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2020
Mechanism of Activation of AMPK by Cordycepin
Hawley, S. A., Ross, F. A., Russell, F. M., Atrih, A., Lamont, D. & Hardie, D. G. (Lead / Corresponding author), 20 Feb 2020, In: Cell Chemical Biology. 27, 2, p. 214-222.e4 14 p.Research output: Contribution to journal › Article › peer-review
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2018
Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2+/CaMKK2 Signaling to Enhance Tumor Cell Survival
Vara Ciruelos, D., Dandapani, M., Gray, A., Agbani, E. O., Evans, A. M. & Hardie, D. G. (Lead / Corresponding author), Feb 2018, In: Molecular Cancer Research. 16, 2, p. 345-357 13 p.Research output: Contribution to journal › Article › peer-review
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2017
Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib
Ross, F. A., Hawley, S. A., Auciello, F. R., Gowans, G. J., Atrih, A., Lamont, D. J. & Hardie, D. G. (Lead / Corresponding author), 20 Jul 2017, In: Cell Chemical Biology. 24, 7, p. 813-824.e4 16 p.Research output: Contribution to journal › Article › peer-review
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2016
AMP-activated protein kinase: a cellular energy sensor that comes in twelve flavours
Ross, F. A., MacKintosh, C. & Hardie, D. G. (Lead / Corresponding author), 24 Mar 2016, In: FEBS Journal. 283, 16, p. 2987-3001 15 p.Research output: Contribution to journal › Article › peer-review
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AMP-activated protein kinase inhibits Kv1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation
Moral-Sanz, J., Mahmoud, A. D., Ross, F. A., Eldstrom, J., Fedida, D., Hardie, D. G. & Evans, A. M. (Lead / Corresponding author), 1 Sept 2016, In: Journal of Physiology. 594, 17, p. 4901-4915 15 p.Research output: Contribution to journal › Article › peer-review
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AMPK Causes Cell Cycle Arrest in LKB1-deficient Cells via Activation of CAMKK2
Fogarty, S., Ross, F. A., Vara Ciruelos, D., Gray, A., Gowans, G. J. & Hardie, D. G. (Lead / Corresponding author), 1 Aug 2016, In: Molecular Cancer Research. 14, 8, p. 683-695 13 p.Research output: Contribution to journal › Article › peer-review
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Bitter Melon (Momordica charantia) Extract Inhibits Tumorigenicity and Overcomes Cisplatin-Resistance in Ovarian Cancer Cells Through Targeting AMPK Signaling Cascade
Yung, M. M. H., Ross, F. A., Hardie, D. G., Leung, T. H. Y., Zhan, J., Ngan, H. Y. S. & Chan, D. W. (Lead / Corresponding author), 2 Aug 2016, In: Integrative Cancer Therapies. 15, 3, p. 376-389 14 p.Research output: Contribution to journal › Article › peer-review
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Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms
Ross, F. A., Jensen, T. E. & Hardie, D. G. (Lead / Corresponding author), 15 Jan 2016, In: Biochemical Journal. 473, 2, p. 189-199 11 p.Research output: Contribution to journal › Article › peer-review
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The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels
Hawley, S., Ford, R. J., Smith, B. K., Gowans, G., Mancini, S. J., Pitt, R. D., A. Day, E., Salt, I. P., Steinberg, G. R. (Lead / Corresponding author) & Hardie, D. G. (Lead / Corresponding author), Sept 2016, In: Diabetes. 65, 9, p. 2784-2794 11 p.Research output: Contribution to journal › Article › peer-review
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2015
Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α
Rog-Zielinska, E. A., Craig, M. A., Manning, J. R., Richardson, R. V., Gowans, G. J., Dunbar, D. R., Gharbi, K., Kenyon, C. J., Holmes, M. C., Hardie, D. G., Smith, G. L. & Chapman, K. E. (Lead / Corresponding author), 1 Jul 2015, In: Cell Death & Differentiation. 22, 7, p. 1106-1116 11 p.Research output: Contribution to journal › Article › peer-review
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Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation
Pirkmajer, S., Kulkarni, S. S., Tom, R. Z., Ross, F. A., Hawley, S. A., Hardie, D. G., Zierath, J. R. & Chibalin, A. V. (Lead / Corresponding author), Feb 2015, In: Diabetes. 64, 2, p. 360-369 10 p.Research output: Contribution to journal › Article › peer-review
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Molecular pathways: is AMPK a friend or a foe in cancer?
