State-of-the-Art Facilities for Structural Biology at the University of Dundee

Hunter, Bill (Investigator)
Lilley, David (Investigator)
Owen-Hughes, Tom (Investigator)
Wyatt, Paul (Investigator)
van Aalten, Daan (Investigator)

59 Article
1 Letter
1 Review article

1 - 50 out of 61 results

2026
Scalable insect cell expression and purification screening applied to CRL4-DCAF substrate receptors
Cowan, A. D. (Lead / Corresponding author), Jaekel, S. & Ciulli, A. (Lead / Corresponding author), Jul 2026, In: Protein Expression and Purification. 241, 11 p., 106907.
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Structure guided optimization of novel inhibitors of Plasmodium lysyl-tRNA synthetase with multistage activity against malaria parasites
Forte, B., Bellany, F., Campbell, P. S., Chemi, G., Dawson, A., Anderson, M., Aniweh, Y., Burkhard, A. Y., Aguiar, A. C. C., Churchyard, A., Cooper, C. A., Ferreira, A. D. S., Famodimu, M. T., Fang, F. G., Hu, X., Huijs, T., Baud, D., Jansen, C., Jiménez-Díaz, M. B. & Bonnert, R. & 49 others, Boyd, S., Crespo-Fernandez, B., Mitasev, B., Montagna, S., Mok, S., Murugesan, D., Narwal, S. K., Norcross, N. R., Okombo, J., Park, H., Peet, C., Pereira, D. B., Post, J. M., Reader, J., Riley, J., Robinson, D. A., Shinkyo, R., Simeons, F. R. C., Simpson, L., Smith, A., Smith, D., Striepen, J., Teles, C. B. G., van der Laak, R., Uhlemann, A. C., Vantaux, A., Wilson, C., Witkowski, B., Wood, G., Yeo, T., Zuccotto, F., Angulo-Barturen, I., Baum, J., Bolscher, J. M., Guido, R. V., Birkholtz, L.-M., Delves, M. J., Dembélé, L., Fidock, D. A., Gamo, F.-J., Kyle, D. E., Maher, S. P., Popovici, J., Walpole, C., Gusovsky, F., Willis, P. A., Read, K. D. (Lead / Corresponding author), Gilbert, I. H. (Lead / Corresponding author) & Baragana, B. (Lead / Corresponding author), 11 Jun 2026, In: Journal of Medicinal Chemistry. 69, 11, p. 13820-13855 36 p.
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2025
Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach
Pearson, L.-A., Petit, A.-P., Mendoza Martinez, C., Bellany, F., Lin, D., Niven, S., Swift, R., Eadsforth, T., Fyfe, P., Paul, M., Postis, V., Hu, X., Cowling, V. & Gray, D. (Lead / Corresponding author), 17 Feb 2025, In: Biochemical Journal. 482, 4, p. 209-224 16 p., BCJ20240608.
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Design and development of lysyl tRNA synthetase inhibitors, for the treatment of tuberculosis
Davis, S. H., Mathieson, M., Buchanan, K. I., Dawson, A., Smith, A., Cocco, M., Tamaki, F. K., Post, J. M., Baragaña, B., Jansen, C., Kiczun, M., Zuccotto, F., Wood, G., Scullion, P., Ray, P. C., Epemolu, O., Lopez-Román, E. M., Guijarro López, L., Engelhart, C. A. & Kim, J. & 8 others, Pino, P. A., Schnappinger, D., Read, K. D., Encinas, L., Bates, R. H., Wyatt, P. G., Green, S. R. & Cleghorn, L. A. T. (Lead / Corresponding author), 14 Aug 2025, In: Journal of Medicinal Chemistry. 68, 15, p. 16459-16482 24 p.
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Frustration in the protein-protein interface plays a central role in the cooperativity of PROTAC ternary complexes
Ma, N., Bhattacharya, S., Muk, S., Jandova, Z., Schmalhorst, P. S., Ghosh, S., Le, K., Diers, E., Trainor, N., Farnaby, W., Roy, M. J., Kofink, C., Greb, P., Weinstabl, H., Ciulli, A., Bader, G., Sankar, K., Bergner, A. (Lead / Corresponding author) & Vaidehi, N., Dec 2025, In: Nature Communications. 16, 1, 8595.
