0.5 billion events per second time correlated single photon counting using CMOS SPAD arrays

Nikola Krstajić; Simon Poland; James Levitt; Richard Walker; Ahmet T. Erdogan; Simon Ameer-Beg; Robert K Henderson

doi:10.1364/OL.40.004305

0.5 billion events per second time correlated single photon counting using CMOS SPAD arrays

Nikola Krstajić, Simon Poland, James Levitt, Richard Walker, Ahmet T. Erdogan, Simon Ameer-Beg, Robert K Henderson

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Abstract

We present a digital architecture for fast acquisition of time correlated single photon counting (TCSPC) events from a 32×32 complementary metal oxide semiconductor (CMOS) single photon avalanche detector (SPAD) array (Megaframe) to the computer memory. Custom firmware was written to transmit event codes from 1024-TCSPC-enabled pixels for fast transfer of TCSPC events. Our 1024-channel TCSPC system is capable of acquiring up to 0.5×10(9) TCSPC events per second with 16 histogram bins spanning a 14 ns width. Other options include 320×10(6) TCSPC events per second with 256 histogram bins spanning either a 14 or 56 ns time window. We present a wide-field fluorescence microscopy setup demonstrating fast fluorescence lifetime data acquisition. To the best of our knowledge, this is the fastest direct TCSPC transfer from a single photon counting device to the computer to date.

Original language	English
Pages (from-to)	4305-8
Number of pages	4
Journal	Optics Letters
Volume	40
Issue number	18
DOIs	https://doi.org/10.1364/OL.40.004305
Publication status	Published - 15 Sept 2015

Keywords

CMOS
SPAD
Optical detectors
fluorescence lifetime
photon counting
Photons

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10.1364/OL.40.004305

Author Accepted Manuscript
© 2015 Optical Society of America. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modifications of the content of this paper are prohibited.
Accepted author manuscript, 1.01 MB

Krstajic, Nikola
- Biomedical Engineering - Reader
Person: Academic

Cite this

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title = "0.5 billion events per second time correlated single photon counting using CMOS SPAD arrays",

abstract = "We present a digital architecture for fast acquisition of time correlated single photon counting (TCSPC) events from a 32×32 complementary metal oxide semiconductor (CMOS) single photon avalanche detector (SPAD) array (Megaframe) to the computer memory. Custom firmware was written to transmit event codes from 1024-TCSPC-enabled pixels for fast transfer of TCSPC events. Our 1024-channel TCSPC system is capable of acquiring up to 0.5×10(9) TCSPC events per second with 16 histogram bins spanning a 14 ns width. Other options include 320×10(6) TCSPC events per second with 256 histogram bins spanning either a 14 or 56 ns time window. We present a wide-field fluorescence microscopy setup demonstrating fast fluorescence lifetime data acquisition. To the best of our knowledge, this is the fastest direct TCSPC transfer from a single photon counting device to the computer to date.",

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AU - Krstajić, Nikola

AU - Poland, Simon

AU - Levitt, James

AU - Walker, Richard

AU - Erdogan, Ahmet T.

AU - Ameer-Beg, Simon

AU - Henderson, Robert K

PY - 2015/9/15

Y1 - 2015/9/15

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AB - We present a digital architecture for fast acquisition of time correlated single photon counting (TCSPC) events from a 32×32 complementary metal oxide semiconductor (CMOS) single photon avalanche detector (SPAD) array (Megaframe) to the computer memory. Custom firmware was written to transmit event codes from 1024-TCSPC-enabled pixels for fast transfer of TCSPC events. Our 1024-channel TCSPC system is capable of acquiring up to 0.5×10(9) TCSPC events per second with 16 histogram bins spanning a 14 ns width. Other options include 320×10(6) TCSPC events per second with 256 histogram bins spanning either a 14 or 56 ns time window. We present a wide-field fluorescence microscopy setup demonstrating fast fluorescence lifetime data acquisition. To the best of our knowledge, this is the fastest direct TCSPC transfer from a single photon counting device to the computer to date.

KW - CMOS

KW - SPAD

KW - Optical detectors

KW - fluorescence lifetime

KW - photon counting

KW - Photons

U2 - 10.1364/OL.40.004305

DO - 10.1364/OL.40.004305

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SP - 4305

EP - 4308

JO - Optics Letters

JF - Optics Letters

IS - 18

ER -

0.5 billion events per second time correlated single photon counting using CMOS SPAD arrays

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Krstajic, Nikola

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