The Contribution of Phytophthora Effectors to Host Range and Non-Host Resistance (Joint with James Hutton Institute and University of Warwick and Industrial Partners)

Research output

Research output per year 2014 2014 2015 2016 2017 2018 2019 2022

• 26 Article
• 2 Chapter (peer-reviewed)

Research output per year

Research output per year

Search results

• 2022

  Exploiting breakdown in nonhost effector-target interactions to boost host disease resistance

  McLellan, H., Harvey, S. E., Steinbrenner, J., Armstrong, M. R., He, Q., Clewes, R., Pritchard, L., Wang, W., Wang, S., Nussbaumer, T., Dohai, B., Luo, Q., Kumari, P., Duan, H., Roberts, A., Boevink, P. C., Neumann, C., Champouret, N., Hein, I., Falter-Braun, P., & 3 othersBeynon, J., Denby, K. & Birch, P. R. J., 30 Aug 2022, In: Proceedings of the National Academy of Sciences. 119, 35, 12 p., e2114064119.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phytophthora infestans 100%
  • Disease Resistance 92%
  • Solanum tuberosum 45%
  • Arabidopsis 45%
  • leucylarginine 17%
  10 Citations (Scopus)

  17 Downloads (Pure)
• 2021

  Evolutionarily distinct Resistance proteins detect a pathogen effector through its association with different host targets

  Wang, H., Trusch, F., Turnbull, D., Aguilera-Galvez, C., Breen, S., Naqvi, S., Jones, J. D. G., Hein, I., Tian, Z., Vleeshouwers, V., Gilroy, E. & Birch, P. R. J., Nov 2021, In: New Phytologist. 232, 3, p. 1368-1381 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phosphoric Monoester Hydrolases 100%
  • disease resistance 93%
  • okadaic acid 66%
  • pathogens 58%
  • mutants 57%
  3 Citations (Scopus)

  65 Downloads (Pure)

• Yeast Two-Hybrid Screening for Identification of Protein-Protein Interactions in Solanum tuberosum

  McLellan, H., Armstrong, M. R. & Birch, P. R. J., 2021, Solanum tuberosum: Methods and Protocols. Dobnik, D., Gruden, K., Ramšak, Ž. & Coll, A. (eds.). 1 ed. New York: Humana Press, p. 95-110 16 p. (Methods in Molecular Biology; vol. 2354).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

  • Solanum tuberosum 100%
  • Yeasts 60%
  • Proteins 27%
  • Phytophthora infestans 20%
  • Reporter Genes 10%
  3 Citations (Scopus)
• 2020

  All roads lead to susceptibility: the many modes-of-action of fungal and oomycete intracellular effectors

  He, Q., McLellan, H., Boevink, P. C. & Birch, P. R. J., 13 Jul 2020, In: Plant Communications. 1, 4, 12 p., 100050.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Oomycetes 100%
  • Effector 64%
  • roads 57%
  • mechanism of action 50%
  • Protein 24%
  63 Citations (Scopus)

  93 Downloads (Pure)
• 2019

  AVR2 targets BSL family members, which act as susceptibility factors to suppress host immunity

  Turnbull, D., Wang, H., Breen, S., Malec, M., Naqvi, S., Yang, L., Welsh, L., Hemsley, P. A., Zhendong, T., Brunner, F., Gilroy, E. M. & Birch, P. R. J., 1 May 2019, In: Plant Physiology. 180, 1, p. 571-581 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phytophthora infestans 100%
  • immunity 45%
  • Immunity 42%
  • Solanum tuberosum 41%
  • Brassinosteroids 37%
  21 Citations (Scopus)

  135 Downloads (Pure)

• Effector PiAVR2 targets BSL family members which act as susceptibility factors to suppress immunity

  Turnbull, D., Wang, H., Breen, S., Malec, M., Naqvi, S., Yang, L., Welsh, L., Hemsley, P., Tian, Z., Brunner, F., Gilroy, E. M. & Birch, P., 1 May 2019, In: Plant Physiology. 180, 1, p. 571-581 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phytophthora infestans 100%
  • Brassinosteroids 47%
  • immunity 45%
  • Immunity 42%
  • Solanum tuberosum 34%
  33 Downloads (Pure)

• Phytophthora infestans effector SFI3 targets potato UBK to suppress early immune transcriptional responses

