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  • John Hayes
2014

Transcription factor Nrf1 Is topologically repartitioned across membranes to enable target gene transactivation through Its acidic glucose-responsive domains

Zhang, Y., Ren, Y., Li, S. & Hayes, J. D., Apr 2014, In : PLoS ONE. 9, 4, 17 p., e93458.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
76 Downloads (Pure)
2019

New insights into nuclear factor erythroid 2-related factors in toxicology and pharmacology

Pi, J., Hayes, J. D. & Yamamoto, M., 15 Mar 2019, In : Toxicology and Applied Pharmacology. 367, p. 33-35 3 p.

Research output: Contribution to journalEditorial

Open Access
File
2 Citations (Scopus)
87 Downloads (Pure)
2014

Phosphoinositide 3-kinases upregulate system xc- via eukaryotic initiation factor 2α and activating transcription factor 4-A pathway active in glioblastomas and epilepsy

Lewerenz, J., Baxter, P., Kassubek, R., Albrecht, P., Van Liefferinge, J., Westhoff, M-A., Halatsch, M-E., Karpel-Massler, G., Meakin, P. J., Hayes, J. D., Aronica, E., Smolders, I., Ludolph, A. C., Methner, A., Conrad, M., Massie, A., Hardingham, G. E. & Maher, P., 28 May 2014, In : Antioxidants & Redox Signaling. 20, 18, p. 2907-2922 16 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)
2012

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

Chowdhry, S., Zhang, Y., McMahon, M., Sutherland, C., Cuadrado, A. & Hayes, J. D., 2012, In : Oncogene. 32, p. 3765-3781 17 p.

Research output: Contribution to journalArticle

262 Citations (Scopus)
2013

A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways

Gan, F-F., Leng, H., Ang, X., Reddy, S. A., Lee, S. S-H., Yang, H., Tan, S-H., Hayes, J. D., Chui, W-K. & Chew, E-H., 1 Nov 2013, In : Toxicology and Applied Pharmacology. 272, 3, p. 852-862 11 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2017
Open Access
File
8 Citations (Scopus)
200 Downloads (Pure)

Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses

Torrente, L., Sanchez, C., Moreno Dorta, R., Chowdhry, S., Cabello, P., Isono, K., Koseki, H., Honda, T., Hayes, J., Dinkova-Kostova, A. & de la Vega, L., 2 Nov 2017, In : Oncogene. 36, 44, p. 6204-6212 9 p.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
214 Downloads (Pure)
2016
Open Access
File
15 Citations (Scopus)
137 Downloads (Pure)
2015

The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic

O'Connell, M. A. & Hayes, J. D., Aug 2015, In : Biochemical Society Transactions. 43, 4, p. 687-689 3 p.

Research output: Contribution to journalArticle

Open Access
File
93 Citations (Scopus)
264 Downloads (Pure)
2018
Open Access
File
7 Citations (Scopus)
145 Downloads (Pure)
2020

Oxidative Stress in Cancer

Hayes, J., Dinkova-Kostova, A. & Tew, K. D., 9 Jul 2020, In : Cancer Cell. 38, 31 p.

Research output: Contribution to journalReview article

2011

Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents

Higgins, L. G. & Hayes, J. D., May 2011, In : Drug Metabolism Reviews. 43, 2, p. 92-137 46 p.

Research output: Contribution to journalReview article

126 Citations (Scopus)
2015

Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants

Agathanggelou, A., Weston, V. J., Perry, T., Davies, N. J., Skowronska, A., Payne, D. T., Fossey, J. S., Oldreive, C. E., Wei, W., Pratt, G., Parry, H., Oscier, D., Coles, S. J., Hole, P. S., Darley, R. L., McMahon, M., Hayes, J. D., Moss, P., Stewart, G., Taylor, A. M. R. & 1 others, Stankovic, T., Aug 2015, In : Haematologica. 100, 8, p. 1076-1085 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2012

Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics

Abdullah, A., Kitteringham, N. R., Jenkins, R. E., Goldring, C., Higgins, L., Yamamoto, M., Hayes, J. & Park, B. K., 2012, In : Pharmacological Reports. 64, 3, p. 680-697 18 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2011

Nrf2-mediated induction of antioxidant response element-driven gene expression by flavonoids is dependent on their chemical structure

Xiao, H., Hourihan, J. M., Brown, L., McMahon, M., Stewart, D. & Hayes, J. D., 18 Dec 2011, In : Toxicology. 290, 2-3, p. 126-127 2 p.

Research output: Contribution to journalBook/Film/Article review

2015

The selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression

Zhang, Y., Li, S., Xiang, Y., Qiu, L., Zhao, H. & Hayes, J. D., 13 Aug 2015, In : Scientific Reports. 5, 30 p., 12983.

Research output: Contribution to journalArticle

Open Access
File
22 Citations (Scopus)
273 Downloads (Pure)
2014

Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 in astrocytes

Deighton, R. F., Márkus, N. M., Al-Mubarak, B., Bell, K. F. S., Papadia, S., Meakin, P. J., Chowdhry, S., Hayes, J. & Hardingham, G. E., 2014, In : Proceedings of the National Academy of Sciences USA. 111, 18, p. E1818-1820 3 p., 24753562.

Research output: Contribution to journalLetter

15 Citations (Scopus)
2012

Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms

Gupta, K., Patani, R., Baxter, P., Serio, A., Story, D., Tsujita, T., Hayes, J. D., Pedersen, R. A., Hardingham, G. E. & Chandran, S., May 2012, In : Cell Death & Differentiation. 19, 5, p. 779-787 9 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
2014

Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes

Tsujita, T., Peirce, V., Baird, L., Matsuyama, Y., Takaku, M., Walsh, S. V., Griffin, J. L., Uruno, A., Yamamoto, M. & Hayes, J. D., Oct 2014, In : Molecular and Cellular Biology. 34, 20, p. 3800-3816 17 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
2012

Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP Axis

Rada, P., Rojo, A. I., Evrard-Todeschi, N., Innamorato, N. G., Cotte, A., Jaworski, T., Tobón-Velasco, J. C., Devijver, H., García-Mayoral, M. F., Van Leuven, F., Hayes, J. D., Bertho, G. & Cuadrado, A., 2012, In : Molecular and Cellular Biology. 32, 17, p. 3486-99 14 p.

Research output: Contribution to journalArticle

147 Citations (Scopus)
2011

SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner

Rada, P., Rojo, A. I., Chowdhry, S., McMahon, M., Hayes, J. D. & Cuadrado, A., Mar 2011, In : Molecular and Cellular Biology. 31, 6, p. 1121-1133 13 p.

Research output: Contribution to journalArticle

353 Citations (Scopus)
2014
93 Citations (Scopus)
243 Downloads (Pure)
757 Citations (Scopus)
2017

Corrigendum to "Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer"

MacLeod, A. K., Acosta-Jimenez, L., Coates, P. J., McMahon, M., Carey, F. A., Honda, T., Hayes, J. D., Henderson, C. J. & Wolf, C. R., 22 Aug 2017, In : British Journal of Cancer. 117, 1 p., e1.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2016

Regulation of the CNC-bZIP transcription factor Nrf2 by Keap1 and the axis between GSK-3 and β-TrCP

Hayes, J. D., Ebisine, K., Sharma, R. S., Chowdhry, S., Dinkova-Kostova, A. T. & Sutherland, C., Dec 2016, In : Current Opinion in Toxicology. 1, p. 92-103 12 p.

Research output: Contribution to journalReview article

Open Access
File
9 Citations (Scopus)
314 Downloads (Pure)
2015
55 Citations (Scopus)
2013
95 Citations (Scopus)
24 Citations (Scopus)
2012

Nrf2 orchestrates fuel partitioning for cell proliferation

Hayes, J. D. & Ashford, M. L. J., 2012, In : Cell Metabolism. 16, 2, p. 139-141 3 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2014

3-(2-oxoethylidene)indolin-2-one derivatives activate Nrf2 and inhibit NF-κB: potential candidates for chemoprevention

Nagle, A. A., Reddy, S. A., Bertrand, H., Tajima, H., Dang, T-M., Wong, S-C., Hayes, J. D., Wells, G. & Chew, E-H., 2014, In : ChemMedChem. 9, 8, p. 1763-1774 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2015

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

Bell, K. F. S., Al-Mubarak, B., Martel, M. A., McKay, S., Wheelan, N., Hasel, P., Márkus, N. M., Baxter, P., Deighton, R. F., Serio, A., Bilican, B., Chowdhry, S., Meakin, P. J., Ashford, M. L. J., Wyllie, D. J. A., Scannevin, R. H., Chandran, S., Hayes, J. D. & Hardingham, G. E., 13 May 2015, In : Nature Communications. 6, 15 p., 7066.

Research output: Contribution to journalArticle

74 Citations (Scopus)
2011

Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning

Bell, K. F., Al-Mubarak, B., Fowler, J. H., Baxter, P. S., Gupta, K., Tsujita, T., Chowdhry, S., Patani, R., Chandran, S., Horsburgh, K., Hayes, J. D. & Hardingham, G. E., 4 Jan 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 1, p. E1-E2 2 p.

Research output: Contribution to journalLetter

92 Citations (Scopus)
2019
2 Citations (Scopus)
2012

Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction

Hancock, R., Bertrand, H. C., Tsujita, T., Naz, S., El-Bakry, A., Laoruchupong, J., Hayes, J. D. & Wells, G., 15 Jan 2012, In : Free Radical Biology and Medicine. 52, 2, p. 444-451 8 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)
2017

Characterization of liver injury, oval cell proliferation and cholangiocarcinogenesis in glutathione S-transferase A3 knockout mice

Crawford, D. R., Ilic, Z., Guest, I., Milne, G. L., Hayes, J. D. & Sell, S., Jul 2017, In : Carcinogenesis. 38, 7, p. 717-727 11 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
138 Downloads (Pure)
2018

A partnership with the proteasome: the destructive nature of GSK3

Robertson, H., Hayes, J. D. & Sutherland, C., Jan 2018, In : Biochemical Pharmacology. 147, p. 77-92 16 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
187 Downloads (Pure)
Open Access
File
42 Citations (Scopus)
145 Downloads (Pure)
2017
Open Access
File
6 Citations (Scopus)
274 Downloads (Pure)
2015

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T. & Hayes, J. D., Nov 2015, In : Free Radical Biology and Medicine. 88, Part B, p. 108-146 39 p.

Research output: Contribution to journalArticle

305 Citations (Scopus)
2019

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

Cuadrado, A., Rojo, A. I., Wells, G., Hayes, J., Cousin, S. P., Rumsey, W. L., Attucks, O. C., Franklin, S., Levonen, A-L., Kensler, T. W. & Dinkova-Kostova, A., Apr 2019, In : Nature Reviews Drug Discovery. 18, 4, p. 295-317 23 p.

Research output: Contribution to journalReview article

Open Access
File
133 Citations (Scopus)
204 Downloads (Pure)
2013

RXRα Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2

Wang, H., Liu, K., Geng, M., Gao, P., Wu, X., Hai, Y., Li, Y., Li, Y., Luo, L., Hayes, J. D., Wang, X. J. & Tang, X., 2013, In : Cancer Research. 73, 10, p. 3097-3108 12 p.

Research output: Contribution to journalArticle

121 Citations (Scopus)