3T MRI investigation of cardiac left ventricular structure and function in a UK population: The tayside screening for the prevention of cardiac events (TASCFORCE) study

TY - JOUR

T1 - 3T MRI investigation of cardiac left ventricular structure and function in a UK population

T2 - The tayside screening for the prevention of cardiac events (TASCFORCE) study

AU - Gandy, Stephen J.

AU - Lambert, Matthew

AU - Belch, Jill

AU - Cavin, Ian

AU - Crowe, Elena

AU - Littleford, Roberta

AU - Macfarlane, Jennifer A.

AU - Matthew, Shona Z.

AU - Martin, Patricia

AU - Nicholas, R. Stephen

AU - Struthers, Allan

AU - Sullivan, Frank

AU - Waugh, Shelley A.

AU - White, Richard D.

AU - Weir-Mccall, Jonathan R.

AU - Houston, J. Graeme

N1 - Funded by Souter Charitable Trust, and Chest, Heart and Stroke Scotland Wellcome Trust . Grant Number: WT 085664 (Clinical Research Fellowship to J.W-McC.)

PY - 2016/10/11

Y1 - 2016/10/11

N2 - Purpose: To scan a volunteer population using 3.0T magnetic resonance imaging (MRI). MRI of the left ventricular (LV) structure and function in healthy volunteers has been reported extensively at 1.5T. Materials and Methods: A population of 1528 volunteers was scanned. A standardized approach was taken to acquire steady-state free precession (SSFP) LV data in the short-axis plane, and images were quantified using commercial software. Six observers undertook the segmentation analysis. Results: Mean values (±standard deviation, SD) were: ejection fraction (EF) = 69 ± 6%, end diastolic volume index (EDVI) = 71 ± 13 ml/m2, end systolic volume index (ESVI) = 22 ± 7 ml/m2, stroke volume index (SVI) = 49 ± 8 ml/m2, and LV mass index (LVMI) = 55 ± 12 g/m2. The mean EF was slightly larger for females (69%) than for males (68%), but all other variables were smaller for females (EDVI 68v77 ml/m2, ESVI 21v25 ml/m2, SVI 46v52 ml/m2, LVMI 49v64 g/m2, all P <0.05). The mean LV volume data mostly decreased with each age decade (EDVI males: -2.9 ± 1.3 ml/m2, females: -3.1 ± 0.8 ml/m2; ESVI males: -1.3 ± 0.7 ml/m2, females: -1.7 ± 0.5 ml/m2; SVI males: -1.7 ± 0.9 ml/m2, females: -1.4 ± 0.6 ml/m2; LVMI males: -1.6 ± 1.1 g/m2, females: -0.2 ± 0.6 g/m2) but the mean EF was virtually stable in males (0.6 ± 0.6%) and rose slightly in females (1.2 ± 0.5%) with age. Conclusion: LV reference ranges are provided in this population-based MR study at 3.0T. The variables are similar to those described at 1.5T, including variations with age and gender. These data may help to support future population-based MR research studies that involve the use of 3.0T MRI scanners.

AB - Purpose: To scan a volunteer population using 3.0T magnetic resonance imaging (MRI). MRI of the left ventricular (LV) structure and function in healthy volunteers has been reported extensively at 1.5T. Materials and Methods: A population of 1528 volunteers was scanned. A standardized approach was taken to acquire steady-state free precession (SSFP) LV data in the short-axis plane, and images were quantified using commercial software. Six observers undertook the segmentation analysis. Results: Mean values (±standard deviation, SD) were: ejection fraction (EF) = 69 ± 6%, end diastolic volume index (EDVI) = 71 ± 13 ml/m2, end systolic volume index (ESVI) = 22 ± 7 ml/m2, stroke volume index (SVI) = 49 ± 8 ml/m2, and LV mass index (LVMI) = 55 ± 12 g/m2. The mean EF was slightly larger for females (69%) than for males (68%), but all other variables were smaller for females (EDVI 68v77 ml/m2, ESVI 21v25 ml/m2, SVI 46v52 ml/m2, LVMI 49v64 g/m2, all P <0.05). The mean LV volume data mostly decreased with each age decade (EDVI males: -2.9 ± 1.3 ml/m2, females: -3.1 ± 0.8 ml/m2; ESVI males: -1.3 ± 0.7 ml/m2, females: -1.7 ± 0.5 ml/m2; SVI males: -1.7 ± 0.9 ml/m2, females: -1.4 ± 0.6 ml/m2; LVMI males: -1.6 ± 1.1 g/m2, females: -0.2 ± 0.6 g/m2) but the mean EF was virtually stable in males (0.6 ± 0.6%) and rose slightly in females (1.2 ± 0.5%) with age. Conclusion: LV reference ranges are provided in this population-based MR study at 3.0T. The variables are similar to those described at 1.5T, including variations with age and gender. These data may help to support future population-based MR research studies that involve the use of 3.0T MRI scanners.

KW - 3.0T

KW - Cardiac

KW - Left ventricle

KW - MRI

KW - Population

UR - https://www.scopus.com/pages/publications/84964951696

U2 - 10.1002/jmri.25267

DO - 10.1002/jmri.25267

M3 - Article

C2 - 27143317

AN - SCOPUS:84964951696

SN - 1053-1807

VL - 44

SP - 1186

EP - 1196

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

IS - 5

M1 - 25267

ER -