Non-canonical Pathways for Regulation of AMPK (Senior Investigator Award)

Research output

Research output per year 2012 2012 2013 2014 2015 2016 2017 2022

• 30 Article
• 12 Review article
• 2 Chapter (peer-reviewed)
• 2 Letter
• 1 More
  • 1 Editorial

Research output per year

Research output per year

Search results

• 2022

  100 years of the Warburg effect: a historical perspective

  Hardie, D. G., Dec 2022, In: Endocrine-Related Cancer. 29, 12, p. T1-T13 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Oxygen 100%
  • Lactic Acid 93%
  • Glycolysis 73%
  • Glucose 44%
  • Fermentation 37%
  1 Citation (Scopus)

  47 Downloads (Pure)
• 2020

  Mechanism of Activation of AMPK by Cordycepin

  Hawley, S. A., Ross, F. A., Russell, F. M., Atrih, A., Lamont, D. & Hardie, D. G., 20 Feb 2020, In: Cell Chemical Biology. 27, 2, p. 214-222.e4 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cordycepin 100%
  • cordycepin 98%
  • AMP-Activated Protein Kinases 74%
  • Protein 25%
  • Adenosine Monophosphate 18%
  28 Citations (Scopus)

  65 Downloads (Pure)
• 2018

  Cell-Free Assays to Measure Effects of Regulatory Ligands on AMPK

  Fyffe, F. A., Hawley, S. A., Gray, A. & Hardie, D. G., 2018, AMPK : Methods and Protocols. Neumann, D. & Viollet, B. (eds.). New York: Humana Press, p. 69-86 18 p. (Methods in Molecular Biology; vol. 1732).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

  • AMP-Activated Protein Kinases 100%
  • Adenosine Triphosphate 65%
  • Adenosine Monophosphate 62%
  • Ligands 59%
  • Adenosine Diphosphate 55%
  6 Citations (Scopus)

• Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2+/CaMKK2 Signaling to Enhance Tumor Cell Survival

  Vara Ciruelos, D., Dandapani, M., Gray, A., Agbani, E. O., Evans, A. M. & Hardie, D. G., Feb 2018, In: Molecular Cancer Research. 16, 2, p. 345-357 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • AMP-Activated Protein Kinases 100%
  • Protein Isoforms 67%
  • Cell Survival 63%
  • Etoposide 44%
  • DNA Damage 36%
  33 Citations (Scopus)

  161 Downloads (Pure)

• Intact Cell Assays to Monitor AMPK and Determine the Contribution of the AMP-Binding or ADaM Sites to Activation

  Hawley, S. A., Fyffe, F. A., Russell, F. M., Gowans, G. J. & Hardie, D. G., 2018, AMPK : Methods and Protocols. Neumann, D. & Viollet, B. (eds.). New York: Humana Press, p. 239-253 15 p. (Methods in Molecular Biology; vol. 1732).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

  • AMP-Activated Protein Kinases 100%
  • Adenosine Monophosphate 93%
  • Binding Sites 64%
  • Phosphotransferases 38%
  • Tissue and Organ Harvesting 25%
  5 Citations (Scopus)
• 2017

  AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System

  Salt, I. P. & Hardie, D. G., 26 May 2017, In: Circulation Research. 120, 11, p. 1825-1841 17 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • AMP-Activated Protein Kinases 100%
  • Cardiovascular System 82%
  • Homeostasis 24%
  • Blood Vessels 19%
  • Anti-Inflammatory Agents 12%
  135 Citations (Scopus)

  138 Downloads (Pure)

• AMP-activated protein kinase - not just an energy sensor

  Hardie, D. G. & Lin, S-C., 22 Sept 2017, In: F1000 Research. 6, p. 1-11 11 p., 1724.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • AMP-Activated Protein Kinases 100%
  • Energy 39%
  • Protein 34%
  • Adenine Nucleotides 23%
  • Nucleotide 22%
  66 Citations (Scopus)