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Identification of a Highly Cooperative PROTAC Degrader Targeting GTP-loaded KRAS(on) Alleles
Vetma, V., Puoti, I., Karolak, N. K., Chakraborti, S., Diers, E., Girardi, E., Khan, S., Kidd, G., Kropatsch, K. G., Mclennan, R., O'Connor, S., Samwer, M., Trainor, N., Whitworth, C., Wijaya, A. J., Wong, J. Y. F., Zollman, D., Farnaby, W., Popow, J. & Ciulli, A. (Lead / Corresponding author) & 2 others, Ettmayer, P. (Lead / Corresponding author) & McAulay, K. (Lead / Corresponding author), 12 Nov 2025, In: Journal of the American Chemical Society. 147, 45, p. 41367-41378 12 p.
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2024
Targeting cancer with small molecule pan-KRAS degraders
Popow, J., Farnaby, W., Gollner, A., Kofink, C., Fischer, G., Wurm, M., Zollman, D., Wijaya, A., Mischerikow, N., Hasenoehrl, C., Prokofeva, P., Arnhof, H., Arce-Solano, S., Bell, S., Boeck, G., Diers, E., Frost, A. B., Goodwin-Tindall, J., Karolyi-Oezguer, J. & Khan, S. & 23 others, Klawatsch, T., Koegl, M., Kousek, R., Kratochvil, B., Kropatsch, K., Lauber, A. A., McLennan, R., Olt, S., Peter, D., Petermann, O., Roessler, V., Stolt-Bergner, P., Strack, P., Strauss, E., Trainor, N., Vetma, V., Whitworth, C., Zhong, S., Quant, J., Weinstabl, H., Kuster, B., Ettmayer, P. (Lead / Corresponding author) & Ciulli, A. (Lead / Corresponding author), 20 Sept 2024, In: Science. 385, 6715, p. 1338-1347 10 p.
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Ternary Complex-Templated Dynamic Combinatorial Chemistry for the Selection and Identification of Homo-PROTACs
Diehl, C. J., Salerno, A. & Ciulli, A. (Lead / Corresponding author), 17 Jun 2024, In: Angewandte Chemie International Edition. 63, 25, 9 p., e202319456.
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2023
Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers
Vu, L. P., Diehl, C. J., Casement, R., Bond, A. G., Steinebach, C., Strašek, N., Bricelj, A., Perdih, A., Schnakenburg, G., Sosič, I., Ciulli, A. (Lead / Corresponding author) & Gütschow, M. (Lead / Corresponding author), 28 Sept 2023, In: Journal of Medicinal Chemistry. 66, 18, p. 12776-12811 36 p.
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Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders
Hanzl, A., Casement, R., Imrichova, H., Hughes, S. J., Barone, E., Testa, A., Bauer, S., Wright, J., Brand, M., Ciulli, A. (Lead / Corresponding author) & Winter, G. E. (Lead / Corresponding author), Mar 2023, In: Nature Chemical Biology. 19, p. 323-333 11 p.
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Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity
Green, S. R. (Lead / Corresponding author), Wilson, C., Eadsforth, T. C., Punekar, A. S., Tamaki, F. K., Wood, G., Caldwell, N., Forte, B., Norcross, N. R., Kiczun, M., Post, J. M., Lopez-Román, E. M., Engelhart, C. A., Lukac, I., Zuccotto, F., Epemolu, O., Boshoff, H. I. M., Schnappinger, D., Walpole, C. & Gilbert, I. H. & 3 others, Read, K. D., Wyatt, P. G. & Baragaña, B. (Lead / Corresponding author), 23 Nov 2023, In: Journal of Medicinal Chemistry. 66, 22, p. 15380-15408 29 p.
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Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2
Ramachandran, S., Makukhin, N., Haubrich, K., Nagala, M., Forrester, B., Lynch, D. M., Casement, R., Testa, A., Bruno, E., Gitto, R. & Ciulli, A. (Lead / Corresponding author), 10 Oct 2023, In: Nature Communications. 14, 17 p., 6345.
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The structure of a tautomerase superfamily member linked to the type VI secretion system of Acinetobacter baumannii
Pankovs, G., Mol Avelar, G., Buchanan, G., Coulthurst, S. J. & Hunter, B. (Lead / Corresponding author), Jan 2023, In: Acta Crystallographica Section F: Structural Biology Communications. 79, 1, p. 8-16 9 p.
