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  • Michael Ferguson
2012

Deep evolutionary conservation of an intramolecular protein kinase activation mechanism

Han, J., Luebbering, N., Cleghon, V., Miranda-Saavedra, D., Singh, A., Sibbet, G. & Ferguson, M. A. J., 3 Jan 2012, In : PLoS ONE. 7, 1, e29702.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2015

Identification of a glycosylphosphatidylinositol anchor-modifying β1-3 galactosyltransferase in Trypanosoma brucei

Izquierdo, L., Acosta-Serrano, A., Mehlert, A. & Ferguson, M. A. J., 2015, In : Glycobiology. 25, 4, p. 438-447 50 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2011

Chemical structure of Trichomonas vaginalis surface lipoglycan: a role for short galactose (beta 1-4/3) N-acetylglucosamine repeats in host cell interaction

Ryan, C. M., Mehlert, A., Richardson, J. M., Ferguson, M. A. J. & Johnson, P. J., 25 Nov 2011, In : Journal of Biological Chemistry. 286, 47, p. 40494-40508 15 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Drug discovery initiative at the University of Dundee: hit-to-lead development for hat and generation of chemical tools

Grimaldi, R., Urich, R., Sienkiewicz, N., Woodland, A., Urbaniak, M. D., Mathieson, T., Eberhard, D., Bantscheff, M., Drewes, G., Ferguson, M. A. J., Gilbert, I. H., Frearson, J. A., Wyatt, P. G. & Fairlamb, A. H., 2011, In : Tropical Medicine & International Health. 16, S.1, p. 212 1 p., 1.3-148.

Research output: Contribution to journalMeeting abstract

2016

Global membrane protein interactome analysis using in vivo crosslinking and MS-based protein correlation profiling

Larance, M., Kirkwood, K. J., Tinti, M., Brenes Murillo, A., Ferguson, M. & Lamond, A., 1 Jul 2016, In : Molecular & Cellular Proteomics. 15, 7, p. 2476-2490 15 p.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
122 Downloads (Pure)
2013

The Scales of Life

Shemilt, E. & Ferguson, M., Sep 2013

Research output: Non-textual formArtefact

4 Citations (Scopus)
2 Downloads (Pure)

A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei

Urbaniak, M. D., Collie, I. T., Fang, W., Aristotelous, T., Eskilsson, S., Raimi, O. G., Harrison, J., Navratilova, I. H., Frearson, J. A., van Aalten, D. M. F. & Ferguson, M. A. J., 20 Sep 2013, In : ACS Chemical Biology. 8, 9, p. 1981-1987 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
101 Citations (Scopus)
2014
Open Access
File
32 Citations (Scopus)
91 Downloads (Pure)
2012

The lipid-linked oligosaccharide donor specificities of Trypanosoma brucei oligosaccharyltransferases

Izquierdo, L., Mehlert, A. & Ferguson, M. A. J., May 2012, In : Glycobiology. 22, 5, p. 696-703 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2013

Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design

Pizarro, J. C., Hills, T., Senisterra, G., Wernimont, A. K., Mackenzie, C., Norcross, N. R., Ferguson, M. A. J., Wyatt, P. G., Gilbert, I. H. & Hui, R., 17 Oct 2013, In : PLoS Neglected Tropical Diseases. 7, 10, e2492.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
131 Downloads (Pure)
2011

Protein O-GlcNAcylation is required for fibroblast growth factor signaling in Drosophila

Mariappa, D., Sauert, K., Marino, K., Turnock, D., Webster, R., van Aalten, D. M. F., Ferguson, M. A. J. & Muller, H. A. J., 20 Dec 2011, In : Science Signaling. 4, 204, p. - 8 p., ra89.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2015

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei

Shameer, S., Logan-Klumpler, F. J., Vinson, F., Cottret, L., Merlet, B., Achcar, F., Boshart, M., Berriman, M., Breitling, R., Bringaud, F., Bütikofer, P., Cattanach, A. M., Bannerman-Chukualim, B., Creek, D. J., Crouch, K., de Koning, H. P., Denise, H., Ebikeme, C., Fairlamb, A. H., Ferguson, M. A. J. & 21 others, Ginger, M. L., Hertz-Fowler, C., Kerkhoven, E. J., Mäser, P., Michels, P. A. M., Nayak, A., Nes, D. W., Nolan, D. P., Olsen, C., Silva-Franco, F., Smith, T. K., Taylor, M. C., Tielens, A. G. M., Urbaniak, M. D., van Hellemond, J. J., Vincent, I. M., Wilkinson, S. R., Wyllie, S., Opperdoes, F. R., Barrett, M. P. & Jourdan, F., 28 Jan 2015, In : Nucleic Acids Research. 43, D1, p. D637-D644 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2016

