3T MRI investigation of cardiac left ventricular structure and function in a UK population

The tayside screening for the prevention of cardiac events (TASCFORCE) study

Stephen J. Gandy, Matthew Lambert, Jill Belch, Ian Cavin, Elena Crowe, Roberta Littleford, Jennifer A. Macfarlane, Shona Z. Matthew, Patricia Martin, R. Stephen Nicholas, Allan Struthers, Frank Sullivan, Shelley A. Waugh, Richard D. White, Jonathan R. Weir-Mccall, J. Graeme Houston (Lead / Corresponding author)

Research output: Contribution to journalArticle

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Abstract

Purpose: To scan a volunteer population using 3.0T magnetic resonance imaging (MRI). MRI of the left ventricular (LV) structure and function in healthy volunteers has been reported extensively at 1.5T. 

Materials and Methods: A population of 1528 volunteers was scanned. A standardized approach was taken to acquire steady-state free precession (SSFP) LV data in the short-axis plane, and images were quantified using commercial software. Six observers undertook the segmentation analysis. 

Results: Mean values (±standard deviation, SD) were: ejection fraction (EF) = 69 ± 6%, end diastolic volume index (EDVI) = 71 ± 13 ml/m2, end systolic volume index (ESVI) = 22 ± 7 ml/m2, stroke volume index (SVI) = 49 ± 8 ml/m2, and LV mass index (LVMI) = 55 ± 12 g/m2. The mean EF was slightly larger for females (69%) than for males (68%), but all other variables were smaller for females (EDVI 68v77 ml/m2, ESVI 21v25 ml/m2, SVI 46v52 ml/m2, LVMI 49v64 g/m2, all P <0.05). The mean LV volume data mostly decreased with each age decade (EDVI males: -2.9 ± 1.3 ml/m2, females: -3.1 ± 0.8 ml/m2; ESVI males: -1.3 ± 0.7 ml/m2, females: -1.7 ± 0.5 ml/m2; SVI males: -1.7 ± 0.9 ml/m2, females: -1.4 ± 0.6 ml/m2; LVMI males: -1.6 ± 1.1 g/m2, females: -0.2 ± 0.6 g/m2) but the mean EF was virtually stable in males (0.6 ± 0.6%) and rose slightly in females (1.2 ± 0.5%) with age. 

Conclusion: LV reference ranges are provided in this population-based MR study at 3.0T. The variables are similar to those described at 1.5T, including variations with age and gender. These data may help to support future population-based MR research studies that involve the use of 3.0T MRI scanners.

Original languageEnglish
Article number25267
Pages (from-to)1186-1196
JournalJournal of Magnetic Resonance Imaging
Volume44
Issue number5
Early online date3 May 2016
DOIs
Publication statusPublished - 11 Oct 2016

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Left Ventricular Function
Magnetic Resonance Imaging
Population
Stroke Volume
Volunteers
Healthy Volunteers
Reference Values
Software
Research