  178 Downloads (Pure)

• Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

  Zhang, C-S., Hawley, S. A., Zong, Y., Li, M., Wang, Z., Gray, A., Ma, T., Cui, J., Feng, J-W., Zhu, M., Wu, Y-Q., Li, T. Y., Ye, Z., Lin, S-Y., Yin, H., Piao, H-L., Hardie, D. G. & Lin, S-C., 3 Aug 2017, In: Nature. 548, 7665, p. 112-116 23 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

  File

  • Fructose-Bisphosphate Aldolase 100%
  • AMP-Activated Protein Kinases 87%
  • Glucose 46%
  • fructose-1,6-diphosphate 43%
  • Adenosine Monophosphate 32%
  347 Citations (Scopus)

  348 Downloads (Pure)

• Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib

  Ross, F. A., Hawley, S. A., Auciello, F. R., Gowans, G. J., Atrih, A., Lamont, D. J. & Hardie, D. G., 20 Jul 2017, In: Cell Chemical Biology. 24, 7, p. 813-824.e4 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • SU6656 100%
  • SU 6656 82%
  • Sorafenib 71%
  • AMP-activated protein kinase kinase 69%
  • Phosphotransferase Inhibitor 57%
  40 Citations (Scopus)

  166 Downloads (Pure)

• The mechanisms of action of metformin

  Rena, G., Hardie, D. G. & Pearson, E. R., Sept 2017, In: Diabetologia. 60, 9, p. 1577-1585 9 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Metformin 100%
  • AMP-Activated Protein Kinases 44%
  • AMP-activated protein kinase kinase 28%
  • Glycerolphosphate Dehydrogenase 27%
  • Glucose 23%
  1059 Citations (Scopus)

  395 Downloads (Pure)
• 2016

  AMP-activated protein kinase: a cellular energy sensor that comes in twelve flavours

  Ross, F. A., MacKintosh, C. & Hardie, D. G., 24 Mar 2016, In: FEBS Journal. 283, 16, p. 2987-3001 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • AMP-Activated Protein Kinases 100%
  • Protein Isoforms 67%
  • Energy 39%
  • Protein 34%
  • Nutrient 29%
  221 Citations (Scopus)

  135 Downloads (Pure)

• AMP-activated protein kinase inhibits K_v1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation

  Moral-Sanz, J., Mahmoud, A. D., Ross, F. A., Eldstrom, J., Fedida, D., Hardie, D. G. & Evans, A. M., 1 Sept 2016, In: Journal of Physiology. 594, 17, p. 4901-4915 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • AMP-Activated Protein Kinases 100%
  • Oxidative Phosphorylation 94%
  • Muscle Cells 76%
  • Hypoxia 65%
  • Lung 44%
  23 Citations (Scopus)

  163 Downloads (Pure)

• AMPK: an energy-sensing pathway with multiple inputs and outputs

  Hardie, D. G., Schaffer, B. E. & Brunet, A., Mar 2016, In: Trends in Cell Biology. 26, 3, p. 190-201 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • AMP-Activated Protein Kinases 100%
  • Adenosine Monophosphate 23%
  • Adenosine Triphosphate 16%
  • Phosphotransferases 16%
  • Phosphorylation 14%
  549 Citations (Scopus)

  457 Downloads (Pure)

• AMPK Causes Cell Cycle Arrest in LKB1-deficient Cells via Activation of CAMKK2

  Fogarty, S., Ross, F. A., Vara Ciruelos, D., Gray, A., Gowans, G. J. & Hardie, D. G., 1 Aug 2016, In: Molecular Cancer Research. 14, 8, p. 683-695 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • AMP-Activated Protein Kinases 100%
  • Cell Cycle Checkpoints 81%
  • Null Lymphocytes 30%
  • Calcimycin 27%
  • Phosphorylation 24%
  49 Citations (Scopus)

  305 Downloads (Pure)

• Bitter Melon (Momordica charantia) Extract Inhibits Tumorigenicity and Overcomes Cisplatin-Resistance in Ovarian Cancer Cells Through Targeting AMPK Signaling Cascade

