Rab Detection Initiative (Joint with Stanford School of Medicine, Max Plank Institute, Neuroscience Research Australia and Parkinsons Institute California)

Research Output

2018

AMPK: Sensing Glucose as well as Cellular Energy Status

Lin, S-C. & Hardie, D., 6 Feb 2018, In : Cell Metabolism. 27, 2, p. 299-313 15 p.

Research output: Contribution to journalReview article

Open Access
File
190 Citations (Scopus)
347 Downloads (Pure)

Cell-Free Assays to Measure Effects of Regulatory Ligands on AMPK

Fyffe, F. A., Hawley, S. A., Gray, A. & Hardie, D. G., 2018, AMPK : Methods and Protocols. Neumann, D. & Viollet, B. (eds.). New York: Humana Press, p. 69-86 18 p. (Methods in Molecular Biology; vol. 1732).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

3 Citations (Scopus)

Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2+/CaMKK2 Signaling to Enhance Tumor Cell Survival

Vara Ciruelos, D., Dandapani, M., Gray, A., Agbani, E. O., Evans, A. M. & Hardie, D. G., Feb 2018, In : Molecular Cancer Research. 16, 2, p. 345-357 13 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
139 Downloads (Pure)

Intact Cell Assays to Monitor AMPK and Determine the Contribution of the AMP-Binding or ADaM Sites to Activation

Hawley, S. A., Fyffe, F. A., Russell, F. M., Gowans, G. J. & Hardie, D. G., 2018, AMPK : Methods and Protocols. Neumann, D. & Viollet, B. (eds.). New York: Humana Press, p. 239-253 15 p. (Methods in Molecular Biology; vol. 1732).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2 Citations (Scopus)

Keeping the home fires burning: AMP-activated protein kinase

Hardie, D. G., Jan 2018, In : Journal of the Royal Society Interface. 15, 138, 23 p., 20170774.

Research output: Contribution to journalReview article

Open Access
File
49 Citations (Scopus)
157 Downloads (Pure)
2017

AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System

Salt, I. P. & Hardie, D. G., 26 May 2017, In : Circulation Research. 120, 11, p. 1825-1841 17 p.

Research output: Contribution to journalReview article

Open Access
File
63 Citations (Scopus)
114 Downloads (Pure)

AMP-activated protein kinase - not just an energy sensor

Hardie, D. G. & Lin, S-C., 22 Sep 2017, In : F1000 Research. 6, p. 1-11 11 p., 1724.

Research output: Contribution to journalReview article

Open Access
File
38 Citations (Scopus)
163 Downloads (Pure)

An Oncogenic Role for the Ubiquitin Ligase UBE2O by Targeting AMPK-α2 for Degradation

Hardie, D. G., 13 Feb 2017, In : Cancer Cell. 31, 2, p. 163-165 3 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
189 Downloads (Pure)

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

Zhang, C-S., Hawley, S. A., Zong, Y., Li, M., Wang, Z., Gray, A., Ma, T., Cui, J., Feng, J-W., Zhu, M., Wu, Y-Q., Li, T. Y., Ye, Z., Lin, S-Y., Yin, H., Piao, H-L., Hardie, D. G. & Lin, S-C., 3 Aug 2017, In : Nature. 548, 7665, p. 112-116 23 p.

Research output: Contribution to journalLetter

Open Access
File
167 Citations (Scopus)
243 Downloads (Pure)

The mechanisms of action of metformin

Rena, G., Hardie, D. G. & Pearson, E. R., Sep 2017, In : Diabetologia. 60, 9, p. 1577-1585 9 p.

Research output: Contribution to journalReview article

Open Access
File
375 Citations (Scopus)
333 Downloads (Pure)
2016

AMP-activated protein kinase: a cellular energy sensor that comes in twelve flavours

Ross, F. A., MacKintosh, C. & Hardie, D. G., 24 Mar 2016, In : FEBS Journal. 283, 16, p. 2987-3001 15 p.

Research output: Contribution to journalArticle

Open Access
File
127 Citations (Scopus)
101 Downloads (Pure)

AMPK: an energy-sensing pathway with multiple inputs and outputs

Hardie, D. G., Schaffer, B. E. & Brunet, A., Mar 2016, In : Trends in Cell Biology. 26, 3, p. 190-201 12 p.

