Research output per year
Research output per year
- 1 - 50 out of 63 results
Search results
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2025
Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach
Gray, D. (Lead / Corresponding author), Pearson, L.-A., Petit, A.-P., Mendoza Martinez, C., Bellany, F., Lin, D., Niven, S., Swift, R., Eadsforth, T., Fyfe, P., Paul, M., Postis, V., Hu, X. & Cowling, V., 17 Feb 2025, In: Biochemical Journal. p. 209-224 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Different chemical scaffolds bind to L-phe site in Mycobacterium tuberculosis Phe-tRNA synthetase
Gade, P., Chang, C., Pryde, D., Fletcher, D., Niven, S., Godoy Magalhaes, L., Robinson, D. A., Saini, J., Ezzat Girgis Fahmy Ibrahim, P., Forte, B., Wower, J., Bodkin, M., Baragana, B. (Lead / Corresponding author), Gilbert, I., Michalska, K. & Joachimiak, A., 5 Apr 2025, In: European Journal of Medicinal Chemistry. 287, 12 p., 117335.Research output: Contribution to journal › Article › peer-review
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Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors
Eadsforth, T., Torrie, L., Rowland, P., Edgar, E. V., MacLean, L., Paterson, C., Robinson, D. A., Shepherd, S. M., Thomas, J., Thomas, M., Gray, D., Postis, V. & De Rycker, M. (Lead / Corresponding author), Jan 2025, In: Journal of Biological Chemistry. 301, 1, 17 p., 108049.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)2 Downloads (Pure) -
2024
Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism
MacLeod, A. K., Coquelin, K.-S., Huertas, L., Simeons, F. R. C., Riley, J., Casado, P., Guijarro, L., Casanueva, R., Frame, L., Pinto, E. G., Ferguson, L., Duncan, C., Mutter, N., Shishikura, Y., Henderson, C. J., Cebrian, D., Wolf, C. R. & Read, K. D. (Lead / Corresponding author), 13 Feb 2024, In: Proceedings of the National Academy of Sciences. 121, 7, p. 1-12 12 p., 2315069121.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)147 Downloads (Pure) -
Accurate prediction of dynamic protein-ligand binding using P-score ranking
E. G. F. Ibrahim, P., Zuccotto, F., Zachariae, U., Gilbert, I. & Bodkin, M. (Lead / Corresponding author), 30 Jul 2024, In: Journal of Computational Chemistry. 45, 20, p. 1762-1778 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)82 Downloads (Pure) -
Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy
Caldwell, N., Peet, C., Miller, P., Colon, B., Taylor, M., Cocco, M., Dawson, A., Lukac, I., Teixeira, J. E., Robinson, L., Frame, L., Seizova, S., Damerow, S., Tamaki, F., Post, J., Riley, J., Mutter, N., Hanna, J. C., Ferguson, L. & Hu, X. & 13 others, , 23 Oct 2024, In: Science Translational Medicine. 16, 770, p. 1-12 12 p., eadm8631.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)172 Downloads (Pure) -
HTS Library Plate Rejuvenation Using a DMSO-Rich Atmosphere
Hughes, F., Cookson, A. (Lead / Corresponding author), Tamaki, F., Bailey, C., Gray, D., Wrobel, K., Cookson, K., Bell, S. & Tarver, G., Dec 2024, In: SLAS Technology. 29, 6, 10 p., 100204.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Identification and Validation of Compounds Targeting Leishmania major Leucyl-Aminopeptidase M17
Aguado, M. E., Carvalho, S., Valdés-Tresanco, M. E., Lin, D., Padilla-Mejia, N., Corpas-Lopez, V., Tesařová, M., Lukeš, J., Gray, D., González-Bacerio, J. (Lead / Corresponding author), Wyllie, S. (Lead / Corresponding author) & Field, M. C. (Lead / Corresponding author), 14 Jun 2024, In: ACS Infectious Diseases. 10, 6, p. 2002-2017 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)74 Downloads (Pure) -
Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity
Izquierdo, M., Lin, D., O'Neill, S., Webster, L. A., Paterson, C., Thomas, J., Aguado, M. E., Colina Araújo, E., Alpízar-Pedraza, D., Joji, H., MacLean, L., Hope, A., Gray, D. W., Zoltner, M., Field, M. C., González-Bacerio, J. (Lead / Corresponding author) & De Rycker, M. (Lead / Corresponding author), 15 Feb 2024, In: PLoS Neglected Tropical Diseases. 18, 2, 20 p., e0011956.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)83 Downloads (Pure) -
ResMAP – a saturation mutagenesis platform enabling parallel profiling of target-specific resistance conferring mutations in Plasmodium
Wall, R. (Lead / Corresponding author), MacGowan, S., Hallyburton, I., Syed, A., Ajay Castro, S., Dey, G., Milne, R., Patterson, S., Phelan, J., Wiedemar, N. W. & Wyllie, S. (Lead / Corresponding author), Oct 2024, In: MBio. 15, 10, 19 p., e01708-24.Research output: Contribution to journal › Article › peer-review
Open AccessFile43 Downloads (Pure) -
Sterol 14-alpha demethylase (CYP51) activity in Leishmania donovani is likely dependent upon cytochrome P450 reductase 1
Tulloch, L., Tinti, M., Wall, R., Weidt, S. K., Corpas Lopez, V., Dey, G., Smith, T. K., Fairlamb, A., Barrett, M. P. & Wyllie, S. (Lead / Corresponding author), 11 Jul 2024, In: PLoS Pathogens. 20, 7, 23 p., e1012382.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)78 Downloads (Pure) -
Synthesis of Nitrostyrylthiazolidine-2,4-dione Derivatives Displaying Antileishmanial Potential
Khoumeri , O. (Lead / Corresponding author), Hutter, S., Primas, N., Castera-Ducros, C., Carvalho, S., Wyllie, S., Lotfi Efrit, M., Fayolle, D., Since, M., Vanelle, P., Verhaeghe, P., Azas, N. & El-Kashef, H., Jul 2024, In: Pharmaceuticals . 17, 7, 23 p., 878.Research output: Contribution to journal › Article › peer-review
Open AccessFile73 Downloads (Pure) -
Validation of Trypanosoma cruzi inactivation techniques for laboratory use
MacLean, L. M. (Lead / Corresponding author), Ariyanayagam, M., Sastry, L., Paterson, C., De Rycker, M. & Fairlamb, A. H. (Lead / Corresponding author), 18 Apr 2024, In: PLoS ONE. 19, 4, 12 p., e0300021.Research output: Contribution to journal › Article › peer-review
Open AccessFile67 Downloads (Pure) -
2023
Chemical pulldown combined with mass spectrometry to identify the molecular targets of antimalarials in cell-free lysates
Smith, R. J., Milne, R., Lopez, V. C., Wiedemar, N., Dey, G., Syed, A. J., Patterson, S. (Lead / Corresponding author) & Wyllie, S. (Lead / Corresponding author), 17 Mar 2023, In: STAR Protocols. 4, 1, 30 p., 102002.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)170 Downloads (Pure) -
Design and synthesis of covalent inhibitors of FabA
Martin, J. S., Mackenzie, C. J., Lin, D., Homeyer, N., Gray, D. W., Zuccotto, F. & Gilbert, I. H. (Lead / Corresponding author), 11 Apr 2023, In: ACS Omega. 8, 14, p. 12787–12804 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)118 Downloads (Pure) -
Design of the Global Health chemical diversity library v2 for screening against infectious diseases
Wilson, C., Gardner, J. M. F., Gray, D., Baragana, B., Wyatt, P., Cookson, A., Thompson, S., Mendoza Martinez, C., Bodkin, M., Gilbert, I. (Lead / Corresponding author) & Tarver, G. (Lead / Corresponding author), 27 Dec 2023, In: PLoS Neglected Tropical Diseases. 17, 12, 13 p., e0011799.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)108 Downloads (Pure) -
Development of a 2,4-diaminothiazole series for the treatment of human African trypanosomiasis highlights the importance of static-cidal screening of analogues
