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2025
NQO1 induction and radiation-based biodistribution study of a new quinoline derivative identified in a screen of 6,8-diiodoquinazolinone sulfonamide conjugates
Soliman, A. M., Ghorab, M. M., Higgins, M., Dinkova-Kostova, A. T., Korany, M., Amin, M. A., Khedr, M. A. & Sakr, T. M., 15 Oct 2025, In: European Journal of Medicinal Chemistry. 296, 12 p., 117855.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)36 Downloads (Pure) -
Tetrazole-containing naphthalene bis-sulfonamide Keap1-Nrf2 interaction inhibitors with unexpected binding modes
Georgakopoulos, N. D., Talapatra, S. K., Dayalan Naidu, S., Dikovskaya, D., Higgins, M., Gatliff, J., Nikoloudaki, R., Schaap, M., Walker, J. M., Wardby, C., Dinkova-Kostova, A. T., Harris, S., Kozielski, F. & Wells, G. (Lead / Corresponding author), Dec 2025, In: Redox Biology. 88, 17 p., 103924.Research output: Contribution to journal › Article › peer-review
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2023
Nrf2 regulates glucose uptake and metabolism in neurons and astrocytes
Esteras, N. (Lead / Corresponding author), Blacker, T. S., Zherebtsov, E. A., Stelmashuk, O. A., Zhang, Y., Wigley, W. C., Duchen, M. R., Dinkova-Kostova, A. T. & Abramov, A. Y. (Lead / Corresponding author), Jun 2023, In: Redox Biology. 62, 13 p., 102672.Research output: Contribution to journal › Article › peer-review
Open AccessFile44 Citations (Scopus)299 Downloads (Pure) -
2022
Biotinylation of an acetylenic tricyclic bis(cyanoenone) lowers its potency as an NRF2 activator while creating a novel activity against BACH1
Moreno, R., Casares, L., Higgins, M., Ali, K. X., Honda, T., Wiel, C., Sayin, V. I., Dinkova-Kostova, A. T. & de la Vega, L. (Lead / Corresponding author), 9 Sept 2022, In: Free Radical Biology and Medicine. 191, p. 203-211 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)281 Downloads (Pure) -
Detection of thermal shift in cellular Keap1 by protein-protein interaction inhibitors using immunoblot- and fluorescence microplate-based assays
Dayalan Naidu, S., Dikovskaya, D., Moore, T. W. & Dinkova-Kostova, A. (Lead / Corresponding author), 17 Jun 2022, In: STAR Protocols. 3, 2, 17 p., 101265.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)592 Downloads (Pure) -
DIA label-free proteomic analysis of murine bone-marrow-derived macrophages
Baker, C. P., Phair, I. R., Brenes, A. J., Atrih, A., Ryan, D. G., Bruderer, R., Dinkova-Kostova, A. T., Lamont, D. J., Arthur, J. S. C. (Lead / Corresponding author) & Howden, A. J. M. (Lead / Corresponding author), 16 Dec 2022, In: STAR Protocols. 3, 4, 17 p., 101725.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)440 Downloads (Pure) -
Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response
Ryan, D. G., Knatko, E. V., Casey, A. M., Hukelmann, J., Dayalan Naidu, S., Brenes, A. J., Ekkunagul, T., Baker, C., Higgins, M., Tronci, L., Nikitopolou, E., Honda, T., Hartley, R. C., O'Neill, L. A. J., Frezza, C., Lamond, A. I., Abramov, A. Y., Arthur, J. S. C., Cantrell, D. A. & Murphy, M. P. & 1 others, , 18 Feb 2022, In: iScience. 25, 2, 21 p., 103827.Research output: Contribution to journal › Article › peer-review
Open AccessFile86 Citations (Scopus)354 Downloads (Pure) -
Pirin, an Nrf2-regulated protein, is overexpressed in human colorectal tumors
Zhang, Y., Knatko, E. V., Higgins, M., Dayalan Naidu, S., Smith, G., Honda, T., de la Vega, L. & Dinkova-Kostova, A. T. (Lead / Corresponding author), 28 Jan 2022, In: Antioxidants . 11, 2, 15 p., 262.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)210 Downloads (Pure) -
The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2
Dayalan Naidu, S., Suzuki, T., Dikovskaya, D., Knatko, E. V., Higgins, M., Sato, M., Novak, M., Villegas, J. A., Moore, T. W., Yamamoto, M. & Dinkova-Kostova, A. (Lead / Corresponding author), 21 Jan 2022, In: iScience. 25, 1, 19 p., 103703.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Citations (Scopus)277 Downloads (Pure) -
The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its activity
Casares, L., Moreno, R., Ali, K. X., Higgins, M., Dayalan Naidu, S., Neill, G., Cassin, L., Kiib, A. E., Svenningsen, E. B., Minassi, A., Honda, T., Poulsen, T. B., Wiel, C., Sayin, V. I., Dinkova-Kostova, A. T., Olagnier, D. & de la Vega, L. (Lead / Corresponding author), May 2022, In: Redox Biology. 51, 12 p., 102291.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Citations (Scopus)198 Downloads (Pure) -
2021
Clinically relevant aberrant Filip1l DNA methylation detected in a murine model of cutaneous squamous cell carcinoma