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2022
A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo
Kofink, C., Trainor, N., Mair, B., Wöhrle, S., Wurm, M., Mischerikow, N., Roy, M. J., Bader, G., Greb, P., Garavel, G., Diers, E., McLennan, R., Whitworth, C., Vetma, V., Rumpel, K., Scharnweber, M., Fuchs, J. E., Gerstberger, T., Cui, Y. & Gremel, G. & 10 others, Chetta, P., Hopf, S., Budano, N., Rinnenthal, J., Gmaschitz, G., Mayer, M., Koegl, M., Ciulli, A., Weinstabl, H. (Lead / Corresponding author) & Farnaby, W. (Lead / Corresponding author), 10 Oct 2022, In: Nature Communications. 13, 15 p., 5969.
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Delineating the activity of the potent nicotinic acetylcholine receptor agonists (+)-anatoxin-a and (−)-hosieine-A
Parker, H. P., Dawson, A., Jones, M. J., Yan, R., Ouyang, J., Hong, R. & Hunter, W. N. (Lead / Corresponding author), 1 Sept 2022, In: Acta Crystallographica Section F: Structural Biology Communications. F78, 9, p. 313-323 11 p.
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Discovery of benzo[d]imidazole-6-sulfonamides as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain
Cipriano, A., Milite, C., Feoli, A., Viviano, M., Pepe, G., Campiglia, P., Sarno, G., Picaud, S., Imaide, S., Makukhin, N., Filippakopoulos, P., Ciulli, A., Castellano, S. (Lead / Corresponding author) & Sbardella, G., 19 Oct 2022, In: ChemMedChem. 17, 20, 14 p., e202200343.
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Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2
Liu, X., Kalogeropulou, A. F., Domingos, S., Makukhin, N., Nirujogi, R., Singh, F., Shpiro, N., Saalfrank, A., Sammler, E., Ganley, I. G., Moreira, R., Alessi, D. R. (Lead / Corresponding author) & Ciulli, A. (Lead / Corresponding author), 21 Sept 2022, In: Journal of the American Chemical Society. 144, 37, p. 16930-16952 23 p.
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2021
Amide-to-ester substitution as a strategy for optimizing PROTAC permeability and cellular activity
Klein, V. G., Bond, A. G., Craigon, C., Lokey, R. S. (Lead / Corresponding author) & Ciulli, A. (Lead / Corresponding author), 23 Dec 2021, In: Journal of Medicinal Chemistry. 64, 24, p. 18082-18101 20 p.
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Automated Determination of Nuclear Magnetic Resonance Chemical Shift Perturbations in Ligand Screening Experiments: The PICASSO Web Server
Laveglia, V., Giachetti, A., Cerofolini, L., Haubrich, K., Fragai, M., Ciulli, A. & Rosato, A. (Lead / Corresponding author), 27 Dec 2021, In: Journal of Chemical Information and Modeling. 61, 12, p. 5726-5733 8 p.
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Building ubiquitination machineries: E3 ligase multi-subunit assembly and substrate targeting by PROTACs and molecular glues
Ramachandran, S. & Ciulli, A. (Lead / Corresponding author), Apr 2021, In: Current Opinion in Structural Biology. 67, p. 110-119 10 p.
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Development of BromoTag: A “Bump-&-Hole”-PROTAC system to induce potent, rapid, and selective degradation of tagged target proteins
Bond, A. G., Craigon, C., Chan, K. H., Testa, A., Karapetsas, A., Fasimoye, R., Macartney, T., Blow, J. J., Alessi, D. R. & Ciulli, A. (Lead / Corresponding author), 28 Oct 2021, In: Journal of Medicinal Chemistry. 64, 20, p. 15477-15502 26 p.
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Estimating the cooperativity of PROTAC-induced ternary complexes using ¹⁹F NMR displacement assay
de Castro, G. V. & Ciulli, A. (Lead / Corresponding author), Oct 2021, In: RSC Medicinal Chemistry. 12, p. 1765-1770 6 p.
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Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity
Imaide, S., Riching, K. M., Makukhin, N., Vetma, V., Whitworth, C., Hughes, S. J., Trainor, N., Mahan, S. D., Murphy, N., Cowan, A., Chan, K.-H., Craigon, C., Test, A., Maniai, C., Urh, M., Daniels, D. L. & Ciulli, A. (Lead / Corresponding author), Nov 2021, In: Nature Chemical Biology. 17, 11, p. 1157-1167 11 p.
