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A Deep Learning Framework for Predicting Response to Therapy in Cancer

Sakellaropoulos, T., Vougas, K., Narang, S., Koinis, F., Kotsinas, A., Polyzos, A., Moss, T. J., Piha-Paul, S., Zhou, H., Kardala, E., Damianidou, E., Alexopoulos, L. G., Aifantis, I., Townsend, P. A., Panayiotidis, M. I., Sfikakis, P., Bartek, J., Fitzgerald, R. C., Thanos, D., Mills Shaw, K. R. & 3 others, Petty, R., Tsirigos, A. & Gorgoulis, V. G., 10 Dec 2019, In : Cell Reports. 29, 11, p. 3367-3373.e4 12 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
47 Downloads (Pure)

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

Baardman, J., Verberk, S. G. S., Prange, K. H. M., van Weeghel, M., van der Velden, S., Ryan, D. G., Wüst, R. C. I., Neele, A. E., Speijer, D., Denis, S. W., Witte, M. E., Houtkooper, R. H., O'neill, L. A., Knatko, E. V., Dinkova-Kostova, A. T., Lutgens, E., de Winther, M. P. J. & Van den Bossche, J., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2044-2052.e5 15 p.

Research output: Contribution to journalArticle

Open Access
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26 Citations (Scopus)
157 Downloads (Pure)

A degradation product of the salicylic acid pathway triggers oxidative stress resulting in down-regulation of Bacillus subtilis biofilm formation on Arabidopsis thaliana roots

Rudrappa, T., Quinn, W. J., Stanley-Wall, N. R. & Bais, H. P., Jul 2007, In : Planta. 226, 2, p. 283-297 15 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

A demonstration pilot trial for colorectal cancer screening in the United Kingdom: a new concept in the introduction of healthcare strategies

Steele, R. J., Parker, R., Patnick, J., Warner, J., Fraser, C., Mowat, N. A. G., Wilson, J., Alexander, F. E., Paterson, J. & United Kingdom Colorectal Screening Pilot Group, 2001, In : Journal of Medical Screening. 8, 4, p. 197-202 6 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
7 Citations (Scopus)

Adenomatous polyposis coli and hypoxia-inducible factor-1 alpha have an antagonistic connection

Newton, I. P., Kenneth, N. S., Appleton, P. L., Nathke, I. & Rocha, S., 1 Nov 2010, In : Molecular Biology of the Cell. 21, 21, p. 3630-3638 9 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Adenosine-5'-triphosphate-sensitive ion channels in neonatal rat cultured central neurones

Ashford, M. L. J., Sturgess, N. C., Trout, N. J., Gardner, N. J. & Hales, C. N., Aug 1988, In : Pflugers Archiv-European Journal of Physiology. 412, 3, p. 297-304 8 p.

Research output: Contribution to journalArticle

203 Citations (Scopus)

Adenosine deaminase, a key enzyme in DNA precursors control, is a new p73 target

Tullo, A., Mastropasqua, G., Bourdon, J. C., Centonze, P., Gostissa, M., Costanzo, A., Levrero, M., Del Sal, G., Saccone, C. & Sbisa, E., 27 Nov 2003, In : Oncogene. 22, 54, p. 8738-8748 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Adenosine Monophosphate-Activated Protein Kinase: Hydroxymethylglutaryl-CoA Reductase Kinase

Carling, D., Clarke, P. R. & Hardie, D. G., 1 Jan 1991, In : Methods in Enzymology. 200, C, p. 362-371 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells

Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. & Cantrell, D. A., 2 Sep 2014, In : PLoS ONE. 9, 9, 7 p., e106710.

Research output: Contribution to journalArticle

Open Access
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15 Citations (Scopus)
156 Downloads (Pure)

A de novo FLCN mutation in a patient with spontaneous pneumothorax and renal cancer; a clinical and molecular evaluation

Menko, F. H., Johannesma, P. C., van Moorselaar, R. J. A., Reinhard, R., van Waesberghe, J. H., Thunnissen, E., Houweling, A. C., Leter, E. M., Waisfisz, Q., van Doorn, M. B., Starink, T. M., Postmus, P. E., Coull, B. J., van Steensel, M. A. M. & Gille, J. J. P., Sep 2013, In : Familial Cancer. 12, 3, p. 373-379 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
Open Access
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5 Citations (Scopus)
184 Downloads (Pure)

Adenylyl cyclase G is activated by an intramolecular osmosensor

Saran, S., Schaap, P. & Devreotes, P. (ed.), 2004, In : Molecular Biology of the Cell. 15, 3, p. 1479-1486 8 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Adequacy of social work practice theories: an evaluative framework

Dixon, D., Holzhalb, C., Kelly, T. B., Leslie, D., Sutphen, R. & Kilpatrick, A., 1995, In : Journal of Applied Social Sciences. 19, 2, p. 451-464 14 p.

