Keyphrases
Trypanosoma Cruzi (T. cruzi)
90%
Drug Discovery
85%
Chagas Disease
57%
Visceral Leishmaniasis
52%
Molecular Targets
48%
Leishmania Donovani
47%
Drug Target
45%
Preclinical Candidate
37%
Trypanosomatids
36%
Plasmodium Falciparum
35%
African Trypanosomes
34%
Trypanosoma Brucei
34%
Infectious Diseases
31%
Protease Inhibitors
31%
Malaria
30%
Mode of Action
29%
Trypanosome
27%
LysR Family
26%
Thermal Proteome Profiling
26%
Benzoxaborole
26%
RapidFire Mass Spectrometry
26%
Mechanism of Action
25%
Leucyl Aminopeptidase
25%
T. Brucei
25%
Leishmania
24%
High-throughput Screening Assays
24%
Cryptosporidium
24%
Plasmodium
23%
New Drugs
23%
Spike Glycoprotein
22%
Dundee
22%
Antileishmanial
22%
Phenotypic Screening
20%
Small Molecules
19%
Alternative Polyadenylation
18%
Covalent Inhibitor
18%
Human African Trypanosomiasis
18%
Bloodstream Forms
18%
Clinical Development
18%
Drug Resistance
18%
Drug Development
18%
Putative Drug Targets
17%
Cas9 Protein
17%
Specificity Factor
16%
Target Engagement
16%
Kinetoplastid
16%
Cysteine
16%
Veterinary
16%
Trypanocidal Activity
16%
Oligo
16%
Murals
16%
Leishmania Major
16%
Fragment Molecular Orbital Method
16%
Guanine
16%
Current Treatment
15%
Protozoan Parasites
15%
Wellcome
14%
Anti-infective
14%
Prodrug
14%
Causative Agents
14%
Neglected Tropical Diseases
13%
Aquaporin-2 (AQP2)
13%
Cytochrome b
13%
Pharmacokinetics
13%
Resistance mutations
12%
Specific Inhibitor
12%
Chymotrypsin
12%
Active Sites
12%
Antimalarial Drug Discovery
12%
Compound Optimization
12%
Pullout
12%
Mass Spectrometry
12%
African Trypanosomiasis
12%
Disease Areas
12%
Antileishmanial Compounds
12%
Neglected Infectious Diseases
12%
EC50
12%
Cross-resistance
12%
Resistance Profiling
12%
Metabolism
12%
Leishmania Infantum
11%
Recombinant
11%
Selective Inhibitor
11%
Low-middle Income Countries
10%
Cytochrome bc1 Complex
10%
Proteasome Inhibition
10%
Rapid Assessment
10%
Pyrrolopyrimidine
10%
Short Course
10%
Mycobacterium Tuberculosis (M. tb)
10%
Binding Affinity
10%
Electron Transport Chain
10%
N7-methyltransferase
10%
New Therapeutics
10%
Pharmacokinetic Properties
10%
Genetic Diversity
10%
DNA Replication
9%
CYP51
9%
Screening Library
9%
Death Rate
9%
Glycoprotein Gene
9%
Parasitic Diseases
9%
New Medicines
9%
Drug pipeline
9%
High-throughput
9%
Potent Inhibitor
9%
High Efficiency
9%
Unbiased Approach
9%
L. Major
9%
Benznidazole
9%
Chagas Disease Drug Discovery
9%
Treatment Options
8%
In Vivo Efficacy
8%
Drug Candidates
8%
Protein Targeting
8%
Mouse Infection
8%
Structure-activity Relationship
8%
Knockdown
8%
Resistance Factor
8%
Oxidosqualene Cyclase
8%
Base Editing
8%
Disubstituted piperazines
8%
Pharmacological Validation
8%
Allosteric Binding Site
8%
DNA Damage Foci
8%
Cell-free Lysate
8%
Antichagasic Activity
8%
Tropical Infectious Diseases
8%
Imaging Rate
8%
Compound Profiling
8%
Target Cleavage
8%
Antibiotic Drug Development
8%
Bias Control
8%
Oxaboroles
8%
Methionyl-tRNA Synthetase
8%
Binding Affinity Prediction
8%
Warhead Reactivity
8%
Covalent Warheads
8%
Non-structural Protein 14
8%
Faba
8%
Drug Discovery Research
8%
Malaria Prevention
8%
Nitroindole
8%
Compound 8
8%
Aryl Aldehydes
8%
Resistance Mapping
8%
Engagement Strategies
8%
Public Engagement
8%
β-lactam Antibiotics
8%
MRNA Abundance
8%
Economic Burden
8%
Protein Synthesis
8%
Malaria Treatment
8%
COVID-19
8%
Drug Resistance mutations
8%
Kinetic Characterization
8%
Codon
8%
Anti-trypanosomatid Drugs
8%
Selection Marker
8%
Apicomplexan
8%
Codon Usage Bias
8%
Oral Drugs
8%
Gluconeogenesis
8%
Allele-specific Expression
8%
Glycerol
8%
Lysate
8%
Multidrug-resistant
8%
Acetyl Coenzyme A (acetyl-CoA)
8%
Epigenetic Inheritance
8%
Regulon
8%
RNA Interference Screen
8%
Tropical Diseases
8%
Water Molecule
8%
Development Needs
8%
Luminescence
8%
Ghana
8%
Expression in Escherichia Coli
8%
Structure-based Design
8%
Ligand Binding
8%
Demethylase
8%
Drug Metabolism
8%
Targeted Gene Delivery
8%
High-content Assay
