Research output per year
Research output per year
Research output
- 12 Article
- 12 results
Search results
-
2020
Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction
Meakin, P. J. (Lead / Corresponding author), Coull, B. M., Tuharska, Z., McCaffery, C., Akoumianakis, I., Antoniades, C., Brown, J., Griffin, K. J., Platt, F., Ozber, C. H., Yuldasheva, N. Y., Makava, N., Skromna, A., Prescott, A. R., McNeilly, A. D., Siddiqui, M. K., Palmer, C. N. A., Khan, F. & Ashford, M. L. J. (Lead / Corresponding author), 3 Aug 2020, In: Journal of Clinical Investigation. 130, 8, p. 4104-4117 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile37 Citations (Scopus)147 Downloads (Pure) -
2018
Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice
Meakin, P. J., Jalicy, S. M., Montagut , G., Allsop, D. J. P., Cavellini, D. L., Irvine, S. W., McGinley, C., Liddell, M. K., McNeilly, A. D., Parmionova, K., Liu, Y.-R., Bailey, C. S. L., Dale, J. K., Heisler, L. K., McCrimmon, R. J. & Ashford, M. L. J., 8 Jan 2018, In: Scientific Reports. 8, 1, p. 55 16 p., 55.Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Citations (Scopus)261 Downloads (Pure) -
Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)
Sharma, R. S., Harrison, D. J., Kisielewski, D., Cassidy, D. M., McNeilly, A. D., Gallagher, J. R., Walsh, S. V., Honda, T., McCrimmon, R. J., Dinkova-Kostova, A. T., Ashford, M. L. J., Dillon, J. F. & Hayes, J. D. (Lead / Corresponding author), 1 Mar 2018, In: Cellular and Molecular Gastroenterology and Hepatology. 5, 3, p. 367-398 32 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile184 Citations (Scopus)324 Downloads (Pure) -
The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling
Botteri, G., Salvadó, L., Gumà, A., Hamilton, D. L., Meakin, P. J., Montagut , G., Ashford, M. L. J., Ceperuelo-Mallafré, V., Fernández-Veledo, S., Vendrell, J., Calderón-Dominguez, M., Serra, D., Herrero, L., Pizarro, J., Barroso, E., Palomer, X. & Vázquez-Carrera, M. (Lead / Corresponding author), Aug 2018, In: Metabolism. 85, p. 59-75 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)172 Downloads (Pure) -
The beta secretase BACE1 regulates the expression of the insulin receptor in the liver
Meakin, P., Mezzapesa, A., Benabou, E., Haas, M., Bonardo, B., Grino, M., Brunel, J.-M., Biddinger, S. B., Desbois-Mouthon, C., Govers, R., Ashford, M. L. J. & Peiretti, F. (Lead / Corresponding author), 3 Apr 2018, In: Nature Communications. 9, p. 1-14 14 p., 1306.Research output: Contribution to journal › Article › peer-review
Open AccessFile60 Citations (Scopus)214 Downloads (Pure) -
2017
High intensity exercise as a dishabituating stimulus restores counterregulatory responses in recurrently hypoglycemic rodents
McNeilly, A. D., Gallagher, J. R., Huang, J.T.-J., Ashford, M. L. J. & McCrimmon, R. J. (Lead / Corresponding author), 1 Jun 2017, In: Diabetes. 66, 6, p. 1696-1702 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (Scopus)403 Downloads (Pure) -
2016
Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation
McGuire, V. A., Ruiz-Zorrilla Diez, T., Emmerich, C. H., Strickson, S., Ritorto, M. S., Sutavani, R. V., Weiβ, A., Houslay, K. F., Knebel, A., Meakin, P. J., Phair, I. R., Ashford, M. L. J., Trost, M. & Arthur, J. S. C. (Lead / Corresponding author), 8 Aug 2016, In: Scientific Reports. 6, p. 1-17 17 p., 31159.Research output: Contribution to journal › Article › peer-review
Open AccessFile88 Citations (Scopus)467 Downloads (Pure) -
2015
BACE1 activity as a determining factor in atherosclerosis development?
Meakin, P., Hamilton, A., Jalicy, S., Khan, F. & Ashford, M., Jul 2015, In: Atherosclerosis. 241, 1, p. e13 1 p., EAS-0263.Research output: Contribution to journal › Article › peer-review
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Mice lacking beta2-integrin function remain glucose tolerant in spite of insulin resistance, neutrophil infiltration and inflammation
Meakin, P. J., Morrison, V. L., Sneddon, C. C., Savinko, T., Uotila, L., Jalicy, S. M., Gabriel, J. L., Kang, L., Ashford, M. L. J. (Lead / Corresponding author) & Fagerholm, S. C., 25 Sept 2015, In: PLoS ONE. 10, 9, 15 p., e0138872.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)193 Downloads (Pure) -
2014
Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes
Hamilton, D. L., Findlay, J. A., Montagut , G., Meakin, P. J., Bestow, D., Jalicy, S. M. & Ashford, M. L. J. (Lead / Corresponding author), Aug 2014, In: Diabetologia. 57, 8, p. 1684-1692 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)187 Downloads (Pure) -
AMPK: regulating energy balance at the cellular and whole body levels
Hardie, D. G. & Ashford, M. L. J., Mar 2014, In: Physiology. 29, 2, p. 99-107 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile232 Citations (Scopus)267 Downloads (Pure) -
Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes, but not with insulin resistance
Meakin, P. J., Chowdhry, S., Sharma, R. S., Ashford, F. B., Walsh, S. V., McCrimmon, R. J., Dinkova-Kostova, A. T., Dillon, J. F., Hayes, J. D. (Lead / Corresponding author) & Ashford, M. L. J. (Lead / Corresponding author), Sept 2014, In: Molecular and Cellular Biology. 34, 17, p. 3305-3320 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile196 Citations (Scopus)475 Downloads (Pure)