100%
  • Mitochondrial Proteins 70%
  • Protein Isoforms 49%
  • Post-Translational Protein Modification 47%
  • Threonine Residue 42%
  27 Citations (Scopus)

  147 Downloads (Pure)

• Proteolysis of HCF-1 by Ser/Thr glycosylation-incompetent O-GlcNAc transferase: UDP-GlcNAc complexes

  Kapuria, V., Röhrig, U. F., Bhuiyan, T., Borodkin, V. S., van Aalten, D. M. F., Zoete, V. & Herr, W., 15 Apr 2016, In: Genes and Development. 30, 8, p. 960-972 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • O-GlcNAc transferase 100%
  • Uridine Diphosphate 79%
  • Glycosylation 63%
  • Proteolysis 57%
  • Catalytic Domain 31%
  11 Citations (Scopus)

  125 Downloads (Pure)