Stratified Medicine in Type 2 Diabetes: Insights from the Study of Drug Response (New Investigator Award)

Pearson, Ewan (Investigator)

Diabetes Endocrinology and Reproductive Biology

79 Article
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2026
Type 2 diabetes risk alleles in peptidyl-glycine alpha-amidating monooxygenase influence GLP-1 levels and response to GLP-1 receptor agonists
Umapathysivam, M. M., Araldi, E., Hastoy, B., Dawed, A. Y., Vatandaslar, H., Mayrhofer, J. E., Lindquist, P., Silva, P. N., Goga, A., Trüllinger, G. O., Godbersen, S., Sengupta, S., Kaufmann, A., Thomsen, S. K., Hartmann, B., Chen, Y. C., Jonsson, A. E., Kabakci, H., Thaman, S. & Grarup, N. & 25 others, Have, C. T., Pallo, L. P., Faerch, K., Gjesing, A. P., Nawaz, S., Cheeseman, J., Neville, M. J., Pedersen, O., Walker, M., Sun, H., Jennison, C., Hattersley, A. T., Rehfeld, J. F., Holman, R. R., Verchere, B. C., Hansen, T., Karpe, F., Holst, J. J., Rosenkilde, M. M., Jones, A. G., Ristow, M., McCarthy, M. I., Pearson, E. R., Stoffel, M. & Gloyn, A. L. (Lead / Corresponding author), 13 Apr 2026, In: Genome Medicine. 18, 1, 40.
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2024
Low-dose sulphonylurea plus DPP4 inhibitor lower blood glucose and enhance beta-cell function without hypoglycaemia
Cordiner, R. L. M., Bedair, K., Mari, A. & Pearson, E. (Lead / Corresponding author), Aug 2024, In: Journal of Clinical Endocrinology and Metabolism. 109, 8, p. 2106-2115 10 p., dgae033.
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The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1: An IMI DIRECT Study
Eriksen, R., White, M. C., Dawed, A. Y., Perez, I. G., Posma, J. M., Haid, M., Sharma, S., Prehn, C., Thomas, E. L., Koivula, R. W., Bizzotto, R., Mari, A., Giordano, G. N., Pavo, I., Schwenk, J. M., De Masi, F. D., Tsirigos, K. D., Brunak, S., Viñuela, A. & Mahajan, A. & 26 others, McDonald, T. J., Kokkola, T., Rutters, F., Beulens, J., Muilwijk, M., Blom, M., Elders, P., Hansen, T. H., Fernandez-Tajes, J., Jones, A., Jennison, C., Walker, M., McCarthy, M. I., Pedersen, O., Ruetten, H., Forgie, I., Holst, J. J., Thomsen, H. S., Ridderstråle, M., Bell, J. D., Adamski, J., Franks, P. W., Hansen, T., Holmes, E., Frost, G. (Lead / Corresponding author) & Pearson, E. R. (Lead / Corresponding author), 1 Sept 2024, In: Journal of Clinical Endocrinology & Metabolism. 109, 9, p. e1697-e1707 11 p., dgae119.
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2023
A phenome-wide comparative analysis of genetic discordance between obesity and type 2 diabetes
Coral, D. E. (Lead / Corresponding author), Fernandez-Tajes, J., Tsereteli, N., Pomares-Millan, H., Fitipaldi, H., Mutie, P. M., Atabaki-Pasdar, N., Kalamajski, S., Poveda, A., Miller-Fleming, T. W., Zhong, X., Giordano, G. N., Pearson, E. R., Cox, N. J. & Franks, P. W. (Lead / Corresponding author), Feb 2023, In: Nature Metabolism. 5, p. 237-247 11 p.