Cleghorn, L. A. T., Wall, R. J., Albrecht, S., MacGowan, S. A., Norval, S., De Rycker, M., Woodland, A., Spinks, D., Thompson, S., Patterson, S., Corpas Lopez, V., Dey, G., Collie, I. T., Hallyburton, I., Kime, R., Simeons, F. R. C., Stojanovski, L., Frearson, J. A., Wyatt, P. G. & Read, K. D. & 2 others, , 13 Jul 2023, In: Journal of Medicinal Chemistry. 66, 13, p. 8896–8916 21 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)105 Downloads (Pure) -
DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1
Braillard, S., Keenan, M., Breese, K. J., Heppell, J., Abbott, M., Islam, R., Shackleford, D. M., Katneni, K., Crighton, E., Chen, G., Patil, R., Lee, G., White, K. L., Carvalho, S., Wall, R. J., Chemi, G., Zuccotto, F., Gonzalez, S., Marco, M. & Deakyne, J. & 18 others, , 13 Dec 2023, In: Science Translational Medicine. 15, 726, 15 p., eadh9902.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)128 Downloads (Pure) -
Mode of action studies confirm on-target engagement of lysyl-tRNA synthetase inhibitor and lead to new selection marker for Cryptosporidium
Hanna, J. C. .., Corpas Lopez, V., Seizova, S., Colon, B. L., Bacchetti, R., Hall, G. M. J., Sands, E. M., Robinson, L., Baragaña, B., Wyllie, S. (Lead / Corresponding author) & Pawlowic, M. (Lead / Corresponding author), 4 Aug 2023, In: Frontiers in Cellular and Infection Microbiology. 13, 14 p., 1236814.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)138 Downloads (Pure) -
RES-Seq – a barcoded library of drug-resistant Leishmania donovani allowing rapid assessment of cross-resistance and relative fitness
Tulloch, L. B., Carvalho, S., Lima, M., Wall, R. J., Tinti, M., Pinto, E. G., MacLean, L. & Wyllie, S. (Lead / Corresponding author), 19 Dec 2023, In: MBio. 14, 6, 15 p., e01803-23.Research output: Contribution to journal › Article › peer-review
Open AccessFile50 Downloads (Pure) -
Short-course combination treatment for experimental chronic Chagas disease
González, S., Wall, R. J., Thomas, J., Braillard, S., Brunori, G., Camino Díaz, I., Cantizani, J., Carvalho, S., Castañeda Casado, P., Chatelain, E., Cotillo, I., Fiandor, J. M., Francisco, A. F., Grimsditch, D., Keenan, M., Kelly, J. M., Kessler, A., Luise, C., Lyon, J. J. & MacLean, L. & 10 others, , 13 Dec 2023, In: Science Translational Medicine. 15, 726, 17 p., adg8105.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)117 Downloads (Pure) -
Small-molecule antibiotic drug development: need and challenges
Bergkessel, M. (Lead / Corresponding author), Forte, B. (Lead / Corresponding author) & Gilbert, I. H. (Lead / Corresponding author), 10 Nov 2023, In: ACS Infectious Diseases. 9, 11, p. 2032-2071 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile27 Citations (Scopus)164 Downloads (Pure) -
SophosQM: Accurate Binding Affinity Prediction in Compound Optimization
Guareschi, R., Lukac, I., Gilbert, I. H. (Lead / Corresponding author) & Zuccotto, F. (Lead / Corresponding author), 2 May 2023, In: ACS Omega. 8, 17, p. 15083-15098 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)205 Downloads (Pure) -
Structure Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors
Thomas, M. G., McGonagle, K., Rowland, P., Robinson, D. A., Dodd, P. G., Camino-Díaz, I., Campbell, L., Cantizani, J., Castañeda, P., Conn, D., Craggs, P. D., Edwards, D., Ferguson, L., Fosberry, A., Frame, L., Goswami, P., Hu, X., Korczynska, J., MacLean, L. & Martin, J. & 21 others, , 10 Aug 2023, In: Journal of Medicinal Chemistry. 66, 15, p. 10413-10431 19 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)140 Downloads (Pure) -
The critical role of mode of action studies in kinetoplastid drug discovery
Fairlamb, A. H. (Lead / Corresponding author) & Wyllie, S. (Lead / Corresponding author), 10 May 2023, In: Frontiers in Drug Discovery. 3, 13 p., 1185679.Research output: Contribution to journal › Article › peer-review
