Physiological Studies of Sperm from Normal and Sub Fertile Men (joint with Universities of Birmingham and Durham)

2019

Novel pharmacological actions of Trequinsin Hydrochloride improve human sperm cell motility and function

McBrinn, R. C., Fraser, J., Hope, A. G., Gray, D. W., Barratt, C. L. R., Martins da Silva, S. J. (Lead / Corresponding author) & Brown, S. G. (Lead / Corresponding author), Dec 2019, In: British Journal of Pharmacology. 176, 23, p. 4521-4536 16 p.

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23 Citations (Scopus)

158 Downloads (Pure)

2018

Homozygous in-frame deletion in CATSPERE in a man producing spermatozoa with loss of CatSper function and compromised fertilizing capacity

Brown, S. G., Miller, M. R., Lishko, P. V., Lester, D. H., Publicover, S. J., Barratt, C. L. R. (Lead / Corresponding author) & Martins Da Silva, S., 1 Oct 2018, In: Human Reproduction. 33, 10, p. 1812-1816 5 p.

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Open Access

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49 Citations (Scopus)

216 Downloads (Pure)

Single-cell analysis of [Ca2+]i signalling in sub-fertile men: characteristics and relation to fertilization outcome

Kelly, M. C., Brown, S. G., Costello, S. M., Ramalingam, M., Drew, E., Publicover, S. J., Barratt, C. L. R. (Lead / Corresponding author) & Martins Da Silva, S., Jun 2018, In: Human Reproduction. 33, 6, p. 1023-1033 11 p.

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Open Access

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28 Citations (Scopus)

171 Downloads (Pure)

2017

Complex CatSper-dependent and independent [Ca²⁺] signaling induced by human follicular fluid

Brown, S. G., Costello, S., Kelly, M., Ramalingam, M., Drew, E., Publicover, S. J., Barratt, C. (Lead / Corresponding author) & Martins Da Silva, S., 1 Oct 2017, In: Human Reproduction. 32, 10, p. 1995-2006 12 p.

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Open Access

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28 Citations (Scopus)

231 Downloads (Pure)

Drug discovery for male subfertility using high-throughput screening: a new approach to an unsolved problem

Martins Da Silva, S. J. (Lead / Corresponding author), Brown, S. G., Sutton, K., King, L. V., Ruso, H., Gray, D. W., Wyatt, P. G., Kelly, M. C., Barratt, C. L. R. & Hope, A. G., May 2017, In: Human Reproduction. 32, 5, p. 974-984 11 p.

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Open Access

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21 Citations (Scopus)

281 Downloads (Pure)

2016

A spontaneous increase in intracellular Ca²⁺ in metaphase II human oocytes in vitro can be prevented by drugs targeting ATP-sensitive K⁺ channels

Fernandes, G., Dasai, N., Kozlova, N., Mojadadi, A., Gall, M., Drew, E., Barratt, E., Madamidola, O. A., Brown, S. G., Milne, A. M., Martins Da Silva, S. J., Whalley, K. M., Barratt, C. L. R. & Jovanovic, A. (Lead / Corresponding author), Feb 2016, In: Human Reproduction. 31, 2, p. 287-297 11 p.

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Open Access

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10 Citations (Scopus)

184 Downloads (Pure)

Depolarization of sperm membrane potential is a common feature of men with subfertility and is associated with low fertilization rate at IVF

Brown, S. G., Publicover, S. J., Mansell, S., Lishko, P. V., Williams, H. L., Ramalingam, M., Wilson, S. M., Barratt, C. L. R. (Lead / Corresponding author), Sutton, K. A. & Da Silva, S. M., 15 Jun 2016, In: Human Reproduction. 31, 6, p. 1147-1157 11 p.

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Open Access

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54 Citations (Scopus)

244 Downloads (Pure)

2015

Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa

Williams, H. L., Mansell, S., Alasmari, W., Brown, S. G., Wilson, S. M., Sutton, K. A., Miller, M. R., Lishko, P. V., Barratt, C. L. R. (Lead / Corresponding author), Publicover, S. J. & Martins da Silva, S., Dec 2015, In: Human Reproduction. 30, 12, p. 2737-2746 10 p.

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80 Citations (Scopus)

218 Downloads (Pure)

2014

Patch clamp studies of human sperm under physiological ionic conditions reveal three functionally and pharmacologically distinct cation channels

Mansell, S. A., Publicover, S. J., Barratt, C. L. R. & Wilson, S. M. (Lead / Corresponding author), May 2014, In: Molecular Human Reproduction. 20, 5, p. 392-408 17 p.

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51 Citations (Scopus)

255 Downloads (Pure)

2013

p,p'-DDE activates CatSper and compromises human sperm function at environmentally relevant concentrations

Tavares, R. S., Mansell, S., Barratt, C. L. R., Wilson, S. M., Publicover, S. J. & Ramalho-Santos, J., Dec 2013, In: Human Reproduction. 28, 12, p. 3167-3177 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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80 Citations (Scopus)

213 Downloads (Pure)

Physiological Studies of Sperm from Normal and Sub Fertile Men (joint with Universities of Birmingham and Durham)

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