Keyphrases
2-pyridone
66%
26S Proteasome
9%
3D Neurospheres
50%
5-dicarbonitriles
66%
AKT Pathway
16%
AKT2
66%
Amino
66%
Anti-glioma
66%
Anticancer Activity
61%
Anticancer Bioactivity
66%
Anticancer Properties
22%
Apoptosis
9%
Betaine
22%
Bioactive
22%
Bone Degeneration
66%
Bortezomib
33%
Breast
22%
Breast Cancer Burden
9%
Cancer Cell Lines
33%
Cancer Cells
33%
Cancer Progression
66%
Catalytic Synthesis
66%
Cell Death
33%
Chlorophenyl
66%
Clinically Significant
44%
Co-target
9%
Constitutive Proteasome
66%
Cytotoxicity
16%
Drug Resistance
33%
Druggable Targets
9%
Dual Inhibition
66%
DYRK2
100%
EC50
16%
Enhanced Cytotoxicity
22%
Glioblastoma
16%
Glioblastoma Cell Lines
38%
Glioblastoma Cells
44%
Glioma
16%
Glioma Cell Lines
16%
Glioma Cells
16%
Glioma Growth
16%
Glioma Malignancy
16%
Glioma Stem Cells
33%
Global Problems
33%
Growth Inhibition
16%
Guanidine Carbonate
22%
Heat Shock Factor 1 (HSF1)
66%
High Mortality Rate
33%
HSF1 Inhibitors
19%
Immunoproteasome Inhibitor
66%
In Vivo Activity
33%
Inhibitor Resistant
9%
Inhibitory Activity
33%
Inhibitory Properties
16%
KRIBB11
9%
Liver
22%
Lung Cancer
22%
Lung Primary
22%
Malignancy
42%
Mouse Xenograft Model
33%
Multiple Myeloma
33%
Myeloma
66%
Myeloma Cells
33%
Natural Products
22%
Neurosphere Formation
33%
Non-cancer
33%
Non-small Cell Lung Cancer (NSCLC)
33%
Novel Therapeutics
16%
Oncogenic Kinases
9%
Oncogenic Pathways
16%
One-pot Two-step Reaction
66%
Orthotopic Xenograft Model
9%
Patient Survival
16%
Patient-derived
50%
Protease Inhibitors
98%
Proteostasis
9%
Proteotoxic Stress
9%
Pseudomonas Syringae
33%
PSMB5
33%
Pyrano
66%
Pyrazole
66%
Resistant Cells
9%
Resistant mutants
33%
Small Molecule Inhibitors
22%
Small Molecule Kinase Inhibitors
22%
Survival Mechanism
9%
Synergistic Cytotoxicity
33%
Syrbactin
66%
Transcription Factor
19%
Triple-negative Breast Cancer
9%
Triple-negative Breast Cancer Cells
33%
Virulence Factors
33%
Biochemistry, Genetics and Molecular Biology
Cell Death
11%
Cytotoxicity
11%
Drug Resistance
11%
Enzyme
11%
HSF1
66%
Infancy
7%
Intravenous Immunoglobulin
66%
Kinase
25%
Low Drug Dose
11%
Mortality Rate
11%
Phosphotransferase
25%
Proteasome
74%
Proteasome Inhibitor
74%
Protein Homeostasis
7%
Pseudomonas syringae
11%
Transcription Factors
14%
Virulence Factor
11%