Keyphrases
Proteolysis Targeting chimera (PROTAC)
92%
Bromodomain-containing Protein 4 (BRD4)
57%
Bump-hole
46%
Melanoma
46%
Sex-determining Region Y-box 2 (SOX2)
46%
Rapid Degradation
46%
Gli1
46%
Transcriptional Complex
46%
Pathway Inhibitors
46%
Selective Degradation
46%
Ternary Complex
46%
Hedgehog
46%
Structural Features
46%
Mechanistic Aspects
46%
Non-canonical
46%
Mode of Action
30%
AlphaLISA
15%
Hook Effect
15%
GLI Signaling
15%
Substoichiometric
15%
Novel Mechanism
15%
Biophysical Methods
15%
E3 Ubiquitin Ligase
15%
Ubiquitination
15%
Binding Model
15%
Holistic Understanding
15%
Catalytic Mechanism
15%
Target Engagement
15%
Ternary Complex Formation
15%
Cooperativity
15%
X-ray Crystallography
15%
Induced Protein Degradation
15%
Cellular Environment
15%
AGB1
11%
CRISPR Knock-in
11%
Heterobifunctional
11%
Degron
11%
E3 Ligase
11%
Mechanistic Data
11%
Biological Therapeutics
11%
Functional Potential
11%
Endogenous Levels
11%
Protein Level
11%
BRD2
11%
Protein Depletion
11%
Therapeutic Potential
11%
Degron Tags
11%
Structure-activity Relationship
11%
Degrons
11%
Pharmacokinetic Profile
11%
Cellular Data
11%
Small Molecules
11%
Chemical Genetics
11%
Genetic Engineering
11%
Hijack
11%
Biological Function
11%
Degrader
11%
Bump
11%
Bromodomain
11%
BRD4 Degrader
7%
Synergistic Antiproliferative Effect
7%
New Targeted Therapy
7%
Smoothened Inhibitor
7%
Human Melanoma
7%
Advanced Melanoma
7%
Proteolysis
7%
Effective Treatment
7%
Chimera
7%
Treatment Regimen
7%
Abrogation
7%
Skin Cancer
7%
Combined Targeting
7%
Pathway Activation
7%
Immune Therapy
7%
Mutational Status
7%
Melanoma Cells
7%
Metastatic Melanoma
7%
Central Pathway
7%
Signal Transduction Inhibitors
7%
Combinational Therapy
7%
Melanoma Model
7%
Antitumor Effect
7%
Biochemistry, Genetics and Molecular Biology
Protein Catabolism
100%
SOX2
46%
Ternary Complex
46%
GLI1
46%
BRD4
46%
Hedgehog
38%
Complex Formation
11%
X-Ray Crystallography
11%
Biological Functions
11%
Ubiquitination
11%
Bromodomain
11%
Cooperation
11%
CRISPR
11%
Chemical Genetics
11%
Ligase
11%
Catalytic Mechanism
11%
Pharmacokinetics
11%
Structure Activity Relation
11%
Ubiquitin-Conjugating Enzyme
11%
Fluorescence Resonance Energy Transfer
11%
Small Molecule
11%
Antiproliferative Activity
7%
Immunity
7%