Keyphrases
3′-untranslated Region (3′-UTR)
7%
Acetyl Coenzyme A (acetyl-CoA)
7%
Active Sites
10%
African Trypanosomes
34%
African Trypanosomiasis
11%
Allele-specific Expression
7%
Allosteric Binding Site
7%
Alternative Polyadenylation
16%
Aminopeptidase
7%
Anti-infective
14%
Anti-trypanosomatid Drugs
7%
Antibiotic Drug Development
7%
Antichagasic Activity
7%
Antileishmanial
21%
Antileishmanial Compounds
11%
Antimalarial Drug Discovery
11%
Apicomplexan
7%
Aquaporin-2 (AQP2)
13%
Aryl Aldehydes
7%
Base Editing
7%
Benznidazole
8%
Benzoxaborole
25%
Bias Control
7%
Binding Affinity
7%
Binding Affinity Prediction
7%
Bloodstream Forms
18%
Carboxypeptidase
7%
Cas9 Protein
17%
Causative Agents
10%
Cell-free Lysate
7%
Chagas Disease
51%
Chagas Disease Drug Discovery
8%
Chemical Diversity
7%
Chronic Chagas Disease
7%
Chymotrypsin
10%
Clinical Development
18%
Codon
7%
Codon Usage Bias
7%
Compound 8
7%
Compound Optimization
11%
Compound Profiling
7%
Covalent Inhibitor
18%
Covalent Warheads
7%
COVID-19
7%
Cross-resistance
7%
Cryptosporidium
23%
Cultural Institutions
7%
Current Treatment
15%
CYP51
9%
Cysteine
15%
Cytochrome bc1 Complex
10%
Cytochrome P450 Reductase
7%
Death Rate
9%
Demethylase
7%
Development Needs
7%
Disease Areas
11%
Disubstituted piperazines
7%
DNA Damage Foci
7%
DNA Replication
9%
Drug Candidates
8%
Drug Development
17%
Drug Discovery
79%
Drug Discovery Research
7%
Drug Metabolism
7%
Drug pipeline
9%
Drug Resistance
14%
Drug Resistance mutations
7%
Drug Target
40%
Dundee
22%
EC50
11%
Economic Burden
7%
Engagement Strategies
7%
Epigenetic Inheritance
7%
Expression in Escherichia Coli
7%
Faba
7%
Fragment Molecular Orbital Method
15%
Genetic Diversity
9%
Genome-scale
7%
Ghana
7%
Global Health
7%
Gluconeogenesis
7%
Glycerol
7%
Glycoprotein Gene
9%
Guanine
7%
Guide RNA (gRNA)
7%
High Efficiency
9%
High-content Assay
7%
High-throughput
9%
High-throughput Screening Assays
23%
Human African Trypanosomiasis
18%
Imaging Rate
7%
In Vivo Efficacy
8%
Infectious Diseases
25%
Jigsaw Puzzle
7%
Kinetic Characterization
7%
Kinetoplastid
15%
Knockdown
8%
L. Major
9%
Leishmania
22%
Leishmania Donovani
47%
Leishmania Infantum
11%
Leishmania Major
15%
Leucyl Aminopeptidase
25%
Ligand Binding
7%
Live Imaging
7%
Low-middle Income Countries
10%
Luminescence
7%
Lysate
7%
LysR Family
26%
Malaria
22%
Malaria Prevention
7%
Malaria Treatment
7%
Mass Spectrometry
11%
Mechanism of Action
21%
Melarsoprol
7%
Metabolism
11%
Methionyl-tRNA Synthetase
7%
Mode of Action
29%
Molecular Targets
44%
Mouse Infection
8%
MRNA Abundance
7%
Multidrug-resistant
7%
Murals
15%
Neglected Infectious Diseases
11%
Neglected Tropical Diseases
13%
New Drugs
19%
New Medicines
9%
New Therapeutics
8%
Nitroindole
7%
Non-structural Protein 14
7%
Oligo
15%
Oral Drugs
7%
Oxaboroles
7%
Oxidosqualene Cyclase
7%
Parasitic Diseases
9%
Peptidase
7%
Pharmacokinetic Properties
10%
Pharmacokinetics
13%
Pharmacological Validation
7%
Phenotypic Screening
20%
Plasmodium
19%
Plasmodium Falciparum
27%
Poor People
7%
Post-transcriptional
7%
Preclinical Candidate
37%
Prodrug
14%
Protease Inhibitors
27%
Proteasome Inhibition
10%
Protein Abundance
7%
Protein Synthesis
7%
Protein Targeting
8%
Protozoan Parasites
12%
Public Engagement
7%
Pullout
11%
Putative Drug Targets
17%
Pyridazinone
7%
Pyrrolopyrimidine
10%
Rapid Assessment
10%
RapidFire Mass Spectrometry
25%
Recombinant
9%
Recombination
7%
Regulon
7%
Relative Fitness
7%
Replication Protein A
7%
Resistance Factor
7%
Resistance Mapping
7%
Resistance mutations
12%
RNA Interference Screen
7%
Scaffold Hopping
7%
Selection Marker
7%
Selective Inhibitor
9%
Short Course
10%
Small Molecules
11%
Specificity Factor
16%
Spike Glycoprotein
22%
Sterols
7%
Structure-activity Relationship
8%
Structure-based Design
7%
Synthetase
7%
T. Brucei
24%
Target Cleavage
7%
Target Engagement
15%
Targeted Gene Delivery
7%
Thermal Proteome Profiling