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2020
A structural rationale for N-methylbicuculline acting as a promiscuous competitive antagonist of inhibitory pentameric ligand gated ion channels
Jones, M. J., Dawson, A., Hales, T. G. & Hunter, W. N. (Lead / Corresponding author), 18 May 2020, In: ChemBioChem. 21, 10, p. 1526-1533 19 p.
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Structure-Based Design of a Macrocyclic PROTAC
Testa, A., Hughes, S. J., Lucas, X., Wright, J. E. & Ciulli, A. (Lead / Corresponding author), 20 Jan 2020, In: Angewandte Chemie International Edition. 59, 4, p. 1727-1734 8 p.
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The thermodynamic profile and molecular interactions of a C(9)-cytisine derivative binding acetylcholine binding protein from Aplysia californica
Davis, S., Campello, H. R., Gallagher, T. & Hunter, B. (Lead / Corresponding author), 1 Feb 2020, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. F76, Part 2, p. 74-80 7 p.
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2019
Burkholderia pseudomallei D-alanine-D-alanine ligase: detailed characterisation and assessment of a potential antibiotic drug target
Díaz‐Sáez, L., Torrie, L. S., McElroy, S. P., Gray, D. & Hunter, W. M. (Lead / Corresponding author), 18 Nov 2019, In: FEBS Journal. 286, 22, p. 4509-4524 16 p.
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Engineering a surrogate human heteromeric α/β glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein
Dawson, A., Trumper, P., de Souza, J. O., Parker, H., Jones, M. J., Hales, T. G. & Hunter, W. N. (Lead / Corresponding author), 1 Nov 2019, In: IUCrJ. 6, Part 6, p. 1014-1023 10 p.
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Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
Baragaña, B., Forte, B., Choi, R., Nakazawa Hewitt, S., Bueren-Calabuig, J. A., Pisco, J. P., Peet, C., Dranow, D. M., Robinson, D. A., Jansen, C., Norcross, N. R., Vinayak, S., Anderson, M., Brooks, C. F., Cooper, C. A., Damerow, S., Delves, M., Dowers, K., Duffy, J. & Edwards, T. E. & 57 others, Hallyburton, I., Horst, B. G., Hulverson, M. A., Ferguson, L., Jiménez-Díaz, M. B., Jumani, R. S., Lorimer, D. D., Love, M. S., Maher, S., Matthews, H., McNamara, C. W., Miller, P., O'Neill, S., Ojo, K. K., Osuna-Cabello, M., Pinto, E., Post, J., Riley, J., Rottmann, M., Sanz, L. M., Scullion, P., Sharma, A., Shepherd, S. M., Shishikura, Y., Simeons, F. R. C., Stebbins, E. E., Stojanovski, L., Straschil, U., Tamaki, F. K., Tamjar, J., Torrie, L. S., Vantaux, A., Witkowski, B., Wittlin, S., Yogavel, M., Zuccotto, F., Angulo-Barturen, I., Sinden, R., Baum, J., Gamo, F.-J., Mäser, P., Kyle, D. E., Winzeler, E. A., Myler, P. J., Wyatt, P. G., Floyd, D., Matthews, D., Sharma, A., Striepen, B., Huston, C. D., Gray, D. W., Fairlamb, A. H., Pisliakov, A. V., Walpole, C., Read, K. D., Van Voorhis, W. C. & Gilbert, I. H. (Lead / Corresponding author), 2 Apr 2019, In: Proceedings of the National Academy of Sciences. 116, 14, p. 7015-7020 6 p.
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2018
Formation of functional, non-amyloidogenic fibres by recombinant Bacillus subtilis TasA
Erskine, E., Morris, R. J., Schor, M., Earl, C., Gillespie, R. M. C., Bromley, K. M., Sukhodub, T., Clark, L., Fyfe, P., Serpell, L. C., Stanley-Wall, N. (Lead / Corresponding author) & MacPhee, C. E., Dec 2018, In: Molecular Microbiology. 110, 6, p. 897-913 17 p.
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Optimization of a “Bump-and-Hole” Approach to Allele-Selective BET Bromodomain Inhibition
Runcie, A., Zengerle, M., Chan, K. H., Testa, A., Van Beurden, L., Baud, M., Epemolu, R., Ellis, L., Read, K., Coulthard, V., Brien, A. & Ciulli, A. (Lead / Corresponding author), 7 Mar 2018, In: Chemical Science. 9, 9, p. 2452-2468 17 p., 2452.