Research output: Contribution to journalReview article

Open Access
File
334 Citations (Scopus)
326 Downloads (Pure)

AMPK Causes Cell Cycle Arrest in LKB1-deficient Cells via Activation of CAMKK2

Fogarty, S., Ross, F. A., Vara Ciruelos, D., Gray, A., Gowans, G. J. & Hardie, D. G., 1 Aug 2016, In : Molecular Cancer Research. 14, 8, p. 683-695 13 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
296 Downloads (Pure)

Bitter Melon (Momordica charantia) Extract Inhibits Tumorigenicity and Overcomes Cisplatin-Resistance in Ovarian Cancer Cells Through Targeting AMPK Signaling Cascade

Yung, M. M. H., Ross, F. A., Hardie, D. G., Leung, T. H. Y., Zhan, J., Ngan, H. Y. S. & Chan, D. W., 2 Aug 2016, In : Integrative Cancer Therapies. 15, 3, p. 376-389 14 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
200 Downloads (Pure)

Regulation of AMP-activated protein kinase by natural and synthetic activators

Grahame Hardie, D., Jan 2016, In : Acta Pharmaceutica Sinica B. 6, 1, p. 1-19 19 p.

Research output: Contribution to journalReview article

Open Access
File
70 Citations (Scopus)
1678 Downloads (Pure)
2015

AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

Hardie, D. G., Apr 2015, In : Current Opinion in Cell Biology. 33, April, p. 1-7 7 p.

Research output: Contribution to journalReview article

252 Citations (Scopus)

Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation

Pirkmajer, S., Kulkarni, S. S., Tom, R. Z., Ross, F. A., Hawley, S. A., Hardie, D. G., Zierath, J. R. & Chibalin, A. V., Feb 2015, In : Diabetes. 64, 2, p. 360-369 10 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
149 Downloads (Pure)

Molecular pathways: is AMPK a friend or a foe in cancer?

Hardie, D. G., 1 Sep 2015, In : Clinical Cancer Research. 21, 17, p. 3836-3840 5 p.

Research output: Contribution to journalArticle

Open Access
File
75 Citations (Scopus)
139 Downloads (Pure)
2014

AMPK-sensing energy while talking to other signaling pathways

Hardie, D. G., 2 Dec 2014, In : Cell Metabolism. 20, 6, p. 939-952 14 p.

Research output: Contribution to journalArticle

Open Access
File
290 Citations (Scopus)
140 Downloads (Pure)

Effects of metformin on breast cancer cell proliferation, the AMPK pathway and the cell cycle

Hadad, S. M., Hardie, D. G., Appleyard, V. & Thompson, A. M., Aug 2014, In : Clinical and Translational Oncology. 16, 8, p. 746-52 7 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

Hawley, S. A., Ross, F. A., Gowans, G. J., Tibarewal, P., Leslie, N. R. & Hardie, D. G., 15 Apr 2014, In : Biochemical Journal. 459, 2, p. 275-287 13 p.

Research output: Contribution to journalArticle

Open Access
File
96 Citations (Scopus)
149 Downloads (Pure)
2013

AMPK: mediating the metabolic effects of salicylate-based drugs?

Steinberg, G. R., Dandapani, M. & Hardie, D. G., Oct 2013, In : Trends in Endocrinology and Metabolism. 24, 10, p. 481-487 7 p.

Research output: Contribution to journalReview article

47 Citations (Scopus)

LKB1 and AMPK and the cancer-metabolism link - ten years after

Hardie, D. G. & Alessi, D. R., 15 Apr 2013, In : BMC Biology. 11, p. 1-11 11 p., 36.

Research output: Contribution to journalArticle

Open Access
File
196 Citations (Scopus)
144 Downloads (Pure)

Metabolism of inflammation limited by AMPK and pseudo-starvation

O'Neill, L. A. J. & Hardie, D. G., 17 Jan 2013, In : Nature. 493, 7432, p. 346-355 10 p.

Research output: Contribution to journalArticle

602 Citations (Scopus)

The LKB1-AMPK Pathway-Friend or Foe in Cancer?

Hardie, D. G., 11 Feb 2013, In : Cancer Cell. 23, 2, p. 131-132 2 p.

Research output: Contribution to journalEditorial

46 Citations (Scopus)