Research output per year
Research output per year
- 1 - 50 out of 55 results
Search results
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2025
Airway macrophage glycolysis controls lung homeostasis and responses to aeroallergen
Albers, G. J., Michalaki, C., Ogger, P. P., Lloyd, A. F., Causton, B., Walker, S. A., Caldwell, A., Halket, J. M., Sinclair, L. V., Forde, S. H., McCarthy, C., Hinks, T. S. C., Lloyd, C. M. & Byrne, A. J. (Lead / Corresponding author), Feb 2025, In: Mucosal Immunology. 18, 1, p. 121-134 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)6 Downloads (Pure) -
Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells
Sinclair, L. V. (Lead / Corresponding author), Youdale, T., Spinelli, L., Gakovic, M., Langlands, A. J., Pathak, S., Howden, A. J. M., Ganley, I. G. & Cantrell, D. A. (Lead / Corresponding author), 27 Feb 2025, In: Nature Immunology. 26, p. 429-443 32 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)4 Downloads (Pure) -
2024
A proteomic map of B cell activation and its shaping by mTORC1, MYC and iron
James, O., Sinclair, L. V., Lefter, N., Salerno, F., Brenes, A. & Howden, A. J. M. (Lead / Corresponding author), 22 Dec 2024, BioRxiv, 40 p.Research output: Working paper/Preprint › Preprint
File6 Downloads (Pure) -
Extensive acute and sustained changes to neutrophil proteomes post-SARS-CoV-2 infection
Long, M. B., Howden, A. J., Keir, H. R., Rollings, C. M., Giam, Y. H., Pembridge, T., Delgado, L., Abo-Leyah, H., Lloyd, A. F., Sollberger, G., Hull, R., Gilmour, A., Hughes, C., New, B. J., Cassidy, D., Shoemark, A., Richardson, H., Lamond, A. I., Cantrell, D. A. & Chalmers, J. D. (Lead / Corresponding author) & 1 others, , 7 Mar 2024, In: The European respiratory journal. 63, 3, 15 p., 2300787.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)112 Downloads (Pure) -
Optimizing Spectronaut Search Parameters to Improve Data Quality with Minimal Proteome Coverage Reductions in DIA Analyses of Heterogeneous Samples
Baker, C. P., Bruderer, R., Abbott, J., Arthur, J. S. C. (Lead / Corresponding author) & Brenes Murillo, A. J. (Lead / Corresponding author), 7 Jun 2024, In: Journal of Proteome Research. 23, 6, p. 1926-1936 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)119 Downloads (Pure) -
PIM kinase control of CD8 T cell protein synthesis and cell trafficking
Marchingo, J. M. (Lead / Corresponding author), Spinelli, L., Pathak, S. & Cantrell, D. A. (Lead / Corresponding author), 24 Jul 2024, In: eLife. p. 1-33 33 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Downloads (Pure) -
Proteomic and functional comparison between human induced and embryonic stem cells
Brenes Murillo, A., Griesser, E., Sinclair, L., Davidson, L., Prescott, A., Singh, F., Hogg, E., Espejo-Serrano, C., Jiang, H., Yoshikawa, H., Platani, M., Swedlow, J., Findlay, G., Cantrell, D. & Lamond, A. (Lead / Corresponding author), 14 Nov 2024, In: eLife. 13, p. 1-32 32 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)115 Downloads (Pure) -
Quantitative proteomics reveals tissue-specific, infection-induced and species-specific neutrophil protein signatures
Sollberger, G. (Lead / Corresponding author), Brenes, A. J., Warner, J., Arthur, J. S. C. & Howden, A. J. M. (Lead / Corresponding author), Dec 2024, In: Scientific Reports. 14, 1, 15 p., 5966.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)152 Downloads (Pure) -
2023
Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses
Hodge, S. H., Krauss, M. Z., Kaymak, I., King, J. I., Howden, A. J. M., Panic, G., Grencis, R. K., Swann, J. R., Sinclair, L. V. & Hepworth, M. R. (Lead / Corresponding author), 6 Mar 2023, In: Journal of Experimental Medicine. 220, 3, 22 p., e20221073.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)153 Downloads (Pure) -
