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Article

A modified Delphi process to establish future research priorities in malignant oesophagogastric surgery

Wilson, M. S. J., Blencowe, N. S., Boyle, C., Knight, S. R., Petty, R., Vohra, R. S. & Underwood, T. J., 16 Dec 2019, In : Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland. 6 p.

Research output: Contribution to journalArticle

Research
Neoplasms
Genomics
Patient Care
Delivery of Health Care
1 Citation (Scopus)

A modified technique for radar tracking of float-drogues in lake water circulation investigations

Duck, R. W., McManus, J. & Charlton, J. A., 1985, In : Hydrological Sciences Journal. 30, 4, p. 513-521

Research output: Contribution to journalArticle

lake water
radar
water
flow velocity
acetate
4 Citations (Scopus)

A modular device to measure the effects of plantar foot pressure on the microcirculation of the heel

Santos, D., Carline, T., Richmond, R. & Abboud, R. J., Mar 2003, In : Foot. 13, 1, p. 30-38 9 p.

Research output: Contribution to journalArticle

Heel
Microcirculation
Foot
Pressure
Equipment and Supplies
78 Citations (Scopus)

A molecular explanation for the recessive nature of parkin-linked Parkinson's disease

Spratt, D. E., Julio Martinez-Torres, R., Noh, Y. J., Mercier, P., Manczyk, N., Barber, K. R., Aguirre, J. D., Burchell, L., Purkiss, A., Walden, H. & Shaw, G. S., 1 Jan 2013, In : Nature Communications. 4, 12 p., 1983.

Research output: Contribution to journalArticle

Parkinson disease
mutations
Ubiquitin
Parkinson Disease
Parkinsonian Disorders
8 Citations (Scopus)
114 Downloads (Pure)

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

Harrison, J. R., Brand, S., Smith, V., Robinson, D. A., Thompson, S., Smith, A., Davies, K., Mok, N., Torrie, L. S., Collie, I., Hallyburton, I., Norval, S., Simeons, F. R. C., Stojanovski, L., Frearson, J. A., Brenk, R., Wyatt, P. G., Gilbert, I. H. & Read, K. D., 12 Sep 2018, In : Journal of Medicinal Chemistry. 61, 18, p. 8374–8389 16 p.

Research output: Contribution to journalArticle

Open Access
File
African Trypanosomiasis
Trypanosoma brucei brucei
Crystallography
Central Nervous System Diseases
Peripheral Nervous System
47 Citations (Scopus)

A molecular method to assess Phytophthora diversity in environmental samples

Scibetta, S., Schena, L., Chimento, A., Cacciola, S. O. & Cooke, D. E. L., Mar 2012, In : Journal of Microbiological Methods. 88, 3, p. 356-368 13 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

A molecular switch driving inactivation in the cardiac K channel hERG

Köpfer, D. A., Hahn, U., Ohmert, I., Vriend, G., Pongs, O., de Groot, B. L. & Zachariae, U., 24 Jul 2012, In : PLoS ONE. 7, 7, e41023.

Research output: Contribution to journalArticle

Action Potentials
Hydrogen
Hydrogen bonds
inactivation
Switches
11 Citations (Scopus)

A monoclonal antibody stains blastemal but not tubular components of Wilms' tumour

Sarawar, S. R., Schlingemann, R. O., Kelsey, A., Fleming, S. & Kumar, S., 1988, In : Journal of Pathology. 156, 4, p. 319-24 6 p.

Research output: Contribution to journalArticle

Wilms Tumor
Coloring Agents
Endothelial Cells
Monoclonal Antibodies
Kidney
15 Citations (Scopus)

A monopolar vortex encounters an isolated topographic feature on a β-plane

van Geffen, J. H. G. M. & Davies, P. A., Mar 2000, In : Dynamics of Atmospheres and Oceans. 32, 1, p. 1-26 26 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

A monopolar vortex encounters a north-south ridge or trough

van Geffen, JHGM. & Davies, PA., Mar 2000, In : Fluid Dynamics Research. 26, 3, p. 157-179 23 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
52 Downloads (Pure)
Open Access
File
Ions
DNA
Enzymes
Substrate Specificity
Catalytic Domain
economics
physical science
persistence
analysis
policy
37 Citations (Scopus)
8 Citations (Scopus)
203 Downloads (Pure)

A Morphological identification cell cytotoxicity assay using cytoplasm-localized fluorescent probe (CLFP) to distinguish living and dead cells

Lai, F., Shen, Z., Wen, H., Chen, J., Zhang, X., Lin, P., Yin, D., Cui, H. & Chen, X., 8 Jan 2017, In : Biochemical and Biophysical Research Communications. 482, 2, p. 257-263 7 p.

