Targeting the Aspartic Protease BACE1 for Inhibition in Order to Increase Hypothalamic Leptin Sensitivity and Reverse Obesity

Project Details

StatusFinished
Effective start/end date1/01/1331/12/15

Funding

  • Medical Research Council (MR/K003291/1): £413,705.00

Research Output

Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction

Meakin, P. J., Coull, B. M., Tuharska, Z., McCaffery, C., Akoumianakis, I., Antoniades, C., Brown, J., Griffin, K. J., Platt, F., Ozber, C. H., Yuldasheva, N. Y., Makava, N., Skromna, A., Prescott, A. R., McNeilly, A. D., Siddiqui, M. K., Palmer, C. N. A., Khan, F. & Ashford, M. L. J., 14 May 2020, In : Journal of Clinical Investigation.

Research output: Contribution to journalArticle

Open Access
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    Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice

    Meakin, P. J., Jalicy, S. M., Montagut, G., Allsop, D. J. P., Cavellini, D. L., Irvine, S. W., McGinley, C., Liddell, M. K., McNeilly, A. D., Parmionova, K., Liu, Y-R., Bailey, C. S. L., Dale, J. K., Heisler, L. K., McCrimmon, R. J. & Ashford, M. L. J., 8 Jan 2018, In : Scientific Reports. 8, 1, p. 55 16 p., 55.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 8 Citations (Scopus)
    176 Downloads (Pure)
    Open Access
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  • 8 Citations (Scopus)
    266 Downloads (Pure)