  Yung, M. M. H., Ross, F. A., Hardie, D. G., Leung, T. H. Y., Zhan, J., Ngan, H. Y. S. & Chan, D. W., 2 Aug 2016, In: Integrative Cancer Therapies. 15, 3, p. 376-389 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Momordica charantia 100%
  • AMP-Activated Protein Kinases 76%
  • Ovarian Neoplasms 58%
  • Cisplatin 57%
  • Nude Mice 10%
  26 Citations (Scopus)

  201 Downloads (Pure)

• Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms

  Ross, F. A., Jensen, T. E. & Hardie, D. G., 15 Jan 2016, In: Biochemical Journal. 473, 2, p. 189-199 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Adenosine Monophosphate 100%
  • ADP 93%
  • Adenosine Diphosphate 89%
  • Protein Isoforms 72%
  • Adenosine Triphosphate 34%
  113 Citations (Scopus)

  120 Downloads (Pure)

• The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels

  Hawley, S., Ford, R. J., Smith, B. K., Gowans, G., Mancini, S. J., Pitt, R. D., A. Day, E., Salt, I. P., Steinberg, G. R. & Hardie, D. G., Sept 2016, In: Diabetes. 65, 9, p. 2784-2794 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Canagliflozin 100%
  • AMP-Activated Protein Kinases 75%
  • Adenosine Monophosphate 70%
  • Phlorhizin 40%
  • Glucose 39%
  233 Citations (Scopus)

  346 Downloads (Pure)
• 2015

  AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

  Hardie, D. G., Apr 2015, In: Current Opinion in Cell Biology. 33, April, p. 1-7 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • AMP-Activated Protein Kinases 100%
  • Homeostasis 61%
  • Phosphorylation 43%
  • AMP-activated protein kinase kinase 31%
  • Physiological Stress 24%
  344 Citations (Scopus)

• Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α

  Rog-Zielinska, E. A., Craig, M. A., Manning, J. R., Richardson, R. V., Gowans, G. J., Dunbar, D. R., Gharbi, K., Kenyon, C. J., Holmes, M. C., Hardie, D. G., Smith, G. L. & Chapman, K. E., 1 Jul 2015, In: Cell Death & Differentiation. 22, 7, p. 1106-1116 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cardiac Myocytes 100%
  • Glucocorticoids 97%
  • Glucocorticoid Receptors 71%
  • Myofibrils 51%
  • In Vitro Techniques 28%
  87 Citations (Scopus)

  122 Downloads (Pure)

• Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation

  Pirkmajer, S., Kulkarni, S. S., Tom, R. Z., Ross, F. A., Hawley, S. A., Hardie, D. G., Zierath, J. R. & Chibalin, A. V., Feb 2015, In: Diabetes. 64, 2, p. 360-369 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • AICA ribonucleotide 100%
  • Methotrexate 63%
  • Skeletal Muscle 51%
  • Lipids 42%
  • Glucose 41%
  52 Citations (Scopus)

  154 Downloads (Pure)

• Molecular pathways: is AMPK a friend or a foe in cancer?

  Hardie, D. G., 1 Sept 2015, In: Clinical Cancer Research. 21, 17, p. 3836-3840 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • AMP-Activated Protein Kinases 100%
  • Adenosine Triphosphate 37%
  • Neoplasms 26%
  • Cell Proliferation 15%
  • Salicylates 15%
  121 Citations (Scopus)

  134 Downloads (Pure)

• PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain

  Jensen, T. E., Ross, F. A., Kleinert, M., Sylow, L., Knudsen, J. R., Gowans, G. J., Hardie, D. G. & Richter, E. A., May 2015, In: Biochemical Journal. 467, 3, p. 461-472 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • AMP-Activated Protein Kinases 100%
  • Electron Transport 91%
  • Cultured Cells 70%
  • Skeletal Muscle 66%
  • Adenosine Monophosphate 34%
  39 Citations (Scopus)

  146 Downloads (Pure)
• 2014

  AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease

  Hardie, D. G., Dec 2014, In: Journal of Internal Medicine. 276, 6, p. 543-559 17 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • AMP-Activated Protein Kinases 100%
  • Salicylates 16%
  • Metformin 13%
  • Aspirin 11%
  • Adenosine Triphosphate 10%
  200 Citations (Scopus)

  158 Downloads (Pure)

• AMP-Activated Protein Kinase: Maintaining Energy Homeostasis at the Cellular and Whole-Body Levels

  Hardie, D. G., Jul 2014, In: Annual Review of Nutrition. 34, p. 31-55 25 p.