26%
Treatment Options
8%
Tropical Diseases
7%
Tropical Infectious Diseases
7%
Trypanocidal Activity
15%
Trypanosoma Brucei
33%
Trypanosoma Cruzi (T. cruzi)
73%
Trypanosomatids
34%
Trypanosome
26%
Unbiased Approach
9%
Veterinary
15%
Visceral Leishmaniasis
51%
Warhead
7%
Warhead Reactivity
7%
Water Molecule
7%
Wellcome
14%
β-lactam Antibiotics
7%
Pharmacology, Toxicology and Pharmaceutical Science
Acoziborole
11%
Adenosine Triphosphate
7%
African Trypanosomiasis
31%
Amastigote
13%
Amino Acid
13%
Aminopeptidase
7%
Antibiotic Agent
7%
Antibiotics
10%
Antimalarial Agent
18%
Antimicrobial Agent
10%
Apicomplexa
7%
Arginine
7%
Bacterial Infection
7%
Benznidazole
9%
Beta Lactam Antibiotic
7%
Binding Site
11%
Carbon 14
7%
Carboxypeptidase
7%
Chagas Disease
66%
Chymotrypsin
8%
Cleavage and Polyadenylation Specificity Factor
15%
Clinical Trial
9%
Coenzyme Q - Cytochrome C Reductase
10%
Combination Therapy
7%
Cryo-Electron Microscopy
7%
Cryptosporidium
15%
Cysteine
23%
Cytochrome B
5%
Cytosol Aminopeptidase
25%
Dimethyl Sulfoxide
7%
Disease
35%
Diseases
5%
Drug Development
22%
Drug Discovery
100%
Drug Metabolism
7%
Drug Resistance
15%
EC50
9%
Electrophile
5%
Enzyme Inhibition
6%
Epimastigote
5%
Escherichia coli
7%
Guanine
7%
Hexachlorophene
9%
High-Throughput Screening
39%
Histidine
7%
Hydration
5%
Infection
46%
Infectious Agent
17%
Kinetoplastida
21%
Lactam
5%
Lead Compound
7%
Leishmania
30%
Leishmania donovani
14%
Leishmania infantum
6%
Leishmania Major
15%
Leishmaniasis
6%
Luciferase
5%
Lysine
7%
Lysine Transfer RNA Ligase
15%
Malate Dehydrogenase (Decarboxylating)
5%
Melarsoprol
7%
Methionine Transfer RNA Ligase
7%
Methyltransferase
7%
Molecular Orbital
7%
Molecular Target
19%
Mouse Model
12%
Parasitosis
13%
Peptidase
7%
Pharmaceutical Chemistry
5%
Pharmacokinetics
33%
Phosphotransferase
5%
Piperazine Derivative
7%
Plasmodium
11%
Prodrug
10%
Proteasome
45%
Proteasome Inhibitor
27%
Protozoon
19%
SARS Coronavirus
7%
Serine
7%
Structure Activity Relationship
12%
Target Identification
5%
Threonine
7%
Tropical Disease
24%
Trypanosoma
11%
Trypanosoma Brucei
14%
Trypanosoma Cruzi
61%
Trypanosomatidae
24%
Ubenimex
5%
Visceral Leishmaniasis
50%
Wild Type Mouse
5%
Immunology and Microbiology
Amastigote
9%
Aminopeptidase
15%
Antimalarial Agent
26%
Antimicrobial Agent
10%
Apicomplexa
7%
Benznidazole
7%
Bestatin
5%
Binding Site
9%
Cell Line
5%
Chagas Disease
57%
Chemotype
10%
Clustered Regularly Interspaced Short Palindromic Repeat
7%
Codon
12%
Codon Usage
5%
Codon Usage Bias
7%
Cosmid
10%
CRISPR/Cas9
23%
Cross-Resistance
7%
Cryo-Electron Microscopy
6%
Cryptosporidium
15%
DNA Damage
7%
DNA Synthesis
7%
DNA Template
10%
Drug Metabolism
7%
Drug Resistance
29%
Drug Sensitivity
7%
EC50
5%
Enantiomer
7%
Epimastigote
6%
Escherichia coli
7%
Essential Gene
7%
Gene Amplification
7%
Gene Editing
7%
Gene Expression
7%
Gene Inactivation
5%
Genetic Transfection
8%
Genetic Variability
9%
Gluconeogenesis
7%
Glycoprotein
13%
High Throughput Screening
23%
Infectious Agent
21%
Infectious Disease
14%
Intracellular Parasite
7%
Kinetoplastida
18%
Leishmania
15%
Leishmania donovani
40%
Leishmania Major
7%
Life Cycle
10%
Metabolite
7%
Mouse Model
8%
Mutagenesis
12%
Neglected Disease
6%
Parasite Load
5%
Parasitic Disease
10%
Parasitology
55%
Pharmacokinetics
5%
Phylogenomics
7%
Plasmodium
9%
Plasmodium falciparum
9%
Polyadenylation
20%
Promastigote
10%
Proteasome
42%
Protein Function
5%
Protein RNA Binding
5%
Protein Synthesis
7%
Protozoa
20%
Regulon
7%
Respiratory Chain
5%
RNAI
7%
Solution and Solubility
6%
Sterol Synthesis
7%
Trans-Splicing
7%
Transcriptome
7%
Transcriptomics
5%
Transfer RNA
7%
Trypanosoma
56%
Trypanosoma Brucei
22%
Trypanosoma Congolense
7%
Trypanosoma Cruzi
58%
Trypanosomatid
41%
Trypomastigote
5%
Untranslated Region
7%
Visceral Leishmaniasis
61%
Whole Genome Sequencing
11%
Wild Type
18%
Wild Type Mouse
7%