Extracellular vesicles in COVID-19 convalescence can regulate T cell metabolism and function
George, M. S., Sanchez, J., Rollings, C., Fear, D., Irving, P., Sinclair, L. V. & Schurich, A. (Lead / Corresponding author), 18 Aug 2023, In: iScience. 26, 8, 17 p., 107280.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)122 Downloads (Pure) -
Mode of action studies confirm on-target engagement of lysyl-tRNA synthetase inhibitor and lead to new selection marker for Cryptosporidium
Hanna, J. C. .., Corpas Lopez, V., Seizova, S., Colon, B. L., Bacchetti, R., Hall, G. M. J., Sands, E. M., Robinson, L., Baragaña, B., Wyllie, S. (Lead / Corresponding author) & Pawlowic, M. (Lead / Corresponding author), 4 Aug 2023, In: Frontiers in Cellular and Infection Microbiology. 13, 14 p., 1236814.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)142 Downloads (Pure) -
Proteomic and functional comparison between human induced and embryonic stem cells
Brenes Murillo, A., Griesser, E., Sinclair, L., Davidson, L., Prescott, A., Singh, F., Hogg, E., Espejo-Serrano, C., Jiang, H., Yoshikawa, H., Platani, M., Swedlow, J., Findlay, G., Cantrell, D. & Lamond, A. (Lead / Corresponding author), 19 Aug 2023, BioRxiv, 34 p.Research output: Working paper/Preprint › Preprint
Open AccessFile120 Downloads (Pure) -
QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations
Pelgrom, L. R., Davis, G. M., O’Shaughnessy, S., Wezenberg, E. J. M., Van Kasteren, S. I. (Lead / Corresponding author), Finlay, D. K. (Lead / Corresponding author) & Sinclair, L. V. (Lead / Corresponding author), 29 Aug 2023, In: Cell Reports. 42, 8, 23 p., 112828.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)175 Downloads (Pure) -
The proliferation of human mucosal-associated invariant T cells requires a MYC-SLC7A5-glycolysis metabolic axis
Kedia-Mehta, N., Pisarska, M. M., Rollings, C., O'Neill, C., De Barra, C., Foley, C., Wood, N. A. W., Wrigley-Kelly, N., Veerapen, N., Besra, G., Bergin, R., Jones, N., O'Shea, D., Sinclair, L. V. (Lead / Corresponding author) & Hogan, A. E. (Lead / Corresponding author), 18 Apr 2023, In: Science Signaling. 16, 781, 13 p., eabo2709.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)111 Downloads (Pure) -
2022
Concomitant deletion of Ptpn6 and Ptpn11 in T cells fails to improve anticancer responses
Ventura, P. M. O., Gakovic, M., Fischer, B. A., Spinelli, L., Rota, G., Pathak, S., Khameneh, H. J., Zenobi, A., Thomson, S., Birchmeier, W., Cantrell, D. A. (Lead / Corresponding author) & Guarda, G. (Lead / Corresponding author), 7 Nov 2022, In: EMBO Reports. 23, 11, 11 p., e55399.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)139 Downloads (Pure) -
Genome-scale RNA interference profiling of Trypanosoma brucei cell cycle progression defects
Marques, C. A., Ridgway, M., Tinti, M., Cassidy, A. & Horn, D. (Lead / Corresponding author), 10 Sept 2022, In: Nature Communications. 13, 16 p., 5326.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)126 Downloads (Pure) -
Protein synthesis, degradation, and energy metabolism in T cell immunity
Marchingo, J. M. & Cantrell, D. A. (Lead / Corresponding author), Mar 2022, In: Cellular & Molecular Immunology. 19, p. 303-315 13 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile73 Citations (Scopus)407 Downloads (Pure) -
Understanding how the immune system works
Spinelli, L. (Contributing member), Cameron, A. (Producer) & Soave, S. (Film-maker), 16 Sept 2022Research output: Non-textual form › Digital or Visual Products
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2021
Extracellular signal-regulated kinase (ERK) pathway control of CD8+ T cell differentiation