  Research output: Contribution to journal › Review article › peer-review

  • AMP-Activated Protein Kinases 100%
  • Adenosine Monophosphate 93%
  • Protein Kinases 77%
  • Adenosine Triphosphate 65%
  • Homeostasis 61%
  172 Citations (Scopus)

• AMPK: a cellular energy sensor primarily regulated by AMP

  Gowans, G. J. & Hardie, D. G., 1 Feb 2014, In: Biochemical Society Transactions. 42, 1, p. 71-75 5 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • AMP-Activated Protein Kinases 100%
  • Adenosine Monophosphate 93%
  • ADP 69%
  • Adenosine Diphosphate 66%
  • Adenosine Triphosphate 65%
  103 Citations (Scopus)

  170 Downloads (Pure)

• AMPK: regulating energy balance at the cellular and whole body levels

  Hardie, D. G. & Ashford, M. L. J., Mar 2014, In: Physiology. 29, 2, p. 99-107 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Adenine Nucleotides 100%
  • AMP-Activated Protein Kinases 95%
  • Eukaryota 82%
  • Energy Intake 80%
  • Energy Metabolism 72%
  201 Citations (Scopus)

  163 Downloads (Pure)

• AMPK-sensing energy while talking to other signaling pathways

  Hardie, D. G., 2 Dec 2014, In: Cell Metabolism. 20, 6, p. 939-952 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • AMP-Activated Protein Kinases 100%
  • Mechanistic Target of Rapamycin Complex 1 42%
  • Nutrients 28%
  • AMP-activated protein kinase kinase 25%
  • Eukaryota 17%
  407 Citations (Scopus)

  159 Downloads (Pure)

• A new protein kinase cascade

  Hardie, D. G., Apr 2014, In: Nature Reviews Molecular Cell Biology. 15, 4, p. 223 1 p.

  Research output: Contribution to journal › Article › peer-review
  3 Citations (Scopus)

• Mechanism of Action of Compound-13: an α1-Selective Small Molecule Activator of AMPK

  Hunter, R. W., Foretz, M., Bultot, L., Fullerton, M. D., Deak, M., Ross, F. A., Hawley, S. A., Shpiro, N., Viollet, B., Barron, D., Kemp, B. E., Steinberg, G. R., Hardie, D. G. & Sakamoto, K., 17 Jul 2014, In: Chemistry & Biology. 21, 7, p. 866-879 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dephosphorylation 100%
  • Adenosine Monophosphate 89%
  • Hepatocytes 44%
  • Prodrug 42%
  • Disorder 34%
  89 Citations (Scopus)

  224 Downloads (Pure)

• Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

  Hawley, S. A., Ross, F. A., Gowans, G. J., Tibarewal, P., Leslie, N. R. & Hardie, D. G., 15 Apr 2014, In: Biochemical Journal. 459, 2, p. 275-287 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • A 769662 100%
  • PTEN Phosphohydrolase 78%
  • Down-Regulation 77%
  • Phosphorylation 75%
  • AMP-Activated Protein Kinases 65%
  149 Citations (Scopus)

  161 Downloads (Pure)
• 2013

  AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

  Gowans, G. J., Hawley, S. A., Ross, F. A. & Hardie, D. G., 1 Oct 2013, In: Cell Metabolism. 18, 4, p. 556-566 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • AMP-Activated Protein Kinases 100%
  • Adenosine Monophosphate 93%
  • Phosphorylation 57%
  • Adenosine Diphosphate 41%
  • Adenosine Triphosphate 16%
  350 Citations (Scopus)

  179 Downloads (Pure)

• AMPK: a target for drugs and natural products with effects on both diabetes and cancer

  Hardie, D. G., Jul 2013, In: Diabetes. 62, 7, p. 2164-2172 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • AMP-Activated Protein Kinases 100%
  • Biological Products 82%
  • Metformin 38%
  • Pharmaceutical Preparations 34%
  • Salicylates 30%
  329 Citations (Scopus)

  158 Downloads (Pure)

• AMPK: mediating the metabolic effects of salicylate-based drugs?

