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Pivotal Role of the Keap1-Nrf2 Pathway in the Pathogenesis and Prevention of Non Alcoholic Steatohepatitis Induced Cirrhosis
Ashford, Michael
(Investigator)
Dillon, John
(Investigator)
Hayes, John
(Investigator)
McCrimmon, Rory
(Investigator)
Molecular and Clinical Medicine
Systems Medicine
Cellular Medicine
Overview
Fingerprint
Research Outputs
(4)
Project Details
Status
Finished
Effective start/end date
1/11/12
→
31/03/16
Funding
Medical Research Council
(MR/J001465/1):
£592,732.00
View all
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Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
NF-E2-Related Factor 2
Medicine & Life Sciences
100%
TBE 31
Medicine & Life Sciences
67%
SKP Cullin F-Box Protein Ligases
Medicine & Life Sciences
57%
Transcription Factors
Medicine & Life Sciences
55%
Purine Nucleotides
Medicine & Life Sciences
50%
Oxidative Stress
Medicine & Life Sciences
49%
Kelch-Like ECH-Associated Protein 1
Medicine & Life Sciences
45%
Unfolded Protein Response
Medicine & Life Sciences
43%
Research output
Research output per year
2012
2012
2014
2015
2018
2018
4
Article
Research output per year
Research output per year
Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)
Sharma, R. S.
,
Harrison, D. J.
,
Kisielewski, D.
,
Cassidy, D. M.
,
McNeilly, A. D.
,
Gallagher, J. R.
,
Walsh, S. V.
,
Honda, T.
,
McCrimmon, R. J.
,
Dinkova-Kostova, A. T.
,
Ashford, M. L. J.
,
Dillon, J. F.
&
Hayes, J. D.
,
1 Mar 2018
,
In:
Cellular and Molecular Gastroenterology and Hepatology.
5
,
3
,
p. 367-398
32 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
TBE 31
100%
NF-E2-Related Factor 2
73%
Fructose
59%
Non-alcoholic Fatty Liver Disease
55%
Liver Cirrhosis
47%
104
Citations (Scopus)
172
Downloads (Pure)
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
Tebay, L. E.
,
Robertson, H.
,
Durant, S. T.
,
Vitale, S. R.
,
Penning, T. M.
,
Dinkova-Kostova, A. T.
&
Hayes, J. D.
,
Nov 2015
,
In:
Free Radical Biology and Medicine.
88
,
Part B
,
p. 108-146
39 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
SKP Cullin F-Box Protein Ligases
100%
Kelch-Like ECH-Associated Protein 1
77%
Cullin 1
65%
Nutrient
64%
Oxidation-Reduction
58%
464
Citations (Scopus)
Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes, but not with insulin resistance
Meakin, P. J.
,
Chowdhry, S.
,
Sharma, R. S.
,
Ashford, F. B.
,
Walsh, S. V.
,
McCrimmon, R. J.
,
Dinkova-Kostova, A. T.
,
Dillon, J. F.
,
Hayes, J. D.
&
Ashford, M. L. J.
,
Sep 2014
,
In:
Molecular and Cellular Biology.
34
,
17
,
p. 3305-3320
16 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
NF-E2-Related Factor 2
100%
Unfolded Protein Response
87%
Fatty Liver
75%
High Fat Diet
70%
Insulin Resistance
57%
130
Citations (Scopus)
365
Downloads (Pure)