Research output per year
Research output per year
- 16 results
Search results
-
2019
Phenformin, but not metformin, delays development of T-cell acute lymphoblastic leukemia/lymphoma via cell-autonomous AMPK activation
Vara Ciruelos, D., Dandapani, M., Russell, F. M., Grzes, K., Atrih, A., Foretz, M., Viollet, B., Lamont, D. J., Cantrell, D. A. & Hardie, D. G. (Lead / Corresponding author), 16 Apr 2019, In: Cell Reports. 27, 3, p. 690-698.e4 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile57 Citations (Scopus)224 Downloads (Pure) -
The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde?
Vara-Ciruelos, D., Russell, F. M. & Hardie, D. G. (Lead / Corresponding author), 10 Jul 2019, In: Open Biology. 9, 7, p. 1-21 21 p., 190099.Research output: Contribution to journal › Article › peer-review
Open AccessFile108 Citations (Scopus)215 Downloads (Pure) -
2018
Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2+/CaMKK2 Signaling to Enhance Tumor Cell Survival
Vara Ciruelos, D., Dandapani, M., Gray, A., Agbani, E. O., Evans, A. M. & Hardie, D. G. (Lead / Corresponding author), Feb 2018, In: Molecular Cancer Research. 16, 2, p. 345-357 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile45 Citations (Scopus)233 Downloads (Pure) -
2017
An Oncogenic Role for the Ubiquitin Ligase UBE2O by Targeting AMPK-α2 for Degradation
Hardie, D. G. (Lead / Corresponding author), 13 Feb 2017, In: Cancer Cell. 31, 2, p. 163-165 3 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)253 Downloads (Pure) -
Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib
Ross, F. A., Hawley, S. A., Auciello, F. R., Gowans, G. J., Atrih, A., Lamont, D. J. & Hardie, D. G. (Lead / Corresponding author), 20 Jul 2017, In: Cell Chemical Biology. 24, 7, p. 813-824.e4 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile52 Citations (Scopus)243 Downloads (Pure) -
2016
AMP-activated protein kinase: a cellular energy sensor that comes in twelve flavours
Ross, F. A., MacKintosh, C. & Hardie, D. G. (Lead / Corresponding author), 24 Mar 2016, In: FEBS Journal. 283, 16, p. 2987-3001 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile297 Citations (Scopus)237 Downloads (Pure) -
AMPK Causes Cell Cycle Arrest in LKB1-deficient Cells via Activation of CAMKK2
Fogarty, S., Ross, F. A., Vara Ciruelos, D., Gray, A., Gowans, G. J. & Hardie, D. G. (Lead / Corresponding author), 1 Aug 2016, In: Molecular Cancer Research. 14, 8, p. 683-695 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile72 Citations (Scopus)373 Downloads (Pure) -
Bitter Melon (Momordica charantia) Extract Inhibits Tumorigenicity and Overcomes Cisplatin-Resistance in Ovarian Cancer Cells Through Targeting AMPK Signaling Cascade
Yung, M. M. H., Ross, F. A., Hardie, D. G., Leung, T. H. Y., Zhan, J., Ngan, H. Y. S. & Chan, D. W. (Lead / Corresponding author), 2 Aug 2016, In: Integrative Cancer Therapies. 15, 3, p. 376-389 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Citations (Scopus)265 Downloads (Pure) -
2015
Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation
Pirkmajer, S., Kulkarni, S. S., Tom, R. Z., Ross, F. A., Hawley, S. A., Hardie, D. G., Zierath, J. R. & Chibalin, A. V. (Lead / Corresponding author), Feb 2015, In: Diabetes. 64, 2, p. 360-369 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile65 Citations (Scopus)219 Downloads (Pure) -
Molecular pathways: is AMPK a friend or a foe in cancer?
Hardie, D. G., 1 Sept 2015, In: Clinical Cancer Research. 21, 17, p. 3836-3840 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile141 Citations (Scopus)188 Downloads (Pure) -
2014
AMPK-sensing energy while talking to other signaling pathways
Hardie, D. G. (Lead / Corresponding author), 2 Dec 2014, In: Cell Metabolism. 20, 6, p. 939-952 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile494 Citations (Scopus)251 Downloads (Pure) -
Effects of metformin on breast cancer cell proliferation, the AMPK pathway and the cell cycle
Hadad, S. M. (Lead / Corresponding author), Hardie, D. G., Appleyard, V. & Thompson, A. M., Aug 2014, In: Clinical and Translational Oncology. 16, 8, p. 746-52 7 p.Research output: Contribution to journal › Article › peer-review
96 Citations (Scopus) -
Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells
Hawley, S. A., Ross, F. A., Gowans, G. J., Tibarewal, P., Leslie, N. R. & Hardie, D. G. (Lead / Corresponding author), 15 Apr 2014, In: Biochemical Journal. 459, 2, p. 275-287 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile178 Citations (Scopus)224 Downloads (Pure) -
2013
AMPK: a target for drugs and natural products with effects on both diabetes and cancer
Hardie, D. G. (Lead / Corresponding author), Jul 2013, In: Diabetes. 62, 7, p. 2164-2172 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile385 Citations (Scopus)273 Downloads (Pure) -
LKB1 and AMPK and the cancer-metabolism link - ten years after
Hardie, D. G. & Alessi, D. R., 15 Apr 2013, In: BMC Biology. 11, p. 1-11 11 p., 36.Research output: Contribution to journal › Article › peer-review
Open AccessFile261 Citations (Scopus)232 Downloads (Pure) -
Metabolism of inflammation limited by AMPK and pseudo-starvation
O'Neill, L. A. J. (Lead / Corresponding author) & Hardie, D. G., 17 Jan 2013, In: Nature. 493, 7432, p. 346-355 10 p.Research output: Contribution to journal › Article › peer-review
969 Citations (Scopus)