  He, Q., McLellan, H., Hughes, R. K., Boevink, P. C., Armstrong, M., Lu, Y., Banfield, M. J., Tian, Z. & Birch, P. R. J., Apr 2019, In: New Phytologist. 222, 1, p. 438-454 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phytophthora infestans 100%
  • Solanum tuberosum 68%
  • immunity 45%
  • Immunity 42%
  • potatoes 39%
  25 Citations (Scopus)

  215 Downloads (Pure)

• Phytophthora infestans RXLR effectors act in concert at diverse subcellular locations to enhance host colonization

  Wang, S., McLellan, H., Bukharova, T., He, Q., Murphy, F., Shi, J., Sun, S., van Weymers, P., Ren, Y., Thilliez, G., Wang, H., Chen, X., Engelhardt, S., Vleeshouwers, V., Gilroy, E. M., Whisson, S. C., Hein, I., Wang, X., Tian, Z., Birch, P. R. J., & 1 othersBoevink, P. C., 1 Jan 2019, In: Journal of Experimental Botany. 70, 1, p. 343-356 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phytophthora infestans 100%
  • fluorescent proteins 32%
  • Nicotiana benthamiana 19%
  • Tobacco 16%
  • pathogens 15%
  55 Citations (Scopus)

  170 Downloads (Pure)

• Phytophthora infestans RXLR effectors target parallel steps in an immune signal transduction pathway

  Ren, Y., Armstrong, M., Qi, Y., McLellan, H., Zhong, C., Du, B., Birch, P. R. J. & Tian, Z., Aug 2019, In: Plant Physiology. 180, 4, p. 2227-2239 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phytophthora infestans 100%
  • mitogen-activated protein kinase kinase kinase 64%
  • cell death 48%
  • signal transduction 45%
  • Signal Transduction 40%
  31 Citations (Scopus)

  161 Downloads (Pure)
• 2018

  Phytophthora infestans RXLR effector SFI5 requires association with calmodulin for PTI/MTI suppressing activity

  Zheng, X., Wagener, N., McLellan, H., Boevink, P. C., Hua, C., Birch, P. R. J. & Brunner, F., 1 Sept 2018, In: New Phytologist. 219, 4, p. 1433-1446 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phytophthora infestans 100%
  • Calmodulin 57%
  • calmodulin 55%
  • immunity 45%
  • Immunity 42%
  30 Citations (Scopus)

  209 Downloads (Pure)

• Plant pathogen effector utilizes host susceptibility factor NRL1 to degrade the immune regulator SWAP70

  He, Q., Naqvi, S., McLellan, H., Boevink, P., Champouret, N., Hein, I. & Birch, P., 14 Aug 2018, In: Proceedings of the National Academy of Sciences. 115, 33, p. E7834-E7843 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phytophthora infestans 100%
  • Immunity 52%
  • Cell Death 29%
  • Proteasome Endopeptidase Complex 27%
  • BTB-POZ Domain 20%
  48 Citations (Scopus)

  176 Downloads (Pure)

• The Potato MAP3K StVIK Is Required for the Phytophthora infestans RXLR Effector Pi17316 to Promote Disease

  Murphy, F., He, Q., Armstrong, M., Giuliani, L. M., Boevink, P. C., Zhang, W., Tian, Z., Birch, P. R. J. & Gilroy, E. M., May 2018, In: Plant Physiology. 177, 1, p. 398-410 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phytophthora infestans 100%
  • mitogen-activated protein kinase kinase kinase 76%
  • Solanum tuberosum 68%
  • phosphotransferases (kinases) 44%
  • Phosphotransferases 40%
  48 Citations (Scopus)

  168 Downloads (Pure)
• 2017

  A new proteinaceous pathogen-associated molecular pattern (PAMP) identified in Ascomycete fungi induces cell death in Solanaceae

  Franco-Orozco, B., Berepiki, A., Ruiz, O., Gamble, L., Griffe, L. L., Wang, S., Birch, P. R. J., Kanyuka, K. & Avrova, A., Jun 2017, In: New Phytologist. 214, 4, p. 1657-1672 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Solanaceae 100%
  • Ascomycota 91%
  • pathogen-associated molecular patterns 82%
  • Pathogen-Associated Molecular Pattern Molecules 82%
  • Nicotiana benthamiana 57%
  36 Citations (Scopus)

• BTB-BACK Domain Protein POB1 Suppresses Immune Cell Death by Targeting Ubiquitin E3 ligase PUB17 for Degradation

