Keyphrases
Trypanosoma Brucei
100%
Antifolate Drugs
75%
Folate
75%
Methotrexate
58%
Folate Transport
50%
Recombinant
50%
Dihydrofolate Reductase-thymidylate Synthase
50%
Thymidine
50%
Recombinant Enzyme
50%
Drug Action
50%
Potent Inhibitor
50%
Dump
50%
Antifolate
50%
Bifunctional
50%
Raltitrexed
41%
Trypanosome
41%
Nolatrexed
33%
African Trypanosomes
33%
ThyA
25%
Elongation Factor Ts
25%
FdUMP
25%
Polyglutamylation
25%
Dihydrofolate
25%
Desalting
25%
Pyrimidine
25%
Purification Process
25%
Culture Media
25%
Trimetrexate
25%
Bacterial Lysates
25%
Kinetic Properties
25%
Glutamate
25%
Purine
25%
Lipophilic
25%
Biological Activity
25%
Escherichia Coli
25%
Causative Agents
25%
Cattle
25%
Sleeping Sickness
25%
Small Molecules
25%
Nagana
25%
Low Folate
25%
Fusion Protein
25%
Pemetrexed
25%
Nucleosides
25%
Folate Transporters
16%
SiRNA Knockdown
16%
Transport Studies
8%
Transport Kinetics
8%
Genome-wide RNAi
8%
Transporter Family
8%
Loss Function
8%
Pyrimethamine
8%
Biopterin
8%
Whole Cell
8%
Bloodstream Forms
8%
Targeted Sequencing
8%
Knockdown
8%
RNA Interference
8%
Tandem Array
8%
RNAi Screen
8%
Major Contributor
8%
Resistance Mechanisms
8%
Drug Uptake
8%
Drug Resistance
8%
Pharmacology, Toxicology and Pharmaceutical Science
Folic Acid
100%
Trypanosoma Brucei
100%
Folic Acid Antagonist
66%
Drug Action
50%
Dihydrofolate Reductase
50%
Recombinant
50%
Thymidylate Synthase
50%
Trypanosoma
48%
Methotrexate
36%
Recombinant Enzyme
33%
Thymidine
33%
Raltitrexed
26%
Nolatrexed
21%
Elongation Factor Ts
16%
Dihydrofolic Acid
16%
Trimetrexate
16%
Nucleoside
16%
Bacterium Lysate
16%
Biological Activity
16%
African Trypanosomiasis
16%
Bovine
16%
Glutamic Acid
16%
Purine
16%
Nagana
16%
Escherichia coli
16%
Synthetase
16%
Pemetrexed
16%
Chimeric Protein
16%
Folate Transporter
10%
Pyrimethamine
5%
Biopterin
5%
Drug Resistance
5%
Biochemistry, Genetics and Molecular Biology
Trypanosoma Brucei
50%
Folic Acid
50%
Recombinant
50%
Thymidylate Synthase
50%
Dihydrofolate Reductase
50%
Enzyme
33%
Copurification
33%
Trypanosoma
33%
Thymidine
33%
Polyglutamylation
16%
Desalting
16%
Elongation Factor Ts
16%
Pemetrexed
16%
Cell Lysate
16%
Nucleoside
16%
Bovine
16%
Small Molecule
16%
Biological Activity
16%
Antifolate
16%
Synthase
16%
Escherichia coli
16%
Raltitrexed
16%
Trimetrexate
16%
Glutamic Acid
16%
Methotrexate
16%
Chimeric Protein
16%