Keywords

  • 3.0T
  • Cardiac
  • Left ventricle
  • MRI
  • Population

Cite this

Gandy, Stephen J. ; Lambert, Matthew ; Belch, Jill ; Cavin, Ian ; Crowe, Elena ; Littleford, Roberta ; Macfarlane, Jennifer A. ; Matthew, Shona Z. ; Martin, Patricia ; Nicholas, R. Stephen ; Struthers, Allan ; Sullivan, Frank ; Waugh, Shelley A. ; White, Richard D. ; Weir-Mccall, Jonathan R. ; Houston, J. Graeme. / 3T MRI investigation of cardiac left ventricular structure and function in a UK population : The tayside screening for the prevention of cardiac events (TASCFORCE) study. In: Journal of Magnetic Resonance Imaging. 2016 ; Vol. 44, No. 5. pp. 1186-1196.
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title = "3T MRI investigation of cardiac left ventricular structure and function in a UK population: The tayside screening for the prevention of cardiac events (TASCFORCE) study",
abstract = "Purpose: To scan a volunteer population using 3.0T magnetic resonance imaging (MRI). MRI of the left ventricular (LV) structure and function in healthy volunteers has been reported extensively at 1.5T. Materials and Methods: A population of 1528 volunteers was scanned. A standardized approach was taken to acquire steady-state free precession (SSFP) LV data in the short-axis plane, and images were quantified using commercial software. Six observers undertook the segmentation analysis. Results: Mean values (±standard deviation, SD) were: ejection fraction (EF) = 69 ± 6{\%}, end diastolic volume index (EDVI) = 71 ± 13 ml/m2, end systolic volume index (ESVI) = 22 ± 7 ml/m2, stroke volume index (SVI) = 49 ± 8 ml/m2, and LV mass index (LVMI) = 55 ± 12 g/m2. The mean EF was slightly larger for females (69{\%}) than for males (68{\%}), but all other variables were smaller for females (EDVI 68v77 ml/m2, ESVI 21v25 ml/m2, SVI 46v52 ml/m2, LVMI 49v64 g/m2, all P <0.05). The mean LV volume data mostly decreased with each age decade (EDVI males: -2.9 ± 1.3 ml/m2, females: -3.1 ± 0.8 ml/m2; ESVI males: -1.3 ± 0.7 ml/m2, females: -1.7 ± 0.5 ml/m2; SVI males: -1.7 ± 0.9 ml/m2, females: -1.4 ± 0.6 ml/m2; LVMI males: -1.6 ± 1.1 g/m2, females: -0.2 ± 0.6 g/m2) but the mean EF was virtually stable in males (0.6 ± 0.6{\%}) and rose slightly in females (1.2 ± 0.5{\%}) with age. Conclusion: LV reference ranges are provided in this population-based MR study at 3.0T. The variables are similar to those described at 1.5T, including variations with age and gender. These data may help to support future population-based MR research studies that involve the use of 3.0T MRI scanners.",
keywords = "3.0T, Cardiac, Left ventricle, MRI, Population",
author = "Gandy, {Stephen J.} and Matthew Lambert and Jill Belch and Ian Cavin and Elena Crowe and Roberta Littleford and Macfarlane, {Jennifer A.} and Matthew, {Shona Z.} and Patricia Martin and Nicholas, {R. Stephen} and Allan Struthers and Frank Sullivan and Waugh, {Shelley A.} and White, {Richard D.} and Weir-Mccall, {Jonathan R.} and Houston, {J. Graeme}",
note = "Funded by Souter Charitable Trust, and Chest, Heart and Stroke Scotland Wellcome Trust . Grant Number: WT 085664 (Clinical Research Fellowship to J.W-McC.)",
year = "2016",
month = "10",
day = "11",
doi = "10.1002/jmri.25267",
language = "English",
volume = "44",
pages = "1186--1196",
journal = "Journal of Magnetic Resonance Imaging",
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Gandy, SJ, Lambert, M, Belch, J, Cavin, I, Crowe, E, Littleford, R, Macfarlane, JA, Matthew, SZ, Martin, P, Nicholas, RS, Struthers, A, Sullivan, F, Waugh, SA, White, RD, Weir-Mccall, JR & Houston, JG 2016, '3T MRI investigation of cardiac left ventricular structure and function in a UK population: The tayside screening for the prevention of cardiac events (TASCFORCE) study', Journal of Magnetic Resonance Imaging, vol. 44, no. 5, 25267, pp. 1186-1196. https://doi.org/10.1002/jmri.25267

3T MRI investigation of cardiac left ventricular structure and function in a UK population : The tayside screening for the prevention of cardiac events (TASCFORCE) study. / Gandy, Stephen J.; Lambert, Matthew; Belch, Jill; Cavin, Ian; Crowe, Elena; Littleford, Roberta; Macfarlane, Jennifer A.; Matthew, Shona Z.; Martin, Patricia; Nicholas, R. Stephen; Struthers, Allan; Sullivan, Frank; Waugh, Shelley A.; White, Richard D.; Weir-Mccall, Jonathan R.; Houston, J. Graeme (Lead / Corresponding author).

In: Journal of Magnetic Resonance Imaging, Vol. 44, No. 5, 25267, 11.10.2016, p. 1186-1196.

Research output: Contribution to journalArticle

TY - JOUR

T1 - 3T MRI investigation of cardiac left ventricular structure and function in a UK population

T2 - The tayside screening for the prevention of cardiac events (TASCFORCE) study

AU - Gandy, Stephen J.

AU - Lambert, Matthew

AU - Belch, Jill

AU - Cavin, Ian

AU - Crowe, Elena

AU - Littleford, Roberta

AU - Macfarlane, Jennifer A.

AU - Matthew, Shona Z.

