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Structure-Guided Drug Discovery for Malaria and Tuberculosis (joint with Structural Genomics Consortium)
Gilbert, Ian
(Investigator)
Gray, David
(Investigator)
Read, Kevin
(Investigator)
Wyatt, Paul
(Investigator)
Drug Discovery Unit
Overview
Fingerprint
Research Outputs
(3)
Research output
Research output per year
2022
2022
2023
2024
2024
3
Article
Research output per year
Research output per year
3 results
Publication Year, Title
(descending)
Publication Year, Title
(ascending)
Title
Type
Filter
Article
Search results
2024
ResMAP – a saturation mutagenesis platform enabling parallel profiling of target-specific resistance conferring mutations in
Plasmodium
Wall, R.
(Lead / Corresponding author),
MacGowan, S.
, Hallyburton, I.,
Syed, A.
,
Ajay Castro, S.
,
Dey, G.
,
Milne, R.
,
Patterson, S.
, Phelan, J., Wiedemar, N. W. &
Wyllie, S.
(Lead / Corresponding author),
27 Aug 2024
, (E-pub ahead of print)
In:
MBio.
e01708-24.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Resistance mutations
100%
Plasmodium
100%
Specific Resistance
100%
Saturation mutagenesis
100%
Parallel Profiling
100%
11
Downloads (Pure)
2023
Chemical pulldown combined with mass spectrometry to identify the molecular targets of antimalarials in cell-free lysates
Smith, R. J.
,
Milne, R.
,
Lopez, V. C.
, Wiedemar, N.,
Dey, G.
,
Syed, A. J.
,
Patterson, S.
(Lead / Corresponding author) &
Wyllie, S.
(Lead / Corresponding author),
17 Mar 2023
,
In:
STAR Protocols.
4
,
1
,
30 p.
, 102002.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Mass Spectrometry
100%
Molecular Targets
100%
Pullout
100%
Cell-free Lysate
100%
Cell Lysate
100%
1
Citation (Scopus)
121
Downloads (Pure)
2022
Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase
Milne, R.
, Wiedemar, N.,
Corpas Lopez, V.
, Moynihan, E.,
Wall, R. J.
,
Dawson, A.
, Robinson, D. A., Shepherd, S. M.,
Smith, R. J.
, Hallyburton, I., Post, J. M., Dowers, K.,
Torrie, L. S.
,
Gilbert, I. H.
,
Baragaña, B.
,
Patterson, S.
&
Wyllie, S.
(Lead / Corresponding author),
9 Sept 2022
,
In:
ACS Infectious Diseases.
8
,
9
,
p. 1962-1974
13 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Drug Discovery
100%
Plasmodium Falciparum
100%
Target Engagement
100%
LysR Family
100%
Thermal Proteome Profiling
100%
11
Citations (Scopus)
190
Downloads (Pure)