The Contribution of Phytophthora Effectors to Host Range and Non-Host Resistance (Joint with James Hutton Institute and University of Warwick and Industrial Partners)

Search results

• 2022

  Exploiting breakdown in nonhost effector-target interactions to boost host disease resistance

  McLellan, H., Harvey, S. E., Steinbrenner, J., Armstrong, M. R., He, Q., Clewes, R., Pritchard, L., Wang, W., Wang, S., Nussbaumer, T., Dohai, B., Luo, Q., Kumari, P., Duan, H., Roberts, A., Boevink, P. C., Neumann, C., Champouret, N., Hein, I. & Falter-Braun, P. & 3 others, Beynon, J., Denby, K. (Lead / Corresponding author) & Birch, P. R. J. (Lead / Corresponding author), 30 Aug 2022, In: Proceedings of the National Academy of Sciences. 119, 35, 12 p., e2114064119.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Orthologues 100%
  • P. Infestans 100%
  • Disease Resistance 100%
  • Non-host 100%
  • Effector Target 100%

  31   Link opens in a new tab Citations (Scopus)

  208 Downloads (Pure)

• 2021

  Evolutionarily distinct Resistance proteins detect a pathogen effector through its association with different host targets

  Wang, H., Trusch, F., Turnbull, D., Aguilera-Galvez, C., Breen, S., Naqvi, S., Jones, J. D. G., Hein, I., Tian, Z., Vleeshouwers, V., Gilroy, E. & Birch, P. R. J. (Lead / Corresponding author), Nov 2021, In: New Phytologist. 232, 3, p. 1368-1381 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Resistance Protein 100%
  • Pathogen Effectors 100%
  • Host Targets 100%
  • BSL-3 100%
  • Infectious Agent 100%

  13   Link opens in a new tab Citations (Scopus)

  238 Downloads (Pure)

• 2020

  All roads lead to susceptibility: the many modes-of-action of fungal and oomycete intracellular effectors

  He, Q., McLellan, H., Boevink, P. C. & Birch, P. R. J., 13 Jul 2020, In: Plant Communications. 1, 4, 12 p., 100050.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mode of Action 100%
  • Oomycetes 100%
  • Host Cell Proteins 100%
  • Intracellular Effectors 100%
  • Infectious Agent 100%

  131   Link opens in a new tab Citations (Scopus)

  298 Downloads (Pure)

• 2019

  AVR2 targets BSL family members, which act as susceptibility factors to suppress host immunity

  Turnbull, D., Wang, H., Breen, S., Malec, M., Naqvi, S., Yang, L., Welsh, L., Hemsley, P. A., Zhendong, T., Brunner, F., Gilroy, E. M. & Birch, P. R. J. (Lead / Corresponding author), 1 May 2019, In: Plant Physiology. 180, 1, p. 571-581 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Family Members 100%
  • Susceptibility Factors 100%
  • Host Immunity 100%
  • BRI1 100%
  • Phytophthora infestans 100%

  39   Link opens in a new tab Citations (Scopus)

  362 Downloads (Pure)

• AVR2 Targets BSL Family Members, Which Act as Susceptibility Factors to Suppress Host Immunity

  Turnbull, D., Wang, H., Breen, S., Malec, M., Naqvi, S., Yang, L., Welsh, L., Hemsley, P., Tian, Z., Brunner, F., Gilroy, E. M. & Birch, P. (Lead / Corresponding author), 1 May 2019, In: Plant Physiology. 180, 1, p. 571-581 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Family Members 100%
  • Susceptibility Factors 100%
  • Host Immunity 100%
  • Phytophthora infestans 100%
  • P. Infestans 75%

  111 Downloads (Pure)

• Phytophthora infestans effector SFI3 targets potato UBK to suppress early immune transcriptional responses

  He, Q., McLellan, H., Hughes, R. K., Boevink, P. C., Armstrong, M., Lu, Y., Banfield, M. J., Tian, Z. (Lead / Corresponding author) & Birch, P. R. J. (Lead / Corresponding author), Apr 2019, In: New Phytologist. 222, 1, p. 438-454 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Potato 100%
  • Phytophthora Infestans 100%
  • Transcriptional Response 100%
  • Phytophthora infestans 100%
  • RXLR Effector 66%

  46   Link opens in a new tab Citations (Scopus)

  386 Downloads (Pure)

• Phytophthora infestans RXLR effectors act in concert at diverse subcellular locations to enhance host colonization

