Targeting the Aspartic Protease BACE1 for Inhibition in Order to Increase Hypothalamic Leptin Sensitivity and Reverse Obesity

Ashford, Michael (Investigator)

Diabetes Endocrinology and Reproductive Biology

12 Article

12 results

2020
Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction
Meakin, P. J. (Lead / Corresponding author), Coull, B. M., Tuharska, Z., McCaffery, C., Akoumianakis, I., Antoniades, C., Brown, J., Griffin, K. J., Platt, F., Ozber, C. H., Yuldasheva, N. Y., Makava, N., Skromna, A., Prescott, A. R., McNeilly, A. D., Siddiqui, M. K., Palmer, C. N. A., Khan, F. & Ashford, M. L. J. (Lead / Corresponding author), 3 Aug 2020, In: Journal of Clinical Investigation. 130, 8, p. 4104-4117 14 p.
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2018
Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice
Meakin, P. J., Jalicy, S. M., Montagut , G., Allsop, D. J. P., Cavellini, D. L., Irvine, S. W., McGinley, C., Liddell, M. K., McNeilly, A. D., Parmionova, K., Liu, Y.-R., Bailey, C. S. L., Dale, J. K., Heisler, L. K., McCrimmon, R. J. & Ashford, M. L. J., 8 Jan 2018, In: Scientific Reports. 8, 1, p. 55 16 p., 55.
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Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)
Sharma, R. S., Harrison, D. J., Kisielewski, D., Cassidy, D. M., McNeilly, A. D., Gallagher, J. R., Walsh, S. V., Honda, T., McCrimmon, R. J., Dinkova-Kostova, A. T., Ashford, M. L. J., Dillon, J. F. & Hayes, J. D. (Lead / Corresponding author), 1 Mar 2018, In: Cellular and Molecular Gastroenterology and Hepatology. 5, 3, p. 367-398 32 p.
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The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling
Botteri, G., Salvadó, L., Gumà, A., Hamilton, D. L., Meakin, P. J., Montagut , G., Ashford, M. L. J., Ceperuelo-Mallafré, V., Fernández-Veledo, S., Vendrell, J., Calderón-Dominguez, M., Serra, D., Herrero, L., Pizarro, J., Barroso, E., Palomer, X. & Vázquez-Carrera, M. (Lead / Corresponding author), Aug 2018, In: Metabolism. 85, p. 59-75 17 p.
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The beta secretase BACE1 regulates the expression of the insulin receptor in the liver
Meakin, P., Mezzapesa, A., Benabou, E., Haas, M., Bonardo, B., Grino, M., Brunel, J.-M., Biddinger, S. B., Desbois-Mouthon, C., Govers, R., Ashford, M. L. J. & Peiretti, F. (Lead / Corresponding author), 3 Apr 2018, In: Nature Communications. 9, p. 1-14 14 p., 1306.
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2017
High intensity exercise as a dishabituating stimulus restores counterregulatory responses in recurrently hypoglycemic rodents
McNeilly, A. D., Gallagher, J. R., Huang, J.T.-J., Ashford, M. L. J. & McCrimmon, R. J. (Lead / Corresponding author), 1 Jun 2017, In: Diabetes. 66, 6, p. 1696-1702 7 p.
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2016
Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation
McGuire, V. A., Ruiz-Zorrilla Diez, T., Emmerich, C. H., Strickson, S., Ritorto, M. S., Sutavani, R. V., Weiβ, A., Houslay, K. F., Knebel, A., Meakin, P. J., Phair, I. R., Ashford, M. L. J., Trost, M. & Arthur, J. S. C. (Lead / Corresponding author), 8 Aug 2016, In: Scientific Reports. 6, p. 1-17 17 p., 31159.
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2015
BACE1 activity as a determining factor in atherosclerosis development?
Meakin, P., Hamilton, A., Jalicy, S., Khan, F. & Ashford, M., Jul 2015, In: Atherosclerosis. 241, 1, p. e13 1 p., EAS-0263.
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Mice lacking beta2-integrin function remain glucose tolerant in spite of insulin resistance, neutrophil infiltration and inflammation
Meakin, P. J., Morrison, V. L., Sneddon, C. C., Savinko, T., Uotila, L., Jalicy, S. M., Gabriel, J. L., Kang, L., Ashford, M. L. J. (Lead / Corresponding author) & Fagerholm, S. C., 25 Sept 2015, In: PLoS ONE. 10, 9, 15 p., e0138872.
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2014
Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes
Hamilton, D. L., Findlay, J. A., Montagut , G., Meakin, P. J., Bestow, D., Jalicy, S. M. & Ashford, M. L. J. (Lead / Corresponding author), Aug 2014, In: Diabetologia. 57, 8, p. 1684-1692 9 p.
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AMPK: regulating energy balance at the cellular and whole body levels
Hardie, D. G. & Ashford, M. L. J., Mar 2014, In: Physiology. 29, 2, p. 99-107 9 p.
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Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes, but not with insulin resistance
Meakin, P. J., Chowdhry, S., Sharma, R. S., Ashford, F. B., Walsh, S. V., McCrimmon, R. J., Dinkova-Kostova, A. T., Dillon, J. F., Hayes, J. D. (Lead / Corresponding author) & Ashford, M. L. J. (Lead / Corresponding author), Sept 2014, In: Molecular and Cellular Biology. 34, 17, p. 3305-3320 16 p.
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Targeting the Aspartic Protease BACE1 for Inhibition in Order to Increase Hypothalamic Leptin Sensitivity and Reverse Obesity

Research output

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2020

2018

2017

2016

2015

2014