  Steinberg, G. R., Dandapani, M. & Hardie, D. G., Oct 2013, In: Trends in Endocrinology and Metabolism. 24, 10, p. 481-487 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • Salicylates 100%
  • AMP-Activated Protein Kinases 93%
  • salicylsalicylic acid 56%
  • Pharmaceutical Preparations 32%
  • Aspirin 28%
  62 Citations (Scopus)

• AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?

  Dandapani, M. & Hardie, D. G., Apr 2013, In: Biochemical Society Transactions. 41, 2, p. 687-693 7 p.

  Research output: Contribution to journal › Article › peer-review

  • AMP-Activated Protein Kinases 100%
  • Glycolysis 70%
  • Metabolic 67%
  • Pharmacological Metabolism 38%
  • Glucose 36%
  37 Citations (Scopus)

• Glycogen Content Regulates Peroxisome Proliferator Activated Receptor-∂ (PPAR-∂) Activity in Rat Skeletal Muscle

  Philp, A., MacKenzie, M. G., Belew, M. Y., Towler, M. C., Corstorphine, A., Papalamprou, A., Hardie, D. G. & Baar, K., 17 Oct 2013, In: PLoS ONE. 8, 10, p. e77200

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Peroxisome Proliferator-Activated Receptors 100%
  • Glycogen 86%
  • Skeletal Muscle 65%
  • Mitochondrial Genes 7%
  • Skeletal Muscle Fibers 6%
  33 Citations (Scopus)

  127 Downloads (Pure)

• LKB1 and AMPK and the cancer-metabolism link - ten years after

  Hardie, D. G. & Alessi, D. R., 15 Apr 2013, In: BMC Biology. 11, p. 1-11 11 p., 36.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • AMP-activated protein kinase 100%
  • AMP-Activated Protein Kinases 86%
  • cancer 68%
  • metabolism 61%
  • neoplasms 55%
  241 Citations (Scopus)

  152 Downloads (Pure)

• Metabolism of inflammation limited by AMPK and pseudo-starvation

  O'Neill, L. A. J. & Hardie, D. G., 17 Jan 2013, In: Nature. 493, 7432, p. 346-355 10 p.

  Research output: Contribution to journal › Article › peer-review

  • AMP-Activated Protein Kinases 100%
  • Starvation 90%
  • Anti-Inflammatory Agents 61%
  • Macrophages 58%
  • Pentose Phosphate Pathway 55%
  802 Citations (Scopus)

• Metformin-Acting through Cyclic AMP as well as AMP?

  Hardie, D. G., 5 Mar 2013, In: Cell Metabolism. 17, 3, p. 313-4 2 p.

  Research output: Contribution to journal › Article › peer-review

  • Adenosine Monophosphate 100%
  • Metformin 96%
  • Glucagon 93%
  • Cyclic AMP 88%
  • Therapeutic Uses 74%
  13 Citations (Scopus)

• Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

  Fullerton, M. D., Galic, S., Marcinko, K., Sikkema, S., Pulinilkunnil, T., Chen, Z-P., O'Neill, H. M., Ford, R. J., Palanivel, R., O'Brien, M., Hardie, D. G., Macaulay, S. L., Schertzer, J. D., Dyck, J. R. B., van Denderen, B. J., Kemp, B. E. & Steinberg, G. R., 2013, In: Nature Medicine. 19, p. 1649-1654 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Metformin 100%
  • AMP-Activated Protein Kinases 84%
  • Acetyl-CoA 57%
  • mouse ACC1 protein 54%
  • Homeostasis 51%
  566 Citations (Scopus)

• The LKB1-AMPK Pathway-Friend or Foe in Cancer?