Open AccessFile74 Downloads (Pure) -
2022
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention
Summers, R. L., Pasaje, C. F. A., Pisco, J. P., Striepen, J., Luth, M. R., Kumpornsin, K., Carpenter, E. F., Munro, J. T., Lin, D., Plater, A., Punekar, A. S., Shepherd, A. M., Shepherd, S. M., Vanaerschot, M., Murithi, J. M., Rubiano, K., Akidil, A., Ottilie, S., Mittal, N. & Dilmore, A. H. & 14 others, , 17 Feb 2022, In: Cell Chemical Biology. 29, 2, p. 191-201.e8 20 p., E8.Research output: Contribution to journal › Article › peer-review
Open AccessFile43 Citations (Scopus)199 Downloads (Pure) -
CRISPR/Cas9-based precision tagging of essential genes in bloodstream form African trypanosomes
Kovářová, J., Novotná, M., Faria, J., Rico, E., Wallace, C., Zoltner, M., Field, M. C. & Horn, D. (Lead / Corresponding author), 10 Apr 2022, In: Molecular and Biochemical Parasitology. 249, 7 p., 111476.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)120 Downloads (Pure) -
CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery
Benns, H. J., Storch, M., Falco, J. A., Fisher, F. R., Tamaki, F., Alves, E., Wincott, C. J., Milne, R., Wiedemar, N., Craven, G., Baragaña, B., Wyllie, S., Baum, J., Baldwin, G. S., Weerapana, E., Tate, E. W. & Child, M. A., 20 Oct 2022, In: Nature Microbiology. 7, 11, p. 1891-1905 30 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)122 Downloads (Pure) -
High-Throughput Screening Platform To Identify Inhibitors of Protein Synthesis with Potential for the Treatment of Malaria
Tamaki, F., Fisher, F., Milne, R., Sánchez-Román Terán, F., Wiedemar, N., Wrobel, K., Edwards, D., Baumann, H., Gilbert, I. H., Baragana, B., Baum, J. & Wyllie, S. (Lead / Corresponding author), Jun 2022, In: Antimicrobial Agents and Chemotherapy. 66, 6, 13 p., e00237-22.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)165 Downloads (Pure) -
Identification and development of a series of disubstituted piperazines for the treatment of Chagas disease
McGonagle, K., Tarver, G. J., Cantizani, J., Cotillo, I., Dodd, P. G., Ferguson, L., Gilbert, I. H., Marco, M., Miles, T., Naylor, C., Osuna-Cabello, M., Paterson, C., Read, K. D., Pinto, E. G., Riley, J., Scullion, P., Shishikura, Y., Simeons, F., Stojanovski, L. & Svensen, N. & 5 others, , 5 Aug 2022, In: European Journal of Medicinal Chemistry. 238, 14 p., 114421.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)141 Downloads (Pure) -
Identification of a proteasome-targeting arylsulfonamide with potential for the treatment of Chagas' disease
Lima, M., Tulloch, L., Corpas Lopez, V., Carvalho, S., Wall, R., Milne, R., Rico Vidal, E., Patterson, S., Gilbert, I., Moniz, S., MacLean, L., Torrie, L., Morgillo, C., Horn, D., Zuccotto, F. & Wyllie, S. (Lead / Corresponding author), 18 Jan 2022, In: Antimicrobial Agents and Chemotherapy. 66, 1, 16 p., e01535-21.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)224 Downloads (Pure) -
Oligo targeting for profiling drug resistance mutations in the parasitic trypanosomatids
Altmann, S., Rico, E., Carvalho, S., Ridgway, M., Trenaman, A., Donnelly, H., Tinti, M., Wyllie, S. & Horn, D. (Lead / Corresponding author), 12 Aug 2022, In: Nucleic Acids Research. 50, 14, p. 1-8 8 p., e79.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)123 Downloads (Pure) -
Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase
Milne, R., Wiedemar, N., Corpas Lopez, V., Moynihan, E., Wall, R. J., Dawson, A., Robinson, D. A., Shepherd, S. M., Smith, R. J., Hallyburton, I., Post, J. M., Dowers, K., Torrie, L. S., Gilbert, I. H., Baragaña, B., Patterson, S. & Wyllie, S. (Lead / Corresponding author), 9 Sept 2022, In: ACS Infectious Diseases. 8, 9, p. 1962-1974 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)220 Downloads (Pure) -