  Orosa, B., He, Q., Mesmar, J., Gilroy, E. M., McLellan, H., Yang, C., Craig, A., Bailey, M., Zhang, C., Moore, J. D., Boevink, P. C., Tian, Z., Birch, P. R. J. & Sadanandom, A., 5 Jan 2017, In: PLoS Genetics. 13, 1, p. 1-26 26 p., e1006540.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • BTB-POZ Domain 100%
  • ubiquitin-protein ligase 78%
  • Ubiquitin-Protein Ligases 70%
  • programmed cell death 69%
  • hypersensitive response 69%
  28 Citations (Scopus)

  236 Downloads (Pure)

• Delivery of cytoplasmic and apoplastic effectors from Phytophthora infestans haustoria by distinct secretion pathways

  Wang, S., Boevink, P. C., Welsh, L., Zhang, R., Whisson, S. C. & Birch, P. J. R., 29 Aug 2017, In: New Phytologist. 29, 8, p. 205-215 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phytophthora infestans 100%
  • Plant Cells 70%
  • haustoria 67%
  • Secretory Pathway 60%
  • secretion 36%
  98 Citations (Scopus)

  323 Downloads (Pure)

• RXLR Effector AVR₂ Up-Regulates a Brassinosteroid-Responsive bHLH Transcription Factor to Suppress Immunity

  Turnbull, D., Yang, L., Naqvi, S., Breen, S., Welsh, L., Stephens, J., Morris, J., Boevink, P. C., Hedley, P. E., Zhan, J., Birch, P. R. J. & Gilroy, E. M., May 2017, In: Plant Physiology. 174, 1, p. 356-369 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Brassinosteroids 100%
  • Basic Helix-Loop-Helix Transcription Factors 75%
  • Phytophthora infestans 70%
  • brassinosteroids 65%
  • Solanum tuberosum 60%
  56 Citations (Scopus)

  329 Downloads (Pure)
• 2016

  A Phytophthora infestans RXLR effector targets plant PP1c isoforms that promote late blight disease

  Boevink, P. C., Wang, X., McLellan, H., He, Q., Naqvi, S., Armstrong, M. R., Zhang, W., Hein, I., Gilroy, E. M., Tian, Z. & Birch, P. R. J., 29 Jan 2016, In: Nature Communications. 7, 10311.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • blight 100%
  • Phytophthora infestans 96%
  • effectors 76%
  • phosphatases 73%
  • Plant Proteins 72%
  100 Citations (Scopus)

  359 Downloads (Pure)

• Oomycetes seek help from the plant : phytophthora infestans effectors target host susceptibility factors

  Boevink, P. C., McLellan, H., Gilroy, E. M., Naqvi, S., He, Q., Yang, L., Wang, X., Turnbull, D., Armstrong, M. R., Tian, Z. & Birch, P. R. J., 2 May 2016, In: Molecular Plant. 9, 5, p. 636-638 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  33 Citations (Scopus)

  217 Downloads (Pure)

• Potato NPH3/RPT2-like protein StNRL1, targeted by a Phytophthora infestans RXLR effector, is a susceptibility factor

  Yang, L., McLellan, H., Naqvi, S., He, Q., Boevink, P. C., Armstrong, M., Giuliani, L. M., Zhang, W., Tian, Z., Zhan, J., Gilroy, E. M. & Birch, P. R. J., May 2016, In: Plant Physiology. 171, 1, p. 645-657 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phytophthora infestans 100%
  • Solanum tuberosum 68%
  • cell death 48%
  • potatoes 39%
  • Cell Death 39%
  64 Citations (Scopus)

  183 Downloads (Pure)

• The cell biology of late blight disease

  Whisson, S. C., Boevink, P. C., Wang, S. & Birch, P. R. J., Dec 2016, In: Current Opinion in Microbiology. 34, p. 127-135 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phytophthora infestans 100%
  • Cell Biology 90%
  • Oomycetes 88%
  • Plant Proteins 75%
  • Lycopersicon esculentum 71%
  94 Citations (Scopus)

  255 Downloads (Pure)
• 2015

  A host KH RNA-binding protein is a susceptibility factor targeted by an RXLR effector to promote late blight disease

  Wang, X., Boevink, P., McLellan, H., Armstrong, M., Bukharova, T., Qin, Z. & Birch, P. R. J., 7 Sept 2015, In: Molecular Plant. 8, 9, p. 1385-1395 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Solanum tuberosum 100%
  • RNA-binding proteins 95%
  • RNA-Binding Proteins 87%
  • Phytophthora infestans 86%
  • Plant Pathology 47%
  55 Citations (Scopus)