8%
Live Imaging
8%
Poor People
8%
Scaffold Hopping
8%
Recombination
8%
Global Health
8%
Carboxypeptidase
8%
Sterols
8%
Pyridazinone
8%
Chemical Diversity
8%
Protein Abundance
8%
Peptidase
8%
Synthetase
8%
Chronic Chagas Disease
8%
Cultural Institutions
8%
Jigsaw Puzzle
8%
Post-transcriptional
8%
Guide RNA (gRNA)
8%
Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
100%
Chagas Disease
71%
Trypanosoma Cruzi
69%
Diseases
54%
Visceral Leishmaniasis
51%
Proteasome
45%
High-Throughput Screening
40%
Pharmacokinetics
32%
Infection
32%
African Trypanosomiasis
32%
Leishmania
30%
Proteasome Inhibitor
27%
Cytosol Aminopeptidase
26%
Drug Development
25%
Tropical Disease
24%
Trypanosomatidae
24%
Cysteine
24%
Molecular Target
23%
Antimalarial Agent
22%
Protozoon
22%
Kinetoplastida
21%
Structure Activity Relationship
20%
Drug Resistance
19%
Infectious Agent
17%
Leishmania Major
16%
Lysine Transfer RNA Ligase
16%
Cryptosporidium
16%
Plasmodium
15%
Cleavage and Polyadenylation Specificity Factor
15%
Trypanosoma Brucei
14%
Leishmania donovani
14%
Amastigote
13%
Cytochrome B
13%
Amino Acid
13%
Mouse Model
12%
Acoziborole
12%
Trypanosoma
12%
Binding Site
11%
Proteome
10%
Coenzyme Q - Cytochrome C Reductase
10%
Antimicrobial Agent
10%
Antibiotics
10%
Prodrug
10%
Hexachlorophene
10%
Clinical Trial
10%
Plasmodium falciparum
10%
Benznidazole
9%
EC50
9%
Parasitosis
8%
Chymotrypsin
8%
Antibiotic Agent
8%
Beta Lactam Antibiotic
8%
Lysine
8%
Aminopeptidase
8%
Serine
8%
Piperazine Derivative
8%
Methionine Transfer RNA Ligase
8%
Escherichia coli
8%
Histidine
8%
Threonine
8%
Arginine
8%
Lead Compound
8%
Methyltransferase
8%
Guanine
8%
Carboxypeptidase
8%
Peptidase
8%
Melarsoprol
8%
Apicomplexa
8%
SARS Coronavirus
8%
Drug Metabolism
8%
Bacterial Infection
8%
Molecular Orbital
8%
Dimethyl Sulfoxide
8%
Carbon 14
8%
Pharmaceutical Chemistry
8%
Cryo-Electron Microscopy
7%
Adenosine Triphosphate
7%
Neglected Disease
7%
Enzyme Inhibition
6%
Leishmaniasis
6%
Leishmania infantum
6%
Combination Therapy
6%
Hydration
6%
Ubenimex
5%
Luciferase
5%
Phosphotransferase
5%
Malate Dehydrogenase (Decarboxylating)
5%
Lactam
5%
Electrophile
5%
Wild Type Mouse
5%
Target Identification
5%
Epimastigote
5%
Immunology and Microbiology
Trypanosoma Cruzi
66%
Visceral Leishmaniasis
64%
Chagas Disease
59%
Trypanosoma
54%
Proteasome
50%
Trypanosomatid
42%
Leishmania donovani
39%
Transfer RNA
38%
Drug Resistance
29%
High Throughput Screening
24%
CRISPR/Cas9
24%
Cryptosporidium
24%
Infectious Agent
23%
Protozoa
23%
Trypanosoma Brucei
22%
Polyadenylation
20%
Kinetoplastida
18%
Wild Type
18%
Mouse Model
18%
Leishmania
17%
Infectious Disease
17%
Aminopeptidase
16%
Glycoprotein
12%
Codon
12%
Mutagenesis
12%
Amastigote
12%
Cosmid
12%
Cytochrome P450
12%
Amino Acid
12%
Whole Genome Sequencing
11%
Antimalarial Agent
10%
Promastigote
10%
Antimicrobial Agent
10%
Plasmodium falciparum
10%
Plasmodium
10%
Parasitic Disease
10%
Life Cycle
10%
Pharmacokinetics
10%
Binding Site
9%
Protein Degradation
9%
Genetic Variability
9%
Genetic Transfection
8%
Protein Synthesis
8%
Sterol Synthesis
8%
Trans-Splicing
8%
Gluconeogenesis
8%
Regulon
8%
Intracellular Parasite
8%
Apicomplexa
8%
Escherichia coli
8%
Drug Sensitivity
8%
Clustered Regularly Interspaced Short Palindromic Repeat
8%
Leishmania Major
8%
Drug Metabolism
8%
Gene Amplification
8%
Enantiomer
8%
Trypanosoma Congolense
8%
DNA Damage
8%
Essential Gene
8%
Gene Editing
8%
Cross-Resistance
8%
Untranslated Region
8%
Wild Type Mouse
8%
Metabolite
8%
DNA Synthesis
8%
RNAI
8%
Phylogenomics
8%
Glycerol
8%
Serine
8%
Cysteine
8%
Codon Usage Bias
8%
Cytochrome
8%
Benznidazole
8%
Transcriptome
8%
Neglected Disease
6%
Epimastigote
6%
Cryo-Electron Microscopy
6%
Chemotype
6%
DNA Template
6%
Solution and Solubility
6%
Parasite Load
6%
EC50
6%
Enzyme Inhibition
6%
Bestatin
5%
Protein RNA Binding
5%
Cell Line
5%
Gene Inactivation
5%
Transcriptomics
5%
Trypomastigote
5%
Codon Usage
5%
Respiratory Chain
5%