Targeting the Aspartic Protease BACE1 for Inhibition in Order to Increase Hypothalamic Leptin Sensitivity and Reverse Obesity

Project Details

StatusFinished
Effective start/end date1/01/13 → 31/12/15

Funding

  • Medical Research Council (MR/K003291/1): £413,705.00
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Research Output

Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction

Meakin, P. J., Coull, B. M., Tuharska, Z., McCaffery, C., Akoumianakis, I., Antoniades, C., Brown, J., Griffin, K. J., Platt, F., Ozber, C. H., Yuldasheva, N. Y., Makava, N., Skromna, A., Prescott, A. R., McNeilly, A. D., Siddiqui, M. K., Palmer, C. N. A., Khan, F. & Ashford, M. L. J., 14 May 2020, In : Journal of Clinical Investigation.

Research output: Contribution to journal › Article

Open Access
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    • 19 Downloads (Pure)

    Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice

    Meakin, P. J., Jalicy, S. M., Montagut, G., Allsop, D. J. P., Cavellini, D. L., Irvine, S. W., McGinley, C., Liddell, M. K., McNeilly, A. D., Parmionova, K., Liu, Y-R., Bailey, C. S. L., Dale, J. K., Heisler, L. K., McCrimmon, R. J. & Ashford, M. L. J., 8 Jan 2018, In : Scientific Reports. 8, 1, p. 55 16 p., 55.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 8 Citations (Scopus)
    176 Downloads (Pure)

    High intensity exercise as a dishabituating stimulus restores counterregulatory responses in recurrently hypoglycemic rodents

    McNeilly, A. D., Gallagher, J. R., Huang, J. T-J., Ashford, M. L. J. & McCrimmon, R. J., 1 Jun 2017, In : Diabetes. 66, 6, p. 1696-1702 7 p.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 8 Citations (Scopus)
    266 Downloads (Pure)