  Wang, S., McLellan, H., Bukharova, T., He, Q., Murphy, F., Shi, J., Sun, S., van Weymers, P., Ren, Y., Thilliez, G., Wang, H., Chen, X., Engelhardt, S., Vleeshouwers, V., Gilroy, E. M., Whisson, S. C., Hein, I., Wang, X., Tian, Z. & Birch, P. R. J. & 1 others, Boevink, P. C. (Lead / Corresponding author), 1 Jan 2019, In: Journal of Experimental Botany. 70, 1, p. 343-356 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phytophthora Infestans 100%
  • Subcellular Location 100%
  • RXLR Effector 100%
  • Host Colonization 100%
  • Infectious Agent 100%

  85   Link opens in a new tab Citations (Scopus)

  365 Downloads (Pure)

• Phytophthora infestans RXLR effectors target parallel steps in an immune signal transduction pathway

  Ren, Y., Armstrong, M., Qi, Y., McLellan, H., Zhong, C., Du, B., Birch, P. R. J. & Tian, Z., Aug 2019, In: Plant Physiology. 180, 4, p. 2227-2239 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cell Death 100%
  • Phytophthora Infestans 100%
  • Signal Transduction Pathway 100%
  • Immune Signaling 100%
  • RXLR Effector 100%

  54   Link opens in a new tab Citations (Scopus)

  305 Downloads (Pure)

• 2018

  Phytophthora infestans RXLR effector SFI5 requires association with calmodulin for PTI/MTI suppressing activity

  Zheng, X., Wagener, N., McLellan, H., Boevink, P. C., Hua, C., Birch, P. R. J. & Brunner, F. (Lead / Corresponding author), 1 Sept 2018, In: New Phytologist. 219, 4, p. 1433-1446 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phytophthora Infestans 100%
  • Calmodulin 100%
  • RXLR Effector 100%
  • MAMP-triggered Immunity 100%
  • Calmodulin Binding 100%

  41   Link opens in a new tab Citations (Scopus)

  319 Downloads (Pure)

• Plant pathogen effector utilizes host susceptibility factor NRL1 to degrade the immune regulator SWAP70

  He, Q., Naqvi, S., McLellan, H., Boevink, P., Champouret, N., Hein, I. & Birch, P. (Lead / Corresponding author), 14 Aug 2018, In: Proceedings of the National Academy of Sciences. 115, 33, p. E7834-E7843 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Plant Pathogen 100%
  • Pathogen Effectors 100%
  • Host Susceptibility Factors 100%
  • SWAP-70 100%
  • Immune Regulator 100%

  82   Link opens in a new tab Citations (Scopus)

  311 Downloads (Pure)

• The Potato MAP3K StVIK Is Required for the Phytophthora infestans RXLR Effector Pi17316 to Promote Disease

  Murphy, F., He, Q., Armstrong, M., Giuliani, L. M., Boevink, P. C., Zhang, W., Tian, Z., Birch, P. R. J. (Lead / Corresponding author) & Gilroy, E. M. (Lead / Corresponding author), May 2018, In: Plant Physiology. 177, 1, p. 398-410 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cell Death 100%
  • Potato 100%
  • Orthologues 100%
  • Phytophthora Infestans 100%
  • RXLR Effector 100%

  66   Link opens in a new tab Citations (Scopus)

  282 Downloads (Pure)

• 2017

  A new proteinaceous pathogen-associated molecular pattern (PAMP) identified in Ascomycete fungi induces cell death in Solanaceae

  Franco-Orozco, B., Berepiki, A., Ruiz, O., Gamble, L., Griffe, L. L., Wang, S., Birch, P. R. J., Kanyuka, K. & Avrova, A. (Lead / Corresponding author), Jun 2017, In: New Phytologist. 214, 4, p. 1657-1672 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Cell Death 100%
  • Pathogen-associated Molecular Patterns 100%
  • Solanaceae 100%
  • Ascomycete Fungi 100%
  • Pathogen-Associated Molecular Pattern 100%

  60   Link opens in a new tab Citations (Scopus)

• BTB-BACK Domain Protein POB1 Suppresses Immune Cell Death by Targeting Ubiquitin E3 ligase PUB17 for Degradation

  Orosa, B., He, Q., Mesmar, J., Gilroy, E. M., McLellan, H., Yang, C., Craig, A., Bailey, M., Zhang, C., Moore, J. D., Boevink, P. C., Tian, Z., Birch, P. R. J. (Lead / Corresponding author) & Sadanandom, A. (Lead / Corresponding author), 5 Jan 2017, In: PLoS Genetics. 13, 1, p. 1-26 26 p., e1006540.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Programmed Cell Death 100%
  • E3 Ubiquitin Ligase 100%
  • Immune Cell Death 100%
  • Immunocompetent Cell 100%
  • Cell Death 100%

