Pivotal Role of the Keap1-Nrf2 Pathway in the Pathogenesis and Prevention of Non Alcoholic Steatohepatitis Induced Cirrhosis

Ashford, Michael (Investigator)
Dillon, John (Investigator)
Hayes, John (Investigator)
McCrimmon, Rory (Investigator)

Status	Finished
Effective start/end date	1/11/12 → 31/03/16

Funding

Medical Research Council (MR/J001465/1): £592,732.00

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4 Article

Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)
Sharma, R. S., Harrison, D. J., Kisielewski, D., Cassidy, D. M., McNeilly, A. D., Gallagher, J. R., Walsh, S. V., Honda, T., McCrimmon, R. J., Dinkova-Kostova, A. T., Ashford, M. L. J., Dillon, J. F. & Hayes, J. D., 1 Mar 2018, In: Cellular and Molecular Gastroenterology and Hepatology. 5, 3, p. 367-398 32 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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104 Citations (Scopus)

172 Downloads (Pure)
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T. & Hayes, J. D., Nov 2015, In: Free Radical Biology and Medicine. 88, Part B, p. 108-146 39 p.
Research output: Contribution to journal › Article › peer-review
464 Citations (Scopus)
Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes, but not with insulin resistance
Meakin, P. J., Chowdhry, S., Sharma, R. S., Ashford, F. B., Walsh, S. V., McCrimmon, R. J., Dinkova-Kostova, A. T., Dillon, J. F., Hayes, J. D. & Ashford, M. L. J., Sep 2014, In: Molecular and Cellular Biology. 34, 17, p. 3305-3320 16 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
130 Citations (Scopus)

365 Downloads (Pure)

Pivotal Role of the Keap1-Nrf2 Pathway in the Pathogenesis and Prevention of Non Alcoholic Steatohepatitis Induced Cirrhosis

Project Details

Funding

Fingerprint

Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes, but not with insulin resistance

Pivotal Role of the Keap1-Nrf2 Pathway in the Pathogenesis and Prevention of Non Alcoholic Steatohepatitis Induced Cirrhosis

Project Details

Funding

Fingerprint

Research output

Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes, but not with insulin resistance