Rab Detection Initiative (Joint with Stanford School of Medicine, Max Plank Institute, Neuroscience Research Australia and Parkinsons Institute California)

Research Output

Filter
Article
2018

Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2+/CaMKK2 Signaling to Enhance Tumor Cell Survival

Vara Ciruelos, D., Dandapani, M., Gray, A., Agbani, E. O., Evans, A. M. & Hardie, D. G., Feb 2018, In : Molecular Cancer Research. 16, 2, p. 345-357 13 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
139 Downloads (Pure)
2017

An Oncogenic Role for the Ubiquitin Ligase UBE2O by Targeting AMPK-α2 for Degradation

Hardie, D. G., 13 Feb 2017, In : Cancer Cell. 31, 2, p. 163-165 3 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
189 Downloads (Pure)
2016

AMP-activated protein kinase: a cellular energy sensor that comes in twelve flavours

Ross, F. A., MacKintosh, C. & Hardie, D. G., 24 Mar 2016, In : FEBS Journal. 283, 16, p. 2987-3001 15 p.

Research output: Contribution to journalArticle

Open Access
File
127 Citations (Scopus)
101 Downloads (Pure)

AMPK Causes Cell Cycle Arrest in LKB1-deficient Cells via Activation of CAMKK2

Fogarty, S., Ross, F. A., Vara Ciruelos, D., Gray, A., Gowans, G. J. & Hardie, D. G., 1 Aug 2016, In : Molecular Cancer Research. 14, 8, p. 683-695 13 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
296 Downloads (Pure)

Bitter Melon (Momordica charantia) Extract Inhibits Tumorigenicity and Overcomes Cisplatin-Resistance in Ovarian Cancer Cells Through Targeting AMPK Signaling Cascade

Yung, M. M. H., Ross, F. A., Hardie, D. G., Leung, T. H. Y., Zhan, J., Ngan, H. Y. S. & Chan, D. W., 2 Aug 2016, In : Integrative Cancer Therapies. 15, 3, p. 376-389 14 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
200 Downloads (Pure)
2015

Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation

Pirkmajer, S., Kulkarni, S. S., Tom, R. Z., Ross, F. A., Hawley, S. A., Hardie, D. G., Zierath, J. R. & Chibalin, A. V., Feb 2015, In : Diabetes. 64, 2, p. 360-369 10 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
149 Downloads (Pure)

Molecular pathways: is AMPK a friend or a foe in cancer?

Hardie, D. G., 1 Sep 2015, In : Clinical Cancer Research. 21, 17, p. 3836-3840 5 p.

Research output: Contribution to journalArticle

Open Access
File
75 Citations (Scopus)
139 Downloads (Pure)
2014

AMPK-sensing energy while talking to other signaling pathways

Hardie, D. G., 2 Dec 2014, In : Cell Metabolism. 20, 6, p. 939-952 14 p.

Research output: Contribution to journalArticle

Open Access
File
290 Citations (Scopus)
140 Downloads (Pure)

Effects of metformin on breast cancer cell proliferation, the AMPK pathway and the cell cycle

Hadad, S. M., Hardie, D. G., Appleyard, V. & Thompson, A. M., Aug 2014, In : Clinical and Translational Oncology. 16, 8, p. 746-52 7 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

Hawley, S. A., Ross, F. A., Gowans, G. J., Tibarewal, P., Leslie, N. R. & Hardie, D. G., 15 Apr 2014, In : Biochemical Journal. 459, 2, p. 275-287 13 p.

Research output: Contribution to journalArticle

Open Access
File
96 Citations (Scopus)
149 Downloads (Pure)
2013

LKB1 and AMPK and the cancer-metabolism link - ten years after

Hardie, D. G. & Alessi, D. R., 15 Apr 2013, In : BMC Biology. 11, p. 1-11 11 p., 36.

Research output: Contribution to journalArticle

Open Access
File
196 Citations (Scopus)
144 Downloads (Pure)

Metabolism of inflammation limited by AMPK and pseudo-starvation

O'Neill, L. A. J. & Hardie, D. G., 17 Jan 2013, In : Nature. 493, 7432, p. 346-355 10 p.

Research output: Contribution to journalArticle

602 Citations (Scopus)