OPTIMISTIC: Observational Prolonged Trial in Myotonic Dystrophy Type 1 to Improve QoL-Standards, a Target Identification Collaboration (joint with Concentris Research Management GmbH,Radboud University Nijmegen-Holland, Newcastle University, Munich University, University of Paris Est Creteil, Glasgow University and Industrial Partner)

Project Details

StatusFinished
Effective start/end date1/11/1230/04/17

Funding

  • COMMISSION OF THE EUROPEAN COMMUNITIES (OPTIMISTIC: 305697): £192,955.00

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  • MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1

    OPTIMISTIC consortium, Flower, M., Lomeikaite, V., Ciosi, M., Cumming, S., Morales, F., Lo, K., Hensman Moss, D., Jones, L., Holmans, P., Monckton, D. G., Tabrizi, S. J., Taylor, L., Treweek, S., Hogarth, F., Littleford, R., Donnan, P., Hapca, A., Mckenzie, E. & Rauchhaus, P., Jul 2019, In: Brain. 142, 7, p. 1876-1886 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
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    95 Citations (Scopus)
    22 Downloads (Pure)
  • Cognitive behaviour therapy plus aerobic exercise training to increase activity in patients with myotonic dystrophy type 1 (DM1) compared to usual care (OPTIMISTIC): Study protocol for randomised controlled trial

    van Engelen, B., Abghari, S., Aschrafi, A., Bouman, S., Cornelissen, Y., Glennon, J., Groot, P., Heerschap, A., Heskamp, L., Heskes, T., Kapusta, K., Klerks, E., Knoop, H., Maas, D., Okkersen, K., Poelmans, G., Rahmadi, R., van Nimwegen, M., Gorman, G., Moreno, C. J., & 37 othersLochmüller, H., Trenell, M., van Laar, S., Wood, L., Schoser, B., Wenninger, S., Schüller, A., Auguston, R., Baptiste, L., Barau, C., Bassez, G., Chevalier, P., Couppey, F., Delmas, S., Deux, J. F., Dogan, C., Hamadouche, A., Hankiewicz, K., Lhermet, L., Minier, L., Rialland, A., Schmitz, D., Monckton, D. G., Cumming, S. A., Adam, B., Donnan, P., Hannah, M., Hogarth, F., Littleford, R., McKenzie, E., Rauchhaus, P., Wilkie, E., Williamson, J., Catt, M., Dittrich, J., Schwalber, A. & Treweek, S., 23 May 2015, In: Trials. 16, 224, 19 p., 224.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    File
    47 Citations (Scopus)
    215 Downloads (Pure)