Towards a Unifying Theory of Parkinson's Disease - Investigation of the Biochemical and Genetic Role of Rab GTPases (joint with German Centre for Neurodegenerative Diseases)

Project Details

StatusFinished
Effective start/end date17/10/16 → 16/10/18

Funding

  • Medical Research Council (MR/P00704X/1): £240,758.00
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Research Output

  • 3 Article
  • 1 Chapter (peer-reviewed)

Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson’s disease kinase

Lis, P., Burel, S., Steger, M., Mann, M., Brown, F., Diez, F., Tonelli, F., Holton, J. L., Winglok Ho, P., Ho, S-L., Chou, M-Y., Polinski, N. K., Martinez, T. N., Davies, P. & Alessi, D. R., 2 Jan 2018, In : Biochemical Journal. 475, 1, p. 1-22 22 p.

Research output: Contribution to journal › Article

Open Access
File
    • 31 Citations (Scopus)
    290 Downloads (Pure)

    Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils

    Fan, Y., Howden, A. J. M., Sarhan, A. R., Lis, P., Ito, G., Martinez, T. N., Brockmann, K., Gasser, T., Alessi, D. R. & Sammler, E., 2 Jan 2018, In : Biochemical Journal. 475, 1, p. 23-44 22 p.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 37 Citations (Scopus)
    190 Downloads (Pure)

    Small-Molecule Inhibitors of LRRK2

    Hatcher, J. M., Choi, H. G., Alessi, D. R. & Gray, N. S., 2017, Leucine-Rich Repeat Kinase 2 (LRRK2). Rideout, H. J. (ed.). Springer International Publishing, p. 241-264 24 p. (Advances in neurobiology; vol. 14).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)

    • 14 Citations (Scopus)