A gene of the β3-glycosyltransferase family encodes N-acetylglucosaminyltransferase II function in Trypanosoma brucei

Damerow, M., Graalfs, F., Guther, M. L. S., Mehlert, A., Izquierdo, L. & Ferguson, M. A. J., 24 Jun 2016, In : Journal of Biological Chemistry. 291, 26, p. 13834-13845 12 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
149 Downloads (Pure)
2019

Reprogramming of Trypanosoma cruzi metabolism triggered by parasite interaction with the host cell extracellular matrix

Mattos, E. C., Canuto, G., Varón, N. C. M., Magalhães, R. D. M., Crozier, T. W. M., Lamont, D. J., Tavares, M. F. M., Colli, W., Ferguson, M. A. J. & Alves, M. J. M., 6 Feb 2019, In : PLoS Neglected Tropical Diseases. 13, 2, p. 1-27 27 p., e0007103.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
117 Downloads (Pure)

Trypanosoma cruzi phosphomannomutase and guanosine diphosphate-mannose pyrophosphorylase ligandability assessment

Zmuda, F., Shepherd, S. M., Ferguson, M. A. J., Gray, D. W., Torrie, L. S. & De Rycker, M., Oct 2019, In : Antimicrobial Agents and Chemotherapy. 63, 10, p. 1-11 11 p., e01082-19.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
83 Downloads (Pure)
2011

Systematic review of performance of non-invasive biomarkers in the evaluation of non-alcoholic fatty liver disease

Miller, M. H., Ferguson, M. A. J. & Dillon, J. F., Apr 2011, In : Liver International. 31, 4, p. 461-473 13 p.

Research output: Contribution to journalReview article

37 Citations (Scopus)
2019

Para-site-seeing: Departure Lounge: LifeSpace science art reserach gallery, University of Dundee

Floyd, A., Yeoman, H., Southern, J., Dillon, R., Cook, S., Fairlamb, A., Ferguson, M., Horn, D., MacLean, L., Manthri, S., Paterson, C., Pearson, L., Prescott, A., Read, K., Shastry, L., Svensen, N. & Thomas, J., 2019

Research output: Non-textual formExhibition

2015

Depletion of UDP-Glucose and UDP-Galactose Using a Degron System Leads to Growth Cessation of Leishmania major

Damerow, S., Hoppe, C., Bandini, G., Zarnovican, P., Buettner, F. R., Lüder, C. G. K., Ferguson, M. A. J. & Routier, F. H., 3 Nov 2015, In : PLoS Neglected Tropical Diseases. 9, 11, e0004205.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
120 Downloads (Pure)
2014
Open Access
File
53 Citations (Scopus)
132 Downloads (Pure)
2013

Creation and characterization of glycosyltransferase mutants of trypanosoma brucei

Izquierdo, L., Güther, M. L. S. & Ferguson, M. A. J., 2013, Glycosyltransferases. Brockhausen, I. (ed.). Humana Press, p. 249-275 27 p. (Methods in Molecular Biology; vol. 1022).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

6 Citations (Scopus)
2012

Chemical Proteomic Analysis Reveals the Drugability of the Kinome of Trypanosoma brucei

Urbaniak, M. D., Mathieson, T., Bantscheff, M., Eberhard, D., Grimaldi, R., Miranda-Saavedra, D., Wyatt, P., Ferguson, M. A. J., Frearson, J. & Drewes, G., 2012, In : ACS Chemical Biology. 7, 11, p. 1858-1865 8 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)
2014

Probing the substrate specificity of Trypanosoma brucei GlcNAc-PI de-N-acetylase with synthetic substrate analogues

Capes, A. S., Crossman, A., Urbaniak, M. D., Gilbert, S. H., Ferguson, M. A. J. & Gilbert, I. H., Mar 2014, In : Organic and Biomolecular Chemistry. 12, 12, p. 1919-1934 16 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
160 Downloads (Pure)
2011

Application of novel method to quantify akt phosphorylation in breast cancer

Thompson, A., Atrih, A., Quinlan, P. R., Bray, S., Ferguson, M. & Huang, J., May 2011, In : Annals of Oncology. 22, S2, p. ii38-iii38 1 p., 65P.

Research output: Contribution to journalMeeting abstract

2012

Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages

Urbaniak, M. D., Guther, M. L. S. & Ferguson, M. A. J., 2012, In : PLoS ONE. 7, 5, p. - 8 p., e36619.

Research output: Contribution to journalArticle

105 Citations (Scopus)
2011

Characterization, localization, essentiality, and high-resolution crystal structure of glucosamine 6-phosphate N-acetyltransferase from Trypanosoma brucei

Marino, K., Guther, M. L. S., Wernimont, A. K., Qiu, W., Hui, R. & Ferguson, M. A. J., Jul 2011, In : Eukaryotic Cell. 10, 7, p. 985-997 13 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2017
Open Access
File
4 Citations (Scopus)
181 Downloads (Pure)
2012

The de novo and salvage pathways of GDP-mannose biosynthesis are both sufficient for the growth of bloodstream-form Trypanosoma brucei

Kuettel, S., Wadum, M. C. T., Guther, M. L. S., Marino, K., Riemer, C. & Ferguson, M. A. J., Apr 2012, In : Molecular Microbiology. 84, 2, p. 340-351 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2020

Treating age-related multimorbidity: the drug discovery challenge

Ermogenous, C., Green, C., Jackson, T., Ferguson, M. & Lord, J. M., 20 Jun 2020, In : Drug Discovery Today. 13 p.

Research output: Contribution to journalReview article

Open Access
2015

Parasite Glycobiology: A Bittersweet Symphony

Rodrigues, J. A., Acosta-Serrano, A., Aebi, M., Ferguson, M. A. J., Routier, F. H., Schiller, I., Soares, S., Spencer, D., Titz, A., Wilson, I. B. H. & Izquierdo, L., 12 Nov 2015, In : PLoS Pathogens. 11, 11, e1005169.

Research output: Contribution to journalReview article

Open Access
File
19 Citations (Scopus)
119 Downloads (Pure)
2011

Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei

Abdelwahab, N. Z., Urbaniak, M. D., Ferguson, M. A. J. & Crossman, A. T., 1 May 2011, In : Carbohydrate Research. 346, 6, p. 708-714 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2016

Proteomic identification of immunodiagnostic antigens for Trypanosoma vivax infections in cattle and generation of a proof-of-concept lateral flow test diagnostic device

Fleming, J. R., Sastry, L., Wall, S. J., Sullivan, L. & Ferguson, M. A. J., 8 Sep 2016, In : PLoS Neglected Tropical Diseases. 10, 9, 11 p., e0004977.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
165 Downloads (Pure)
2018

African trypanosomes evade immune clearance by O-glycosylation of the VSG surface coat

Pinger, J., Nešić, D., Ali, L., Aresta-Branco, F., Lilic, M., Chowdhury, S., Kim, H. S., Verdi, J., Raper, J., Ferguson, M. A. J., Papavasiliou, F. N. & Stebbins, C. E., Aug 2018, In : Nature Microbiology. 3, 8, p. 932-938 7 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
242 Downloads (Pure)
2012

Modeling of the N-Glycosylated Transferrin Receptor Suggests How Transferrin Binding Can Occur within the Surface Coat of Trypanosoma brucei

Mehlert, A., Wormald, M. R. & Ferguson, M. A. J., Apr 2012, In : PLoS Pathogens. 8, 4, p. - 11 p., e1002618.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2011

Novel non-invasive scoring system for the detection of NASH from a NAFLD population

Miller, M., Jafferbhoy, H., Crowther, D., Walsh, S., Ferguson, M. A. & Dillon, J. F., Oct 2011, In : Hepatology. 54, p. 1113A-1113A 1 p.

Research output: Contribution to journalMeeting abstract

1 Citation (Scopus)
2013

Genetic and structural validation of Aspergillus fumigatus N-acetylphosphoglucosamine mutase as an antifungal target

Fang, W., Du, T., Raimi, O. G., Hurtado-Guerrero, R., Mariño, K., Ibrahim, A. F. M., Albarbarawi, O., Ferguson, M. A. J., Jin, C. & Van Aalten, D. M. F., 11 Jul 2013, In : Bioscience Reports. 33, 5, 11 p., e00063.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2018

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

Wyllie, S., Thomas, M., Patterson, S., Crouch, S., De Rycker, M., Lowe, R., Gresham, S., Urbaniak, M. D., Otto, T. D., Stojanovski, L., Simeons, F. R. C., Manthri, S., MacLean, L. M., Zuccotto, F., Homeyer, N., Pflaumer, H., Boesche, M., Sastry, L., Connolly, P., Albrecht, S. & 12 others, Berriman, M., Drewes, G., Gray, D. W., Ghidelli-Disse, S., Dixon, S., Fiandor, J. M., Wyatt, P. G., Ferguson, M. A. J., Fairlamb, A. H., Miles, T. J., Read, K. D. & Gilbert, I. H., 9 Aug 2018, In : Nature. 560, 7717, p. 192-197 6 p.

Research output: Contribution to journalArticle

Open Access
File
34 Citations (Scopus)
447 Downloads (Pure)
2014
Open Access
File
3 Citations (Scopus)
148 Downloads (Pure)
2017

Fluorescent mannosides serve as acceptor substrates for glycosyltransferase and sugar-1-phosphate transferase activities in Euglena gracilis membranes

Ivanova, I. M., Nepogodiev, S. A., Saalbach, G., O'Neill, E. C., Urbaniak, M. D., Ferguson, M. A. J., Gurcha, S. S., Besra, G. S. & Field, R. A., 13 Jan 2017, In : Carbohydrate Research. 438, p. 26-38 13 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
130 Downloads (Pure)
2018

N-glycan microheterogeneity regulates interactions of plasma proteins

Wu, D., Struwe, W. B., Harvey, D. J., Ferguson, M. A. J. & Robinson, C. V., 28 Aug 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 35, p. 8763-8768 6 p., 201807439.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
127 Downloads (Pure)
2017
Open Access
File
137 Citations (Scopus)
297 Downloads (Pure)
2012

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

Brand, S., Cleghorn, L. A. T., McElroy, S. P., Robinson, D. A., Smith, V. C., Hallyburton, I., Harrison, J. R., Norcross, N. R., Spinks, D., Bayliss, T., Norval, S., Stojanovski, L., Torrie, L. S., Frearson, J. A., Brenk, R., Fairlamb, A. H., Ferguson, M. A. J., Read, K. D., Wyatt, P. G. & Gilbert, I. H., 12 Jan 2012, In : Journal of Medicinal Chemistry. 55, 1, p. 140-152 13 p.

Research output: Contribution to journalArticle

Open Access
File
76 Citations (Scopus)
442 Downloads (Pure)
2013

Structure of a complex phosphoglycan epitope from gp72 of Trypanosoma cruzi

Allen, S., Richardson, J. M., Mehlert, A. & Ferguson, M. A. J., 19 Apr 2013, In : Journal of Biological Chemistry. 288, 16, p. 11093-11105 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2012

Inhibitors incorporating zinc-binding groups target the GlcNAc-PI de-N-acetylase in Trypanosoma brucei, the causative agent of African sleeping sickness

Abdelwahab, N. Z., Crossman, A. T., Sullivan, L., Ferguson, M. A. J. & Urbaniak, M. D., Mar 2012, In : Chemical Biology & Drug Design. 79, 3, p. 270-278 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2018

The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei

Kelner, A., Tinti, M., Guther, M., Foth, B. J., Chappell, L., Berriman, M., Cowling, V. & Ferguson, M., 24 Jul 2018, In : PLoS ONE. 13, 7, p. 1-14 14 p., e0201263.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
122 Downloads (Pure)
2011

Probing Elongating and Branching beta-D-Galactosyltransferase Activities in Leishmania Parasites by Making Use of Synthetic Phosphoglycans

Sizova, O. V., Ross, A. J., Ivanova, I. A., Borodkin, V. S., Ferguson, M. A. J. & Nikolaev, A. V., Jun 2011, In : ACS Chemical Biology. 6, 6, p. 648-657 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Investigation of copper(II) tetrafluoroborate catalysed epoxide opening

Capes, A. S., Crossman, A. T., Webster, L. A., Ferguson, M. A. J. & Gilbert, I. H., 28 Dec 2011, In : Tetrahedron Letters. 52, 52, p. 7091-7094 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
13 Downloads (Pure)
2012

Phosphoglucomutase is absent in Trypanosoma brucei and redundantly substituted by phosphomannomutase and phospho-N-acetylglucosamine mutase

Bandini, G., Marino, K., Güther, M. L. S., Wernimont, A. K., Kuettel, S., Qiu, W., Afzal, S., Kelner, A., Hui, R. & Ferguson, M. A. J., 2012, In : Molecular Microbiology. 85, 3, p. 513-534 22 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2014

Evaluation of the diagnostic accuracy of prototype rapid tests for human African trypanosomiasis

Sternberg, J. M., Gierlinski, M., Biéler, S., Ferguson, M. A. J. & Ndung'u, J. M., Dec 2014, In : PLoS Neglected Tropical Diseases. 8, 12, p. e3373 8 p.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
156 Downloads (Pure)