Research output per year
Research output per year
- 13 results
Search results
-
2022
Mapping of a N-terminal α-helix domain required for human PINK1 stabilization, Serine228 autophosphorylation and activation in cells
Kakade, P., Ojha, H., Raimi, O. G., Shaw, A., Waddell, A. D., Ault, J. R., Burel, S., Brockmann, K., Kumar, A., Ahangar, M. S., Krysztofinska, E. M., Macartney, T., Bayliss, R., Fitzgerald, J. C. & Muqit, M. M. K. (Lead / Corresponding author), Jan 2022, In: Open Biology. 12, 1, p. 1-16 16 p., 210264.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)134 Downloads (Pure) -
2021
Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms
Malik, A. U., Karapetsas, A., Nirujogi, R. S., Mathea, S., Chatterjee, D., Pal, P., Lis, P., Taylor, M., Purlyte, E., Gourlay, R., Dorward, M., Weidlich, S., Toth, R., Polinski, N. K., Knapp, S., Tonelli, F. (Lead / Corresponding author) & Alessi, D. (Lead / Corresponding author), 10 Feb 2021, In: Biochemical Journal. 478, 3, p. 553-578 26 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile27 Citations (Scopus)201 Downloads (Pure) -
Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites
Nirujogi, R. S. (Lead / Corresponding author), Tonelli, F., Taylor, M., Lis, P., Zimprich, A., Sammler, E. & Alessi, D. R. (Lead / Corresponding author), 22 Jan 2021, In: Biochemical Journal. 478, 2, p. 299-326 28 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile33 Citations (Scopus)194 Downloads (Pure) -
Impact of Type II LRRK2 inhibitors on signaling and mitophagy
Tasegian, A., Singh, F., Ganley, I. G., Reith, A. D. & Alessi, D. R. (Lead / Corresponding author), 15 Oct 2021, In: Biochemical Journal. 478, 19, p. 3555-3573 19 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile32 Citations (Scopus)133 Downloads (Pure) -
2020
Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease
Taylor, M. & Alessi, D. (Lead / Corresponding author), Apr 2020, In: Current Opinion in Cell Biology. 63, p. 102-113 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile72 Citations (Scopus)265 Downloads (Pure) -
Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity
Kalogeropulou, A. F. (Lead / Corresponding author), Freemantle, J. B., Lis, P., Vides, E. G., Polinski, N. K. & Alessi, D. R. (Lead / Corresponding author), 27 Nov 2020, In: Biochemical Journal. 477, 22, p. 4397-4423 27 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile37 Citations (Scopus)145 Downloads (Pure) -
Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson’s Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation
Fan, Y., Tonelli, F., Padmanabhan, S., Baptista, M., Riley, L., Smith, D., Marras, C., Howden, A., Alessi, D. & Sammler, E. (Lead / Corresponding author), 22 Mar 2020, In: JoVE: Journal of Visualized Experiments. 157, e58956.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)263 Downloads (Pure) -
Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2
Waschbüsch, D., Purlyte, E., Pal, P., McGrath, E., Alessi, D. R. & Khan, A. R. (Lead / Corresponding author), 7 Apr 2020, In: Structure. 28, 4, p. 406-417.e6 19 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile43 Citations (Scopus)141 Downloads (Pure) -
2019
PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
Berndsen, K., Lis, P., Yeshaw, W. M., Wawro, P. S., Nirujogi, R., Wightman, M., Macartney, T., Dorward, M., Knebel, A., Tonelli, F., Pfeffer, S. R. & Alessi, D. (Lead / Corresponding author), 12 Nov 2019, In: eLife. 8, 37 p., e50416.Research output: Contribution to journal › Article › peer-review
Open AccessFile77 Citations (Scopus)171 Downloads (Pure) -
2018
Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson’s disease kinase
Lis, P., Burel, S., Steger, M., Mann, M., Brown, F., Diez, F., Tonelli, F., Holton, J. L., Winglok Ho, P., Ho, S.-L., Chou, M.-Y., Polinski, N. K., Martinez, T. N., Davies, P. & Alessi, D. R. (Lead / Corresponding author), 2 Jan 2018, In: Biochemical Journal. 475, 1, p. 1-22 22 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile92 Citations (Scopus)490 Downloads (Pure) -
Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils
Fan, Y., Howden, A. J. M., Sarhan, A. R., Lis, P., Ito, G., Martinez, T. N., Brockmann, K., Gasser, T., Alessi, D. R. (Lead / Corresponding author) & Sammler, E. (Lead / Corresponding author), 2 Jan 2018, In: Biochemical Journal. 475, 1, p. 23-44 22 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile108 Citations (Scopus)297 Downloads (Pure) -
LRRK2 activation in idiopathic Parkinson's disease
Di Maio, R., Hoffman, E. K., Rocha, E. M., Keeney, M. T., Sanders, L. H., De Miranda, B. R., Zharikov, A., Van Laar, A., Stepan, A. F., Lanz, T. A., Kofler, J. K., Burton, E. A., Alessi, D. R., Hastings, T. G. & Timothy Greenamyre, J. (Lead / Corresponding author), 25 Jul 2018, In: Science Translational Medicine. 10, 451, p. 1-12 12 p., eaar5429.Research output: Contribution to journal › Article › peer-review
Open AccessFile336 Citations (Scopus)395 Downloads (Pure) -
2017
Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis
Steger, M., Diez, F., Dhekne, H. S., Lis, P., Nirujogi, R. S., Karayel, O., Tonelli, F., Martinez, T. N., Lorentzen, E., Pfeffer, S. R., Alessi, D. R. (Lead / Corresponding author) & Mann, M., 10 Nov 2017, In: eLife. 6, p. 1-22 22 p., e31012.Research output: Contribution to journal › Article › peer-review
Open AccessFile288 Citations (Scopus)368 Downloads (Pure)