Research output per year
Research output per year
- 16 results
Search results
-
2019
Phenformin, but not metformin, delays development of T-cell acute lymphoblastic leukemia/lymphoma via cell-autonomous AMPK activation
Vara Ciruelos, D., Dandapani, M., Russell, F. M., Grzes, K., Atrih, A., Foretz, M., Viollet, B., Lamont, D. J., Cantrell, D. A. & Hardie, D. G., 16 Apr 2019, In: Cell Reports. 27, 3, p. 690-698.e4 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Citations (Scopus)141 Downloads (Pure) -
The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde?
Vara-Ciruelos, D., Russell, F. M. & Hardie, D. G., 10 Jul 2019, In: Open Biology. 9, 7, p. 1-21 21 p., 190099.Research output: Contribution to journal › Article › peer-review
Open AccessFile73 Citations (Scopus)114 Downloads (Pure) -
2018
Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2+/CaMKK2 Signaling to Enhance Tumor Cell Survival
Vara Ciruelos, D., Dandapani, M., Gray, A., Agbani, E. O., Evans, A. M. & Hardie, D. G., Feb 2018, In: Molecular Cancer Research. 16, 2, p. 345-357 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile34 Citations (Scopus)163 Downloads (Pure) -
2017
An Oncogenic Role for the Ubiquitin Ligase UBE2O by Targeting AMPK-α2 for Degradation
Hardie, D. G., 13 Feb 2017, In: Cancer Cell. 31, 2, p. 163-165 3 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)206 Downloads (Pure) -
Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib
Ross, F. A., Hawley, S. A., Auciello, F. R., Gowans, G. J., Atrih, A., Lamont, D. J. & Hardie, D. G., 20 Jul 2017, In: Cell Chemical Biology. 24, 7, p. 813-824.e4 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile41 Citations (Scopus)168 Downloads (Pure) -
2016
AMP-activated protein kinase: a cellular energy sensor that comes in twelve flavours
Ross, F. A., MacKintosh, C. & Hardie, D. G., 24 Mar 2016, In: FEBS Journal. 283, 16, p. 2987-3001 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile232 Citations (Scopus)139 Downloads (Pure) -
AMPK Causes Cell Cycle Arrest in LKB1-deficient Cells via Activation of CAMKK2
Fogarty, S., Ross, F. A., Vara Ciruelos, D., Gray, A., Gowans, G. J. & Hardie, D. G., 1 Aug 2016, In: Molecular Cancer Research. 14, 8, p. 683-695 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile51 Citations (Scopus)308 Downloads (Pure) -
Bitter Melon (Momordica charantia) Extract Inhibits Tumorigenicity and Overcomes Cisplatin-Resistance in Ovarian Cancer Cells Through Targeting AMPK Signaling Cascade
Yung, M. M. H., Ross, F. A., Hardie, D. G., Leung, T. H. Y., Zhan, J., Ngan, H. Y. S. & Chan, D. W., 2 Aug 2016, In: Integrative Cancer Therapies. 15, 3, p. 376-389 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)203 Downloads (Pure) -
2015
Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation
Pirkmajer, S., Kulkarni, S. S., Tom, R. Z., Ross, F. A., Hawley, S. A., Hardie, D. G., Zierath, J. R. & Chibalin, A. V., Feb 2015, In: Diabetes. 64, 2, p. 360-369 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile53 Citations (Scopus)157 Downloads (Pure) -
Molecular pathways: is AMPK a friend or a foe in cancer?
Hardie, D. G., 1 Sept 2015, In: Clinical Cancer Research. 21, 17, p. 3836-3840 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile122 Citations (Scopus)137 Downloads (Pure) -
2014
AMPK-sensing energy while talking to other signaling pathways
Hardie, D. G., 2 Dec 2014, In: Cell Metabolism. 20, 6, p. 939-952 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile417 Citations (Scopus)165 Downloads (Pure) -
Effects of metformin on breast cancer cell proliferation, the AMPK pathway and the cell cycle
Hadad, S. M., Hardie, D. G., Appleyard, V. & Thompson, A. M., Aug 2014, In: Clinical and Translational Oncology. 16, 8, p. 746-52 7 p.Research output: Contribution to journal › Article › peer-review
85 Citations (Scopus) -
Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells
Hawley, S. A., Ross, F. A., Gowans, G. J., Tibarewal, P., Leslie, N. R. & Hardie, D. G., 15 Apr 2014, In: Biochemical Journal. 459, 2, p. 275-287 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile152 Citations (Scopus)163 Downloads (Pure) -
2013
AMPK: a target for drugs and natural products with effects on both diabetes and cancer
Hardie, D. G., Jul 2013, In: Diabetes. 62, 7, p. 2164-2172 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile334 Citations (Scopus)163 Downloads (Pure) -
LKB1 and AMPK and the cancer-metabolism link - ten years after
Hardie, D. G. & Alessi, D. R., 15 Apr 2013, In: BMC Biology. 11, p. 1-11 11 p., 36.Research output: Contribution to journal › Article › peer-review
Open AccessFile243 Citations (Scopus)155 Downloads (Pure) -
Metabolism of inflammation limited by AMPK and pseudo-starvation
O'Neill, L. A. J. & Hardie, D. G., 17 Jan 2013, In: Nature. 493, 7432, p. 346-355 10 p.Research output: Contribution to journal › Article › peer-review
822 Citations (Scopus)