3D Monte Carlo radiation transfer modelling of photodynamic therapy

C. Louise Campbell; Craig Christison; C. Tom A Brown; Kenneth Wood; Ronan M. Valentine; Harry Moseley

doi:10.1117/12.2180744

3D Monte Carlo radiation transfer modelling of photodynamic therapy

C. Louise Campbell, Craig Christison, C. Tom A Brown, Kenneth Wood, Ronan M. Valentine, Harry Moseley

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Citations (Scopus)

Abstract

The effects of ageing and skin type on Photodynamic Therapy (PDT) for different treatment methods have been theoretically investigated. A multilayered Monte Carlo Radiation Transfer model is presented where both daylight activated PDT and conventional PDT are compared. It was found that light penetrates deeper through older skin with a lighter complexion, which translates into a deeper effective treatment depth. The effect of ageing was found to be larger for darker skin types. The investigation further strengthens the usage of daylight as a potential light source for PDT where effective treatment depths of about 2 mm can be achieved.

Original language	English
Title of host publication	Biophotonics South America
Editors	Cristina Kurachi, Katarina Svanberg, Bruce J. Tromberg, Vanderlei S. Bagnato
Place of Publication	Bellingham
Publisher	SPIE-International Society for Optical Engineering
ISBN (Print)	9781628416961
DOIs	https://doi.org/10.1117/12.2180744
Publication status	Published - 2015
Event	SPIE Biophotonics South America 2015 - Copacabana Palace Hotel, Rio de Janeiro, Brazil Duration: 23 May 2015 → 25 May 2015 http://spie.org/x113829.xml

Publication series

Name	Proceedings of SPIE
Publisher	SPIE
Volume	9531

Name	Progress in biomedical optics and imaging
Publisher	SPIE
Number	52
Volume	16

Conference

Conference	SPIE Biophotonics South America 2015
Country/Territory	Brazil
City	Rio de Janeiro
Period	23/05/15 → 25/05/15
Internet address	http://spie.org/x113829.xml

Keywords

Daylight activated photodynamic therapy
Monte Carlo radiation Transfer modelling of Photodynamic Therapy
Skin ageing
Theoretical investigation of Photodynamic therapy
Tissue optics

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Electronic, Optical and Magnetic Materials
Biomaterials
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.2180744

Cite this

Campbell, C. L., Christison, C., Brown, C. T. A., Wood, K., Valentine, R. M., & Moseley, H. (2015). 3D Monte Carlo radiation transfer modelling of photodynamic therapy. In C. Kurachi, K. Svanberg, B. J. Tromberg, & V. S. Bagnato (Eds.), Biophotonics South America Article 95311H (Proceedings of SPIE; Vol. 9531), (Progress in biomedical optics and imaging; Vol. 16, No. 52). SPIE-International Society for Optical Engineering. https://doi.org/10.1117/12.2180744

Campbell, C. Louise ; Christison, Craig ; Brown, C. Tom A et al. / 3D Monte Carlo radiation transfer modelling of photodynamic therapy. Biophotonics South America. editor / Cristina Kurachi ; Katarina Svanberg ; Bruce J. Tromberg ; Vanderlei S. Bagnato. Bellingham : SPIE-International Society for Optical Engineering, 2015. (Proceedings of SPIE). (Progress in biomedical optics and imaging; 52).

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title = "3D Monte Carlo radiation transfer modelling of photodynamic therapy",

abstract = "The effects of ageing and skin type on Photodynamic Therapy (PDT) for different treatment methods have been theoretically investigated. A multilayered Monte Carlo Radiation Transfer model is presented where both daylight activated PDT and conventional PDT are compared. It was found that light penetrates deeper through older skin with a lighter complexion, which translates into a deeper effective treatment depth. The effect of ageing was found to be larger for darker skin types. The investigation further strengthens the usage of daylight as a potential light source for PDT where effective treatment depths of about 2 mm can be achieved.",

keywords = "Daylight activated photodynamic therapy, Monte Carlo radiation Transfer modelling of Photodynamic Therapy, Skin ageing, Theoretical investigation of Photodynamic therapy, Tissue optics",

author = "Campbell, {C. Louise} and Craig Christison and Brown, {C. Tom A} and Kenneth Wood and Valentine, {Ronan M.} and Harry Moseley",