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Identification of biomarkers for glycaemic deterioration in type 2 diabetes
Slieker, R. C., Donnelly, L. A., Akalestou, E., Lopez-Noriega, L., Melhem, R., Güneş, A., Abou Azar, F., Efanov, A., Georgiadou, E., Muniangi-Muhitu, H., Sheikh, M., Giordano, G. N., Åkerlund, M., Ahlqvist, E., Ali, A., Banasik, K., Brunak, S., Barovic, M., Bouland, G. A. & Burdet, F. & 46 others, Canouil, M., Dragan, I., Elders, P. J. M., Fernandez, C., Festa, A., Fitipaldi, H., Froguel, P., Gudmundsdottir, V., Gudnason, V., Gerl, M. J., van der Heijden, A. A., Jennings, L. L., Hansen, M. K., Kim, M., Leclerc, I., Klose, C., Kuznetsov, D., Mansour Aly, D., Mehl, F., Marek, D., Melander, O., Niknejad, A., Ottosson, F., Pavo, I., Duffin, K., Syed, S. K., Shaw, J. L., Cabrera, O., Pullen, T. J., Simons, K., Solimena, M., Suvitaival, T., Wretlind, A., Rossing, P., Lyssenko, V., Legido Quigley, C., Groop, L., Thorens, B., Franks, P. W., Lim, G. E., Estall, J., Ibberson, M., Beulens, J. W. J., 't Hart, L. M. (Lead / Corresponding author), Pearson, E. R. (Lead / Corresponding author) & Rutter, G. A. (Lead / Corresponding author), 3 May 2023, In: Nature Communications. 14, 18 p., 2533.
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Patient preference for second- and third-line therapies in type 2 diabetes: a prespecified secondary endpoint of the TriMaster study
Shields, B. M., Angwin, C. D., Shepherd, M. H., Britten, N., Jones, A. G., Sattar, N., Holman, R., Pearson, E. R. & Hattersley, A. T. (Lead / Corresponding author), Feb 2023, In: Nature Medicine. 29, p. 384–391 8 p.
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Patient stratification for determining optimal second-line and third-line therapy for type 2 diabetes: the TriMaster study
Shields, B. M., Dennis, J. M., Angwin, C. D., Warren, F., Henley, W. E., Farmer, A. J., Sattar, N., Holman, R. R., Jones, A. G., Pearson, E. R., Hattersley, A. T. (Lead / Corresponding author) & TriMaster Study group, Feb 2023, In: Nature Medicine. 29, p. 376–383 8 p.
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Pharmacogenomics of GLP-1 Receptor Agonists: a genome-wide analysis of observational data and large randomised controlled trials
Dawed, A. Y. (Lead / Corresponding author), Mari, A., Brown, A., McDonald, T. J., Li, L., Wang, S., Hong, M.-G., Sharma, S., Robertson, N. R., Mahajan, A., Wang, X., Walker, M., Gough, S., 't Hart, L. M., Zhou, K., Forgie, I., Ruetten, H., Pavo, I., Bhatnagar, P. & Jones, A. G. & 2 others, Pearson, E. R. (Lead / Corresponding author) & DIlinRECT consortium, 1 Jan 2023, In: The Lancet Diabetes and Endocrinology. 11, 1, p. 33-41 9 p.
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Weight variability and cardiovascular outcomes: a systematic review and meta-analysis
Massey, R. J., Siddiqui, M. K., Pearson, E. R. & Dawed, A. Y. (Lead / Corresponding author), 9 Jan 2023, In: Cardiovascular Diabetology. 22, 12 p., 5.
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2022
Development of a treatment selection algorithm for SGLT2 and DPP-4 inhibitor therapies in people with type 2 diabetes: a retrospective cohort study
Dennis, J. M. (Lead / Corresponding author), Young, K. G., McGovern, A. P., Mateen, B. A., Vollmer, S. J., Simpson, M. D., Henley, W. E., Holman, R. R., Sattar, N., Pearson, E. R., Hattersley, A. T., Jones, A. G., Shields, B. M. & MASTERMIND consortium, Dec 2022, In: The Lancet Digital Health. 4, 12, p. E873-E883 11 p.
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Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study
IMI DIRECT Consortium, Wesolowska-Andersen, A., Brorsson, C. A., Bizzotto, R., Mari, A., Tura, A., Koivula, R., Mahajan, A., Vinuela, A., Tajes, J. F., Sharma, S., Haid, M., Prehn, C., Artati, A., Hong, M.-G., Musholt, P. B., Kurbasic, A., De Masi, F., Tsirigos, K. & Pedersen, H. K. & 41 others, Gudmundsdottir, V., Thomas, C. E., Banasik, K., Jennison, C., Jones, A., Kennedy, G., Bell, J., Thomas, L., Frost, G., Thomsen, H., Allin, K., Hansen, T. H., Vestergaard, H., Hansen, T., Rutters, F., Elders, P., t'Hart, L., Bonnefond, A., Canouil, M., Brage, S., Kokkola, T., Heggie, A., McEvoy, D., Hattersley, A., McDonald, T., Teare, H., Ridderstrale, M., Walker, M., Forgie, I., Giordano, G. N., Froguel, P., Pavo, I., Ruetten, H., Pedersen, O., Dermitzakis, E. T., Franks, P. W., Schwenk, J. M., Adamski, J., Pearson, E. (Lead / Corresponding author), McCarthy, M. I. (Lead / Corresponding author) & Brunak, S. (Lead / Corresponding author), 18 Jan 2022, In: Cell Reports Medicine. 3, 1, 32 p., 100477.
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Heterogeneity in phenotype, disease progression and drug response in type 2 diabetes
Thakarakkattil Narayanan Nair, A., Wesolowska-Andersen, A., Brorsson, C. A., Lathika Rajendrakumar, A., Hapca, S., Gan, S., Dawed, A. Y., Donnelly, L. A., McCrimmon, R., Doney, A. S. F., Palmer, C. N. A., Mohan, V., Anjana, R. M., Hattersley, A. T., Dennis, J. M. & Pearson, E. R. (Lead / Corresponding author), 9 May 2022, In: Nature Medicine. 28, p. 982-988 7 p.
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Young onset diabetes in Asian Indians is associated with lower measured and genetically determined beta-cell function: an INSPIRED study
Siddiqui, M. K. (Lead / Corresponding author), Anjana, R. M., Dawed, A. Y., Martoeau, C., Srinivasan, S., Saravanan, J., Madanagopa, S. K., Taylor, A., Bell, S., Veluchamy, A., Pradeepa, R., Sattar, N., Venkatesan, R., Palmer, C. N. A., Pearson, E. R. (Lead / Corresponding author) & Mohan, V., Jun 2022, In: Diabetologia. 65, p. 973-983 11 p.
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2021
A Polygenic Score for Type 2 Diabetes Risk is Associated with Both the Acute and Sustained Response to Sulfonylureas
Li, J. H., Szczerbinski, L., Dawed, A. Y., Kaur, V., Todd, J. N., Pearson, E. R. & Florez, J. C. (Lead / Corresponding author), 1 Jan 2021, In: Diabetes. 70, 1, p. 293-300 8 p.
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Distinct molecular signatures of clinical clusters in people with type 2 diabetes: an IMI-RHAPSODY study
Slieker, R. C., Donnelly, L. A., Fitipaldi, H., Bouland, G. A., Giordano, G. N., Åkerlund, M., Gerl, M. J., Ahlqvist, E., Ali, A., Dragan, L., Elders, P. J. M., Festa, A., Hansen, M. K., van der Heijden, A. A., Mansour Aly, D., Kim, M., Kuznetsov, D., Mehl, F., Klose, C. & Simons, K. & 15 others, Pavo, I., Pullen, T. J., Suvitaival, T., Wretlind, A., Rossing, P., Lyssenko, V., Legido-Quigley, C., Groop, L., Thorens, B., Franks, P. W., Ibberson, M., Rutter, G. A., Beulens, J. W. J., 't Hart, L. M. (Lead / Corresponding author) & Pearson, E. R. (Lead / Corresponding author), Nov 2021, In: Diabetes. 70, 11, p. 2683-2693 11 p.
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Dorothy Hodgkin Lecture 2021: Drugs, genes and diabetes
Pearson, E. R. (Lead / Corresponding author), Dec 2021, In: Diabetic Medicine. 38, 12, 7 p., e14726.
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Genome-Wide Association Analysis of Pancreatic Beta Cell Glucose Sensitivity
Deshmukh, H. A., Madsen, A. L., Viñuela, A., Have, C. T., Grarup, N., Tura, A., Mahajan, A., Heggie, A. J., Koivula, R. W., De Masi, F., Tsirigos, K. K., Linneberg, A., Drivsholm, T., Pedersen, O., Sørensen, T. I. A., Astrup, A., Gjesing, A. A. P., Pavo, I., Wood, A. R. & Ruetten, H. & 14 others, Jones, A. G., Koopman, A. D. M., Cederberg, H., Rutters, F., Ridderstrale, M., Laakso, M., McCarthy, M. I., Frayling, T. M., Ferrannini, E., Franks, P. W., Pearson, E. R., Mari, A. (Lead / Corresponding author), Hansen, T. (Lead / Corresponding author) & Walker, M. (Lead / Corresponding author), Jan 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 1, p. 80-90 11 p.
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Genome-wide meta-analysis identifies genetic variants associated with glycemic response to sulfonylureas
Dawed, A. Y., Yee, S. W., Zhou, K., van Leeuwen, N., Zhang, Y., Siddiqui, M. K., Etheridge, A., Innocenti, F., Xu, F., Li, J. H., Beulens, J. W., van der Heijden, A. A., Slieker, R. C., Chang, Y.-C., Mercader, J. M., Kaur, V., Witte, J. S., Lee, M. T. M., Kamatani, Y. & Momozawa, Y. & 7 others, Kubo, M., Palmer, C. N. A., Florez, J. C., Hedderson, M. M., 't Hart, L. M., Giacomini, K. M. (Lead / Corresponding author) & Pearson, E. R. (Lead / Corresponding author), 1 Dec 2021, In: Diabetes Care. 44, 12, p. 2673-2682 10 p.
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In a cohort of individuals with type 2 diabetes using the drug sulfasalazine, HbA1c lowering is associated with haematological changes
N'Dow, S. M. S., Donnelly, L. A., Pearson, E. R. & Rena, G. (Lead / Corresponding author), 16 Aug 2021, In: Diabetic Medicine. 38, 9, 9 p., e14463.
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Interaction between Omeprazole and Gliclazide in Relation to CYP2C19 Phenotype
Dujic, T. (Lead / Corresponding author), Cvijic, S., Elezovic, A., Bego, T., Imamovic Kadric, S., Malenica, M., Elezovic, A., Pearson, E. R. & Kulo, A., 3 May 2021, In: Journal of Personalized Medicine. 11, 5, 21 p., 367.
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Polymorphism in INSR Locus Modifies Risk of Atrial Fibrillation in Patients on Thyroid Hormone Replacement Therapy
Soto-Pedre, E. (Lead / Corresponding author), Siddiqui, M. K., Maroteau, C., Dawed, A. Y., Doney, A. S., Palmer, C. N. A., Pearson, E. R. & Leese, G. P., 23 Jun 2021, In: Frontiers in Genetics. 12, 7 p., 652878.
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Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study
Slieker, R. C., Donnelly, L. A., Fitipaldi, H., Bouland, G. A., Giordano, G. N., Åkerlund, M., Gerl, M. J., Ahlqvist, E., Ali, A., Dragan, I., Festa, A., Hansen, M. K., Mansour Aly, D., Kim, M., Kuznetsov, D., Mehl, F., Klose, C., Simons, K., Pavo, I. & Pullen, T. J. & 13 others, Suvitaival, T., Wretlind, A., Rossing, P., Lyssenko, V., Legido-Quigley, C., Groop, L., Thorens, B., Franks, P. W., Ibberson, M., Rutter, G. A., Beulens, J. W. J., 't Hart, L. M. (Lead / Corresponding author) & Pearson, E. R. (Lead / Corresponding author), Sept 2021, In: Diabetologia. 64, p. 1982-1989 8 p.
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The Impact of Low-dose Gliclazide on the Incretin Effect and Indices of Beta-cell Function
Cordiner, R. L. M., Mari, A., Tura, A. & Pearson, E. R. (Lead / Corresponding author), Jul 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 7, p. 2036-2046 11 p.
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Utilizing Large Electronic Medical Record Data Sets to Identify Novel Drug–Gene Interactions for Commonly Used Drugs
Malki, M. A., Dawed, A. Y., Haywood, C., Doney, A. & Pearson, E. R. (Lead / Corresponding author), Sept 2021, In: Clinical Pharmacology & Therapeutics. 110, 3, p. 816-825 10 p.
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2020
Circulating tissue factor-positive procoagulant microparticles in patients with type 1 diabetes
Zhang, C., Ou, Q., Gu, Y., Cheng, G., Du, R., Yuan, L., Cordiner, R., Kang, D., Zhang, J., Huang, Q., Yu, C., Kang, L., Wang, X., Sun, X., Mo, X., Tian, H., Pearson, E., Meng, W. (Lead / Corresponding author) & Li, S. (Lead / Corresponding author), 3 Jan 2020, In: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 12, p. 2819-2828 10 p.
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Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study
Eriksen, R. (Lead / Corresponding author), Perez, I. G., Posma, J. M., Haid, M., Sharma, S., Prehn, C., Thomas, L. E., Koivula, R. W., Bizzotto, R., Prehn, C., Mari, A., Giordano, G. N., Pavo, I., Schwenk, J. M., De Masi, F., Tsirigos, K. D., Brunak, S., Viñuela, A., Mahajan, A. & McDonald, T. J. & 18 others, Kokkola, T., Rutter, F., Teare, H., Hansen, T. H., Fernandez, J., Jones, A., Jennison, C., Walker, M., McCarthy, M. I., Pedersen, O., Ruetten, H., Forgie, I., Bell, J. D., Pearson, E. R., Franks, P. W., Adamski, J., Holmes, E. & Frost, G. (Lead / Corresponding author), Aug 2020, In: EBioMedicine. 58, 9 p., 102932.
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Efficacy of Modern Diabetes Treatments DPP-4i, SGLT-2i, and GLP-1RA in White and Asian Patients With Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Gan, S., Dawed, A. Y., Donnelly, L. A., Nair, A. T. N., Palmer, C. N. A., Mohan, V. & Pearson, E. R. (Lead / Corresponding author), Aug 2020, In: Diabetes Care. 43, 8, p. 1948-1957 10 p.
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Genetic Risk of Diverticular Disease Predicts Early Stoppage of Nicorandil
Noyes, J., Mordi, I. R., Doney, A. S., Palmer, C. N. A., Pearson, E. R. & Lang, C. C. (Lead / Corresponding author), Dec 2020, In: Clinical Pharmacology & Therapeutics. 108, 6, p. 1171-1175 5 p.
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Metformin increases fasting glucose clearance and endogenous glucose production in non-diabetic individuals
McCreight, L. J., Mari, A., Coppin, L., Jackson, N., Umpleby, A. M. & Pearson, E. (Lead / Corresponding author), Feb 2020, In: Diabetologia. 63, p. 444-447 4 p.
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Monogenic diabetes: From genetic insights to population-based precision in care. Reflections from a diabetes care editors’ expert forum
Riddle, M. C. (Lead / Corresponding author), Philipson, L. H., Rich, S. S., Carlsson, A., Franks, P. W., Greeley, S. A. W., Nolan, J. J., Pearson, E. R., Zeitler, P. S. & Hattersley, A. T., Dec 2020, In: Diabetes Care. 43, 12, p. 3117-3128 12 p.
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Novel subgroups of type 2 diabetes and their association with microvascular outcomes in an Asian Indian population: a data-driven cluster analysis: the INSPIRED study
Anjana, R. M., Baskar, V., Nair, A. T. N., Jebarani, S., Siddiqui, M. K., Pradeepa, R., Unnikrishnan, R., Palmer, C., Pearson, E. & Mohan, V. (Lead / Corresponding author), 17 Aug 2020, In: BMJ Open Diabetes Research and Care. 8, 1, 8 p., e001506.
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Obesity, clinical, and genetic predictors for glycemic progression in Chinese patients with type 2 diabetes: A cohort study using the Hong Kong Diabetes Register and Hong Kong Diabetes Biobank
Jiang, G., Luk, A. O., Tam, C. H. T., Lau, E. S., Ozaki, R., Chow, E. Y. K., Kong, A. P. S., Lim, C. K. P., Lee, K. F., Siu, S. C., Hui, G., Tsang, C. C., Lau, K. P., Leung, J. Y. Y., Tsang, M.-W., Kam, G., Lau, I. T., Li, J. K., Yeung, V. T. & Lau, E. & 10 others, Lo, S., Fung, S. K. S., Cheng, Y. L., Chow, C. C., Pearson, E. R., So, W. Y., Chan, J. C. N., Ma, R. C. W. (Lead / Corresponding author), Hong Kong Diabetes Biobank Study Group & Hong Kong Diabetes Register TRS Study Group, 28 Jul 2020, In: PLoS Medicine. 17, 7, 19 p., e1003209.
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Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
Chung, W. K., Erion, K., Florez, J. C., Hattersley, A. T., Hivert, M.-F., Lee, C. G., McCarthy, M. I., Nolan, J. J., Norris, J. M., Pearson, E. R., Philipson, L., McElvaine, A. T., Cefalu, W. T., Rich, S. S. & Franks, P. W. (Lead / Corresponding author), 1 Sept 2020, In: Diabetologia. 63, 9, p. 1671-1693 23 p.
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Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
Chung, W. K., Erion, K., Florez, J. C., Hattersley, A. T., Hivert, M.-F., Lee, C. G., McCarthy, M. I., Nolan, J. J., Norris, J. M., Pearson, E. R., Philipson, L., McElvaine, A. T., Cefalu, W. T., Rich, S. S. & Franks, P. W. (Lead / Corresponding author), Jul 2020, In: Diabetes Care. 43, 7, p. 1617-1635 19 p.
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Response to Comment on Gan et al. Efficacy of Modern Diabetes Treatments DPP-4i, SGLT-2i, and GLP-1RA in White and Asian Patients With Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Diabetes Care 2020;43:1948–1957
Gan, S., Dawed, A. Y., Donnelly, L. A., Nair, A. T. N., Palmer, C. N. A., Mohan, V. & Pearson, E. R. (Lead / Corresponding author), Dec 2020, In: Diabetes Care. 43, 12, p. e202-e203 2 p.
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Risk factors for genital infections in people initiating SGLT2 inhibitors and their impact on discontinuation
McGovern, A. P. (Lead / Corresponding author), Hogg, M., Shields, B. M., Sattar, N. A., Holman, R. R., Pearson, E. R., Hattersley, A. T., Jones, A. G., Dennis, J. M. & MASTERMIND consortium, 24 May 2020, In: BMJ Open Diabetes Research and Care. 8, 1, 8 p., e001238.
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Risk of anemia with metformin use in type 2 diabetes: A MASTERMIND study
Donnelly, L. A., Dennis, J. M., Coleman, R. L., Sattar, N., Hattersley, A. T., Holman, R. R. & Pearson, E. R. (Lead / Corresponding author), Oct 2020, In: Diabetes Care. 43, 10, p. 2493-2499 7 p.
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TriMaster: Randomised double-blind crossover study of a DPP4 inhibitor, SGLT2 inhibitor and thiazolidinedione as second-line or third-line therapy in patients with type 2 diabetes who have suboptimal glycaemic control on metformin treatment with or without a sulfonylurea - A MASTERMIND study protocol
Angwin, C., Jenkinson, C., Jones, A., Jennison, C., Henley, W., Farmer, A., Sattar, N., Holman, R. R., Pearson, E., Shields, B. (Lead / Corresponding author) & Hattersley, A., Dec 2020, In: BMJ Open. 10, 12, 10 p., e042784.
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Visit-to-visit HbA_1c variability is associated with cardiovascular disease and microvascular complications in patients with newly diagnosed type 2 diabetes
Li, S., Nemeth, I., Donnelly, L., Hapca, S., Zhou, K. & Pearson, E. (Lead / Corresponding author), 20 Jan 2020, In: Diabetes Care. 43, 2, p. 426-432 7 p.
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2019
A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy
Grubb, A. L., McDonald, T. J., Rutters, F., Donnelly, L., Hattersley, A. T., Oram, R. A., Palmer, C., van der Heijden, A. A., Carr, F., Elders, P. J. M., Weedon, M., Slieker, R. C., 't Hart, L. M., Pearson, E., Shields, B. M. & Jones, A. G. (Lead / Corresponding author), 1 Feb 2019, In: Diabetes Care. 42, 2, p. 208-214 7 p.
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Development and validation of multivariable clinical diagnostic models to identify type 1 diabetes requiring rapid insulin therapy in adults aged 18-50 years
Lynam, A., McDonald, T., Hill, A., Dennis, J., Oram, R., Pearson, E., Weedon, M., Hattersley, A., Owen, K., Shields, B. & Jones, A., 26 Sept 2019, In: BMJ Open. 9, 9, 10 p., e031586.
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Diabetes: Is there a future for Pharmacogenomics guided treatment?
Pearson, E. (Lead / Corresponding author), 12 Jul 2019, In: Clinical Pharmacology & Therapeutics. 106, 2, p. 329-337 9 p.
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Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium
Koivula, R. W., Forgie, I. M., Kurbasic, A., Viñuela, A., Heggie, A., Giordano, G. N., Hansen, T. H., Hudson, M., Koopman, A. D. M., Rutters, F., Siloaho, M., Allin, K. H., Brage, S., Brorsson, C. A., Dawed, A. Y., De Masi, F., Groves, C. J., Kokkola, T., Mahajan, A. & Perry, M. H. & 31 others, Rauh, S. P., Ridderstråle, M., Teare, H. J. A., Thomas, E. L., Tura, A., Vestergaard, H., White, T., Adamski, J., Bell, J. D., Beulens, J. W., Brunak, S., Dermitzakis, E. T., Froguel, P., Frost, G., Gupta, R., Hansen, T., Hattersley, A., Jablonka, B., Kaye, J., Laakso, M., McDonald, T. J., Pedersen, O., Schwenk, J. M., Pavo, I., Mari, A., McCarthy, M. I., Ruetten, H., Walker, M., Pearson, E. (Lead / Corresponding author), Franks, P. W. (Lead / Corresponding author) & for the IMI DIRECT Consortium, 1 Sept 2019, In: Diabetologia. 62, 9, p. 1601-1615 15 p.
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Time trends in prescribing of type 2 diabetes drugs, glycaemic response and risk factors: a retrospective analysis of primary care data, 2010-2017
Dennis, J. M., Henley, W. E., McGovern, A. P., Farmer, A. J., Sattar, N., Holman, R. R., Pearson, E. R., Hattersley, A. T., Shields, B. M. (Lead / Corresponding author), Jones, A. G. (Lead / Corresponding author) & MASTERMIND consortium, Jul 2019, In: Diabetes, Obesity & Metabolism. 21, 7, p. 1576-1584 9 p.
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Variation in the plasma membrane monoamine transporter (PMAT) (encoded by SLC29A4) and organic cation transporter 1 (OCT1) (encoded by SLC22A1) and gastrointestinal intolerance to metformin in type 2 diabetes: An IMI direct study
Dawed, A., Zhou, K., van Leeuwen, N., Mahajan, A., Robertson, N. R., Koivula, R. W., Elders, P. J. M., Rauh, S. P., Jones, A. G., Holl, R. W. .., Stingl, J. C., Franks, P. W., McCarthy, M. I., 't Hart, L. M., Pearson, E. R. (Lead / Corresponding author) & IMI DIRECT Consortium, Jun 2019, In: Diabetes Care. 42, 6, p. 1027-1033 7 p.
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What to do with diabetes therapies when HbA1c lowering is inadequate: add, switch, or continue? A MASTERMIND study
MASTERMIND consortium, McGovern, A. P. (Lead / Corresponding author), Dennis, J. M., Shields, B. M., Hattersley, A. T., Pearson, E. R. & Jones, A. G., 12 Apr 2019, In: BMC Medicine. 17, 1, p. 1-17 17 p., 79.
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2018
A UK nationwide prospective study of treatment change in MODY: genetic subtype and clinical characteristics predict optimal glycaemic control after discontinuing insulin and metformin
UNITED study, Shepherd, M. H. (Lead / Corresponding author), Shields, B. M., Hudson, M., Pearson, E. R., Hyde, C., Ellard, S., Hattersley, A. T. & Patel, K. A., Dec 2018, In: Diabetologia. 61, 12, p. 2520-2527 8 p.
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Characteristics of people with high visit-to-visit glycaemic variability in Type 2 diabetes
Noyes, J. D., Soto-Pedre, E., Donnelly, L. A. & Pearson, E. (Lead / Corresponding author), 14 Jan 2018, In: Diabetic Medicine. 35, 2, p. 262-267 6 p.
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Cohort Profile: Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS)
Hébert, H. L. (Lead / Corresponding author), Shepherd, B., Milburn, K., Veluchamy, A., Meng, W., Carr, F., Donnelly, L. A., Tavendale, R., Leese, G., Colhoun, H. M., Dow, E., Morris, A. D., Doney, A. S., Lang, C. C., Pearson, E. R., Smith, B. H. & Palmer, C. N. A., 1 Apr 2018, In: International Journal of Epidemiology. 47, 2, p. 380-381j 12 p.
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C-peptide decline in type 1 diabetes has two phases: An initial exponential fall and a subsequent stable phase
Shields, B. M., McDonald, T. J., Oram, R., Hill, A., Hudson, M., Leete, P., Pearson, E. R., Richardson, S. J., Morgan, N. G. & Hattersley, A. T. (Lead / Corresponding author), 1 Jul 2018, In: Diabetes Care. 41, 7, p. 1486-1492 7 p.
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Stratified Medicine in Type 2 Diabetes: Insights from the Study of Drug Response (New Investigator Award)

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