  Hardie, D. G., 11 Feb 2013, In: Cancer Cell. 23, 2, p. 131-132 2 p.

  Research output: Contribution to journal › Editorial › peer-review

  • Biguanides 100%
  • Metformin 37%
  • Neoplasms 33%
  • Incidence 16%
  • Therapeutics 5%
  57 Citations (Scopus)
• 2012

  AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern

  Hardie, D. G., Ross, F. A. & Hawley, S. A., 26 Oct 2012, In: Chemistry & Biology. 19, 10, p. 1222-36 15 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • AMP-Activated Protein Kinases 100%
  • Metformin 89%
  • Cyclic AMP-Dependent Protein Kinases 86%
  • Adenosine Triphosphate 48%
  • Drug 44%
  287 Citations (Scopus)

  162 Downloads (Pure)

• AMPK: a nutrient and energy sensor that maintains energy homeostasis

  Hardie, D. G., Ross, F. A. & Hawley, S. A., 1 Apr 2012, In: Nature Reviews Molecular Cell Biology. 13, 4, p. 251-262 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • AMP-Activated Protein Kinases 100%
  • Nutrients 71%
  • Adenosine Triphosphate 65%
  • Homeostasis 61%
  • Biosynthetic Pathways 33%
  2920 Citations (Scopus)

  287 Downloads (Pure)

• AMPK activators inhibit the proliferation of human melanomas bearing the activated MAPK pathway

  Petti, C., Vegetti, C., Molla, A., Bersani, I., Cleris, L., Mustard, K. J., Formelli, F., Hardie, G. D., Sensi, M. & Anichini, A., 2012, In: Melanoma Research. 22, 5, p. 341-350 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Melanoma 100%
  • acadesine 86%
  • 4-aminoimidazole 80%
  • Phenformin 54%
  • Mitogen-Activated Protein Kinase Kinases 37%
  38 Citations (Scopus)

• AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells

  Lee, C-W., Wong, L. L-Y., Tse, E. Y-T., Liu, H-F., Leong, V. Y-L., Lee, J. M-F., Hardie, D. G., Ng, I. O-L. & Ching, Y-P., 2012, In: Cancer Research. 72, 17, p. 4394-4404 11 p.

  Research output: Contribution to journal › Article › peer-review

  • AMP-Activated Protein Kinases 100%
  • Acetylation 87%
  • Liver Neoplasms 83%
  • Phosphorylation 57%
  • Hepatocellular Carcinoma 37%
  162 Citations (Scopus)

• Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells

  Turban, S., Stretton, C., Drouin, O., Green, C. J., Watson, M. L., Gray, A., Ross, F., Lantier, L., Viollet, B., Hardie, D. G., Marette, A. & Hundal, H. S., 8 Jun 2012, In: Journal of Biological Chemistry. 287, 24, p. 20088-20099 12 p.

  Research output: Contribution to journal › Article › peer-review

  • AMP-activated protein kinase kinase 100%
  • Metformin 94%
  • AMP-Activated Protein Kinases 79%
  • Protein Kinase C 62%
  • Muscle Cells 60%
  74 Citations (Scopus)

• The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

  Hawley, S. A., Fullerton, M. D., Ross, F. A., Schertzer, J. D., Chevtzoff, C., Walker, K. J., Peggie, M. W., Zibrova, D., Green, K. A., Mustard, K. J., Kemp, B. E., Sakamoto, K., Steinberg, G. R. & Hardie, D. G., 18 May 2012, In: Science. 336, 6083, p. 918-922 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Salicylates 100%
  • AMP-Activated Protein Kinases 93%
  • salicylsalicylic acid 85%
  • Adenosine Monophosphate 52%
  • Aspirin 43%
  567 Citations (Scopus)

• The role of ATM in response to metformin treatment and activation of AMPK reply

  Zhou, K., Bellenguez, C., Sutherland, C., Hardie, G., Palmer, C., Donnelly, P. & Pearson, E., Apr 2012, In: Nature Genetics. 44, 4, p. 361-362 2 p.

  Research output: Contribution to journal › Letter › peer-review
  15 Citations (Scopus)