year = "2015",

doi = "10.1117/12.2180744",

language = "English",

isbn = "9781628416961",

series = "Proceedings of SPIE",

publisher = "SPIE-International Society for Optical Engineering",

editor = "Kurachi, {Cristina } and Svanberg, {Katarina } and Tromberg, {Bruce J. } and Bagnato, {Vanderlei S. }",

booktitle = "Biophotonics South America",

note = "SPIE Biophotonics South America 2015 ; Conference date: 23-05-2015 Through 25-05-2015",

url = "http://spie.org/x113829.xml",

}

Campbell, CL, Christison, C, Brown, CTA, Wood, K, Valentine, RM & Moseley, H 2015, 3D Monte Carlo radiation transfer modelling of photodynamic therapy. in C Kurachi, K Svanberg, BJ Tromberg & VS Bagnato (eds), Biophotonics South America., 95311H, Proceedings of SPIE, vol. 9531, Progress in biomedical optics and imaging, no. 52, vol. 16, SPIE-International Society for Optical Engineering, Bellingham, SPIE Biophotonics South America 2015, Rio de Janeiro, Brazil, 23/05/15. https://doi.org/10.1117/12.2180744

3D Monte Carlo radiation transfer modelling of photodynamic therapy. / Campbell, C. Louise; Christison, Craig; Brown, C. Tom A et al.
Biophotonics South America. ed. / Cristina Kurachi; Katarina Svanberg; Bruce J. Tromberg; Vanderlei S. Bagnato. Bellingham: SPIE-International Society for Optical Engineering, 2015. 95311H (Proceedings of SPIE; Vol. 9531), (Progress in biomedical optics and imaging; Vol. 16, No. 52).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - 3D Monte Carlo radiation transfer modelling of photodynamic therapy

AU - Campbell, C. Louise

AU - Christison, Craig

AU - Brown, C. Tom A

AU - Wood, Kenneth

AU - Valentine, Ronan M.

AU - Moseley, Harry

PY - 2015

Y1 - 2015

N2 - The effects of ageing and skin type on Photodynamic Therapy (PDT) for different treatment methods have been theoretically investigated. A multilayered Monte Carlo Radiation Transfer model is presented where both daylight activated PDT and conventional PDT are compared. It was found that light penetrates deeper through older skin with a lighter complexion, which translates into a deeper effective treatment depth. The effect of ageing was found to be larger for darker skin types. The investigation further strengthens the usage of daylight as a potential light source for PDT where effective treatment depths of about 2 mm can be achieved.

AB - The effects of ageing and skin type on Photodynamic Therapy (PDT) for different treatment methods have been theoretically investigated. A multilayered Monte Carlo Radiation Transfer model is presented where both daylight activated PDT and conventional PDT are compared. It was found that light penetrates deeper through older skin with a lighter complexion, which translates into a deeper effective treatment depth. The effect of ageing was found to be larger for darker skin types. The investigation further strengthens the usage of daylight as a potential light source for PDT where effective treatment depths of about 2 mm can be achieved.

KW - Daylight activated photodynamic therapy

KW - Monte Carlo radiation Transfer modelling of Photodynamic Therapy

KW - Skin ageing

KW - Theoretical investigation of Photodynamic therapy

KW - Tissue optics

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DO - 10.1117/12.2180744

M3 - Conference contribution

AN - SCOPUS:84938942933

SN - 9781628416961

T3 - Proceedings of SPIE

BT - Biophotonics South America

A2 - Kurachi, Cristina

A2 - Svanberg, Katarina

A2 - Tromberg, Bruce J.

A2 - Bagnato, Vanderlei S.

PB - SPIE-International Society for Optical Engineering

CY - Bellingham

T2 - SPIE Biophotonics South America 2015

Y2 - 23 May 2015 through 25 May 2015

ER -

Campbell CL, Christison C, Brown CTA, Wood K, Valentine RM, Moseley H. 3D Monte Carlo radiation transfer modelling of photodynamic therapy. In Kurachi C, Svanberg K, Tromberg BJ, Bagnato VS, editors, Biophotonics South America. Bellingham: SPIE-International Society for Optical Engineering. 2015. 95311H. (Proceedings of SPIE). (Progress in biomedical optics and imaging; 52). doi: 10.1117/12.2180744

3D Monte Carlo radiation transfer modelling of photodynamic therapy

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