OPTIMISTIC: Observational Prolonged Trial in Myotonic Dystrophy Type 1 to Improve QoL-Standards, a Target Identification Collaboration (joint with Concentris Research Management GmbH,Radboud University Nijmegen-Holland, Newcastle University, Munich University, University of Paris Est Creteil, Glasgow University and Industrial Partner)

Project Details

Effective start/end date1/11/1230/04/17




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  • MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1

    OPTIMISTIC consortium, Flower, M., Lomeikaite, V., Ciosi, M., Cumming, S., Morales, F., Lo, K., Hensman Moss, D., Jones, L., Holmans, P., Monckton, D. G., Tabrizi, S. J., Taylor, L., Treweek, S., Hogarth, F., Littleford, R., Donnan, P., Hapca, A., Mckenzie, E. & Rauchhaus, P., Jul 2019, In: Brain. 142, 7, p. 1876-1886 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    95 Citations (Scopus)
    22 Downloads (Pure)
  • Cognitive behaviour therapy plus aerobic exercise training to increase activity in patients with myotonic dystrophy type 1 (DM1) compared to usual care (OPTIMISTIC): Study protocol for randomised controlled trial

    van Engelen, B., Abghari, S., Aschrafi, A., Bouman, S., Cornelissen, Y., Glennon, J., Groot, P., Heerschap, A., Heskamp, L., Heskes, T., Kapusta, K., Klerks, E., Knoop, H., Maas, D., Okkersen, K., Poelmans, G., Rahmadi, R., van Nimwegen, M., Gorman, G., Moreno, C. J., & 37 othersLochmüller, H., Trenell, M., van Laar, S., Wood, L., Schoser, B., Wenninger, S., Schüller, A., Auguston, R., Baptiste, L., Barau, C., Bassez, G., Chevalier, P., Couppey, F., Delmas, S., Deux, J. F., Dogan, C., Hamadouche, A., Hankiewicz, K., Lhermet, L., Minier, L., Rialland, A., Schmitz, D., Monckton, D. G., Cumming, S. A., Adam, B., Donnan, P., Hannah, M., Hogarth, F., Littleford, R., McKenzie, E., Rauchhaus, P., Wilkie, E., Williamson, J., Catt, M., Dittrich, J., Schwalber, A. & Treweek, S., 23 May 2015, In: Trials. 16, 224, 19 p., 224.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    47 Citations (Scopus)
    215 Downloads (Pure)