| Status | Finished |
|---|---|
| Effective start/end date | 30/09/14 → 27/02/18 |
Funding
- Biotechnology and Biological Sciences Research Council (BB/L01923X/1): £318,080.00
Related content
Research Outputs
The role of Nrf2 signaling in counteracting neurodegenerative diseases
Research output: Contribution to journal › Review article
The emerging role of Nrf2 in mitochondrial function
Research output: Contribution to journal › Article
SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models
Research output: Contribution to journal › Article
Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model
Research output: Contribution to journal › Article
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
Research output: Contribution to journal › Review article
Nrf2 activation in the treatment of neurodegenerative diseases: A focus on its role in mitochondrial bioenergetics and function
Research output: Contribution to journal › Article
Measuring the Interaction of Transcription Factor Nrf2 with Its Negative Regulator Keap1 in Single Live Cells by an Improved FRET/FLIM Analysis
Research output: Contribution to journal › Article
Phenethyl isothiocyanate, a dual activator of transcription factors NRF2 and HSF1
Research output: Contribution to journal › Review article
KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy
Research output: Contribution to journal › Article
Transcription factors NRF2 and HSF1 have opposing functions in autophagy
Research output: Contribution to journal › Article
KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients
Research output: Contribution to journal › Article
KEAP1 and done? Targeting the NRF2 pathway with sulforaphane: Targeting the NRF2 Pathway with Sulforaphane
Research output: Contribution to journal › Review article
The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics
Research output: Contribution to journal › Article
Activation of Nrf2 signaling augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity
Research output: Contribution to journal › Article
Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection
Research output: Contribution to journal › Article
Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species
Research output: Contribution to journal › Review article
Design, synthesis, and evaluation of triazole derivatives that induce Nrf2 dependent gene products and inhibit the Keap1-Nrf2 protein-protein interaction
Research output: Contribution to journal › Article
Oxidative stress and chronic inflammation in osteoarthritis: can Nrf2 counteract these partners in crime?
Research output: Contribution to journal › Review article
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
Research output: Contribution to journal › Article
New monocyclic, bicyclic, and tricyclic ethynylcyanodienones as activators of the Keap1/Nrf2/ARE pathway and inhibitors of inducible nitric oxide synthase
Research output: Contribution to journal › Article
Broccoli or Sulforaphane: Is It the Source or Dose That Matters?
Research output: Contribution to journal › Review article
Regulation of the mammalian heat shock factor 1
Research output: Contribution to journal › Review article