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Targeting the Aspartic Protease BACE1 for Inhibition in Order to Increase Hypothalamic Leptin Sensitivity and Reverse Obesity
Ashford, Michael
(Investigator)
Systems Medicine
Overview
Research Outputs
(12)
Project Details
Status
Finished
Effective start/end date
1/01/13
→
31/12/15
Funding
Medical Research Council
(MR/K003291/1):
£413,705.00
View all
View less
Research Output
Research Output per year
2014
2020
12
Article
Research Output per year
Research Output per year
Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction
Meakin, P. J.
, Coull, B. M., Tuharska, Z., McCaffery, C., Akoumianakis, I., Antoniades, C., Brown, J., Griffin, K. J., Platt, F., Ozber, C. H., Yuldasheva, N. Y., Makava, N., Skromna, A.,
Prescott, A. R.
,
McNeilly, A. D.
,
Siddiqui, M. K.
,
Palmer, C. N. A.
,
Khan, F.
&
Ashford, M. L. J.
,
3 Aug 2020
,
In:
Journal of Clinical Investigation.
130
,
8
,
p. 4104-4117
14 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Amyloid
Obesity
Diet
Blood Vessels
Cyclic GMP-Dependent Protein Kinases
1
Citation (Scopus)
52
Downloads (Pure)
Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice
Meakin, P. J., Jalicy, S. M., Montagut, G., Allsop, D. J. P., Cavellini, D. L., Irvine, S. W., McGinley, C., Liddell, M. K.,
McNeilly, A. D.
, Parmionova, K., Liu, Y-R., Bailey, C. S. L.,
Dale, J. K.
, Heisler, L. K.,
McCrimmon, R. J.
&
Ashford, M. L. J.
,
8 Jan 2018
,
In:
Scientific Reports.
8
,
1
,
p. 55
16 p.
, 55.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Obese Mice
Leptin
Amyloid
Obesity
Homeostasis
13
Citations (Scopus)
198
Downloads (Pure)
Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)
Sharma, R. S.
, Harrison, D. J.,
Kisielewski, D.
, Cassidy, D. M.,
McNeilly, A. D.
,
Gallagher, J. R.
, Walsh, S. V., Honda, T.,
McCrimmon, R. J.
,
Dinkova-Kostova, A. T.
,
Ashford, M. L. J.
,
Dillon, J. F.
&
Hayes, J. D.
,
1 Mar 2018
,
In:
CMGH: Cellular and Molecular Gastroenterology and Hepatology.
5
,
3
,
p. 367-398
32 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
TBE 31
NF-E2-Related Factor 2
Fructose
Non-alcoholic Fatty Liver Disease
Liver Cirrhosis
62
Citations (Scopus)
168
Downloads (Pure)