  249 Downloads (Pure)

• Five reasons to consider Phytophthora infestans a reemerging pathogen

  Fry, W. E., Birch, P. R. J., Judelson, H. S., Grünwald, N. J., Danies, G., Everts, K. L., Gevens, A. J., Gugino, B. K., Johnson, D. A., Johnson, S. B., McGrath, M. T., Myers, K. L., Ristaino, J. B., Roberts, P. D., Secor, G. & Smart, C. D., Jul 2015, In: Phytopathology. 105, 7, p. 966-981 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Phytophthora infestans 100%
  • pathogens 30%
  • Oomycetes 29%
  • Famine 26%
  • Research Personnel 24%
  213 Citations (Scopus)

• Phytophthora infestans RXLR Effector AVR1 Interacts with Exocyst Component Sec5 to Manipulate Plant Immunity

  Du, Y., Mpina, M. H., Birch, P. R. J., Bouwmeester, K. & Govers, F., Nov 2015, In: Plant Physiology. 169, 3, p. 1975-1990 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Phytophthora infestans 100%
  • Plant Immunity 91%
  • callose 67%
  • cell death 48%
  • immunity 45%
  94 Citations (Scopus)

• The Top 10 oomycete pathogens in molecular plant pathology

  Kamoun, S., Furzer, O., Jones, J. D. G., Judelson, H. S., Ali, G. S., Dalio, R. J. D., Roy, S. G., Schena, L., Zambounis, A., Panabières, F., Cahill, D., Ruocco, M., Figueiredo, A., Chen, X. R., Hulvey, J., Stam, R., Lamour, K., Gijzen, M., Tyler, B. M., Grünwald, N. J., & 14 othersMukhtar, M. S., Tomé, D. F. A., Tör, M., Van Den Ackerveken, G., McDowell, J., Daayf, F., Fry, W. E., Lindqvist-Kreuze, H., Meijer, H. J. G., Petre, B., Ristaino, J., Yoshida, K., Birch, P. R. J. & Govers, F., May 2015, In: Molecular Plant Pathology. 16, 4, p. 413-434 22 p.

  Research output: Contribution to journal › Article › peer-review

  • Plant Pathology 100%
  • Phytophthora 95%
  • Oomycetes 90%
  • plant pathology 70%
  • Molecular Pathology 60%
  532 Citations (Scopus)
• 2014

  Functionally Redundant RXLR Effectors from Phytophthora infestans Act at Different Steps to Suppress Early flg22-Triggered Immunity

  Zheng, X., McLellan, H., Fraiture, M., Liu, X., Boevink, P. C., Gilroy, E. M., Chen, Y., Kandel, K., Sessa, G., Birch, P. R. J. & Brunner, F., 2014, In: PLoS Pathogens. 10, 4, 17 p., e1004057.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phytophthora infestans 100%
  • Lycopersicon esculentum 57%
  • immunity 45%
  • Immunity 42%
  • Arabidopsis 40%
  101 Citations (Scopus)

  283 Downloads (Pure)

• In vivo protein-protein interaction studies with BiFC: conditions, cautions, and caveats

  Boevink, P., McLellan, H., Bukharova, T., Engelhardt, S. & Birch, P., 15 Feb 2014, Plant-pathogen interactions: methods and protocols. Birch, P., Jones, J. T. & Bos, J. I. B. (eds.). New York: Humana Press, p. 81-90 10 p. (Methods in Molecular Biology; vol. 1127).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)

  • Fluorescence 100%
  • Proteins 45%
  • Plant Cells 41%
  • Confocal Microscopy 29%
  10 Citations (Scopus)

• The role of effectors in nonhost resistance to filamentous plant pathogens

  Stam, R., Mantelin, S., McLellan, H. & Thilliez, G., 5 Nov 2014, In: Frontiers in Plant Science. 5, 582.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • plant pathogens 100%
  • pathogen-associated molecular patterns 57%
  • pathogens 37%
  • Oomycetes 24%
  • resistance mechanisms 21%
  55 Citations (Scopus)

  259 Downloads (Pure)

• The zigzag model of plant-microbe interactions: is it time to move on?

  Pritchard, L. & Birch, P. R. J., Dec 2014, In: Molecular Plant Pathology. 15, 9, p. 865-870 6 p.

  Research output: Contribution to journal › Article › peer-review
  51 Citations (Scopus)