Damasio, M. P., Marchingo, J. M., Spinelli, L., Hukelmann, J. L., Cantrell, D. A. (Lead / Corresponding author) & Howden, A. J. M. (Lead / Corresponding author), 13 Jan 2021, In: Biochemical Journal. 478, 1, p. 79-98 20 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Citations (Scopus)261 Downloads (Pure) -
Mitochondrial translation is required for sustained killing by cytotoxic T cells
Lisci, M., Barton, P. R., Randzavola, L. O., Ma, C. Y., Marchingo, J. M., Cantrell, D. A., Paupe, V., Prudent, J., Stinchcombe, J. C. & Griffiths, G. M. (Lead / Corresponding author), 15 Oct 2021, In: Science. 374, 6565Research output: Contribution to journal › Article › peer-review
Open AccessFile75 Citations (Scopus)697 Downloads (Pure) -
Phosphoinositide 3-Kinase p110 Delta Differentially Restrains and Directs Naïve Versus Effector CD8+ T Cell Transcriptional Programs
Spinelli, L., Marchingo, J. M., Nomura, A., Damasio, M. P. & Cantrell, D. A. (Lead / Corresponding author), 18 Jun 2021, In: Frontiers in Immunology. 12, 19 p., 691997.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)204 Downloads (Pure) -
Quantitative Analyses Reveal How Hypoxia Reconfigures the Proteome of Primary Cytotoxic T Lymphocytes
Ross, S. H. (Lead / Corresponding author), Rollings, C. M. & Cantrell, D. A., 17 Sept 2021, In: Frontiers in Immunology. 12, 18 p., 712402.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)117 Downloads (Pure) -
2020
Characterisation of the biochemical and cellular roles of native and pathogenic amelogenesis imperfecta mutants of FAM83H
Tachie-Menson, T., Gázquez-Gutiérrez, A., Fulcher, L., Macartney, T., Wood, N., Varghese, J., Gourlay, R., Filipe Soares, R. & Sapkota, G. (Lead / Corresponding author), Aug 2020, In: Cellular Signalling. 72, 17 p., 109632.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)261 Downloads (Pure) -
Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation
Marchingo, J., Sinclair, L. (Lead / Corresponding author), Howden, A. & Cantrell, D. (Lead / Corresponding author), 4 Mar 2020, In: eLife. 9, 23 p., e53725.Research output: Contribution to journal › Article › peer-review
Open AccessFile130 Citations (Scopus)186 Downloads (Pure) -
Single Cell Glucose Uptake Assays: A Cautionary Tale
Sinclair, L. V. (Lead / Corresponding author), Barthelemy, C. & Cantrell, D. A. (Lead / Corresponding author), 17 Aug 2020, In: Immunometabolism. 2, 4, 13 p., e200029.Research output: Contribution to journal › Article › peer-review
Open AccessFile48 Citations (Scopus)201 Downloads (Pure) -
2019
Antigen receptor control of methionine metabolism in T cells
Sinclair, L. V. (Lead / Corresponding author), Howden, A., Brenes Murillo, A., Spinelli, L., Hukelmann, J., Macintyre, A. N., Liu, X., Thomson, S., Taylor, P., Rathmell, J. C., Locasale, J. W., Lamond, A. & Cantrell, D. A. (Lead / Corresponding author), 27 Mar 2019, In: eLife. 8, p. 1-29 29 p., e44210.Research output: Contribution to journal › Article › peer-review
Open AccessFile155 Citations (Scopus)255 Downloads (Pure) -
A post-transcriptional respiratome regulon in trypanosomes
Trenaman, A., Glover, L., Hutchinson, S. & Horn, D. (Lead / Corresponding author), 26 Jul 2019, In: Nucleic Acids Research. 47, 13, p. 7063-7077 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)108 Downloads (Pure) -
Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex
Correia Faria, J., Glover, L., Hutchinson, S., Boehm, C., Field, M. C. & Horn, D. (Lead / Corresponding author), 9 Jul 2019, In: Nature Communications. 10, p. 1-14 14 p., 3023.Research output: Contribution to journal › Article › peer-review
Open AccessFile44 Citations (Scopus)206 Downloads (Pure) -
Move to metabolism
Cantrell, D. A. (Lead / Corresponding author), 29 Mar 2019, In: Nature Reviews Immunology. 19, 1 p., 270.Research output: Contribution to journal › Comment/debate › peer-review
