Keyphrases
Murine Double Minute 2 (MDM2)
100%
Ubiquitin Receptor
100%
E3 Ligase
50%
Proteasomal Degradation
50%
Repressor
50%
Knockdown
22%
PSMD4
16%
Protein Degradation
12%
Cancer Dependency
10%
ADRM1
10%
Ubiquitinated Proteins
10%
Therapeutic Target
10%
Cancer Cell Lines
10%
Targets of Interest
10%
Cancer Therapy
10%
Redundancy
10%
Tumor Protein p53 (TP53)
10%
Ubiquitin-interacting Motif
6%
Rpn10
6%
Degradation Rate
6%
Relative Stability
6%
Alternative Pathway
6%
Cell Signaling
6%
P53 Activation
6%
Cell Proliferation
6%
Dominant Role
6%
P53 Protein
6%
E3 Ubiquitin Ligase
6%
Independent Pathway
6%
Overexpression
6%
Human Cells
6%
Transcriptional Activity
6%
P53 Pathway
6%
P53 Level
6%
Rescue Experiments
6%
Dominant Negative
6%
Biochemistry, Genetics and Molecular Biology
Ubiquitin
100%
P53
100%
Repressor
50%
Mdm2
50%
Ligase
50%
Proteasome
14%
Cancer Cell
10%