Research output per year
Research output per year
- 15 results
Search results
-
2024
A unified analysis of evolutionary and population constraint in protein domains highlights structural features and pathogenic sites
MacGowan, S. A., Madeira, F., Britto-Borges, T. & Barton, G. J. (Lead / Corresponding author), 11 Apr 2024, (E-pub ahead of print) In: Communications Biology. 7, 10 p., 447.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)72 Downloads (Pure) -
Classification of likely functional class for ligand binding sites identified from fragment screening
Utgés, J. S., MacGowan, S. A., Ives, C. M. & Barton, G. J. (Lead / Corresponding author), 13 Mar 2024, In: Communications Biology. 7, 13 p., 320.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)95 Downloads (Pure) -
Comparative evaluation of methods for the prediction of protein-ligand binding sites
S. Utges, J. & Barton, G. J. (Lead / Corresponding author), 11 Nov 2024, In: Journal of Cheminformatics. 16, 35 p., 126.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)50 Downloads (Pure) -
Computers and Biological Research
Barton, G. (Contributing member), Cameron, A. (Producer), Soave, S. (Film-maker), Sknepnek, R. (Contributing member), Schweikert, G. (Contributing member), Zachariae, U. (Contributing member) & Duce, S. (Contributing member), 2024Research output: Non-textual form › Digital or Visual Products
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2022
Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19: A case study in affinity predictions of interface variants
MacGowan, S. A., Barton, M. I., Kutuzov, M., Dushek, O., van der Merwe, P. A. & Barton, G. J. (Lead / Corresponding author), 2 Mar 2022, In: PLoS Computational Biology. 18, 3, p. 1-25 25 p., e1009922.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)111 Downloads (Pure) -
2021
Ankyrin repeats in context with human population variation
Utgés,, J. S., Tsenkov, M. I., Dietrich, N. J. M., MacGowan, S. A. & Barton, G. J. (Lead / Corresponding author), Aug 2021, In: PLoS Computational Biology. 17, 8, 26 p., e1009335.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)130 Downloads (Pure) -
Ankyrin repeats in context with human population variation
Utgés, J. S., Tsenkov, M. I., Dietrich, N. J. M., MacGowan, S. A. & Barton, G. J. (Lead / Corresponding author), 30 May 2021, BioRxiv, 26 p.Research output: Working paper/Preprint › Preprint
Open AccessFile69 Downloads (Pure) -
Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand the human ACE2 receptor on binding affinity and kinetics
Barton, M. I., MacGowan, S. A., Kutuzov, M. A., Dushek, O., Barton, G. J. (Lead / Corresponding author) & van der Merwe, P. A. (Lead / Corresponding author), Aug 2021, In: eLife. 10, 19 p., e70658.Research output: Contribution to journal › Article › peer-review
Open AccessFile248 Citations (Scopus)137 Downloads (Pure) -
Effects of common mutations in the SARS-CoV-2 Spike RBD domain and its ligand the human ACE2 receptor on binding affinity and kinetics
Barton, M. I., MacGowan, S., Kutuzov, M., Dushek, O., Barton, G. J. (Lead / Corresponding author) & Merwe, P. A. V. D. (Lead / Corresponding author), 24 May 2021, BioRxiv, 39 p.Research output: Working paper/Preprint › Preprint
File119 Downloads (Pure) -
Missense variants in human ACE2 modify binding to SARS-CoV-2 Spike
MacGowan, S. A., Barton, M. I. (Lead / Corresponding author), Kutuzov, M., Dushek, O., Merwe, P. A. V. D. & Barton, G. J., 21 May 2021, BioRxiv, 28 p.Research output: Working paper/Preprint › Preprint
File109 Downloads (Pure) -
2020
Disease related single point mutations alter the global dynamics of a tetratricopeptide (TPR) α-solenoid domain
Llabrés, S. (Lead / Corresponding author), Tsenkov, M. I., MacGowan, S., Barton, G. & Zachariae, U. (Lead / Corresponding author), 1 Jan 2020, In: Journal of Structural Biology. 209, 1, 8 p., 107405.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)143 Downloads (Pure) -
Missense variants in ACE2 are predicted to encourage and inhibit interaction with SARS-CoV-2 Spike and contribute to genetic risk in COVID-19
MacGowan, S. A. (Lead / Corresponding author) & Barton, G. J. (Lead / Corresponding author), 4 May 2020, Cold Spring Harbor Laboratory: BioRxiv, 38 p.Research output: Working paper/Preprint › Preprint
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PDBE-KB: A community-driven resource for structural and functional annotations
PDBe-KB consortium, 8 Jan 2020, In: Nucleic Acids Research. 48, D1, p. D344-D353 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile87 Citations (Scopus)115 Downloads (Pure) -
The Dundee Resource for Sequence Analysis and Structure Prediction
MacGowan, S., Madeira, F., Britto-Borges, T., Warowny, M., Drozdetskiy, A., Procter, J. & Barton, G. (Lead / Corresponding author), Jan 2020, In: Protein Science. 29, 1, p. 277-297 21 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)141 Downloads (Pure) -
2018
JABAWS 2.2 Distributed Web Services for Bioinformatics: Protein Disorder, Conservation and RNA Secondary Structure
Troshin, P. V., Procter, J. B., Sherstnev, A., Barton, D. L., Madeira, F. & Barton, G. J. (Lead / Corresponding author), 1 Jun 2018, In: Bioinformatics. 34, 11, p. 1939-1940 2 p., byt045.Research output: Contribution to journal › Article › peer-review
Open AccessFile37 Citations (Scopus)292 Downloads (Pure)