Research output per year
Research output per year
Research output
- 15 Article
- 15 results
Search results
-
2024
CMG helicase disassembly is essential and driven by two pathways in budding yeast
Polo Rivera, C., Deegan, T. D. (Lead / Corresponding author) & Labib, K. (Lead / Corresponding author), 22 Jul 2024, In: The EMBO Journal. 43, 18, p. 3818-3845 28 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)23 Downloads (Pure) -
Mechanism of human PINK1 activation at the TOM complex in a reconstituted system
Raimi, O. G., Ojha, H., Ehses, K., Dederer, V., Lange, S. M., Rivera, C. P., Deegan, T. D., Chen, Y., Wightman, M., Toth, R., Labib, K. P. M., Mathea, S., Ranson, N., Fernández-Busnadiego, R. & Muqit, M. M. K. (Lead / Corresponding author), Jun 2024, In: Science Advances. 10, 23, 16 p., eadn7191.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)48 Downloads (Pure) -
2023
DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans
Xia, Y., Sonneville, R., Jenkyn-Bedford, M., Ji, L., Alabert, C., Hong, Y. (Lead / Corresponding author), Yeeles, J. T. P. (Lead / Corresponding author) & Labib, K. P. M. (Lead / Corresponding author), 22 Sept 2023, In: Science. 381, 6664, p. eadi4932 30 p., adi4932.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)354 Downloads (Pure) -
DONSON is required for CMG helicase assembly in the mammalian cell cycle
Evrin, C., Alvarez, V., Ainsworth, J., Fujisawa, R., Alabert, C. (Lead / Corresponding author) & Labib, K. P. M. (Lead / Corresponding author), 6 Nov 2023, In: EMBO Reports. 24, 11, p. 1-11 11 p., e57677.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)60 Downloads (Pure) -
2022
Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase
Fujisawa, R., Polo Rivera, C. & Labib, K. (Lead / Corresponding author), 15 Aug 2022, In: eLife. 11, 27 p., e76763.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)93 Downloads (Pure) -
Replicon-seq: seeing is believing
Polo Rivera, C. & Deegan, T. D. (Lead / Corresponding author), 26 May 2022, (E-pub ahead of print) In: Trends in Genetics. 38, 10, p. 987-988 2 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)52 Downloads (Pure) -
2021
CUL2LRR1, TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle
Villa, F., Fujisawa, R., Ainsworth, J., Nishimura, K., Lie-A-Ling, M., Lacaud, G. & Labib, K. (Lead / Corresponding author), 3 Mar 2021, In: EMBO Reports. 22, 3, 13 p., e52164.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Citations (Scopus)215 Downloads (Pure) -
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase
Basu, S. (Lead / Corresponding author), Mak, T. (Lead / Corresponding author), Ulferts, R., Wu, M., Deegan, T., Fujisawa, R., Tan, K. W., Lim, C. T., Basier, C., Canal, B., Curran, J. F., Drury, L. S., McClure, A. W., Roberts, E. L., Weissmann, F., Zeisner, T. U., Beale, R., Cowling, V. H., Howell, M. & Labib, K. & 1 others, , 2 Jul 2021, In: Biochemical Journal. 478, 13, p. 2481-2497 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile34 Citations (Scopus)160 Downloads (Pure) -
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease
Canal, B., Fujisawa, R., McClure, A. W., Deegan, T. D., Wu, M., Ulferts, R., Weissmann, F., Drury, L. S., Bertolin, A. P., Zeng, J., Beale, R., Howell, M., Labib, K. & Diffley, J. F. X. (Lead / Corresponding author), 2 Jul 2021, In: Biochemical Journal. 478, 13, p. 2465-2479 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile33 Citations (Scopus)155 Downloads (Pure) -
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease
Milligan, J. C., Zeisner, T. U., Papageorgiou, G., Joshi, D., Soudy, C., Ulferts, R., Wu, M., Lim, C. T., Tan, K. W., Weissmann, F., Canal, B., Fujisawa, R., Deegan, T., Nagaraj, H., Bineva-Todd, G., Basier, C., Curran, J. F., Howell, M., Beale, R. & Labib, K. & 2 others, , 2 Jul 2021, In: Biochemical Journal. 478, 13, p. 2499-2515 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile29 Citations (Scopus)150 Downloads (Pure) -
Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes
Le, T. T., Ainsworth, J., Polo Rivera, C., Macartney, T. & Labib, K. P. M. (Lead / Corresponding author), 23 Jul 2021, In: Biochemical Journal. 478, 14, p. 2825-2842 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)109 Downloads (Pure) -
The fate of two unstoppable trains after arriving destination: Replisome disassembly during DNA replication termination
Xia, Y. (Lead / Corresponding author), 21 Jul 2021, In: Frontiers in Cell and Developmental Biology. 9, 7 p., 658003.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)73 Downloads (Pure) -
TIMELESS-TIPIN and UBXN-3 promote replisome disassembly during DNA replication termination in Caenorhabditis elegans
Xia, Y., Fujisawa, R., Deegan, T. D., Sonneville, R. (Lead / Corresponding author) & Labib, K. (Lead / Corresponding author), 1 Sept 2021, In: The EMBO Journal. 40, 17, 18 p., e108053.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)154 Downloads (Pure) -
2020
CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold
Deegan, T. D. (Lead / Corresponding author), Mukherjee, P. P., Fujisawa, R., Polo Rivera, C. & Labib, K. P. M. (Lead / Corresponding author), 17 Aug 2020, In: eLife. 9, 33 p., e60371.Research output: Contribution to journal › Article › peer-review
Open AccessFile47 Citations (Scopus)156 Downloads (Pure) -
2019
TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication
Sonneville, R., Bhowmick, R., Hoffmann, S., Mailand, N., Hickson, I. D. (Lead / Corresponding author) & Labib, K. (Lead / Corresponding author), 23 Sept 2019, In: eLife. 8, p. 1-19 19 p., e48686.Research output: Contribution to journal › Article › peer-review
Open AccessFile56 Citations (Scopus)133 Downloads (Pure)