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Structure and activity of ChiX, a peptidoglycan hydrolase required for chitinase secretion by Serratia marcescens
Owen, R. A., Fyfe, P. K., Lodge, A., Biboy, J., Vollmer, W., Hunter, W. N. & Sargent, F. (Lead / Corresponding author), 23 Jan 2018, In: Biochemical Journal. 475, 2, p. 415-428 14 p.
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Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome
Sundaramoorthy, R., Hughes, A., El-Mkami, H., Norman, D. & Owen-Hughes, T. (Lead / Corresponding author), 6 Aug 2018, In: eLife. 2018, 7, p. 1-28 28 p., e35720.
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2017
An improved model of the Trypanosoma brucei CTP synthetase glutaminase domain-acivicin complex
de Souza, J. O., Dawson, A. & Hunter, W. N. (Lead / Corresponding author), 20 Apr 2017, In: ChemMedChem. 12, 8, p. 577-579 3 p.
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Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery
Linciano, P., Dawson, A., Pöhner, I., Costa, D. M., Sá, M. S., Cordeiro Da Silva, A., Luciani, R., Gul, S., Witt, G., Ellinger, B., Kuzikov, M., Gribbon, P., Reinshagen, J., Wolf, M., Behrens, B., Hannaert, V., Michels, P. A. M., Nerini, E., Pozzi, C. & di Pisa, F. & 19 others, Landi, G., Santarem, N., Ferrari, S., Saxena, P., Lazzari, S., Cannazza, G., Freitas-Junior, L. H., Moraes, C. B., Pascoalino, B. S., Alcântara, L. M., Bertolacini, C. P., Fontana, V., Wittig, U., Müller, W., Wade, R. C., Hunter, W. N. (Lead / Corresponding author), Mangani, S. (Lead / Corresponding author), Costantino, L. (Lead / Corresponding author) & Costi, M. P. (Lead / Corresponding author), 30 Sept 2017, In: ACS Omega. 2, 9, p. 5666-5683 18 p.
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Open and compressed conformations of Francisella tularensis ClpP
Díaz-Sáez, L., Pankov, G. & Hunter, W. N. (Lead / Corresponding author), Jan 2017, In: Proteins: Structure, Function, and Bioinformatics. 85, 1, p. 188-194 7 p.
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Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes
Sundaramoorthy, R., Hughes, A. L., Singh, V., Wiechens, N., Ryan, D. P., El-Mkami, H., Petoukhov, M., Svergun, D. I., Treutlein, B., Quack, S., Fischer, M., Michaelis, J., Bottcher, B., Norman, D. G. & Owen-Hughes, T. (Lead / Corresponding author), 13 Apr 2017, In: eLife. 6, 28 p., e22510.
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2016
EssC: domain structures inform on the elusive translocation channels in the Type VII secretion system.
Zoltner, M., Ng, W. M. A. V., Money, J. J., Fyfe, P. K., Kneuper, H., Palmer, T. & Hunter, W. N. (Lead / Corresponding author), Jul 2016, In: Biochemical Journal. 473, 13, p. 1941-1952 12 p.
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The histone chaperone Vps75 forms multiple oligomeric assemblies capable of mediating exchange between histone H3–H4 tetramers and Asf1–H3–H4 complexes
Hammond, C. M., Sundaramoorthy, R., Larance, M., Lamond, A., Stevens, M. A., El-Mkami, H., Norman, D. & Owen-Hughes, T. (Lead / Corresponding author), 27 Jul 2016, In: Nucleic Acids Research. 44, 13, p. 6157-6172 16 p.
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The structure of a Trypanosoma cruzi glucose-6-phosphate dehydrogenase reveals differences from the mammalian enzyme
Mercaldi, G. F., Dawson, A., Hunter, W. N. & Cordeiro, A. T. (Lead / Corresponding author), 19 Aug 2016, In: FEBS Letters. 590, 16, p. 2776-2786 11 p.
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2015
Assembly and structure of Lys³³-linked polyubiquitin reveals distinct conformations
Kristariyanto, Y. A., Choi, S.-Y., Rehman, S. A. A., Ritorto, M. S., Campbell, D. G., Morrice, N. A., Toth, R. & Kulathu, Y. (Lead / Corresponding author), 15 Apr 2015, In: Biochemical Journal. 467, 2, p. 345-352 8 p.