Hardie, D. G., 1 Sept 2015, In: Clinical Cancer Research. 21, 17, p. 3836-3840 5 p.Research output: Contribution to journal › Article › peer-review
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PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain
Jensen, T. E. (Lead / Corresponding author), Ross, F. A., Kleinert, M., Sylow, L., Knudsen, J. R., Gowans, G. J., Hardie, D. G. & Richter, E. A., May 2015, In: Biochemical Journal. 467, 3, p. 461-472 12 p.Research output: Contribution to journal › Article › peer-review
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2014
AMPK: regulating energy balance at the cellular and whole body levels
Hardie, D. G. & Ashford, M. L. J., Mar 2014, In: Physiology. 29, 2, p. 99-107 9 p.Research output: Contribution to journal › Article › peer-review
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AMPK-sensing energy while talking to other signaling pathways
Hardie, D. G. (Lead / Corresponding author), 2 Dec 2014, In: Cell Metabolism. 20, 6, p. 939-952 14 p.Research output: Contribution to journal › Article › peer-review
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A new protein kinase cascade
Hardie, D. G. (Lead / Corresponding author), Apr 2014, In: Nature Reviews Molecular Cell Biology. 15, 4, p. 223 1 p.Research output: Contribution to journal › Article › peer-review
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Mechanism of Action of Compound-13: an α1-Selective Small Molecule Activator of AMPK
Hunter, R. W., Foretz, M., Bultot, L., Fullerton, M. D., Deak, M., Ross, F. A., Hawley, S. A., Shpiro, N., Viollet, B., Barron, D., Kemp, B. E., Steinberg, G. R., Hardie, D. G. & Sakamoto, K. (Lead / Corresponding author), 17 Jul 2014, In: Chemistry & Biology. 21, 7, p. 866-879 14 p.Research output: Contribution to journal › Article › peer-review
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Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells
Hawley, S. A., Ross, F. A., Gowans, G. J., Tibarewal, P., Leslie, N. R. & Hardie, D. G. (Lead / Corresponding author), 15 Apr 2014, In: Biochemical Journal. 459, 2, p. 275-287 13 p.Research output: Contribution to journal › Article › peer-review
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2013
AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation
Gowans, G. J., Hawley, S. A., Ross, F. A. & Hardie, D. G. (Lead / Corresponding author), 1 Oct 2013, In: Cell Metabolism. 18, 4, p. 556-566 11 p.Research output: Contribution to journal › Article › peer-review
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AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?
Dandapani, M. & Hardie, D. G. (Lead / Corresponding author), Apr 2013, In: Biochemical Society Transactions. 41, 2, p. 687-693 7 p.Research output: Contribution to journal › Article › peer-review
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AMPK: a target for drugs and natural products with effects on both diabetes and cancer
Hardie, D. G. (Lead / Corresponding author), Jul 2013, In: Diabetes. 62, 7, p. 2164-2172 9 p.Research output: Contribution to journal › Article › peer-review
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Glycogen Content Regulates Peroxisome Proliferator Activated Receptor-∂ (PPAR-∂) Activity in Rat Skeletal Muscle
Philp, A., MacKenzie, M. G., Belew, M. Y., Towler, M. C., Corstorphine, A., Papalamprou, A., Hardie, D. G. & Baar, K. (Lead / Corresponding author), 17 Oct 2013, In: PLoS ONE. 8, 10, p. e77200Research output: Contribution to journal › Article › peer-review
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LKB1 and AMPK and the cancer-metabolism link - ten years after
Hardie, D. G. & Alessi, D. R., 15 Apr 2013, In: BMC Biology. 11, p. 1-11 11 p., 36.Research output: Contribution to journal › Article › peer-review
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Metabolism of inflammation limited by AMPK and pseudo-starvation
O'Neill, L. A. J. (Lead / Corresponding author) & Hardie, D. G., 17 Jan 2013, In: Nature. 493, 7432, p. 346-355 10 p.Research output: Contribution to journal › Article › peer-review
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Metformin-Acting through Cyclic AMP as well as AMP?
Hardie, D. G., 5 Mar 2013, In: Cell Metabolism. 17, 3, p. 313-4 2 p.Research output: Contribution to journal › Article › peer-review
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Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
Fullerton, M. D., Galic, S., Marcinko, K., Sikkema, S., Pulinilkunnil, T., Chen, Z.-P., O'Neill, H. M., Ford, R. J., Palanivel, R., O'Brien, M., Hardie, D. G., Macaulay, S. L., Schertzer, J. D., Dyck, J. R. B., van Denderen, B. J., Kemp, B. E. & Steinberg, G. R., 2013, In: Nature Medicine. 19, p. 1649-1654 6 p.Research output: Contribution to journal › Article › peer-review
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2012
AMPK activators inhibit the proliferation of human melanomas bearing the activated MAPK pathway
Petti, C., Vegetti, C., Molla, A., Bersani, I., Cleris, L., Mustard, K. J., Formelli, F., Hardie, G. D., Sensi, M. & Anichini, A., 2012, In: Melanoma Research. 22, 5, p. 341-350 10 p.Research output: Contribution to journal › Article › peer-review
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AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells
Lee, C.-W., Wong, L.L.-Y., Tse, E.Y.-T., Liu, H.-F., Leong, V.Y.-L., Lee, J.M.-F., Hardie, D. G., Ng, I.O.-L. & Ching, Y.-P., 2012, In: Cancer Research. 72, 17, p. 4394-4404 11 p.Research output: Contribution to journal › Article › peer-review
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Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells
Turban, S., Stretton, C., Drouin, O., Green, C. J., Watson, M. L., Gray, A., Ross, F., Lantier, L., Viollet, B., Hardie, D. G., Marette, A. & Hundal, H. S. (Lead / Corresponding author), 8 Jun 2012, In: Journal of Biological Chemistry. 287, 24, p. 20088-20099 12 p.Research output: Contribution to journal › Article › peer-review
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The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase
Hawley, S. A., Fullerton, M. D., Ross, F. A., Schertzer, J. D., Chevtzoff, C., Walker, K. J., Peggie, M. W., Zibrova, D., Green, K. A., Mustard, K. J., Kemp, B. E., Sakamoto, K., Steinberg, G. R. & Hardie, D. G. (Lead / Corresponding author), 18 May 2012, In: Science. 336, 6083, p. 918-922 5 p.Research output: Contribution to journal › Article › peer-review
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