Research output per year
Research output per year
Research output
- 7 Article
Search results
-
2016
Phosphoproteomics reveals that Parkinson’s disease kinase LRRK2 regulates a subset of Rab GTPases
Steger, M., Tonelli, F., Ito, G., Davies, P., Trost, M., Vetter, M., Wachter, S., Lorentzen, E., Duddy, G., Wilson, S., Baptista, M. A. S., Fiske, B. K., Fell, M. J., Morrow, J. A., Reith, A. D., Alessi, D. R. (Lead / Corresponding author) & Mann, M. (Lead / Corresponding author), 29 Jan 2016, In: eLife. 5, p. 1-28 28 p., e12813.Research output: Contribution to journal › Article › peer-review
Open AccessFile695 Citations (Scopus)396 Downloads (Pure) -
Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors
Ito, G. (Lead / Corresponding author), Katsemonova, K., Tonelli, F., Lis, P., Baptista, M., Shpiro, N., Duddy, G., Wilson, S., Wing-Lok Ho, P., Ho, S.-L., Reith, A. D. & Alessi, D. R. (Lead / Corresponding author), 30 Aug 2016, In: Biochemical Journal. 473, 17, p. 2671-2685 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile123 Citations (Scopus)510 Downloads (Pure) -
2015
Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation
Kazlauskaite, A., Martínez-Torres, R. J., Wilkie, S., Kumar, A., Peltier, J., Gonzalez, A., Johnson, C., Zhang, J., Hope, A. G., Peggie, M., Trost, M., van Aalten, D. M., Alessi, D. R., Prescott, A. R., Knebel, A., Walden, H. & Muqit, M. M. (Lead / Corresponding author), 1 Aug 2015, In: EMBO Reports. 16, 8, p. 939-954 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile190 Citations (Scopus)283 Downloads (Pure) -
Discovery of a pyrrolopyrimidine (JH-II-127), a highly potent, selective, and brain penetrant LRRK2 inhibitor
Hatcher, J. M., Zhang, J., Choi, H. G., Ito, G., Alessi, D. R. (Lead / Corresponding author) & Gray, N. S. (Lead / Corresponding author), 14 May 2015, In: ACS Medicinal Chemistry Letters. 6, 5, p. 584-589 6 p.Research output: Contribution to journal › Article › peer-review
49 Citations (Scopus) -
Structural characterization of LRRK2 inhibitors
Gilsbach, B. K., Messias, A. C., Ito, G., Sattler, M., Alessi, D. R., Wittinghofer, A. & Kortholt, A. (Lead / Corresponding author), 14 May 2015, In: Journal of Medicinal Chemistry. 58, 9, p. 3751-3756 6 p.Research output: Contribution to journal › Article › peer-review
33 Citations (Scopus) -
2014
Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Serine65
Kazlauskaite, A. (Lead / Corresponding author), Kondapalli, C., Gourlay, R., Campbell, D. G., Ritorto, M. S., Hofmann, K., Alessi, D. R., Knebel, A., Trost, M. & Muqit, M. M. K. (Lead / Corresponding author), 15 May 2014, In: Biochemical Journal. 460, 1, p. 127-139 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile649 Citations (Scopus)227 Downloads (Pure) -
2012
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
Kondapalli, C., Kazlauskaite, A., Zhang, N., Woodroof, H. I., Campbell, D. G., Gourlay, R., Burchell, L., Walden, H., MacArtney, T. J., Deak, M., Knebel, A., Alessi, D. R. & Muqit, M. M. K. (Lead / Corresponding author), 2012, In: Open Biology. 2, 120080.Research output: Contribution to journal › Article › peer-review
741 Citations (Scopus)