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Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido based inhibitors of Trypanosoma brucei FolD and testing for antiparasitic activity
Eadsforth, T. C., Pinto, A., Luciani, R., Tamborini, L., Cullia, G., De Micheli, C., Marinelli, L., Cosconati, S., Novellino, E., Lo Presti, L., Cordeiro Da Silva, A., Conti, P. (Lead / Corresponding author), Hunter, W. N. (Lead / Corresponding author) & Costi, M. P. (Lead / Corresponding author), 22 Oct 2015, In: Journal of Medicinal Chemistry. 58, 20, p. 7938-7948 11 p.
Research output: Contribution to journal › Article › peer-review
11 Link opens in a new tab Citations (Scopus)
Crystal structure of the C-terminal domain of tubulin-binding cofactor C from Leishmania major
Barrack, K. L., Fyfe, P. K., Finney, A. J. & Hunter, W. N. (Lead / Corresponding author), May 2015, In: Molecular and Biochemical Parasitology. 201, 1, p. 26-30 5 p.
Research output: Contribution to journal › Article › peer-review
4 Link opens in a new tab Citations (Scopus)
Development of small-molecule Trypanosoma brucei N-myristoyltransferase inhibitors: discovery and optimisation of a novel binding mode
Spinks, D., Smith, V., Thompson, S., Robinson, D. A., Luksch, T., Smith, A., Torrie, L. S., McElroy, S., Stojanovski, L., Norval, S., Collie, I. T., Hallyburton, I., Rao, B., Brand, S., Brenk, R., Frearson, J. A., Read, K. D., Wyatt, P. G. & Gilbert, I. H., Nov 2015, In: ChemMedChem. 10, 11, p. 1821-1836 16 p.
Research output: Contribution to journal › Article › peer-review
23 Link opens in a new tab Citations (Scopus)
K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of K29 polyubiquitin
Kristariyanto, Y. A., Abdul Rehman, S. A., Campbell, D. G., Morrice, N. A., Johnson, C., Toth, R. & Kulathu, Y., 2 Apr 2015, In: Molecular Cell. 58, 1, p. 83-94 12 p.
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Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1
Zhang, N., Gordon, S. L., Fritsch, M. J., Esoof, N., Campbell, D. G., Gourlay, R., Srikannathasan, V., Macartney, T., Peggie, M., van Aalten, D. M. F., Cousin, M. A. (Lead / Corresponding author) & Alessi, D. R. (Lead / Corresponding author), 11 Feb 2015, In: Journal of Neuroscience. 35, 6, p. 2492-2507 16 p.
Research output: Contribution to journal › Article › peer-review

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Structures of Pseudomonas aeruginosa β-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crystal form
Baum, B., Lecker, L. S. M., Zoltner, M., Jaenicke, E., Schnell, R., Hunter, W. N. (Lead / Corresponding author) & Brenk, R. (Lead / Corresponding author), Aug 2015, In: Acta Crystallographica Section F: Structural Biology Communications. 71, 8, p. 1020-1026 7 p.
Research output: Contribution to journal › Article › peer-review
6 Link opens in a new tab Citations (Scopus)
The structure of tubulin-binding cofactor A from Leishmania major infers a mode of association during the early stages of microtubule assembly
Barrack, K. L., Fyfe, P. K. & Hunter, W. N. (Lead / Corresponding author), May 2015, In: Acta Crystallographica Section F: Structural Biology Communications. 71, 5, p. 539-546 8 p.
Research output: Contribution to journal › Article › peer-review
4 Link opens in a new tab Citations (Scopus)
2014
Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment
O'Rourke, P. E. F., Kalinowska-Tłuścik, J., Fyfe, P. K., Dawson, A. & Hunter, W. N. (Lead / Corresponding author), 10 Jan 2014, In: BMC Structural Biology. 14, 12 p., 1.
Research output: Contribution to journal › Article › peer-review

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High-resolution structure of the M14-type cytosolic carboxypeptidase from Burkholderia cenocepacia refined exploiting PDB_REDO strategies
Rimsa, V., Eadsforth, T. C., Joosten, R. P. & Hunter, W. N. (Lead / Corresponding author), Feb 2014, In: Acta Crystallographica Section D: Biological Crystallography. 70, 2, p. 279-289 11 p.
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