What binds us: A mural for Stobswell
Floyd, A., 5 Dec 2022, Newsflash, 57, p. 1-2 2 p.Research output: Contribution to specialist publication › Article
Open AccessFile15 Downloads (Pure) -
2021
Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7 Methyltransferase Using RapidFire Mass Spectrometry
Pearson, L.-A., Green, C., Lin, D., Petit, A.-P., Gray, D. (Lead / Corresponding author), Cowling, V. & Fordyce, E. (Lead / Corresponding author), Jul 2021, In: SLAS Discovery. 26, 6, p. 749-756 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)136 Downloads (Pure) -
DNDI-6148: A novel benzoxaborole preclinical candidate for the treatment of visceral leishmaniasis
Mowbray, C. E. (Lead / Corresponding author), Braillard, S., Glossop, P. A., Whitlock, G. A., Jacobs, R. T., Speake, J., Pandi, B., Nare, B., Maes, L., Yardley, V., Freund, Y., Wall, R. J., Carvalho, S., Bello, D., Van den Kerkhof, M., Caljon, G., Gilbert, I. H., Corpas-Lopez, V., Lukac, I. & Patterson, S. & 2 others, , 11 Nov 2021, In: Journal of Medicinal Chemistry. 64, 21, p. 16159-16176 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile46 Citations (Scopus)440 Downloads (Pure) -
Expression in Escherichia coli, purification and kinetic characterization of LAPLm, a Leishmania major M17-aminopeptidase
Aguado, M. E., González-Matos, M., Izquierdo, M., Quintana, J., Field, M. C. & González-Bacerio, J. (Lead / Corresponding author), Jul 2021, In: Protein Expression and Purification. 183, 12 p., 105877.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)129 Downloads (Pure) -
Identification of resistance determinants for a promising antileishmanial oxaborole series
Van den Kerkhof, M., Leprohon, P., Mabille, D., Hendrickx, S., Tulloch, L. B., Wall, R. J., Wyllie, S., Chatelain, E., Mowbray, C. E., Braillard, S., Ouellette , M., Maes, L. & Calijon, G. (Lead / Corresponding author), 29 Jun 2021, In: Microorganisms. 9, 7, 15 p., 1408.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)88 Downloads (Pure) -
Ligand binding: evaluating the contribution of the water molecules network using the Fragment Molecular Orbital method
Lukac, I., Wyatt, P. G. (Lead / Corresponding author), Gilbert, I. H. & Zuccotto, F. (Lead / Corresponding author), Oct 2021, In: Journal of Computer-Aided Molecular Design. 35, p. 1025-1036 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)163 Downloads (Pure) -
Live-imaging rate-of-kill compound profiling for Chagas disease drug discovery with a new automated high-content assay
Svensen, N., Wyllie, S., Gray, D. W. & De Rycker, M. (Lead / Corresponding author), 11 Oct 2021, In: PLoS Neglected Tropical Diseases. 15, 10, 14 p., e0009870.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)83 Downloads (Pure) -
Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial
S. Paradela, L., Wall, R. J., Carvalho, S., Chemi, G., Corpas-Lopez, V., Moynihan, E., Bello, D., Patterson, S., S. Guther, M. L., Fairlamb, A. H., Ferguson, M. A. J., Zuccotto, F., Martin, J., Gilbert, I. H. & Wyllie, S. (Lead / Corresponding author), 20 May 2021, In: Cell Chemical Biology. 28, 5, p. 711-721.e8 20 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)149 Downloads (Pure) -
Plasmodium Kinases as Potential Drug Targets for Malaria: Challenges and Opportunities
Arendse, L. B. (Lead / Corresponding author), Wyllie, S., Chibale, K. & Gilbert, I. H. (Lead / Corresponding author), 12 Mar 2021, In: ACS Infectious Diseases. 7, 3, p. 518-534 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile53 Citations (Scopus)575 Downloads (Pure) -