Roth, K., Coussement, L., Knatko, E., Higgins, M., Steyaert, S., Proby, C., de Meyer, T. & Dinkova-Kostova, A. (Lead / Corresponding author), May 2021, In: EBioMedicine. 67, 12 p., 103383.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)171 Downloads (Pure) -
Novel iodinated quinazolinones bearing sulfonamide as new scaffold targeting radiation induced oxidative stress
Soliman, A. M. (Lead / Corresponding author), Mekkawy, M. H., Karam, H. M., Higgins, M., Dinkova-kostova, A. T. & Ghorab, M. M. (Lead / Corresponding author), 15 Jun 2021, In: Bioorganic & Medicinal Chemistry Letters. 42, 9 p., 128002.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)173 Downloads (Pure) -
Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer
Knatko, E. V., Castro, C., Higgins, M., Zhang, Y., Honda, T., Henderson, C. J., Wolf, C. R., Griffin, J. L. & Dinkova-Kostova, A. T. (Lead / Corresponding author), 15 Sept 2021, In: Communications Biology. 4, 16 p., 1081.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)145 Downloads (Pure) -
The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner
Zhang, Y., Gilmour, A., Ahn, Y.-H., de la Vega, L. & Dinkova-Kostova, A. (Lead / Corresponding author), Jun 2021, In: Phytomedicine. 86, 6 p., 153062.Research output: Contribution to journal › Article › peer-review
Open AccessFile32 Citations (Scopus)266 Downloads (Pure) -
The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress
Moreno Dorta, R., Banerjee, S., Jackson, A. W., Quinn, J., Baillie, G., Dixon, J. E., Dinkova-Kostova, A., Edwards, J. & de la Vega, L. (Lead / Corresponding author), May 2021, In: Cell Death & Differentiation. 28, p. 1563-1578 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile30 Citations (Scopus)158 Downloads (Pure) -
2020
Downregulation of Keap1 confers features of a fasted metabolic state
Knatko, E. V., Tatham, M. H., Zhang, Y., Castro, C., Higgins, M., Dayalan Naidu, S., Leonardi, C., de la Vega, L., Honda, T., Griffin, J. L., Hay, R. T. & Dinkova-Kostova, A. T. (Lead / Corresponding author), 23 Oct 2020, In: iScience. 23, 10, 48 p., 101638.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Citations (Scopus)232 Downloads (Pure) -
High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro
Torrente Fernandez, L., Maan, G., Rezig, A. O., Quinn, J., Jackson, A., Grilli, A., Casares, L., Zhang, Y., Kulesskiy, E., Saarela, J., Bicciato, S., Edwards, J., Dinkova-Kostova, A. & de la Vega, L. (Lead / Corresponding author), Oct 2020, In: Biomolecules. 10, 10, 16 p., 1365.Research output: Contribution to journal › Article › peer-review
Open AccessFile32 Citations (Scopus)123 Downloads (Pure) -
Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity
Casares Perez, L., Unciti-Broceta, J. D., Prados, M. E., Caprioglio, D., Mattoteia, D., Higgins, M., Apendino, G., Dinkova-Kostova, A. T., Muñoz, E. & de la Vega, L. (Lead / Corresponding author), Oct 2020, In: Redox Biology. 37, 10 p., 101689.Research output: Contribution to journal › Article › peer-review
Open AccessFile34 Citations (Scopus)141 Downloads (Pure) -
Measuring Changes in Keap1‐Nrf2 Protein Complex Conformation in Individual Cells by FLIM‐FRET
Dikovskaya, D. (Lead / Corresponding author) & Dinkova-Kostova, A., Sept 2020, In: Current Protocols in Toxicology. 85, 1, 34 p., e96.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)199 Downloads (Pure) -
Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety
Soliman, A. M. (Lead / Corresponding author), Karam, H. M., Mekkawy, M. H., Higgins, M., Dinkova-Kostova, A. & Ghorab, M. M. (Lead / Corresponding author), 15 Aug 2020, In: European Journal of Medicinal Chemistry. 200, 12 p., 112467.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)245 Downloads (Pure) -
Sulfoxythiocarbamate S-4 inhibits HSP90 in human cutaneous squamous cell carcinoma cells
Zhang, Y., VanHecke, G. C., Ahn, Y.-H., Proby, C. M. & Dinkova-Kostova, A. T. (Lead / Corresponding author), 15 Dec 2020, In: European Journal of Pharmacology. 889, 9 p., 173609.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)197 Downloads (Pure) -
2019
Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model
Kalin, J. H. (Lead / Corresponding author), Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T. (Lead / Corresponding author), 13 Mar 2019, In: PLoS ONE. 14, 3, 13 p., e0213095.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)183 Downloads (Pure) -
Measuring the Interaction of Transcription Factor Nrf2 with Its Negative Regulator Keap1 in Single Live Cells by an Improved FRET/FLIM Analysis
Dikovskaya, D. (Lead / Corresponding author), Appleton, P., Bento-Pereira, C. & Dinkova-Kostova, A. (Lead / Corresponding author), 18 Mar 2019, In: Chemical Research in Toxicology. 32, 3, p. 500-512 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)324 Downloads (Pure)