MRC PPU Covid Research

Project Details

StatusFinished
Effective start/end date18/10/20 → 17/07/21

Funding

  • Medical Research Council (MR/V03541X/1): £201,620.00

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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  • A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research

    Rihn, S. J., Merits, A., Bakshi, S., Turnbull, M. L., Wickenhagen, A., Alexander, A. J. T., Baillie, C., Brennan, B., Brown, F., Brunker, K., Bryden, S. R., Burness, K. A., Carmichael, S., Cole, S. J., Cowton, V. M., Davies, P., Davis, C., De Lorenzo, G., Donald, C. L., Dorward, M., & 62 othersDunlop, J. I., Elliott, M., Fares, M., da Silva Filipe, A., Freitas, J. R., Furnon, W., Gestuveo, R. J., Geyer, A., Giesel, D., Goldfarb, D. M., Goodman, N., Gunson, R., Hastie, C. J., Herder, V., Hughes, J., Johnson, C., Johnson, N., Kohl, A., Kerr, K., Leech, H., Lello, L. S., Li, K., Lieber, G., Liu, X., Lingala, R., Loney, C., Mair, D., McElwee, M. J., McFarlane, S., Nichols, J., Nomikou, K., Orr, A., Orton, R. J., Palmarini, M., Parr, Y. A., Pinto, R. M., Raggett, S., Reid, E., Robertson, D. L., Royle, J., Cameron-Ruiz, N., Shepherd, J. G., Smollett, K., Stewart, D. G., Stewart, M., Sugrue, E., Szemiel, A. M., Taggart, A., Thomson, E. C., Tong, L., Torrie, L. S., Toth, R., Varjak, M., Wang, S., Wilkinson, S. G., Wyatt, P. G., Zusinaite, E., Alessi, D. R., Patel, A. H., Zaid, A., Wilson, S. J. & Mahalingam, S., 25 Feb 2021, In: PLoS Biology. 19, 2, 22 p., e3001091.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File
    86 Citations (Scopus)
    172 Downloads (Pure)

  • Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies

    Armstrong, L. A., Lange, S. M., de Cesare, V., Matthews, S. P., Nirujogi, R. S., Cole, I., Hope, A., Cunningham, F., Toth, R., Mukherjee, R., Bojkova, D., Gruber, F., Gray, D., Wyatt, P. G., Cinatl, J., Dikic, I., Davies, P. & Kulathu, Y., 16 Jul 2021, In: PLoS ONE. 16, 7, 25 p., e0253364.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File
    29 Citations (Scopus)
    77 Downloads (Pure)

  • Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

    Gordon, D. E., Hiatt, J., Bouhaddou, M., Rezelj, V. V., Ulferts, S., Braberg, H., Jureka, A. S., Obernier, K., Guo, J. Z., Batra, J., Kaake, R. M., Weckstein, A. R., Owens, T. W., Gupta, M., Pourmal, S., Titus, E. W., Cakir, M., Soucheray, M., McGregor, M., Cakir, Z., & 40 othersJang, G., O'Meara, M. J., Tummino, T. A., Zhang, Z., Foussard, H., Rojc, A., Zhou, Y., Kuchenov, D., Hüttenhain, R., Xu, J., Eckhardt, M., Swaney, D. L., Fabius, J. M., Ummadi, M., Tutuncuoglu, B., Rathore, U., Modak, M., Haas, P., Haas, K. M., Williams, D. M., Hastie, C. J., Elliott, M., Brown, F., Burness, K. A., Reid, E., Baillie, C., Raggett, S., Toth, R., Alessi, D. R., Davies, P., García-Sastre, A., Rassen, J. A., Grosse, R., Rosenberg, O. S., Verba, K. A., Basler, C. F., Vignuzzi, M., Peden, A. A., Beltrao, P. & Krogan, N. J., 4 Dec 2020, In: Science (New York, N.Y.). 370, 6521, 28 p., eabe9403.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File
    376 Citations (Scopus)
    133 Downloads (Pure)
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