  43   Link opens in a new tab Citations (Scopus)

  367 Downloads (Pure)

• Delivery of cytoplasmic and apoplastic effectors from Phytophthora infestans haustoria by distinct secretion pathways

  Wang, S., Boevink, P. C., Welsh, L., Zhang, R., Whisson, S. C. & Birch, P. J. R. (Lead / Corresponding author), 29 Aug 2017, In: New Phytologist. 29, 8, p. 205-215 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Plant Cells 100%
  • Haustorium 100%
  • Phytophthora Infestans 100%
  • Secretion Systems 100%
  • Cytoplasmic Effectors 100%

  131   Link opens in a new tab Citations (Scopus)

  540 Downloads (Pure)

• RXLR Effector AVR₂ Up-Regulates a Brassinosteroid-Responsive bHLH Transcription Factor to Suppress Immunity

  Turnbull, D., Yang, L., Naqvi, S., Breen, S., Welsh, L., Stephens, J., Morris, J., Boevink, P. C., Hedley, P. E., Zhan, J., Birch, P. R. J. & Gilroy, E. M. (Lead / Corresponding author), May 2017, In: Plant Physiology. 174, 1, p. 356-369 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Transcription Factor 100%
  • Basic Helix-loop-helix (bHLH) 100%
  • RXLR Effector 100%
  • Brassinosteroids 100%
  • Infectious Agent 100%

  73   Link opens in a new tab Citations (Scopus)

  481 Downloads (Pure)

• 2016

  A Phytophthora infestans RXLR effector targets plant PP1c isoforms that promote late blight disease

  Boevink, P. C., Wang, X., McLellan, H., He, Q., Naqvi, S., Armstrong, M. R., Zhang, W., Hein, I., Gilroy, E. M., Tian, Z. & Birch, P. R. J. (Lead / Corresponding author), 29 Jan 2016, In: Nature Communications. 7, 10311.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Protein Phosphatase 100%
  • Phytophthora Infestans 100%
  • Plant Protein 100%
  • RXLR Effector 100%
  • Late Blight Disease 100%

  133   Link opens in a new tab Citations (Scopus)

  502 Downloads (Pure)

• Oomycetes seek help from the plant : phytophthora infestans effectors target host susceptibility factors

  Boevink, P. C., McLellan, H., Gilroy, E. M., Naqvi, S., He, Q., Yang, L., Wang, X., Turnbull, D., Armstrong, M. R., Tian, Z. & Birch, P. R. J. (Lead / Corresponding author), 2 May 2016, In: Molecular Plant. 9, 5, p. 636-638 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  38   Link opens in a new tab Citations (Scopus)

  290 Downloads (Pure)

• Potato NPH3/RPT2-like protein StNRL1, targeted by a Phytophthora infestans RXLR effector, is a susceptibility factor

  Yang, L., McLellan, H., Naqvi, S., He, Q., Boevink, P. C., Armstrong, M., Giuliani, L. M., Zhang, W., Tian, Z., Zhan, J. (Lead / Corresponding author), Gilroy, E. M. & Birch, P. R. J. (Lead / Corresponding author), May 2016, In: Plant Physiology. 171, 1, p. 645-657 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Potato 100%
  • Phytophthora Infestans 100%
  • RXLR Effector 100%
  • Susceptibility Factors 100%
  • RPT2 100%

  83   Link opens in a new tab Citations (Scopus)

  336 Downloads (Pure)

• The cell biology of late blight disease

  Whisson, S. C., Boevink, P. C., Wang, S. & Birch, P. R. J. (Lead / Corresponding author), Dec 2016, In: Current Opinion in Microbiology. 34, p. 127-135 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cell Biology 100%
  • RXLR Effector 100%
  • Late Blight Disease 100%
  • Phytophthora infestans 100%
  • Plant Cells 50%

  121   Link opens in a new tab Citations (Scopus)

  464 Downloads (Pure)

• 2015

  A host KH RNA-binding protein is a susceptibility factor targeted by an RXLR effector to promote late blight disease

  Wang, X., Boevink, P., McLellan, H., Armstrong, M., Bukharova, T., Qin, Z. (Lead / Corresponding author) & Birch, P. R. J. (Lead / Corresponding author), 7 Sept 2015, In: Molecular Plant. 8, 9, p. 1385-1395 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • RNA-binding Protein 100%
  • K-homology 100%
  • RXLR Effector 100%
  • Late Blight Disease 100%
  • Susceptibility Factors 100%

