Find Research Outputs

Search in all content

Filters for Research Outputs

Search concepts
Selected filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2014
  • 2013
  • 2012
  • 2011

Author

  • Leeanne McGurk
2011

Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: Loss of ADAR1 in insects

Keegan, L. P., McGurk, L., Palavicini, J. P., Brindle, J., Paro, S., Li, X., Rosenthal, J. J. C. & O'Connell, M. A., 1 Sep 2011, In : Nucleic Acids Research. 39, 16, p. 7249-7262 14 p.

Research output: Contribution to journalArticle

Open Access
File
34 Citations (Scopus)
57 Downloads (Pure)

Yeast informs Alzheimer's disease

McGurk, L. & Bonini, N. M., 2 Dec 2011, In : Science. 334, 6060, p. 1212-1213 2 p.

Research output: Contribution to journalShort survey

7 Citations (Scopus)
2012
Open Access
File
16 Citations (Scopus)
56 Downloads (Pure)
2014

Poly-A binding protein-1 localization to a subset of TDP-43 inclusions in amyotrophic lateral sclerosis occurs more frequently in patients harboring an expansion in C9orf72

McGurk, L., Lee, V. M., Trojanowksi, J. Q., Van Deerlin, V. M., Lee, E. B. & Bonini, N. M., 1 Sep 2014, In : Journal of Neuropathology and Experimental Neurology. 73, 9, p. 837-845 9 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

Kim, H. J., Raphael, A. R., Ladow, E. S., Mcgurk, L., Weber, R. A., Trojanowski, J. Q., Lee, V. M. Y., Finkbeiner, S., Gitler, A. D. & Bonini, N. M., Feb 2014, In : Nature Genetics. 46, 2, p. 152-160 9 p.

Research output: Contribution to journalArticle

199 Citations (Scopus)
2018

Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis

McGurk, L., Mojsilovic-Petrovic, J., Van Deerlin, V. M., Shorter, J., Kalb, R. G., Lee, V. M., Trojanowski, J. Q., Lee, E. B. & Bonini, N. M., 29 Aug 2018, In : Acta Neuropathologica Communications. 6, 1, p. 1-15 15 p., 84.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
57 Downloads (Pure)

Poly(ADP-ribose) Engages the TDP-43 Nuclear-Localization Sequence to Regulate Granulo-Filamentous Aggregation

McGurk, L., Gomes, E., Guo, L., Shorter, J. & Bonini, N. M., 26 Dec 2018, In : Biochemistry. 57, 51, p. 6923-6926 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization

McGurk, L., Gomes, E., Guo, L., Mojsilovic-Petrovic, J., Tran, V., Kalb, R. G., Shorter, J. & Bonini, N. M., 6 Sep 2018, In : Molecular Cell. 71, 5, p. 703-717.e9 24 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)
2019

Poly(ADP-Ribosylation) in Age-Related Neurological Disease

McGurk, L., Rifai, O. M. & Bonini, N. M., Aug 2019, In : Trends in Genetics. 35, 8, p. 601-613 13 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)
2020

Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila

Deng, P., Khan, A., Jacobson, D., Sambrani, N., McGurk, L., Li, X., Jayasree, A., Hejatko, J., Shohat-Ophir, G., O'Connell, M. A., Li, J. B. & Keegan, L. P., 27 Mar 2020, In : Nature Communications. 11, 1, p. 1580 1580.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
36 Downloads (Pure)

First person - Leeanne McGurk

McGurk, L., Jun 2020, In : Journal of Cell Science. 133, 12, 2 p., jcs.248773.

Research output: Contribution to journalComment/debate

Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy

Khan, A., Paro, S., McGurk, L., Sambrani, N., Hogg, M. C., Brindle, J., Pennetta, G., Keegan, L. P. & O'Connell, M. A., 14 Feb 2020, In : BMC Biology. 18, 1, 16 p., 15.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
42 Downloads (Pure)

TDP-43, a protein central to amyotrophic lateral sclerosis, is destabilized by tankyrase-1 and -2

McGurk, L., Rifai, O. & Bonini, N. M., 23 Jun 2020, In : Journal of Cell Science. 133, 12

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
17 Downloads (Pure)