Research output: Contribution to journalArticle

A descriptive feast but an evaluative famine: systematic review of published articles on primary care computing during 1980-97

Mitchell, E. & Sullivan, F., Feb 2001, In : BMJ. 322, 7281, p. 279-282 4 p.

Research output: Contribution to journalArticle

220 Citations (Scopus)

A Descriptive Study: Observing Behavioral Patterns of Preschool Children in Turkey and Belgium

Ocak Karabay, S., Asi, D. S. & Swennen, A., Feb 2015, In : Creative Education . 6, 2, p. 181-185 5 p.

Research output: Contribution to journalArticle

Open Access
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75 Downloads (Pure)

A descriptive study of hot aches: a previously unreported winter climbing phenomenon

Melvin, A. & George, J., 12 Sep 2016, In : Sports Medicine - Open. 2, 5 p., 36.

Research output: Contribution to journalArticle

Open Access
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191 Downloads (Pure)

A designed inhibitor of a clc antiporter blocks function through a unique binding mode

Howery, A. E., Elvington, S., Abraham, S. J., Choi, K-H., Dworschak-Simpson, S., Phillips, S., Ryan, C. M., Sanford, R. L., Almqvist, J., Tran, K., Chew, T. A., Zachariae, U., Andersen, O. S., Whitelegge, J., Matulef, K., Du Bois, J. & Maduke, M. C., 2012, In : Chemistry & Biology. 19, 11, p. 1460-1470 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

A developmental study of the infrahumanization hypothesis

Martin, J., Bennett, M. & Murray, W. S., Jun 2008, In : British Journal of Developmental Psychology. 26, p. 153-161 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

ADHD symptoms in children aged 5 to 15 years in Zhabei District, Shanghai

Jin, W. L., Li, G. Z., Du, Y. S., Coghill, D., Au, S. & Zhong, X. Y., 1 Jul 2016, In : European Journal of Psychiatry. 30, 3, p. 173-182 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Adherence and cytokine induction in caco-2 cells by bacterial populations from a three-stage continuous-culture model of the large intestine

Bahrami, B., Child, M. W., Macfarlane, S. & Macfarlane, G. T., May 2011, In : Applied and Environmental Microbiology. 77, 9, p. 2934-2942 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
42 Citations (Scopus)

Adherence to angiotensin-converting-enzyme inhibitors and illness beliefs in older heart failure patients

Molloy, G. J., Gao, C., Johnston, D. W., Johnston, M., Witham, M. D., Struthers, A. D. & McMurdo, M. E. T., Jul 2009, In : European Journal of Heart Failure. 11, 7, p. 715-720 6 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Adherence to antiepileptic drugs in children with epilepsy in a Scottish population cohort

Shetty, J., Greene, S. A., Mesalles-Naranjo, O. & Kirkpatrick, M., May 2016, In : Developmental Medicine and Child Neurology. 58, 5, p. 469-474 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Adherence to insulin and its association with glycaemic control in patients with type 2 diabetes

Donnelly, L. A., Morris, A. D., Evans, J. M. M. & DARTS/MEMO Collaboration, Jun 2007, In : QJM : an International Journal of Medicine. 100, 6, p. 345-50 6 p.

Research output: Contribution to journalArticle

151 Citations (Scopus)

Adherence to insulin treatment, glycaemic control, and ketoacidosis in insulin-dependent diabetes mellitus

Morris, A. D., Boyle, D. I. R., McMahon, A. D., Greene, S. A., MacDonald, T. M. & Newton, R. W., 22 Nov 1997, In : Lancet. 350, 9090, p. 1505-1510 6 p.

