3D Monte Carlo radiation transfer modelling of photodynamic therapy

C. Louise Campbell, Craig Christison, C. Tom A Brown, Kenneth Wood, Ronan M. Valentine, Harry Moseley

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    3 Citations (Scopus)

    Abstract

    The effects of ageing and skin type on Photodynamic Therapy (PDT) for different treatment methods have been theoretically investigated. A multilayered Monte Carlo Radiation Transfer model is presented where both daylight activated PDT and conventional PDT are compared. It was found that light penetrates deeper through older skin with a lighter complexion, which translates into a deeper effective treatment depth. The effect of ageing was found to be larger for darker skin types. The investigation further strengthens the usage of daylight as a potential light source for PDT where effective treatment depths of about 2 mm can be achieved.

    Original languageEnglish
    Title of host publicationBiophotonics South America
    EditorsCristina Kurachi, Katarina Svanberg, Bruce J. Tromberg, Vanderlei S. Bagnato
    Place of PublicationBellingham
    PublisherSPIE-International Society for Optical Engineering
    ISBN (Print)9781628416961
    DOIs
    Publication statusPublished - 2015
    EventSPIE Biophotonics South America 2015 - Copacabana Palace Hotel, Rio de Janeiro, Brazil
    Duration: 23 May 201525 May 2015
    http://spie.org/x113829.xml

    Publication series

    NameProceedings of SPIE
    PublisherSPIE
    Volume9531
    NameProgress in biomedical optics and imaging
    PublisherSPIE
    Number52
    Volume16

    Conference

    ConferenceSPIE Biophotonics South America 2015
    CountryBrazil
    CityRio de Janeiro
    Period23/05/1525/05/15
    Internet address

    Keywords

    • Daylight activated photodynamic therapy
    • Monte Carlo radiation Transfer modelling of Photodynamic Therapy
    • Skin ageing
    • Theoretical investigation of Photodynamic therapy
    • Tissue optics

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