Stratified Medicine in Type 2 Diabetes: Insights from the Study of Drug Response (New Investigator Award)

Project Details

StatusFinished
Effective start/end date16/02/15 → 15/08/21

Funding

  • Wellcome Trust (102820/Z/13/Z): £1,795,764.00
  • Wellcome Trust (COVID 19 Supplement): £36,709.88

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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  • Identification of biomarkers for glycaemic deterioration in type 2 diabetes

    Slieker, R. C., Donnelly, L. A., Akalestou, E., Lopez-Noriega, L., Melhem, R., Güneş, A., Abou Azar, F., Efanov, A., Georgiadou, E., Muniangi-Muhitu, H., Sheikh, M., Giordano, G. N., Åkerlund, M., Ahlqvist, E., Ali, A., Banasik, K., Brunak, S., Barovic, M., Bouland, G. A., Burdet, F., & 46 othersCanouil, M., Dragan, I., Elders, P. J. M., Fernandez, C., Festa, A., Fitipaldi, H., Froguel, P., Gudmundsdottir, V., Gudnason, V., Gerl, M. J., van der Heijden, A. A., Jennings, L. L., Hansen, M. K., Kim, M., Leclerc, I., Klose, C., Kuznetsov, D., Mansour Aly, D., Mehl, F., Marek, D., Melander, O., Niknejad, A., Ottosson, F., Pavo, I., Duffin, K., Syed, S. K., Shaw, J. L., Cabrera, O., Pullen, T. J., Simons, K., Solimena, M., Suvitaival, T., Wretlind, A., Rossing, P., Lyssenko, V., Legido Quigley, C., Groop, L., Thorens, B., Franks, P. W., Lim, G. E., Estall, J., Ibberson, M., Beulens, J. W. J., 't Hart, L. M., Pearson, E. R. & Rutter, G. A., 3 May 2023, In: Nature Communications. 14, 18 p., 2533.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File
    3 Downloads (Pure)

  • Pharmacogenomics of GLP-1 Receptor Agonists: a genome-wide analysis of observational data and large randomised controlled trials

    Dawed, A. Y., Mari, A., Brown, A., McDonald, T. J., Li, L., Wang, S., Hong, M-G., Sharma, S., Robertson, N. R., Mahajan, A., Wang, X., Walker, M., Gough, S., 't Hart, L. M., Zhou, K., Forgie, I., Ruetten, H., Pavo, I., Bhatnagar, P., Jones, A. G., & 1 othersPearson, E. R., 1 Jan 2023, In: The Lancet Diabetes and Endocrinology. 11, 1, p. 33-41 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File
    4 Citations (Scopus)
    53 Downloads (Pure)

  • A roadmap to achieve pharmacological precision medicine in diabetes

    Florez, J. C. & Pearson, E. R., Nov 2022, In: Diabetologia. 65, 11, p. 1830-1838 9 p.

    Research output: Contribution to journal › Review article › peer-review

    Open Access
    File
    8 Citations (Scopus)
    20 Downloads (Pure)
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