Open Access2 Citations (Scopus) -
Phenformin, but not metformin, delays development of T-cell acute lymphoblastic leukemia/lymphoma via cell-autonomous AMPK activation
Vara Ciruelos, D., Dandapani, M., Russell, F. M., Grzes, K., Atrih, A., Foretz, M., Viollet, B., Lamont, D. J., Cantrell, D. A. & Hardie, D. G. (Lead / Corresponding author), 16 Apr 2019, In: Cell Reports. 27, 3, p. 690-698.e4 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile57 Citations (Scopus)232 Downloads (Pure) -
Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation
Howden, A. J. M., Hukelmann, J. L., Brenes, A., Spinelli, L., Sinclair, L. V., Lamond, A. I. (Lead / Corresponding author) & Cantrell, D. A. (Lead / Corresponding author), Nov 2019, In: Nature Immunology. 20, 11, p. 1542-1554 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile143 Citations (Scopus)179 Downloads (Pure) -
2018
Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice
Loftus, R. M., Assmann, N., Kedia-Mehta, N., O'Brien, K. L., Garcia, A., Gillespie, C., Hukelmann, J. L., Oefner, P. J., Lamond, A. I., Gardiner, C. M., Dettmer, K., Cantrell, D. A., Sinclair, L. V. & Finlay, D. K. (Lead / Corresponding author), 14 Jun 2018, In: Nature Communications. 9, 1, p. 1-15 15 p., 2341.Research output: Contribution to journal › Article › peer-review
Open AccessFile286 Citations (Scopus)283 Downloads (Pure) -
Interleukin-2 shapes the cytotoxic T cell proteome and immune environment sensing programs
Rollings, C., Sinclair, L., Brady, H. J. M., Cantrell, D. (Lead / Corresponding author) & Ross, S. H. (Lead / Corresponding author), 17 Apr 2018, In: Science Signaling. 11, 526, p. 1-16 16 p., eaap8112.Research output: Contribution to journal › Article › peer-review
Open AccessFile64 Citations (Scopus)326 Downloads (Pure) -
Signaling and Function of Interleukin-2 in T Lymphocytes
Ross, S. H. & Cantrell, D. A., 26 Apr 2018, In: Annual Review of Immunology. 36, p. 411-433 23 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile673 Citations (Scopus)372 Downloads (Pure) -
Single cell analysis of kynurenine and System L amino acid transport in T cells
Sinclair, L. (Lead / Corresponding author), Neyens, D., Ramsay, G., Taylor, P. & Cantrell, D. (Lead / Corresponding author), 17 May 2018, In: Nature Communications. 9, 1, 11 p., 1981 (2018).Research output: Contribution to journal › Article › peer-review
Open AccessFile141 Citations (Scopus)232 Downloads (Pure) -
2017
Control of amino-acid transport coordinates metabolic reprogramming in T cell malignancy
Grzes, K. M., Swamy, M., Hukelmann, J. L., Emslie, E., Sinclair, L. V. & Cantrell, D. A., 26 May 2017, In: Leukemia. 31, p. 2771-2779 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile37 Citations (Scopus)275 Downloads (Pure) -
Interkinetic nuclear migration and basal tethering facilitates post-mitotic daughter separation in intestinal organoids
Carroll, T. D., Langlands, A. J., Osborne, J. M., Newton, I. P., Appleton, P. L. & Nathke, I. (Lead / Corresponding author), 15 Nov 2017, In: Journal of Cell Science. 130, 22, p. 3862-3877 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Citations (Scopus)242 Downloads (Pure) -
2016
Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy
Swamy, M., Pathak, S., Grzes, K. M., Damerow, S., Sinclair, L. V., van Aalten, D. M. F. & Cantrell, D. A. (Lead / Corresponding author), Jun 2016, In: Nature Immunology. 17, 6, p. 712-720 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile280 Citations (Scopus)289 Downloads (Pure) -
The cytotoxic T cell proteome and its shaping by the kinase mTOR
Hukelmann, J. L., Anderson, K. E., Sinclair, L. V., Grzes, K. M., Brenes Murillo, A., Hawkins, P. T., Stephens, L. R., Lamond, A. I. & Cantrell, D. A. (Lead / Corresponding author), Jan 2016, In: Nature Immunology. 17, 1, p. 104-112 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile174 Citations (Scopus)377 Downloads (Pure) -