Research output: Contribution to journalArticle

405 Citations (Scopus)

Adherence to once-daily and twice-daily direct acting antiviral therapy for hepatitis C infection among people with recent injection drug use or current opioid agonist therapy

Cunningham, E. B., Hajarizadeh, B., Amin, J., Litwin, A. H., Gane, E., Cooper, C., Lacombe, K., Hellard, M., Read, P., Powis, J., Dalgard, O., Bruneau, J., Matthews, G. V., Feld, J. J., Dillon, J. F., Shaw, D., Bruggmann, P., Conway, B., Fraser, C., Marks, P. & 2 others, Dore, G. J. & Grebely, J., 2 Nov 2019, In : Clinical Infectious Diseases. 10 p., ciz1089.

Research output: Contribution to journalArticle

Adherence to oral glucose-lowering therapies and associations with 1-year HbA1c: A retrospective cohort analysis in a large primary care database

Farmer, A. J., Rodgers, L. R., Lonergan, M., Shields, B., Weedon, M. N., Donnelly, L., Holman, R. R., Pearson, E. R. & Hattersley, A. T., 1 Feb 2016, In : Diabetes Care. 39, 2, p. 258-263 6 p.

Research output: Contribution to journalArticle

Open Access
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38 Citations (Scopus)
136 Downloads (Pure)

Adherence to oral hypoglycaemic agents prior to insulin therapy in Type 2 diabetes

Evans, J. M. M., Donnan, P. T. & Morris, A. D., Aug 2002, In : Diabetic Medicine. 19, 8, p. 685-688 4 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)
336 Citations (Scopus)

Adherence to sofosbuvir and velpatasvir among people with chronic HCV infection and recent injection drug use: The SIMPLIFY study

Cunningham, E. B., Amin, J., Feld, J. J., Bruneau, J., Dalgard, O., Powis, J., Hellard, M., Cooper, C., Read, P., Conway, B., Dunlop, A. J., Norton, B., Litwin, A. H., Hajarizadeh, B., Thurnheer, M. C., Dillon, J. F., Weltman, M., Shaw, D., Bruggmann, P., Gane, E. & 8 others, Fraser, C., Marks, P., Applegate, T. L., Quiene, S., Siriragavan, S., Matthews, G. V., Dore, G. J. & Grebely, J., Dec 2018, In : International Journal of Drug Policy. 62, p. 14-23 10 p.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
53 Downloads (Pure)

Adherence to statin treatment and readmission of patients after myocardial infarction: a six year follow up study

Wei, L., Wang, J., Thompson, P., Wong, S., Struthers, A. D. & MacDonald, T. M., 2002, In : Heart (British Cardiac Society). 88, 3, p. 229-33 5 p.

Research output: Contribution to journalArticle

220 Citations (Scopus)

Adhesion molecule in untreated inflammatory arthritis

Mulherin, D. M., Veale, D. J., Belch, J. J. F., Bresnihan, B. & Fitzgerald, O., 1996, In : Quarterly Journal of Medicine. 89, 3, p. 195-203 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Adhesion molecules in inflammatory bowel disease

Jones, S. C., Banks, R. E., Haidar, A., Gearing, A. J., Hemingway, I. K., Ibbotson, S. H., Dixon, M. F. & Axon, A. T., 1995, In : Gut. 36, 5, p. 724-730 7 p.

Research output: Contribution to journalArticle

166 Citations (Scopus)

Adhesion of protein residues to substituted (111) diamond surfaces: an insight from density functional theory and classical molecular dynamics simulations

Borisenko, K. B., Reavy, H. J., Zhao, Q. & Abel, E. W., 15 Sep 2008, In : Journal of Biomedical Materials Research Part A. 86A, 4, p. 1113-1121 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Ladds, M. J. G. W., Van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A. R., Popova, G., Pastor Fernández, A., Mollick, T., Darekar, S., Sedimbi, S. K., Nekulova, M., Sachweh, M. C. C., Campbell, J., Higgins, M., Tuck, C., Popa, M., Safont, M. M., Gelebart, P., Fandalyuk, Z., Thompson, A. M. & 26 others, Svensson, R., Gustavsson, A. L., Johansson, L., Färnegårdh, K., Yngve, U., Saleh, A., Haraldsson, M., D'Hollander, A. C. A., Franco, M., Zhao, Y., Håkansson, M., Walse, B., Larsson, K., Peat, E. M., Pelechano, V., Lunec, J., Vojtesek, B., Carmena, M., Earnshaw, W. C., McCarthy, A. R., Westwood, N. J., Arsenian-Henriksson, M., Lane, D. P., Bhatia, R., McCormack, E. & Laín, S., 16 Mar 2018, In : Nature Communications. 9, p. 1-14 14 p., 1107.

Research output: Contribution to journalArticle

Open Access
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20 Citations (Scopus)
178 Downloads (Pure)

A Dictyostelium homologue of the metazoan Cbl proteins regulates STAT signalling

Langenick, J., Araki, T., Yamada, Y. & Williams, J. G., 1 Nov 2008, In : Journal of Cell Science. 121, 21, p. 3524-3530 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

A Dictyostelium SH2 adaptor protein required for correct DIF-1 signaling and pattern formation

Sugden, C., Ross, S., Annesley, S. J., Cole, C., Bloomfield, G., Ivens, A., Skelton, J., Fisher, P. R., Barton, G. & Williams, J. G., 15 May 2011, In : Developmental Biology. 353, 2, p. 290-301 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice

Dinkova-Kostova, A. T., Jenkins, S. N., Wehage, S. L., Huso, D. L., Benedict, A. L., Stephenson, K. K., Fahey, J. W., Liu, H., Liby, K. T., Honda, T., Gribble, G. W., Sporn, M. B. & Talalay, P., 21 Mar 2008, In : Biochemical and Biophysical Research Communications. 367, 4, p. 859-865 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Adiposity, compared with masculinity, serves as a more valid cue to immunocompetence in human mate choice

Rantala, M. J., Coetzee, V., Moore, F. R., Skrinda, I., Kecko, S., Krama, T., Kivleniece, I. & Krams, I., 22 Jan 2013, In : Proceedings of the Royal Society B. 280, 1751, 20122495 .

Research output: Contribution to journalArticle

43 Citations (Scopus)

Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data

Timpson, N. J., Lindgren, C. M., Weedon, M. N., Randall, J., Ouwehand, W. H., Strachan, D. P., Rayner, N. W., Walker, M., Hitman, G. A., Doney, A. S. F., Palmer, C. N. A., Morris, A. D., Hattersley, A. T., Zeggini, E., Frayling, T. M. & McCarthy, M. I., Feb 2009, In : Diabetes. 58, 2, p. 505-510 6 p.

Research output: Contribution to journalArticle

Open Access
78 Citations (Scopus)

A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing

Ajuh, P., Sleeman, J., Chusainow, J. & Lamond, A. I., 2001, In : Journal of Biological Chemistry. 276, 45, p. 42370-42381 12 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification

Stavridis, M. P., Lunn, J. S., Collins, B. J. & Storey, K. G., 2007, In : Development. 134, 16, p. 2889-94 6 p.

Research output: Contribution to journalArticle

213 Citations (Scopus)

A disease resistance locus on potato and tomato chromosome 4 exhibits a conserved multipartite structure displaying different rates of evolution in different lineages

Destefanis, M., Nagy, I., Rigney, B., Bryan, G. J., McLean, K., Hein, I., Griffin, D. & Milbourne, D., 24 Oct 2015, In : Functional Plant Biology. 15, 13 p., 255.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
161 Downloads (Pure)

A distinct p53 protein isoform signature reflects the onset of induction chemotherapy for acute myeloid leukemia

Anensen, N., Oyan, A. M., Bourdon, J-C., Kalland, K. H., Bruserud, O. & Gjertsen, B. T., 1 Jul 2006, In : Clinical Cancer Research. 12, 13, p. 3985-3992 8 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

A distributed energy-balance melt model of an alpine debris-covered glacier

Fyffe, C. L., Reid, T. D., Brock, B. W., Kirkbride, M. P., Diolaiuti, G., Smiraglia, C. & Diotri, F., 1 Jun 2014, In : Journal of Glaciology. 60, 221, p. 587–602 16 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

A distributed source coding scheme for source estimation in wireless sensor networks

Tang, Z., Glover, I. A., Monro, D. M. & He, J., Jan 2007, In : IEICE Transactions on Communications. E90-B, 1, p. 152-155 4 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Adjusting for BMI in analyses of volumetric mammographic density and breast cancer risk

Hudson, S., Hjerkind, K. V., Vinnicombe, S., Allen, S., Trewin, C. B., Ursin, G., dos Santos Silva, I. & De Stavola, B. L., 29 Dec 2018, In : Breast Cancer Research. 20, p. 1-10 10 p., 156.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
148 Downloads (Pure)