Research output per year
Research output per year
Search results
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2024
Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation
Erickson, E. C., You, I., Perry, G., Dugourd, A., Donovan, K. A., Crafter, C., Johannes, J. W., Williamson, S., Moss, J. I., Ros, S., Ziegler, R. E., Barry, S. T., Fischer, E. S., Gray, N. S., Madsen, R. R. (Lead / Corresponding author) & Toker, A. (Lead / Corresponding author), 27 Feb 2024, In: Science Signaling. 17, 825Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)97 Downloads (Pure) -
Oncogenic PIK3CA corrupts growth factor signaling specificity
Madsen, R. R. (Lead / Corresponding author), Le Marois, A., Mruk, O., Voliotis, M., Yin, S., Sufi, J., Qin, X., Zhao, S. J., Gorczynska, J., Morelli, D., Davidson, L., Sahai, E., Korolchuk, V. I., Tape, C. J. & Vanhaesebroeck, B., 20 Dec 2024, In: Molecular Systems Biology. 32 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile27 Downloads (Pure) -
Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer
Hillis, A. L. (Lead / Corresponding author), Martin, T. D., Manchester, H. E., Högström, J., Zhang, N., Lecky, E., Kozlova, N., Lee, J., Persky, N. S., Root, D. E., Brown, M., Cichowski, K., Elledge, S. J., Muranen, T., Fruman, D. A., Barry, S. T., Clohessy, J. G., Madsen, R. R. & Toker, A. (Lead / Corresponding author), 1 Oct 2024, In: Cancer Research. 84, 19, p. 3250-3266 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)26 Downloads (Pure) -
Tunable ligand discrimination via kinetic sorting
Dixit, P. (Lead / Corresponding author), Goetz, A. & Madsen, R., 2 Oct 2024, BioRxiv, 17 p.Research output: Working paper/Preprint › Preprint
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2023
PI3K Signaling Through a Biochemical Systems Lens
Madsen, R. R. (Lead / Corresponding author) & Toker, A. (Lead / Corresponding author), Oct 2023, In: Journal of Biological Chemistry. 299, 10, 19 p., 105224.Research output: Contribution to journal › Review article › peer-review
Open AccessFile8 Citations (Scopus)65 Downloads (Pure) -
2021
NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CAH1047R homozygosity in pluripotent stem cells
Madsen, R. R., Longden, J., Knox, R. G., Robin, X., Völlmy, F., Macleod, K. G., Moniz, L. S., Carragher, N. O., Linding, R., Vanhaesebroeck, B. & Semple, R. K., Mar 2021, In: DMM Disease Models and Mechanisms. 14, 3, 12 p., dmm048298.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)48 Downloads (Pure) -
Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype
Madsen, R. R., Erickson, E. C., Rueda, O. M., Robin, X., Caldas, C., Toker, A., Semple, R. K. & Vanhaesebroeck, B., 11 Nov 2021, In: PLoS Genetics. 17, 11, 23 p., e1009876.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)59 Downloads (Pure) -
Transcriptomically-inferred PI3K activity and stemness show a counterintuitive correlation with PIK3CA genotype in breast cancer
Madsen, R. R., Rueda, O. M., Robin, X., Caldas, C., Semple, R. K. & Vanhaesebroeck, B., 15 Apr 2021, BioRxiv, 20 p.Research output: Working paper/Preprint › Preprint
File2 Downloads (Pure)