Research output: Contribution to journalArticle

Open Access
File
Cytotoxicity
Fluorescent Dyes
Assays
Cytoplasm
Cells
26 Citations (Scopus)

A morphometric comparison of the nuclear morphology of fresh and frozen-thawed human zona-bound and unbound sperm

Thompson, L. A., Brook, P. F., Warren, M. A., Barratt, C. L. R. & Cooke, I. D., Jul 1994, In : Journal of Andrology. 15, 4, p. 337-42 6 p.

Research output: Contribution to journalArticle

Herpes Zoster
Spermatozoa
Sperm Head
Zona Pellucida
Cryopreservation
1 Citation (Scopus)

Amorphous semiconductors

Reynolds, S. & Belford, R. E., 1987, In : Physics in Technology. 18, 5, p. 193-203 11 p.

Research output: Contribution to journalArticle

Amorphous semiconductors
Crystal atomic structure
amorphous semiconductors
Thin film transistors
Solar energy

'A Most Serviceable Drudge': The Papermills of the Water of Leith

Bromage, S., McCleery, A. & Finkelstein, D., 2007, In : The Quarterly: the Journal of the British Association of Paper Historians. 63, p. 9-16

Research output: Contribution to journalArticle

27 Citations (Scopus)

A moving interface finite element formulation for layered structures

Funari, M. F., Greco, F. & Lonetti, P., 1 Jul 2016, In : Composites Part B: Engineering. 96, p. 325-337 13 p.

Research output: Contribution to journalArticle

Debonding
Crack propagation
Composite materials
1464 Citations (Scopus)

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

Hardie, D. G., Oct 2007, In : Nature Reviews Molecular Cell Biology. 8, 10, p. 774-85 12 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Cell Polarity
Eukaryotic Cells
Catalytic Domain
Homeostasis
103 Citations (Scopus)
68 Downloads (Pure)

AMP-activated protein kinase: a cellular energy sensor that comes in twelve flavours

Ross, F. A., MacKintosh, C. & Hardie, D. G., 24 Mar 2016, In : FEBS Journal. 283, 16, p. 2987-3001 15 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Flavors
Protein Isoforms
Tumors
Sensors
114 Citations (Scopus)
345 Citations (Scopus)

AMP-activated protein kinase: Greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform

Salt, I., Celler, J. W., Hawley, S. A., Prescott, A., Woods, A., Carling, D. & Hardie, D. G., 15 Aug 1998, In : Biochemical Journal. 334, 1, p. 177-187 11 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Adenosine Monophosphate
Protein Isoforms
Phosphotransferases
Adenosine Triphosphate

AMP-activated protein kinase (AMPK): A key mediator of hypoglycemia-sensing in the ventromedial hypothalamus (VMH)

McCrimmon, R. J., Shaw, M., Fan, X., Cheng, H., Ding, Y., Wang, A. & Sherwin, R. S., Jun 2006, In : Diabetes. 55, Suppl 1, p. A15-A15 1 p., 62-OR.

Research output: Contribution to journalArticle

17 Citations (Scopus)

AMP-activated protein kinase (AMPK)α2 plays a role in determining the cellular fate of glucose in insulin-resistant mouse skeletal muscle

Lee-Young, R. S., Bonner, J. S., Mayes, W. H., Iwueke, I., Barrick, B. A., Hasenour, C. M., Kang, L. & Wasserman, D. H., Mar 2013, In : Diabetologia. 56, 3, p. 608-617 10 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Skeletal Muscle
Insulin
Nitric Oxide Synthase Type II
Lipids
8 Citations (Scopus)
184 Downloads (Pure)

AMP-activated protein kinase activator A-769662 increases intracellular calcium and ATP release from astrocytes in an AMPK-independent manner

Vlachaki Walker, J. M., Robb, J. L., Cruz, A. M., Malhi, A., Weightman Potter, P. G., Ashford, M. L. J., McCrimmon, R. J., Ellacott, K. L. J. & Beall, C., 21 Apr 2017, In : Diabetes, Obesity & Metabolism. 19, 7, p. 997-1005 9 p.

Research output: Contribution to journalArticle

Open Access
File
A 769662
AMP-Activated Protein Kinases
Astrocytes
Adenosine Triphosphate
Calcium
27 Citations (Scopus)

AMP-activated protein kinase and hypoxic pulmonary vasoconstriction

Robertson, T. P., Mustard, K. J. W., Lewis, T. H., Clark, J. H., Wyatt, C. N., Blanco, E. A., Peers, C., Hardie, D. G. & Evans, A. M., 24 Oct 2008, In : European Journal of Pharmacology. 595, 1-3, p. 39-43 5 p.

Research output: Contribution to journalArticle

324 Citations (Scopus)

AMP-activated protein kinase as a drug target

Hardie, D. G., Feb 2007, In : Annual Review of Pharmacology and Toxicology. 47, p. 185-210 26 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Pharmaceutical Preparations
Adenosine Triphosphate
Biguanides
Thiazolidinediones
11 Citations (Scopus)
94 Downloads (Pure)

AMP-activated protein kinase inhibits Kv1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation

Moral-Sanz, J., Mahmoud, A. D., Ross, F. A., Eldstrom, J., Fedida, D., Hardie, D. G. & Evans, A. M., 1 Sep 2016, In : Journal of Physiology. 594, 17, p. 4901-4915 15 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Oxidative Phosphorylation
Muscle Cells
Lung
A 769662
904 Citations (Scopus)

AMP-activated protein kinase in metabolic control and insulin signaling

Towler, M. C. & Hardie, D. G., 16 Feb 2007, In : Circulation Research. 100, 3, p. 328-41 14 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Adenosine Triphosphate
Adenosine Monophosphate
Insulin
Physiological Stress
48 Citations (Scopus)

AMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: a randomised glycaemia-controlled crossover study

Boyle, J. G., Logan, P. J., Jones, G. C., Small, M., Sattar, N., Connell, J. M. C., Cleland, S. J. & Salt, I. P., 2011, In : Diabetologia. 54, 7, p. 1799-1809 11 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)
102 Citations (Scopus)

AMP-activated protein kinase mediates preconditioning in cardiomyocytes by regulating activity and trafficking of sarcolemmal ATP-sensitive K(+) channels

Sukhodub, A., Jovanović, S., Du, Q., Budas, G., Clelland, A. K., Shen, M., Sakamoto, K., Tian, R. & Jovanovic, A., Jan 2007, In : Journal of Cellular Physiology. 210, 1, p. 224-36 13 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Cardiac Myocytes
Adenosine Triphosphate
KATP Channels
Mitochondrial Membrane Potential
53 Citations (Scopus)

AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase

Bultot, L., Guigas, B., Von Wilamowitz-Moellendorff, A., Maisin, L., Vertommen, D., Hussain, N., Beullens, M., Guinovart, J. J., Foretz, M., Viollet, B., Sakamoto, K., Hue, L. & Rider, M. H., 1 Apr 2012, In : Biochemical Journal. 443, p. 193-203 11 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

AMPA receptor channels with long-lasting desensitization in bipolar interneurons contribute to synaptic depression in a novel feedback circuit in layer 2/3 of rat neocortex

Rozov, A., Jerecic, J., Sakmann, B. & Burnashev, N., Oct 2001, In : Journal of Neuroscience. 21, 20, p. 8062-8071 10 p.

Research output: Contribution to journalArticle

AMPA Receptors
Neocortex
Interneurons
Pyramidal Cells
Glutamic Acid
212 Citations (Scopus)
82 Downloads (Pure)

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

Gowans, G. J., Hawley, S. A., Ross, F. A. & Hardie, D. G., 1 Oct 2013, In : Cell Metabolism. 18, 4, p. 556-566 11 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Adenosine Monophosphate
Phosphorylation
Adenosine Diphosphate
Adenosine Triphosphate
213 Citations (Scopus)
76 Downloads (Pure)

AMPK: a target for drugs and natural products with effects on both diabetes and cancer

Hardie, D. G., Jul 2013, In : Diabetes. 62, 7, p. 2164-2172 9 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Biological Products
Metformin
Pharmaceutical Preparations
Neoplasms
142 Citations (Scopus)
94 Downloads (Pure)

AMPK: regulating energy balance at the cellular and whole body levels

Hardie, D. G. & Ashford, M. L. J., Mar 2014, In : Physiology. 29, 2, p. 99-107 9 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Adenine Nucleotides
Energy Intake
Eukaryota
Energy Metabolism
30 Citations (Scopus)

AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?

Dandapani, M. & Hardie, D. G., Apr 2013, In : Biochemical Society Transactions. 41, 2, p. 687-693 7 p.

Research output: Contribution to journalArticle

441 Citations (Scopus)

AMPK: a key regulator of energy balance in the single cell and the whole organism

Hardie, D. G., Sep 2008, In : International Journal of Obesity. 32, p. S7-S12 6 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

AMPK activators inhibit the proliferation of human melanomas bearing the activated MAPK pathway

Petti, C., Vegetti, C., Molla, A., Bersani, I., Cleris, L., Mustard, K. J., Formelli, F., Hardie, G. D., Sensi, M. & Anichini, A., 2012, In : Melanoma Research. 22, 5, p. 341-350 10 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Melanoma
Phenformin
Mitogen-Activated Protein Kinase Kinases
Phosphorylation
34 Citations (Scopus)

AMPK and SNF1: snuffing out stress

Hardie, D. G., 7 Nov 2007, In : Cell Metabolism. 6, 5, p. 339-40 2 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Adenosine Monophosphate
Glycogen
Homeostasis
Nucleotides
40 Citations (Scopus)

AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B

Johanns, M., Lai, Y. C., Hsu, M. F., Jacobs, R., Vertommen, D., Van Sande, J., Dumont, J. E., Woods, A., Carling, D., Hue, L., Viollet, B., Foretz, M. & Rider, M. H., 8 Mar 2016, In : Nature Communications. 7, 10856.

Research output: Contribution to journalArticle

Open Access
cyclic AMP
Type 4 Cyclic Nucleotide Phosphodiesterase
adenosine monophosphate
phosphorylation
Phosphorylation
25 Citations (Scopus)
244 Downloads (Pure)

AMPK Causes Cell Cycle Arrest in LKB1-deficient Cells via Activation of CAMKK2

Fogarty, S., Ross, F. A., Vara Ciruelos, D., Gray, A., Gowans, G. J. & Hardie, D. G., 1 Aug 2016, In : Molecular Cancer Research. 14, 8, p. 683-695 13 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Cell Cycle Checkpoints
Null Lymphocytes
Phosphorylation
Calcimycin
23 Citations (Scopus)

AMPK dilates resistance arteries via activation of SERCA and BKCa channels in smooth muscle

Schneider, H., Schubert, K. M., Blodow, S., Kreutz, C-P., Erdogmus, S., Wiedenmann, M., Qiu, J., Fey, T., Ruth, P., Lubomirov, L. T., Pfitzer, G., Mederos y Schnitzler, M., Hardie, D. G., Gudermann, T. & Pohl, U., Jul 2015, In : Hypertension. 66, 1, p. 108-116 9 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Smooth Muscle
Arteries
Vascular Smooth Muscle
Smooth Muscle Myocytes
333 Citations (Scopus)
123 Downloads (Pure)

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

Claret, M., Smith, M. A., Batterham, R. L., Selman, C., Choudhury, A. I., Fryer, L. G. D., Clements, M., Al-Qassab, H., Heffron, H., Xu, A. W., Speakman, J. R., Barsh, G. S., Viollet, B., Vaulont, S., Ashford, M. L. J., Carling, D. & Withers, D. J., Aug 2007, In : Journal of Clinical Investigation. 117, 8, p. 2325-2336 12 p.

Research output: Contribution to journalArticle

Open Access
File
Pro-Opiomelanocortin
AMP-Activated Protein Kinases
Homeostasis
Leptin
Neurons
12 Citations (Scopus)

AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to KATP channels

Beall, C., Watterson, K. R., McCrimmon, R. J. & Ashford, M. L. J., Jun 2013, In : Journal of Bioenergetics and Biomembranes. 45, 3, p. 229-241 13 p.

Research output: Contribution to journalArticle

KATP Channels
AMP-Activated Protein Kinases
Insulin-Secreting Cells
Glucose
Adenylate Kinase
120 Citations (Scopus)

AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells

Lee, C-W., Wong, L. L-Y., Tse, E. Y-T., Liu, H-F., Leong, V. Y-L., Lee, J. M-F., Hardie, D. G., Ng, I. O-L. & Ching, Y-P., 2012, In : Cancer Research. 72, 17, p. 4394-4404 11 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Acetylation
Liver Neoplasms
Phosphorylation
Hepatocellular Carcinoma
249 Citations (Scopus)
87 Downloads (Pure)

AMPK-sensing energy while talking to other signaling pathways

Hardie, D. G., 2 Dec 2014, In : Cell Metabolism. 20, 6, p. 939-952 14 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Food
Lysosomes
Eukaryota
Catalytic Domain
107 Citations (Scopus)

AMPKα1: a glucose sensor that controls CD8 T-cell memory

Rolf, J., Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. & Cantrell, D. A., Apr 2013, In : European Journal of Immunology. 43, 4, p. 889-896 8 p.

Research output: Contribution to journalArticle

149 Citations (Scopus)

Amplification and increased expression of alpha class glutathione S-transferase-encoding genes associated with resistance to nitrogen mustards

Lewis, A. D., Hickson, I. D., Robson, C. N., Harris, A. L., Hayes, J. D., Griffiths, S. A., Manson, M. M., Hall, A. E., Moss, J. E. & Wolf, C. R., Nov 1988, In : Proceedings of the National Academy of Sciences of the United States of America. 85, 22, p. 8511-5 5 p.

Research output: Contribution to journalArticle

Mechlorethamine
Glutathione Transferase
Pharmaceutical Preparations
Genes
Glutathione