AU - Martin, Patricia

AU - Nicholas, R. Stephen

AU - Struthers, Allan

AU - Sullivan, Frank

AU - Waugh, Shelley A.

AU - White, Richard D.

AU - Weir-Mccall, Jonathan R.

AU - Houston, J. Graeme

N1 - Funded by Souter Charitable Trust, and Chest, Heart and Stroke Scotland Wellcome Trust . Grant Number: WT 085664 (Clinical Research Fellowship to J.W-McC.)

PY - 2016/10/11

Y1 - 2016/10/11

N2 - Purpose: To scan a volunteer population using 3.0T magnetic resonance imaging (MRI). MRI of the left ventricular (LV) structure and function in healthy volunteers has been reported extensively at 1.5T. Materials and Methods: A population of 1528 volunteers was scanned. A standardized approach was taken to acquire steady-state free precession (SSFP) LV data in the short-axis plane, and images were quantified using commercial software. Six observers undertook the segmentation analysis. Results: Mean values (±standard deviation, SD) were: ejection fraction (EF) = 69 ± 6%, end diastolic volume index (EDVI) = 71 ± 13 ml/m2, end systolic volume index (ESVI) = 22 ± 7 ml/m2, stroke volume index (SVI) = 49 ± 8 ml/m2, and LV mass index (LVMI) = 55 ± 12 g/m2. The mean EF was slightly larger for females (69%) than for males (68%), but all other variables were smaller for females (EDVI 68v77 ml/m2, ESVI 21v25 ml/m2, SVI 46v52 ml/m2, LVMI 49v64 g/m2, all P <0.05). The mean LV volume data mostly decreased with each age decade (EDVI males: -2.9 ± 1.3 ml/m2, females: -3.1 ± 0.8 ml/m2; ESVI males: -1.3 ± 0.7 ml/m2, females: -1.7 ± 0.5 ml/m2; SVI males: -1.7 ± 0.9 ml/m2, females: -1.4 ± 0.6 ml/m2; LVMI males: -1.6 ± 1.1 g/m2, females: -0.2 ± 0.6 g/m2) but the mean EF was virtually stable in males (0.6 ± 0.6%) and rose slightly in females (1.2 ± 0.5%) with age. Conclusion: LV reference ranges are provided in this population-based MR study at 3.0T. The variables are similar to those described at 1.5T, including variations with age and gender. These data may help to support future population-based MR research studies that involve the use of 3.0T MRI scanners.

AB - Purpose: To scan a volunteer population using 3.0T magnetic resonance imaging (MRI). MRI of the left ventricular (LV) structure and function in healthy volunteers has been reported extensively at 1.5T. Materials and Methods: A population of 1528 volunteers was scanned. A standardized approach was taken to acquire steady-state free precession (SSFP) LV data in the short-axis plane, and images were quantified using commercial software. Six observers undertook the segmentation analysis. Results: Mean values (±standard deviation, SD) were: ejection fraction (EF) = 69 ± 6%, end diastolic volume index (EDVI) = 71 ± 13 ml/m2, end systolic volume index (ESVI) = 22 ± 7 ml/m2, stroke volume index (SVI) = 49 ± 8 ml/m2, and LV mass index (LVMI) = 55 ± 12 g/m2. The mean EF was slightly larger for females (69%) than for males (68%), but all other variables were smaller for females (EDVI 68v77 ml/m2, ESVI 21v25 ml/m2, SVI 46v52 ml/m2, LVMI 49v64 g/m2, all P <0.05). The mean LV volume data mostly decreased with each age decade (EDVI males: -2.9 ± 1.3 ml/m2, females: -3.1 ± 0.8 ml/m2; ESVI males: -1.3 ± 0.7 ml/m2, females: -1.7 ± 0.5 ml/m2; SVI males: -1.7 ± 0.9 ml/m2, females: -1.4 ± 0.6 ml/m2; LVMI males: -1.6 ± 1.1 g/m2, females: -0.2 ± 0.6 g/m2) but the mean EF was virtually stable in males (0.6 ± 0.6%) and rose slightly in females (1.2 ± 0.5%) with age. Conclusion: LV reference ranges are provided in this population-based MR study at 3.0T. The variables are similar to those described at 1.5T, including variations with age and gender. These data may help to support future population-based MR research studies that involve the use of 3.0T MRI scanners.

KW - 3.0T

KW - Cardiac

KW - Left ventricle

KW - MRI

KW - Population

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