  73   Link opens in a new tab Citations (Scopus)

  395 Downloads (Pure)

• Five reasons to consider Phytophthora infestans a reemerging pathogen

  Fry, W. E. (Lead / Corresponding author), Birch, P. R. J., Judelson, H. S., Grünwald, N. J., Danies, G., Everts, K. L., Gevens, A. J., Gugino, B. K., Johnson, D. A., Johnson, S. B., McGrath, M. T., Myers, K. L., Ristaino, J. B., Roberts, P. D., Secor, G. & Smart, C. D., Jul 2015, In: Phytopathology. 105, 7, p. 966-981 16 p.

  Research output: Contribution to journal › Article › peer-review

  • P. Infestans 100%
  • Phytophthora Infestans 100%
  • Re-emerging Pathogen 100%
  • Infectious Agent 100%
  • Phytophthora infestans 100%

  311   Link opens in a new tab Citations (Scopus)

• Phytophthora infestans RXLR Effector AVR1 Interacts with Exocyst Component Sec5 to Manipulate Plant Immunity

  Du, Y., Mpina, M. H., Birch, P. R. J., Bouwmeester, K. & Govers, F. (Lead / Corresponding author), Nov 2015, In: Plant Physiology. 169, 3, p. 1975-1990 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Phytophthora Infestans 100%
  • Induced Cell Death 100%
  • Exocyst 100%
  • RXLR Effector 100%
  • Plant Immunity 100%

  126   Link opens in a new tab Citations (Scopus)

• The Top 10 oomycete pathogens in molecular plant pathology

  Kamoun, S. (Lead / Corresponding author), Furzer, O., Jones, J. D. G., Judelson, H. S., Ali, G. S., Dalio, R. J. D., Roy, S. G., Schena, L., Zambounis, A., Panabières, F., Cahill, D., Ruocco, M., Figueiredo, A., Chen, X. R., Hulvey, J., Stam, R., Lamour, K., Gijzen, M., Tyler, B. M. & Grünwald, N. J. & 14 others, Mukhtar, M. S., Tomé, D. F. A., Tör, M., Van Den Ackerveken, G., McDowell, J., Daayf, F., Fry, W. E., Lindqvist-Kreuze, H., Meijer, H. J. G., Petre, B., Ristaino, J., Yoshida, K., Birch, P. R. J. & Govers, F., May 2015, In: Molecular Plant Pathology. 16, 4, p. 413-434 22 p.

  Research output: Contribution to journal › Article › peer-review

  • Plant Pathogen 100%
  • Oomycetes 100%
  • Oomycete Pathogen 100%
  • Top 10 100%
  • Molecular Plant Pathology 100%

  819   Link opens in a new tab Citations (Scopus)

• 2014

  Functionally Redundant RXLR Effectors from Phytophthora infestans Act at Different Steps to Suppress Early flg22-Triggered Immunity

  Zheng, X., McLellan, H., Fraiture, M., Liu, X., Boevink, P. C., Gilroy, E. M., Chen, Y., Kandel, K., Sessa, G., Birch, P. R. J. (Lead / Corresponding author) & Brunner, F. (Lead / Corresponding author), 2014, In: PLoS Pathogens. 10, 4, 17 p., e1004057.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phytophthora Infestans 100%
  • RXLR Effector 100%
  • Flg22 100%
  • Infectious Agent 100%
  • Arabidopsis 100%

  123   Link opens in a new tab Citations (Scopus)

  401 Downloads (Pure)

• The role of effectors in nonhost resistance to filamentous plant pathogens

  Stam, R. (Lead / Corresponding author), Mantelin, S., McLellan, H. & Thilliez, G., 5 Nov 2014, In: Frontiers in Plant Science. 5, 582.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Nonhost Resistance 100%
  • Filamentous Plant Pathogen 100%
  • Pathogenicity 100%
  • Plant Pathogens 100%
  • Oomycetes 100%

  59   Link opens in a new tab Citations (Scopus)

  334 Downloads (Pure)

• The zigzag model of plant-microbe interactions: is it time to move on?

  Pritchard, L. (Lead / Corresponding author) & Birch, P. R. J. (Lead / Corresponding author), Dec 2014, In: Molecular Plant Pathology. 15, 9, p. 865-870 6 p.

  Research output: Contribution to journal › Article › peer-review

  63   Link opens in a new tab Citations (Scopus)