State-of-the-Art Facilities for Structural Biology at the University of Dundee

Hunter, Bill (Investigator)
Lilley, David (Investigator)
Owen-Hughes, Tom (Investigator)
Wyatt, Paul (Investigator)
van Aalten, Daan (Investigator)

Status	Finished
Effective start/end date	1/03/12 → 28/02/17

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

SDG 3 Good Health and Well-being

Crystal Structure of compound 4 in complex with KRAS G12V C118S GDP and pVHL:ElonginC:ElonginB
Zollman, D. (Creator), Farnaby, W. (Creator) & Ciulli, A. (Creator), Research Collaboratory for Structural Bioinformatics Protein Data Bank, 6 Dec 2023
DOI: 10.2210/pdb8qw7/pdb
Dataset
BindingDB Entry 50002798: Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.
BindingDB, Lucas, X. (Creator), Van-Molle, I. (Creator) & Ciulli, A. (Creator), BindingDB, 17 Aug 2020
DOI: 10.7270/q2639scc
Dataset
PROTAC-mediated complex of KRAS with VHL/Elongin-B/Elongin-C/Cullin-2/Rbx1
Fischer, G. (Creator), Peter, D. (Creator), Arce-Solano, S. (Creator) & Ciulli, A. (Creator), Research Collaboratory for Structural Bioinformatics Protein Data Bank, 6 Dec 2023
DOI: 10.2210/pdb8qu8/pdb
Dataset

59 Article
1 Letter
1 Review article

Scalable insect cell expression and purification screening applied to CRL4-DCAF substrate receptors
Cowan, A. D. (Lead / Corresponding author), Jaekel, S. & Ciulli, A. (Lead / Corresponding author), Jul 2026, In: Protein Expression and Purification. 241, 11 p., 106907.
Research output: Contribution to journal › Article › peer-review

Open Access
File
13 Downloads (Pure)
Structure guided optimization of novel inhibitors of Plasmodium lysyl-tRNA synthetase with multistage activity against malaria parasites
Forte, B., Bellany, F., Campbell, P. S., Chemi, G., Dawson, A., Anderson, M., Aniweh, Y., Burkhard, A. Y., Aguiar, A. C. C., Churchyard, A., Cooper, C. A., Ferreira, A. D. S., Famodimu, M. T., Fang, F. G., Hu, X., Huijs, T., Baud, D., Jansen, C., Jiménez-Díaz, M. B. & Bonnert, R. & 49 others, Boyd, S., Crespo-Fernandez, B., Mitasev, B., Montagna, S., Mok, S., Murugesan, D., Narwal, S. K., Norcross, N. R., Okombo, J., Park, H., Peet, C., Pereira, D. B., Post, J. M., Reader, J., Riley, J., Robinson, D. A., Shinkyo, R., Simeons, F. R. C., Simpson, L., Smith, A., Smith, D., Striepen, J., Teles, C. B. G., van der Laak, R., Uhlemann, A. C., Vantaux, A., Wilson, C., Witkowski, B., Wood, G., Yeo, T., Zuccotto, F., Angulo-Barturen, I., Baum, J., Bolscher, J. M., Guido, R. V., Birkholtz, L.-M., Delves, M. J., Dembélé, L., Fidock, D. A., Gamo, F.-J., Kyle, D. E., Maher, S. P., Popovici, J., Walpole, C., Gusovsky, F., Willis, P. A., Read, K. D. (Lead / Corresponding author), Gilbert, I. H. (Lead / Corresponding author) & Baragana, B. (Lead / Corresponding author), 11 Jun 2026, In: Journal of Medicinal Chemistry. 69, 11, p. 13820-13855 36 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
32 Downloads (Pure)
Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach
Pearson, L.-A., Petit, A.-P., Mendoza Martinez, C., Bellany, F., Lin, D., Niven, S., Swift, R., Eadsforth, T., Fyfe, P., Paul, M., Postis, V., Hu, X., Cowling, V. & Gray, D. (Lead / Corresponding author), 17 Feb 2025, In: Biochemical Journal. 482, 4, p. 209-224 16 p., BCJ20240608.
Research output: Contribution to journal › Article › peer-review

Open Access
File
6 Link opens in a new tab Citations (Scopus)

93 Downloads (Pure)

State-of-the-Art Facilities for Structural Biology at the University of Dundee

Project Details

UN Sustainable Development Goals

Fingerprint

Crystal Structure of compound 4 in complex with KRAS G12V C118S GDP and pVHL:ElonginC:ElonginB

BindingDB Entry 50002798: Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.

PROTAC-mediated complex of KRAS with VHL/Elongin-B/Elongin-C/Cullin-2/Rbx1

Scalable insect cell expression and purification screening applied to CRL4-DCAF substrate receptors

Structure guided optimization of novel inhibitors of Plasmodium lysyl-tRNA synthetase with multistage activity against malaria parasites

Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach

State-of-the-Art Facilities for Structural Biology at the University of Dundee

Project Details

UN Sustainable Development Goals

Fingerprint

Datasets

Crystal Structure of compound 4 in complex with KRAS G12V C118S GDP and pVHL:ElonginC:ElonginB

BindingDB Entry 50002798: Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.

PROTAC-mediated complex of KRAS with VHL/Elongin-B/Elongin-C/Cullin-2/Rbx1

Research output

Scalable insect cell expression and purification screening applied to CRL4-DCAF substrate receptors

Structure guided optimization of novel inhibitors of Plasmodium lysyl-tRNA synthetase with multistage activity against malaria parasites

Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach