Stratified Medicine in Type 2 Diabetes: Insights from the Study of Drug Response (New Investigator Award)

Research output

Research output per year 2014 2016 2017 2018 2019 2020 2021 2024

• 78 Article
• 10 Review article
• 2 Comment/debate
• 2 Letter
• 1 More
  • 1 Chapter (peer-reviewed)

Research output per year

Research output per year

Search results

• 2024

  Low-dose sulphonylurea plus DPP4 inhibitor lower blood glucose and enhance beta-cell function without hypoglycaemia

  Cordiner, R. L. M., Bedair, K., Mari, A. & Pearson, E. (Lead / Corresponding author), Aug 2024, In: Journal of Clinical Endocrinology and Metabolism. 109, 8, p. 2106-2115 10 p., dgae033.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hypoglycemia 100%
  • β-cell Function 100%
  • Sulfonylurea 100%
  • Dipeptidyl peptidase-4 (DPP-4) 100%
  • Low Blood Glucose 100%
  2 Citations (Scopus)

  53 Downloads (Pure)

• The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1: An IMI DIRECT Study

  Eriksen, R., White, M. C., Dawed, A. Y., Perez, I. G., Posma, J. M., Haid, M., Sharma, S., Prehn, C., Thomas, E. L., Koivula, R. W., Bizzotto, R., Mari, A., Giordano, G. N., Pavo, I., Schwenk, J. M., De Masi, F. D., Tsirigos, K. D., Brunak, S., Viñuela, A. & Mahajan, A. & 26 others, McDonald, T. J., Kokkola, T., Rutters, F., Beulens, J., Muilwijk, M., Blom, M., Elders, P., Hansen, T. H., Fernandez-Tajes, J., Jones, A., Jennison, C., Walker, M., McCarthy, M. I., Pedersen, O., Ruetten, H., Forgie, I., Holst, J. J., Thomsen, H. S., Ridderstråle, M., Bell, J. D., Adamski, J., Franks, P. W., Hansen, T., Holmes, E., Frost, G. (Lead / Corresponding author) & Pearson, E. R. (Lead / Corresponding author), 1 Sept 2024, In: Journal of Clinical Endocrinology & Metabolism. 109, 9, p. e1697-e1707 11 p., dgae119.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cardiometabolic Disease 100%
  • Glucagon-like 100%
  • Innovative Medicines Initiative 100%
  • Lifestyle Parameters 100%
  • Medicine 100%
  48 Downloads (Pure)
• 2023

  A phenome-wide comparative analysis of genetic discordance between obesity and type 2 diabetes

  Coral, D. E. (Lead / Corresponding author), Fernandez-Tajes, J., Tsereteli, N., Pomares-Millan, H., Fitipaldi, H., Mutie, P. M., Atabaki-Pasdar, N., Kalamajski, S., Poveda, A., Miller-Fleming, T. W., Zhong, X., Giordano, G. N., Pearson, E. R., Cox, N. J. & Franks, P. W. (Lead / Corresponding author), Feb 2023, In: Nature Metabolism. 5, p. 237-247 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Comparative Analysis 100%
  • Type 2 Diabetes Mellitus (T2DM) 100%
  • Obesity 100%
  • Phenome-wide 100%
  • Blood Pressure 100%
  23 Citations (Scopus)

  99 Downloads (Pure)

• Identification of biomarkers for glycaemic deterioration in type 2 diabetes

  Slieker, R. C., Donnelly, L. A., Akalestou, E., Lopez-Noriega, L., Melhem, R., Güneş, A., Abou Azar, F., Efanov, A., Georgiadou, E., Muniangi-Muhitu, H., Sheikh, M., Giordano, G. N., Åkerlund, M., Ahlqvist, E., Ali, A., Banasik, K., Brunak, S., Barovic, M., Bouland, G. A. & Burdet, F. & 46 others, Canouil, M., Dragan, I., Elders, P. J. M., Fernandez, C., Festa, A., Fitipaldi, H., Froguel, P., Gudmundsdottir, V., Gudnason, V., Gerl, M. J., van der Heijden, A. A., Jennings, L. L., Hansen, M. K., Kim, M., Leclerc, I., Klose, C., Kuznetsov, D., Mansour Aly, D., Mehl, F., Marek, D., Melander, O., Niknejad, A., Ottosson, F., Pavo, I., Duffin, K., Syed, S. K., Shaw, J. L., Cabrera, O., Pullen, T. J., Simons, K., Solimena, M., Suvitaival, T., Wretlind, A., Rossing, P., Lyssenko, V., Legido Quigley, C., Groop, L., Thorens, B., Franks, P. W., Lim, G. E., Estall, J., Ibberson, M., Beulens, J. W. J., 't Hart, L. M. (Lead / Corresponding author), Pearson, E. R. (Lead / Corresponding author) & Rutter, G. A. (Lead / Corresponding author), 3 May 2023, In: Nature Communications. 14, 18 p., 2533.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lipids 100%
  • Type 2 Diabetes Mellitus (T2DM) 100%
  • Rapid Progression 100%
  • Glycaemic Deterioration 100%
  • Biological Marker 100%
  21 Citations (Scopus)

  198 Downloads (Pure)

• Patient preference for second- and third-line therapies in type 2 diabetes: a prespecified secondary endpoint of the TriMaster study

  Shields, B. M., Angwin, C. D., Shepherd, M. H., Britten, N., Jones, A. G., Sattar, N., Holman, R., Pearson, E. R. & Hattersley, A. T. (Lead / Corresponding author), Feb 2023, In: Nature Medicine. 29, p. 384–391 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Patient Preference 100%
  • Type 2 Diabetes Mellitus (T2DM) 100%
  • Second-line Therapy 100%
  • Canagliflozin 100%
  • Third-line Therapy 100%
  11 Citations (Scopus)

  100 Downloads (Pure)

• Patient stratification for determining optimal second-line and third-line therapy for type 2 diabetes: the TriMaster study

  Shields, B. M., Dennis, J. M., Angwin, C. D., Warren, F., Henley, W. E., Farmer, A. J., Sattar, N., Holman, R. R., Jones, A. G., Pearson, E. R., Hattersley, A. T. (Lead / Corresponding author) & TriMaster Study group, Feb 2023, In: Nature Medicine. 29, p. 376–383 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Type 2 Diabetes Mellitus (T2DM) 100%
  • Patient Stratification 100%
  • Third-line Therapy 100%
  • Sitagliptin 100%
  • Maturity Onset Diabetes of the Young 100%
  33 Citations (Scopus)

  254 Downloads (Pure)

• Pharmacogenomics of GLP-1 Receptor Agonists: a genome-wide analysis of observational data and large randomised controlled trials

  Dawed, A. Y. (Lead / Corresponding author), Mari, A., Brown, A., McDonald, T. J., Li, L., Wang, S., Hong, M.-G., Sharma, S., Robertson, N. R., Mahajan, A., Wang, X., Walker, M., Gough, S., 't Hart, L. M., Zhou, K., Forgie, I., Ruetten, H., Pavo, I., Bhatnagar, P. & Jones, A. G. & 2 others, Pearson, E. R. (Lead / Corresponding author) & DIlinRECT consortium, 1 Jan 2023, In: The Lancet Diabetes and Endocrinology. 11, 1, p. 33-41 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Randomized Controlled Trial 100%
  • Observational Data 100%
  • Genome-wide Analysis 100%
  • Pharmacogenomics 100%
  • GLP-1 Receptor Agonist 100%
  41 Citations (Scopus)

  505 Downloads (Pure)

• Weight variability and cardiovascular outcomes: a systematic review and meta-analysis

  Massey, R. J., Siddiqui, M. K., Pearson, E. R. & Dawed, A. Y. (Lead / Corresponding author), 9 Jan 2023, In: Cardiovascular Diabetology. 22, 12 p., 5.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Meta-analysis 100%
  • Relative Risk 100%
  • Cardiovascular Outcomes 100%
  • Systematic Meta-analysis 100%
  • Weight Variability 100%
  13 Citations (Scopus)

  126 Downloads (Pure)
• 2022

  Development of a treatment selection algorithm for SGLT2 and DPP-4 inhibitor therapies in people with type 2 diabetes: a retrospective cohort study

  Dennis, J. M. (Lead / Corresponding author), Young, K. G., McGovern, A. P., Mateen, B. A., Vollmer, S. J., Simpson, M. D., Henley, W. E., Holman, R. R., Sattar, N., Pearson, E. R., Hattersley, A. T., Jones, A. G., Shields, B. M. & MASTERMIND consortium, Dec 2022, In: The Lancet Digital Health. 4, 12, p. E873-E883 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Type 2 Diabetes Mellitus (T2DM) 100%
  • Retrospective Cohort Study 100%
  • Inhibitor Therapy 100%
  • Treatment Selection 100%
  • Selection Algorithm 100%
  25 Citations (Scopus)

  249 Downloads (Pure)

• Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study

  IMI DIRECT Consortium, Wesolowska-Andersen, A., Brorsson, C. A., Bizzotto, R., Mari, A., Tura, A., Koivula, R., Mahajan, A., Vinuela, A., Tajes, J. F., Sharma, S., Haid, M., Prehn, C., Artati, A., Hong, M.-G., Musholt, P. B., Kurbasic, A., De Masi, F., Tsirigos, K. & Pedersen, H. K. & 41 others, Gudmundsdottir, V., Thomas, C. E., Banasik, K., Jennison, C., Jones, A., Kennedy, G., Bell, J., Thomas, L., Frost, G., Thomsen, H., Allin, K., Hansen, T. H., Vestergaard, H., Hansen, T., Rutters, F., Elders, P., t'Hart, L., Bonnefond, A., Canouil, M., Brage, S., Kokkola, T., Heggie, A., McEvoy, D., Hattersley, A., McDonald, T., Teare, H., Ridderstrale, M., Walker, M., Forgie, I., Giordano, G. N., Froguel, P., Pavo, I., Ruetten, H., Pedersen, O., Dermitzakis, E. T., Franks, P. W., Schwenk, J. M., Adamski, J., Pearson, E. (Lead / Corresponding author), McCarthy, M. I. (Lead / Corresponding author) & Brunak, S. (Lead / Corresponding author), 18 Jan 2022, In: Cell Reports Medicine. 3, 1, 32 p., 100477.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Type 2 Diabetes Mellitus (T2DM) 100%
  • Newly Diagnosed 100%
  • Etiological Heterogeneity 100%
  • Clinical Heterogeneity 100%
  • Insulin Resistance 100%
  59 Citations (Scopus)

  121 Downloads (Pure)

• Heterogeneity in phenotype, disease progression and drug response in type 2 diabetes

  Thakarakkattil Narayanan Nair, A., Wesolowska-Andersen, A., Brorsson, C. A., Lathika Rajendrakumar, A., Hapca, S., Gan, S., Dawed, A. Y., Donnelly, L. A., McCrimmon, R., Doney, A. S. F., Palmer, C. N. A., Mohan, V., Anjana, R. M., Hattersley, A. T., Dennis, J. M. & Pearson, E. R. (Lead / Corresponding author), 9 May 2022, In: Nature Medicine. 28, p. 982-988 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Type 2 Diabetes Mellitus (T2DM) 100%
  • Disease Progression 100%
  • Drug Response 100%
  • Diabetes 100%
  • Maturity Onset Diabetes of the Young 100%
  72 Citations (Scopus)

  1493 Downloads (Pure)

• Young onset diabetes in Asian Indians is associated with lower measured and genetically determined beta-cell function: an INSPIRED study

  Siddiqui, M. K. (Lead / Corresponding author), Anjana, R. M., Dawed, A. Y., Martoeau, C., Srinivasan, S., Saravanan, J., Madanagopa, S. K., Taylor, A., Bell, S., Veluchamy, A., Pradeepa, R., Sattar, N., Venkatesan, R., Palmer, C. N. A., Pearson, E. R. (Lead / Corresponding author) & Mohan, V., Jun 2022, In: Diabetologia. 65, p. 973-983 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • β-cell Function 100%
  • Asian Indians 100%
  • Young-onset Diabetes 100%
  • Diabetes 100%
  • Cell Function 100%
  45 Citations (Scopus)

  145 Downloads (Pure)
• 2021

  A Polygenic Score for Type 2 Diabetes Risk is Associated with Both the Acute and Sustained Response to Sulfonylureas

  Li, J. H., Szczerbinski, L., Dawed, A. Y., Kaur, V., Todd, J. N., Pearson, E. R. & Florez, J. C. (Lead / Corresponding author), 1 Jan 2021, In: Diabetes. 70, 1, p. 293-300 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Type 2 Diabetes Mellitus (T2DM) 100%
  • Type 2 Diabetes Risk 100%
  • Sulfonylurea 100%
  • Acute Response 100%
  • Sustained Response 100%
  21 Citations (Scopus)

  140 Downloads (Pure)

• Distinct molecular signatures of clinical clusters in people with type 2 diabetes: an IMI-RHAPSODY study

  Slieker, R. C., Donnelly, L. A., Fitipaldi, H., Bouland, G. A., Giordano, G. N., Åkerlund, M., Gerl, M. J., Ahlqvist, E., Ali, A., Dragan, L., Elders, P. J. M., Festa, A., Hansen, M. K., van der Heijden, A. A., Mansour Aly, D., Kim, M., Kuznetsov, D., Mehl, F., Klose, C. & Simons, K. & 15 others, Pavo, I., Pullen, T. J., Suvitaival, T., Wretlind, A., Rossing, P., Lyssenko, V., Legido-Quigley, C., Groop, L., Thorens, B., Franks, P. W., Ibberson, M., Rutter, G. A., Beulens, J. W. J., 't Hart, L. M. (Lead / Corresponding author) & Pearson, E. R. (Lead / Corresponding author), Nov 2021, In: Diabetes. 70, 11, p. 2683-2693 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Type 2 Diabetes Mellitus (T2DM) 100%
  • Molecular Signature 100%
  • Blood Plasma 100%
  • Non Insulin Dependent Diabetes Mellitus 100%
  • Insulin Resistance 50%
  38 Citations (Scopus)

  121 Downloads (Pure)

• Dorothy Hodgkin Lecture 2021: Drugs, genes and diabetes

  Pearson, E. R. (Lead / Corresponding author), Dec 2021, In: Diabetic Medicine. 38, 12, 7 p., e14726.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Diabetes 100%
  • Sulfonylurea 100%
  • Drug-gene 100%
  • Thomas Hodgkin 100%
  • Glycon 87%
  6 Citations (Scopus)

  96 Downloads (Pure)

• Genome-Wide Association Analysis of Pancreatic Beta Cell Glucose Sensitivity

  Deshmukh, H. A., Madsen, A. L., Viñuela, A., Have, C. T., Grarup, N., Tura, A., Mahajan, A., Heggie, A. J., Koivula, R. W., De Masi, F., Tsirigos, K. K., Linneberg, A., Drivsholm, T., Pedersen, O., Sørensen, T. I. A., Astrup, A., Gjesing, A. A. P., Pavo, I., Wood, A. R. & Ruetten, H. & 14 others, Jones, A. G., Koopman, A. D. M., Cederberg, H., Rutters, F., Ridderstrale, M., Laakso, M., McCarthy, M. I., Frayling, T. M., Ferrannini, E., Franks, P. W., Pearson, E. R., Mari, A. (Lead / Corresponding author), Hansen, T. (Lead / Corresponding author) & Walker, M. (Lead / Corresponding author), Jan 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 1, p. 80-90 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pancreatic β-cells 100%
  • Genome-wide Association Analysis 100%
  • Beta Cell Glucose Sensitivity 100%
  • Single-Nucleotide Polymorphism 100%
  • Genome Wide Association Study 100%
  7 Citations (Scopus)

  107 Downloads (Pure)

• Genome-wide meta-analysis identifies genetic variants associated with glycemic response to sulfonylureas

  Dawed, A. Y., Yee, S. W., Zhou, K., van Leeuwen, N., Zhang, Y., Siddiqui, M. K., Etheridge, A., Innocenti, F., Xu, F., Li, J. H., Beulens, J. W., van der Heijden, A. A., Slieker, R. C., Chang, Y.-C., Mercader, J. M., Kaur, V., Witte, J. S., Lee, M. T. M., Kamatani, Y. & Momozawa, Y. & 7 others, Kubo, M., Palmer, C. N. A., Florez, J. C., Hedderson, M. M., 't Hart, L. M., Giacomini, K. M. (Lead / Corresponding author) & Pearson, E. R. (Lead / Corresponding author), 1 Dec 2021, In: Diabetes Care. 44, 12, p. 2673-2682 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genetic Variants 100%
  • Glycemic Response 100%
  • Sulfonylurea 100%
  • Genome-wide Meta-analysis 100%
  • Glycemic 100%
  26 Citations (Scopus)

  199 Downloads (Pure)

• In a cohort of individuals with type 2 diabetes using the drug sulfasalazine, HbA1c lowering is associated with haematological changes

  N'Dow, S. M. S., Donnelly, L. A., Pearson, E. R. & Rena, G. (Lead / Corresponding author), 16 Aug 2021, In: Diabetic Medicine. 38, 9, 9 p., e14463.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Type 2 Diabetes Mellitus (T2DM) 100%
  • Hemoglobin A1c (HbA1c) 100%
  • Sulfasalazine 100%
  • Hematological Changes 100%
  • Maturity Onset Diabetes of the Young 100%
  1 Citation (Scopus)

  198 Downloads (Pure)

• Interaction between Omeprazole and Gliclazide in Relation to CYP2C19 Phenotype

  Dujic, T. (Lead / Corresponding author), Cvijic, S., Elezovic, A., Bego, T., Imamovic Kadric, S., Malenica, M., Elezovic, A., Pearson, E. R. & Kulo, A., 3 May 2021, In: Journal of Personalized Medicine. 11, 5, 21 p., 367.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Gliclazide 100%
  • Omeprazole 100%
  • CYP2C19 Polymorphism 100%
  • CYP2C19 100%
  • Pharmacokinetics 100%
  8 Citations (Scopus)

  165 Downloads (Pure)

• Polymorphism in INSR Locus Modifies Risk of Atrial Fibrillation in Patients on Thyroid Hormone Replacement Therapy

  Soto-Pedre, E. (Lead / Corresponding author), Siddiqui, M. K., Maroteau, C., Dawed, A. Y., Doney, A. S., Palmer, C. N. A., Pearson, E. R. & Leese, G. P., 23 Jun 2021, In: Frontiers in Genetics. 12, 7 p., 652878.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Polymorphism 100%
  • Atrial Fibrillation 100%
  • Thyroxine 100%
  • Thyroid Hormone Replacement 100%
  • Thyroid Hormone 100%
  1 Citation (Scopus)

  69 Downloads (Pure)

• Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study

  Slieker, R. C., Donnelly, L. A., Fitipaldi, H., Bouland, G. A., Giordano, G. N., Åkerlund, M., Gerl, M. J., Ahlqvist, E., Ali, A., Dragan, I., Festa, A., Hansen, M. K., Mansour Aly, D., Kim, M., Kuznetsov, D., Mehl, F., Klose, C., Simons, K., Pavo, I. & Pullen, T. J. & 13 others, Suvitaival, T., Wretlind, A., Rossing, P., Lyssenko, V., Legido-Quigley, C., Groop, L., Thorens, B., Franks, P. W., Ibberson, M., Rutter, G. A., Beulens, J. W. J., 't Hart, L. M. (Lead / Corresponding author) & Pearson, E. R. (Lead / Corresponding author), Sept 2021, In: Diabetologia. 64, p. 1982-1989 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Type 2 Diabetes Mellitus (T2DM) 100%
  • Clinical Variables 100%
  • LDL Cholesterol 100%
  • Diabetes Subtypes 100%
  • Diabetes Clusters 100%
  53 Citations (Scopus)

  107 Downloads (Pure)

• The Impact of Low-dose Gliclazide on the Incretin Effect and Indices of Beta-cell Function

  Cordiner, R. L. M., Mari, A., Tura, A. & Pearson, E. R. (Lead / Corresponding author), Jul 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 7, p. 2036-2046 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Low Drug Dose 100%
  • Cell Function 100%
  • Beta Cell 100%
  • Gliclazide 100%
  • Incretin 100%
  14 Citations (Scopus)

  140 Downloads (Pure)

• Utilizing Large Electronic Medical Record Data Sets to Identify Novel Drug–Gene Interactions for Commonly Used Drugs

  Malki, M. A., Dawed, A. Y., Haywood, C., Doney, A. & Pearson, E. R. (Lead / Corresponding author), Sept 2021, In: Clinical Pharmacology & Therapeutics. 110, 3, p. 816-825 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • UK Biobank 100%
  • Electronic Medical Record Data 100%
  • CYP2D6 100%
  • CYP2C9 100%
  • Pharmacokinetics 100%
  5 Citations (Scopus)

  129 Downloads (Pure)
• 2020

  Circulating tissue factor-positive procoagulant microparticles in patients with type 1 diabetes

  Zhang, C., Ou, Q., Gu, Y., Cheng, G., Du, R., Yuan, L., Cordiner, R., Kang, D., Zhang, J., Huang, Q., Yu, C., Kang, L., Wang, X., Sun, X., Mo, X., Tian, H., Pearson, E., Meng, W. (Lead / Corresponding author) & Li, S. (Lead / Corresponding author), 3 Jan 2020, In: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 12, p. 2819-2828 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Patient with Type 1 Diabetes 100%
  • Microparticle 100%
  • Membrane Microparticle 100%
  • Thromboplastin 100%
  • Type I Diabetes 100%
  4 Citations (Scopus)

  89 Downloads (Pure)

• Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study

  Eriksen, R. (Lead / Corresponding author), Perez, I. G., Posma, J. M., Haid, M., Sharma, S., Prehn, C., Thomas, L. E., Koivula, R. W., Bizzotto, R., Prehn, C., Mari, A., Giordano, G. N., Pavo, I., Schwenk, J. M., De Masi, F., Tsirigos, K. D., Brunak, S., Viñuela, A., Mahajan, A. & McDonald, T. J. & 18 others, Kokkola, T., Rutter, F., Teare, H., Hansen, T. H., Fernandez, J., Jones, A., Jennison, C., Walker, M., McCarthy, M. I., Pedersen, O., Ruetten, H., Forgie, I., Bell, J. D., Pearson, E. R., Franks, P. W., Adamski, J., Holmes, E. & Frost, G. (Lead / Corresponding author), Aug 2020, In: EBioMedicine. 58, 9 p., 102932.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Metabolic Profiling 100%
  • Metabolic Risk Factors 100%
  • Nutrition Risk 100%
  • Innovative Medicines Initiative 100%
  • Dietary Metabolites 100%
  5 Citations (Scopus)

  99 Downloads (Pure)

• Efficacy of Modern Diabetes Treatments DPP-4i, SGLT-2i, and GLP-1RA in White and Asian Patients With Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials

  Gan, S., Dawed, A. Y., Donnelly, L. A., Nair, A. T. N., Palmer, C. N. A., Mohan, V. & Pearson, E. R. (Lead / Corresponding author), Aug 2020, In: Diabetes Care. 43, 8, p. 1948-1957 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Diabetes Management 100%
  • Patients with Diabetes 100%
  • Systematic Meta-analysis 100%
  • Meta-analysis of Randomized Controlled Trials 100%
  • White Patients 100%
  54 Citations (Scopus)

  140 Downloads (Pure)

• Genetic Risk of Diverticular Disease Predicts Early Stoppage of Nicorandil

  Noyes, J., Mordi, I. R., Doney, A. S., Palmer, C. N. A., Pearson, E. R. & Lang, C. C. (Lead / Corresponding author), Dec 2020, In: Clinical Pharmacology & Therapeutics. 108, 6, p. 1171-1175 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Diverticular Disease 100%
  • Genetic Risk 100%
  • Nicorandil 100%
  • Stoppages 100%
  • Diverticulitis 100%
  5 Citations (Scopus)

  83 Downloads (Pure)

• Metformin increases fasting glucose clearance and endogenous glucose production in non-diabetic individuals

  McCreight, L. J., Mari, A., Coppin, L., Jackson, N., Umpleby, A. M. & Pearson, E. (Lead / Corresponding author), Feb 2020, In: Diabetologia. 63, p. 444-447 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  22 Citations (Scopus)

  127 Downloads (Pure)

• Monogenic diabetes: From genetic insights to population-based precision in care. Reflections from a diabetes care editors’ expert forum

  Riddle, M. C. (Lead / Corresponding author), Philipson, L. H., Rich, S. S., Carlsson, A., Franks, P. W., Greeley, S. A. W., Nolan, J. J., Pearson, E. R., Zeitler, P. S. & Hattersley, A. T., Dec 2020, In: Diabetes Care. 43, 12, p. 3117-3128 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Diabetes Management 100%
  • In Care 100%
  • Population-based 100%
  • Monogenic Diabetes 100%
  • Expert Forums 100%
  74 Citations (Scopus)

• Novel subgroups of type 2 diabetes and their association with microvascular outcomes in an Asian Indian population: a data-driven cluster analysis: the INSPIRED study

  Anjana, R. M., Baskar, V., Nair, A. T. N., Jebarani, S., Siddiqui, M. K., Pradeepa, R., Unnikrishnan, R., Palmer, C., Pearson, E. & Mohan, V. (Lead / Corresponding author), 17 Aug 2020, In: BMJ Open Diabetes Research and Care. 8, 1, 8 p., e001506.

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  138 Citations (Scopus)

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• Obesity, clinical, and genetic predictors for glycemic progression in Chinese patients with type 2 diabetes: A cohort study using the Hong Kong Diabetes Register and Hong Kong Diabetes Biobank

  Jiang, G., Luk, A. O., Tam, C. H. T., Lau, E. S., Ozaki, R., Chow, E. Y. K., Kong, A. P. S., Lim, C. K. P., Lee, K. F., Siu, S. C., Hui, G., Tsang, C. C., Lau, K. P., Leung, J. Y. Y., Tsang, M.-W., Kam, G., Lau, I. T., Li, J. K., Yeung, V. T. & Lau, E. & 10 others, Lo, S., Fung, S. K. S., Cheng, Y. L., Chow, C. C., Pearson, E. R., So, W. Y., Chan, J. C. N., Ma, R. C. W. (Lead / Corresponding author), Hong Kong Diabetes Biobank Study Group & Hong Kong Diabetes Register TRS Study Group, 28 Jul 2020, In: PLoS Medicine. 17, 7, 19 p., e1003209.

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  36 Citations (Scopus)

  101 Downloads (Pure)

• Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

  Chung, W. K., Erion, K., Florez, J. C., Hattersley, A. T., Hivert, M.-F., Lee, C. G., McCarthy, M. I., Nolan, J. J., Norris, J. M., Pearson, E. R., Philipson, L., McElvaine, A. T., Cefalu, W. T., Rich, S. S. & Franks, P. W. (Lead / Corresponding author), 1 Sept 2020, In: Diabetologia. 63, 9, p. 1671-1693 23 p.

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  • American Diabetes Association 100%
  • Consensus Document 100%
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  126 Citations (Scopus)

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• Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

  Chung, W. K., Erion, K., Florez, J. C., Hattersley, A. T., Hivert, M.-F., Lee, C. G., McCarthy, M. I., Nolan, J. J., Norris, J. M., Pearson, E. R., Philipson, L., McElvaine, A. T., Cefalu, W. T., Rich, S. S. & Franks, P. W. (Lead / Corresponding author), Jul 2020, In: Diabetes Care. 43, 7, p. 1617-1635 19 p.

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  • Diabetes 100%
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  • American Diabetes Association 100%
  • Consensus Document 100%
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  236 Citations (Scopus)

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• Response to Comment on Gan et al. Efficacy of Modern Diabetes Treatments DPP-4i, SGLT-2i, and GLP-1RA in White and Asian Patients With Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Diabetes Care 2020;43:1948–1957

  Gan, S., Dawed, A. Y., Donnelly, L. A., Nair, A. T. N., Palmer, C. N. A., Mohan, V. & Pearson, E. R. (Lead / Corresponding author), Dec 2020, In: Diabetes Care. 43, 12, p. e202-e203 2 p.

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  3 Citations (Scopus)

• Risk factors for genital infections in people initiating SGLT2 inhibitors and their impact on discontinuation

  McGovern, A. P. (Lead / Corresponding author), Hogg, M., Shields, B. M., Sattar, N. A., Holman, R. R., Pearson, E. R., Hattersley, A. T., Jones, A. G., Dennis, J. M. & MASTERMIND consortium, 24 May 2020, In: BMJ Open Diabetes Research and Care. 8, 1, 8 p., e001238.

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  • Risk Factors 100%
  • Sodium-glucose Cotransporter 2 Inhibitors (SGLT2i) 100%
  • Genital Infection 100%
  • Genital Tract Infection 100%
  • Sodium Glucose Cotransporter 2 Inhibitor 100%
  60 Citations (Scopus)

  118 Downloads (Pure)

• Risk of anemia with metformin use in type 2 diabetes: A MASTERMIND study

  Donnelly, L. A., Dennis, J. M., Coleman, R. L., Sattar, N., Hattersley, A. T., Holman, R. R. & Pearson, E. R. (Lead / Corresponding author), Oct 2020, In: Diabetes Care. 43, 10, p. 2493-2499 7 p.

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  • Metformin 100%
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  43 Citations (Scopus)

  309 Downloads (Pure)

• TriMaster: Randomised double-blind crossover study of a DPP4 inhibitor, SGLT2 inhibitor and thiazolidinedione as second-line or third-line therapy in patients with type 2 diabetes who have suboptimal glycaemic control on metformin treatment with or without a sulfonylurea - A MASTERMIND study protocol

  Angwin, C., Jenkinson, C., Jones, A., Jennison, C., Henley, W., Farmer, A., Sattar, N., Holman, R. R., Pearson, E., Shields, B. (Lead / Corresponding author) & Hattersley, A., Dec 2020, In: BMJ Open. 10, 12, 10 p., e042784.

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  • Type 2 Diabetic Patients 100%
  • Sulfonylurea 100%
  • Randomized Double-blind Crossover Study 100%
  • Metformin Treatment 100%
  • Suboptimal Glycemic Control 100%
  13 Citations (Scopus)

  105 Downloads (Pure)

• Visit-to-visit HbA_1c variability is associated with cardiovascular disease and microvascular complications in patients with newly diagnosed type 2 diabetes

  Li, S., Nemeth, I., Donnelly, L., Hapca, S., Zhou, K. & Pearson, E. (Lead / Corresponding author), 20 Jan 2020, In: Diabetes Care. 43, 2, p. 426-432 7 p.

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  • Cardiovascular Disease 100%
  • Vascular Complications 100%
  • New-onset Type 2 Diabetes 100%
  • Disease Complications 100%
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  104 Citations (Scopus)

  294 Downloads (Pure)
• 2019

  A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy

  Grubb, A. L., McDonald, T. J., Rutters, F., Donnelly, L., Hattersley, A. T., Oram, R. A., Palmer, C., van der Heijden, A. A., Carr, F., Elders, P. J. M., Weedon, M., Slieker, R. C., 't Hart, L. M., Pearson, E., Shields, B. M. & Jones, A. G. (Lead / Corresponding author), 1 Feb 2019, In: Diabetes Care. 42, 2, p. 208-214 7 p.

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  • Insulin Therapy 100%
  • Type 2 Diabetes Mellitus (T2DM) 100%
  • GAD65 Autoantibodies 100%
  • Type 1 Diabetes Genetic Risk Score 100%
  • Maturity Onset Diabetes of the Young 100%
  37 Citations (Scopus)

  682 Downloads (Pure)

• Development and validation of multivariable clinical diagnostic models to identify type 1 diabetes requiring rapid insulin therapy in adults aged 18-50 years

  Lynam, A., McDonald, T., Hill, A., Dennis, J., Oram, R., Pearson, E., Weedon, M., Hattersley, A., Owen, K., Shields, B. & Jones, A., 26 Sept 2019, In: BMJ Open. 9, 9, 10 p., e031586.

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  • Type I Diabetes 100%
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  • Insulin Therapy 100%
  • Multivariable 100%
  • Clinical Diagnostic Model 100%
  48 Citations (Scopus)

  124 Downloads (Pure)

• Diabetes: Is there a future for Pharmacogenomics guided treatment?

  Pearson, E. (Lead / Corresponding author), 12 Jul 2019, In: Clinical Pharmacology & Therapeutics. 106, 2, p. 329-337 9 p.

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  • Diabetes 100%
  • Pharmacogenomics 100%
  • Guided Therapy 100%
  • Genotyping 100%
  • Genetics 66%
  34 Citations (Scopus)

  207 Downloads (Pure)

• Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium

  Koivula, R. W., Forgie, I. M., Kurbasic, A., Viñuela, A., Heggie, A., Giordano, G. N., Hansen, T. H., Hudson, M., Koopman, A. D. M., Rutters, F., Siloaho, M., Allin, K. H., Brage, S., Brorsson, C. A., Dawed, A. Y., De Masi, F., Groves, C. J., Kokkola, T., Mahajan, A. & Perry, M. H. & 31 others, Rauh, S. P., Ridderstråle, M., Teare, H. J. A., Thomas, E. L., Tura, A., Vestergaard, H., White, T., Adamski, J., Bell, J. D., Beulens, J. W., Brunak, S., Dermitzakis, E. T., Froguel, P., Frost, G., Gupta, R., Hansen, T., Hattersley, A., Jablonka, B., Kaye, J., Laakso, M., McDonald, T. J., Pedersen, O., Schwenk, J. M., Pavo, I., Mari, A., McCarthy, M. I., Ruetten, H., Walker, M., Pearson, E. (Lead / Corresponding author), Franks, P. W. (Lead / Corresponding author) & for the IMI DIRECT Consortium, 1 Sept 2019, In: Diabetologia. 62, 9, p. 1601-1615 15 p.

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  • Type 2 Diabetes Mellitus (T2DM) 100%
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  • Innovative Medicines Initiative 100%
  • Descriptive Characteristics 100%
  23 Citations (Scopus)

  102 Downloads (Pure)

• Time trends in prescribing of type 2 diabetes drugs, glycaemic response and risk factors: a retrospective analysis of primary care data, 2010-2017

  Dennis, J. M., Henley, W. E., McGovern, A. P., Farmer, A. J., Sattar, N., Holman, R. R., Pearson, E. R., Hattersley, A. T., Shields, B. M. (Lead / Corresponding author), Jones, A. G. (Lead / Corresponding author) & MASTERMIND consortium, Jul 2019, In: Diabetes, Obesity & Metabolism. 21, 7, p. 1576-1584 9 p.

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  • Risk Factors 100%
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  • Glycemic Response 100%
  • Retrospective Analysis 100%
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  67 Citations (Scopus)

  266 Downloads (Pure)

• Variation in the plasma membrane monoamine transporter (PMAT) (encoded by SLC29A4) and organic cation transporter 1 (OCT1) (encoded by SLC22A1) and gastrointestinal intolerance to metformin in type 2 diabetes: An IMI direct study

  Dawed, A., Zhou, K., van Leeuwen, N., Mahajan, A., Robertson, N. R., Koivula, R. W., Elders, P. J. M., Rauh, S. P., Jones, A. G., Holl, R. W. .., Stingl, J. C., Franks, P. W., McCarthy, M. I., 't Hart, L. M., Pearson, E. R. (Lead / Corresponding author) & IMI DIRECT Consortium, Jun 2019, In: Diabetes Care. 42, 6, p. 1027-1033 7 p.

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  • Metformin 100%
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  • Gastrointestinal Tolerance 100%
  52 Citations (Scopus)

  269 Downloads (Pure)

• What to do with diabetes therapies when HbA1c lowering is inadequate: add, switch, or continue? A MASTERMIND study

  MASTERMIND consortium, McGovern, A. P. (Lead / Corresponding author), Dennis, J. M., Shields, B. M., Hattersley, A. T., Pearson, E. R. & Jones, A. G., 12 Apr 2019, In: BMC Medicine. 17, 1, p. 1-17 17 p., 79.

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  • Hemoglobin A1c (HbA1c) 100%
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  • Diabetes 100%
  • Hemoglobin A1c 100%
  • Drug Therapy 30%
  21 Citations (Scopus)

  184 Downloads (Pure)
• 2018

  A UK nationwide prospective study of treatment change in MODY: genetic subtype and clinical characteristics predict optimal glycaemic control after discontinuing insulin and metformin

  UNITED study, Shepherd, M. H. (Lead / Corresponding author), Shields, B. M., Hudson, M., Pearson, E. R., Hyde, C., Ellard, S., Hattersley, A. T. & Patel, K. A., Dec 2018, In: Diabetologia. 61, 12, p. 2520-2527 8 p.

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  • Genetic Diagnosis 100%
  • Insulin 100%
  • Metformin 100%
  • Clinical Characteristics 100%
  • Glycemic Control 100%
  75 Citations (Scopus)

  132 Downloads (Pure)

• Characteristics of people with high visit-to-visit glycaemic variability in Type 2 diabetes

  Noyes, J. D., Soto-Pedre, E., Donnelly, L. A. & Pearson, E. (Lead / Corresponding author), 14 Jan 2018, In: Diabetic Medicine. 35, 2, p. 262-267 6 p.

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  • Diabetes 100%
  • Glycemic 100%
  28 Citations (Scopus)

  194 Downloads (Pure)

• Cohort Profile: Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS)

  Hébert, H. L. (Lead / Corresponding author), Shepherd, B., Milburn, K., Veluchamy, A., Meng, W., Carr, F., Donnelly, L. A., Tavendale, R., Leese, G., Colhoun, H. M., Dow, E., Morris, A. D., Doney, A. S., Lang, C. C., Pearson, E. R., Smith, B. H. & Palmer, C. N. A., 1 Apr 2018, In: International Journal of Epidemiology. 47, 2, p. 380-381j 12 p.

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  58 Citations (Scopus)

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• C-peptide decline in type 1 diabetes has two phases: An initial exponential fall and a subsequent stable phase

  Shields, B. M., McDonald, T. J., Oram, R., Hill, A., Hudson, M., Leete, P., Pearson, E. R., Richardson, S. J., Morgan, N. G. & Hattersley, A. T. (Lead / Corresponding author), 1 Jul 2018, In: Diabetes Care. 41, 7, p. 1486-1492 7 p.

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  • Type I Diabetes 100%
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  82 Citations (Scopus)

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• Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study

  Neonatal Diabetes International Collaborative Group, Bowman, P., Sulen, Å., Barbetti, F., Beltrand, J., Svalastoga, P., Codner, E., Tessmann, E. H., Juliusson, P. B., Skrivarhaug, T., Pearson, E. R., Flanagan, S. E., Babiker, T., Thomas, N. J., Shepherd, M. H., Ellard, S., Klimes, I., Szopa, M., Polak, M. & Iafusco, D. & 2 others, Hattersley, A. T. (Lead / Corresponding author) & Njølstad, P. R., 1 Aug 2018, In: The Lancet Diabetes and Endocrinology. 6, 8, p. 637-646 10 p.

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  • KCNJ11 Gene 100%
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  136 Citations (Scopus)

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