Research output per year
Research output per year
- 21 results
Search results
-
2023
Nrf2 regulates glucose uptake and metabolism in neurons and astrocytes
Esteras, N. (Lead / Corresponding author), Blacker, T. S., Zherebtsov, E. A., Stelmashuk, O. A., Zhang, Y., Wigley, W. C., Duchen, M. R., Dinkova-Kostova, A. T. & Abramov, A. Y. (Lead / Corresponding author), Jun 2023, In: Redox Biology. 62, 13 p., 102672.Research output: Contribution to journal › Article › peer-review
Open AccessFile27 Citations (Scopus)178 Downloads (Pure) -
2022
Biotinylation of an acetylenic tricyclic bis(cyanoenone) lowers its potency as an NRF2 activator while creating a novel activity against BACH1
Moreno, R., Casares, L., Higgins, M., Ali, K. X., Honda, T., Wiel, C., Sayin, V. I., Dinkova-Kostova, A. T. & de la Vega, L. (Lead / Corresponding author), 9 Sept 2022, In: Free Radical Biology and Medicine. 191, p. 203-211 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)197 Downloads (Pure) -
Detection of thermal shift in cellular Keap1 by protein-protein interaction inhibitors using immunoblot- and fluorescence microplate-based assays
Dayalan Naidu, S., Dikovskaya, D., Moore, T. W. & Dinkova-Kostova, A. (Lead / Corresponding author), 17 Jun 2022, In: STAR Protocols. 3, 2, 17 p., 101265.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)412 Downloads (Pure) -
DIA label-free proteomic analysis of murine bone-marrow-derived macrophages
Baker, C. P., Phair, I. R., Brenes, A. J., Atrih, A., Ryan, D. G., Bruderer, R., Dinkova-Kostova, A. T., Lamont, D. J., Arthur, J. S. C. (Lead / Corresponding author) & Howden, A. J. M. (Lead / Corresponding author), 16 Dec 2022, In: STAR Protocols. 3, 4, 17 p., 101725.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)267 Downloads (Pure) -
Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response
Ryan, D. G., Knatko, E. V., Casey, A. M., Hukelmann, J., Dayalan Naidu, S., Brenes, A. J., Ekkunagul, T., Baker, C., Higgins, M., Tronci, L., Nikitopolou, E., Honda, T., Hartley, R. C., O'Neill, L. A. J., Frezza, C., Lamond, A. I., Abramov, A. Y., Arthur, J. S. C., Cantrell, D. A. & Murphy, M. P. & 1 others, , 18 Feb 2022, In: iScience. 25, 2, 21 p., 103827.Research output: Contribution to journal › Article › peer-review
Open AccessFile64 Citations (Scopus)247 Downloads (Pure) -
Pirin, an Nrf2-regulated protein, is overexpressed in human colorectal tumors
Zhang, Y., Knatko, E. V., Higgins, M., Dayalan Naidu, S., Smith, G., Honda, T., de la Vega, L. & Dinkova-Kostova, A. T. (Lead / Corresponding author), 28 Jan 2022, In: Antioxidants . 11, 2, 15 p., 262.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)132 Downloads (Pure) -
The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2
Dayalan Naidu, S., Suzuki, T., Dikovskaya, D., Knatko, E. V., Higgins, M., Sato, M., Novak, M., Villegas, J. A., Moore, T. W., Yamamoto, M. & Dinkova-Kostova, A. (Lead / Corresponding author), 21 Jan 2022, In: iScience. 25, 1, 19 p., 103703.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)198 Downloads (Pure) -
The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its activity
Casares, L., Moreno, R., Ali, K. X., Higgins, M., Dayalan Naidu, S., Neill, G., Cassin, L., Kiib, A. E., Svenningsen, E. B., Minassi, A., Honda, T., Poulsen, T. B., Wiel, C., Sayin, V. I., Dinkova-Kostova, A. T., Olagnier, D. & de la Vega, L. (Lead / Corresponding author), May 2022, In: Redox Biology. 51, 12 p., 102291.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)111 Downloads (Pure) -
2021
Clinically relevant aberrant Filip1l DNA methylation detected in a murine model of cutaneous squamous cell carcinoma
Roth, K., Coussement, L., Knatko, E., Higgins, M., Steyaert, S., Proby, C., de Meyer, T. & Dinkova-Kostova, A. (Lead / Corresponding author), May 2021, In: EBioMedicine. 67, 12 p., 103383.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)124 Downloads (Pure) -
Novel iodinated quinazolinones bearing sulfonamide as new scaffold targeting radiation induced oxidative stress
Soliman, A. M. (Lead / Corresponding author), Mekkawy, M. H., Karam, H. M., Higgins, M., Dinkova-kostova, A. T. & Ghorab, M. M. (Lead / Corresponding author), 15 Jun 2021, In: Bioorganic & Medicinal Chemistry Letters. 42, 9 p., 128002.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)115 Downloads (Pure) -
Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer
Knatko, E. V., Castro, C., Higgins, M., Zhang, Y., Honda, T., Henderson, C. J., Wolf, C. R., Griffin, J. L. & Dinkova-Kostova, A. T. (Lead / Corresponding author), 15 Sept 2021, In: Communications Biology. 4, 16 p., 1081.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)111 Downloads (Pure) -
The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner
Zhang, Y., Gilmour, A., Ahn, Y.-H., de la Vega, L. & Dinkova-Kostova, A. (Lead / Corresponding author), Jun 2021, In: Phytomedicine. 86, 6 p., 153062.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)220 Downloads (Pure) -
The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress
Moreno Dorta, R., Banerjee, S., Jackson, A. W., Quinn, J., Baillie, G., Dixon, J. E., Dinkova-Kostova, A., Edwards, J. & de la Vega, L. (Lead / Corresponding author), May 2021, In: Cell Death & Differentiation. 28, p. 1563-1578 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (Scopus)116 Downloads (Pure) -
2020
Downregulation of Keap1 confers features of a fasted metabolic state
Knatko, E. V., Tatham, M. H., Zhang, Y., Castro, C., Higgins, M., Dayalan Naidu, S., Leonardi, C., de la Vega, L., Honda, T., Griffin, J. L., Hay, R. T. & Dinkova-Kostova, A. T. (Lead / Corresponding author), 23 Oct 2020, In: iScience. 23, 10, 48 p., 101638.Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Citations (Scopus)147 Downloads (Pure) -
High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro
Torrente Fernandez, L., Maan, G., Rezig, A. O., Quinn, J., Jackson, A., Grilli, A., Casares, L., Zhang, Y., Kulesskiy, E., Saarela, J., Bicciato, S., Edwards, J., Dinkova-Kostova, A. & de la Vega, L. (Lead / Corresponding author), Oct 2020, In: Biomolecules. 10, 10, 16 p., 1365.Research output: Contribution to journal › Article › peer-review
Open AccessFile29 Citations (Scopus)94 Downloads (Pure) -
Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity
Casares Perez, L., Unciti-Broceta, J. D., Prados, M. E., Caprioglio, D., Mattoteia, D., Higgins, M., Apendino, G., Dinkova-Kostova, A. T., Muñoz, E. & de la Vega, L. (Lead / Corresponding author), Oct 2020, In: Redox Biology. 37, 10 p., 101689.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Citations (Scopus)110 Downloads (Pure) -
Measuring Changes in Keap1‐Nrf2 Protein Complex Conformation in Individual Cells by FLIM‐FRET
Dikovskaya, D. (Lead / Corresponding author) & Dinkova-Kostova, A., Sept 2020, In: Current Protocols in Toxicology. 85, 1, 34 p., e96.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)150 Downloads (Pure) -
Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety
Soliman, A. M. (Lead / Corresponding author), Karam, H. M., Mekkawy, M. H., Higgins, M., Dinkova-Kostova, A. & Ghorab, M. M. (Lead / Corresponding author), 15 Aug 2020, In: European Journal of Medicinal Chemistry. 200, 12 p., 112467.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)194 Downloads (Pure) -
Sulfoxythiocarbamate S-4 inhibits HSP90 in human cutaneous squamous cell carcinoma cells
Zhang, Y., VanHecke, G. C., Ahn, Y.-H., Proby, C. M. & Dinkova-Kostova, A. T. (Lead / Corresponding author), 15 Dec 2020, In: European Journal of Pharmacology. 889, 9 p., 173609.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)157 Downloads (Pure) -
2019
Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model
Kalin, J. H. (Lead / Corresponding author), Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T. (Lead / Corresponding author), 13 Mar 2019, In: PLoS ONE. 14, 3, 13 p., e0213095.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)166 Downloads (Pure) -
Measuring the Interaction of Transcription Factor Nrf2 with Its Negative Regulator Keap1 in Single Live Cells by an Improved FRET/FLIM Analysis
Dikovskaya, D. (Lead / Corresponding author), Appleton, P., Bento-Pereira, C. & Dinkova-Kostova, A. (Lead / Corresponding author), 18 Mar 2019, In: Chemical Research in Toxicology. 32, 3, p. 500-512 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)283 Downloads (Pure)