Prioritization of Molecular Targets for Antimalarial Drug Discovery
Forte, B., Ottilie, S., Plater, A., Campo, B., Dechering, K. J., Gamo, F. J., Goldberg, D. E., Istvan, E. S., Lee, M., Lukens, A. K., McNamara, C. W., Niles, J., Okombo, J., Pasaje, C. F. A., Siegel, M. G., Wirth, D. F., Wyllie, S., Fidock, D. A., Baragaña, B. (Lead / Corresponding author) & Winzeler, E. A. (Lead / Corresponding author) & 1 others, , 8 Oct 2021, In: ACS Infectious Diseases. 7, 10, p. 2764-2776 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile53 Citations (Scopus)243 Downloads (Pure) -
Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis
Thomas, M., Brand, S., De Rycker, M., Zuccotto, F., Lukac, I., Dodd, P., Ko, E.-J., Manthri, S., McGonagle, K., Osuna-Cabello, M., Riley, J., Pont, C., Simeons, F., Stojanovski, L., Thomas, J., Thompson, S., Viayna, E., Fiandor, J. M., Martín, J. & Wyatt, P. G. & 4 others, , 13 May 2021, In: Journal of Medicinal Chemistry. 64, 9, p. 5905-5930 26 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile33 Citations (Scopus)249 Downloads (Pure) -
Synthesis of a Series of Diaminoindoles
Martin, J. S., Mackenzie, C. J. & Gilbert, I. H. (Lead / Corresponding author), 3 Sept 2021, In: Journal of Organic Chemistry. 86, 17, p. 11333-11340 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)123 Downloads (Pure) -
Utilizing thermal proteome profiling to identify the molecular targets of anti-leishmanial compounds
Corpas Lopez, V. (Lead / Corresponding author) & Wyllie, S. (Lead / Corresponding author), 17 Sept 2021, In: STAR Protocols. 2, 3, 19 p., 100704.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)133 Downloads (Pure) -
2020
Development of a High-Throughput Screening Assay to Identify Inhibitors of the Major M17-Leucyl Aminopeptidase from Trypanosoma cruzi Using RapidFire Mass Spectrometry
Izquierdo, M., Lin, D., O'Neill, S., Zoltner, M., Webster, L., Hope, A., Gray, D. W., Field, M. C. & González-Bacerio, J. (Lead / Corresponding author), 1 Oct 2020, In: SLAS Discovery. 25, 9, p. 1064-1071 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)70 Downloads (Pure) -
Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase
Torrie, L. S., Robinson, D. A., Thomas, M. G., Hobrath, J. V., Shepherd, S. M., Post, J. M., Ko, E. J., Ferreira, R. A., Mackenzie, C. J., Wrobel, K., Edwards, D. P., Gilbert, I. H., Gray, D. W. (Lead / Corresponding author), Fairlamb, A. H. & De Rycker, M. (Lead / Corresponding author), 8 May 2020, In: ACS Infectious Diseases. 6, 5, p. 1044-1057 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)147 Downloads (Pure) -
Setting our sights on infectious diseases
De Rycker, M., Horn, D., Aldridge, B., Amewu, R. K., Barry, C. E., Buckner, F. S., Cook, S., Ferguson, M. A. J., Gobeau, N., Herrmann, J., Herrling, P., Hope, W., Keiser, J., Lafuente-Monasterio, M. J., Leeson, P. D., Leroy, D., Manjunatha, U. H., McCarthy, J., Miles, T. J. & Mizrahi, V. & 17 others, , 10 Jan 2020, In: ACS Infectious Diseases. 6, p. 3-13 11 p.Research output: Contribution to journal › Article › peer-review
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Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs
Giordani, F. (Lead / Corresponding author), Paape, D., Vincent, I. M., Pountain, A. W., Fernández-Cortés, F., Rico, E., Zhang, N., Morrison, L. J., Freund, Y., Witty, M. J., Peter, R., Edwards, D. Y., Wilkes, J. M., van der Hooft, J. J. J., Regnault, C., Read, K. D., Horn, D., Field, M. C. & Barrett, M. P., 3 Nov 2020, In: PLoS Pathogens. 16, 11, 20 p., e1008932.Research output: Contribution to journal › Article › peer-review
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