2015
ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation
Stone, E. L., Pepper, M., Katayama, C. D., Kerdiles, Y. M., Lai, C.-Y., Emslie, E., Lin, Y. C., Yang, E., Goldrath, A. W., Li, M. O., Cantrell, D. A. & Hedrick, S. M. (Lead / Corresponding author), 17 Feb 2015, In: Immunity. 42, 2, p. 239-251 13 p.Research output: Contribution to journal › Article › peer-review
192 Citations (Scopus) -
Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells
Pallett, L. J., Gill, U. S., Quaglia, A., Sinclair, L. V., Jover-Cobos, M., Schurich, A., Singh, K. P., Thomas, N., Das, A., Chen, A., Fusai, G., Bertoletti, A., Cantrell, D. A., Kennedy, P. T., Davies, N. A., Haniffa, M. & Maini, M. K. (Lead / Corresponding author), 11 May 2015, In: Nature Medicine. 21, 6, p. 591-600 10 p.Research output: Contribution to journal › Article › peer-review
242 Citations (Scopus) -
Signaling in lymphocyte activation
Cantrell, D., Jun 2015, In: Cold spring harbor perspectives in biology. 7, 6, 14 p., a018788.Research output: Contribution to journal › Article › peer-review
73 Citations (Scopus) -
Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes
Preston, G. C., Sinclair, L. V., Kaskar, A., Hukelmann, J. L., Navarro, M., Ferrero, I., MacDonald, H. R., Cowling, V. H. & Cantrell, D. A. (Lead / Corresponding author), 4 Aug 2015, In: EMBO Journal. 34, 15, p. 2008-2024 17 p.Research output: Contribution to journal › Article › peer-review
Open Access134 Citations (Scopus) -
2014
Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells
Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. & Cantrell, D. A. (Lead / Corresponding author), 2 Sept 2014, In: PLoS ONE. 9, 9, 7 p., e106710.Research output: Contribution to journal › Article › peer-review
Open AccessFile38 Citations (Scopus)229 Downloads (Pure) -
Protein kinase D2 is a digital amplifier of T cell receptor-stimulated diacylglycerol signaling in naïve CD8+ T cells
Navarro, M. N., Feijoo-Carnero, C., Gonzalez Arandilla, A., Trost, M. & Cantrell, D. A. (Lead / Corresponding author), 21 Oct 2014, In: Science Signaling. 7, 348, 12 p., ra99.Research output: Contribution to journal › Article › peer-review
30 Citations (Scopus) -
Quantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks
Navarro, M. N., Goebel, J., Hukelmann, J. L. & Cantrell, D. A. (Lead / Corresponding author), Dec 2014, In: Molecular & Cellular Proteomics. 13, 12, p. 3544-3557 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)221 Downloads (Pure) -
Serine-threonine kinases in TCR signaling
Navarro, M. N. & Cantrell, D. A. (Lead / Corresponding author), Sept 2014, In: Nature Immunology. 15, 9, p. 808-814 7 p.Research output: Contribution to journal › Article › peer-review
70 Citations (Scopus) -
2013
AMPKα1: a glucose sensor that controls CD8 T-cell memory
Rolf, J., Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. & Cantrell, D. A., Apr 2013, In: European Journal of Immunology. 43, 4, p. 889-896 8 p.Research output: Contribution to journal › Article › peer-review
201 Citations (Scopus) -
Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
Sinclair, L. V., Rolf, J., Emslie, E., Shi, Y.-B., Taylor, P. M. & Cantrell, D. A. (Lead / Corresponding author), May 2013, In: Nature Immunology. 14, 5, p. 500-508 9 p.Research output: Contribution to journal › Article › peer-review
731 Citations (Scopus) -
LKB1 Mediates the Development of Conventional and Innate T Cells via AMP-Dependent Kinase Autonomous Pathways
Zarrouk, M., Rolf, J. & Cantrell, D. A., 22 Mar 2013, In: PLoS ONE. 8, 3, 9 p., e60217.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus)